Published in Retrovirology on May 28, 2012
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. Nature (2015) 1.83
Eradicating HIV-1 infection: seeking to clear a persistent pathogen. Nat Rev Microbiol (2014) 1.65
New generation humanized mice for virus research: comparative aspects and future prospects. Virology (2013) 1.38
Targeted cytotoxic therapy kills persisting HIV infected cells during ART. PLoS Pathog (2014) 1.32
Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells. Clin Exp Immunol (2013) 1.13
Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice. PLoS Pathog (2013) 1.08
Macrophages sustain HIV replication in vivo independently of T cells. J Clin Invest (2016) 1.04
HIV restriction by APOBEC3 in humanized mice. PLoS Pathog (2013) 1.00
BLT humanized mice as a small animal model of HIV infection. Curr Opin Virol (2015) 1.00
HIV-1 Nef: a multifaceted modulator of T cell receptor signaling. Cell Commun Signal (2012) 0.99
HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice. J Virol (2014) 0.94
Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice. PLoS One (2013) 0.93
Small molecule inhibitors of the HIV-1 virulence factor, Nef. Drug Discov Today Technol (2013) 0.90
The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex. J Virol (2014) 0.90
In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis. Retrovirology (2013) 0.86
An AAV vector-mediated gene delivery approach facilitates reconstitution of functional human CD8+ T cells in mice. PLoS One (2014) 0.85
Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix. Retrovirology (2012) 0.85
Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen. Retrovirology (2013) 0.83
Studies of retroviral infection in humanized mice. Virology (2015) 0.83
Synthesis and structure-activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor. Bioorg Med Chem Lett (2014) 0.81
In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection. Retrovirology (2016) 0.80
Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency. PLoS One (2014) 0.80
The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner. J Biol Chem (2014) 0.80
In vivo analysis of Nef's role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss. Retrovirology (2015) 0.79
Impacts of humanized mouse models on the investigation of HIV-1 infection: illuminating the roles of viral accessory proteins in vivo. Viruses (2015) 0.78
APOBEC3G and APOBEC3F Act in Concert To Extinguish HIV-1 Replication. J Virol (2016) 0.78
Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdA. PLoS One (2016) 0.77
HIV-specific CD8⁺ T-cell immunity in humanized bone marrow-liver-thymus mice. J Infect Dis (2013) 0.77
Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Dimerization in AP-2 Recruitment and CD4 downregulation. J Biol Chem (2016) 0.75
Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms. Retrovirology (2013) 0.75
Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep (2017) 0.75
Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell (1991) 13.69
Changes in thymic function with age and during the treatment of HIV infection. Nature (1998) 10.27
New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol (2003) 8.25
Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med (1995) 8.15
Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med (2008) 5.81
Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI. Virology (1991) 5.54
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat Med (2006) 5.36
The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J Exp Med (1994) 5.22
Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1. J Exp Med (2007) 3.75
Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study. J Infect Dis (2009) 3.48
Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell (1998) 3.22
Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J (1993) 3.13
Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice. Proc Natl Acad Sci U S A (2006) 3.07
Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood (2006) 2.94
HIV-1 pathogenesis. Nat Med (2003) 2.88
HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation. Immunity (2004) 2.86
Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes. AIDS Res Hum Retroviruses (1994) 2.72
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol (2009) 2.70
Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J Virol (1994) 2.45
Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection. J Virol (2005) 2.05
Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor. J Virol (1998) 1.99
Evidence for increased T cell turnover and decreased thymic output in HIV infection. J Immunol (2001) 1.97
Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice. PLoS One (2010) 1.88
Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J Virol (1996) 1.80
Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1. J Virol (1990) 1.70
Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1. N Engl J Med (1999) 1.69
Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses. J Virol (2007) 1.58
Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc Natl Acad Sci U S A (2007) 1.56
RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther (2009) 1.55
Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation. AIDS (2003) 1.50
Humanized mouse models of HIV infection. AIDS Rev (2011) 1.49
Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo. J Virol (1999) 1.43
A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS One (2011) 1.43
Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. J Virol (2006) 1.41
Mechanisms of HIV-associated lymphocyte apoptosis: 2010. Cell Death Dis (2010) 1.40
T-cell repopulation and thymic volume in HIV-1-infected adult patients after highly active antiretroviral therapy. Blood (2002) 1.39
HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein. J Biol Chem (2008) 1.38
Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rgammanull mice. Hum Immunol (2010) 1.35
Chicken ovalbumin upstream promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type 1 long terminal repeat. J Virol (1991) 1.31
Characterization of three nef-defective human immunodeficiency virus type 1 strains associated with long-term nonprogression. Australian Long-Term Nonprogressor Study Group. J Virol (2000) 1.29
Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source. J Virol (2006) 1.19
Lentivirus Nef specifically activates Pak2. J Virol (2000) 1.18
Activation of the human immunodeficiency virus type 2 enhancer is dependent on purine box and kappa B regulatory elements. J Virol (1992) 1.17
Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo. Retrovirology (2007) 1.17
Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism. J Virol (2008) 1.15
Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice. J Virol (2012) 1.14
Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection. Blood (2007) 1.13
Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol (2003) 1.11
Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection. Retrovirology (2008) 1.10
Regions of human immunodeficiency virus type 1 nef required for function in vivo. J Virol (1998) 1.09
Identification of attenuated variants of HIV-1 circulating recombinant form 01_AE that are associated with slow disease progression due to gross genetic alterations in the nef/long terminal repeat sequences. J Infect Dis (2005) 1.07
Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice. J Virol (2012) 1.05
Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort. J Infect Dis (1999) 1.03
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Blood (2005) 1.02
TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF. J Virol (2005) 1.01
Separation of human immunodeficiency virus type 1 replication from nef-mediated pathogenesis in the human thymus. J Virol (2001) 1.00
HIV-1 and the thymus. AIDS (1997) 0.98
R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4+ T-cell cultures than X4 HIV-1. J Virol (2004) 0.98
Disease progression due to dual infection in an HLA-B57-positive asymptomatic long-term nonprogressor infected with a nef-defective HIV-1 strain. Virology (2010) 0.97
Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element. Structure (2008) 0.93
Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo. Retrovirology (2009) 0.91
Vpr-host interactions during HIV-1 viral life cycle. J Neuroimmune Pharmacol (2011) 0.90
The Sydney Blood Bank Cohort: implications for viral fitness as a cause of elite control. Curr Opin HIV AIDS (2011) 0.88
Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice. Virol J (2011) 0.82
CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection. Virology (2006) 0.79
Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med (2008) 5.81
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat Med (2006) 5.36
Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1. J Exp Med (2007) 3.75
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature (2009) 3.18
Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A (2004) 2.75
Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A (2007) 2.44
Inhibition of endosomal/lysosomal degradation increases the infectivity of human immunodeficiency virus. J Virol (2002) 2.43
Generation of HIV latency in humanized BLT mice. J Virol (2011) 2.20
Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest (2013) 2.15
Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection. J Virol (2005) 2.05
Dengue fever in humanized NOD/SCID mice. J Virol (2005) 1.96
HIV-1 Nef: at the crossroads. Retrovirology (2008) 1.88
Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice. PLoS One (2010) 1.88
Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model. Cell Host Microbe (2010) 1.77
RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J Immunol (2009) 1.73
Production of transgenic rats by lentiviral transduction of male germ-line stem cells. Proc Natl Acad Sci U S A (2002) 1.68
Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci U S A (2010) 1.67
Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission. PLoS Pathog (2015) 1.61
Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol (2004) 1.60
Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol (2008) 1.58
Nef: agent of cell subversion. Microbes Infect (2002) 1.41
Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. J Virol (2006) 1.41
Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. J Virol (2007) 1.40
Novel humanized murine models for HIV research. Curr HIV/AIDS Rep (2009) 1.40
Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine. Dig Dis Sci (2014) 1.38
Molecular mechanisms of autosomal recessive hypercholesterolemia. Hum Mol Genet (2002) 1.33
Human breast milk and antiretrovirals dramatically reduce oral HIV-1 transmission in BLT humanized mice. PLoS Pathog (2012) 1.30
Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus. J Virol (2004) 1.24
Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors. Blood (2003) 1.23
Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection. J Reprod Immunol (2011) 1.22
Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun (2012) 1.18
Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice. Trends Microbiol (2012) 1.15
Development and activation of human dendritic cells in vivo in a xenograft model of human hematopoiesis. Stem Cells (2005) 1.14
Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. Proc Natl Acad Sci U S A (2010) 1.11
Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse. J Virol (2011) 1.11
A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2. J Virol (2006) 1.10
Mechanisms of HIV-1 Nef function and intracellular signaling. J Neuroimmune Pharmacol (2011) 1.04
Macrophages sustain HIV replication in vivo independently of T cells. J Clin Invest (2016) 1.04
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med (2009) 1.04
Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol (2008) 1.01
Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp. Infect Immun (2007) 1.01
Role of Nef in HIV-1 replication and pathogenesis. Adv Pharmacol (2007) 1.00
HIV restriction by APOBEC3 in humanized mice. PLoS Pathog (2013) 1.00
In vivo analysis of Nef function. Curr HIV Res (2003) 1.00
Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun (2010) 0.97
M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery. Eur J Immunol (2011) 0.97
Cryptopatches are essential for the development of human GALT. Cell Rep (2013) 0.96
Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock. Am J Physiol Heart Circ Physiol (2004) 0.96
Antigen-sampling cells in the salmonid intestinal epithelium. Dev Comp Immunol (2010) 0.94
HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice. J Virol (2014) 0.94
Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice. PLoS One (2013) 0.93
New horizon of mucosal immunity and vaccines. Curr Opin Immunol (2009) 0.93
NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis. J Immunol (2014) 0.92
Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation. J Virol (2005) 0.92
CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable. Virology (2006) 0.92
Inefficient vaginal transmission of tenofovir-resistant HIV-1. J Virol (2012) 0.91
Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol J (2013) 0.91
The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J Immunol (2011) 0.90
Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain. J Virol (2008) 0.89
Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun (2013) 0.87
A cluster of virus-encoded microRNAs accelerates acute systemic Epstein-Barr virus infection but does not significantly enhance virus-induced oncogenesis in vivo. J Virol (2013) 0.87
In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis. Retrovirology (2013) 0.86
The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest. DNA Cell Biol (2008) 0.85
Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix. Retrovirology (2012) 0.85
Self-association of the Lentivirus protein, Nef. Retrovirology (2010) 0.84
Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine (2009) 0.84
In vivo fluorescent labeling of corneal wound healing fibroblasts. Exp Eye Res (2003) 0.83
Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex. J Virol (2005) 0.83
RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine. Vaccine (2012) 0.82
HIV pathogenesis: Nef loses control. Cell (2006) 0.81
HIV-1 transcriptional activity during frequent longitudinal sampling in aviremic patients on antiretroviral therapy. AIDS (2016) 0.81