Published in Blood on January 12, 2006
Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med (2008) 5.81
Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer (2012) 2.76
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol (2009) 2.70
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe (2011) 2.59
Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol (2014) 2.28
A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood (2009) 2.25
Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood (2011) 2.24
Generation of HIV latency in humanized BLT mice. J Virol (2011) 2.20
Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice. PLoS One (2010) 1.88
An effective approach to prevent immune rejection of human ESC-derived allografts. Cell Stem Cell (2014) 1.73
Human hemato-lymphoid system mice: current use and future potential for medicine. Annu Rev Immunol (2013) 1.70
Eradicating HIV-1 infection: seeking to clear a persistent pathogen. Nat Rev Microbiol (2014) 1.65
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood (2008) 1.60
BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection. Blood (2013) 1.57
RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther (2009) 1.55
Renaissance for mouse models of human hematopoiesis and immunobiology. Nat Immunol (2009) 1.54
Humanized mouse models of HIV infection. AIDS Rev (2011) 1.49
Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells. PLoS One (2011) 1.41
Novel humanized murine models for HIV research. Curr HIV/AIDS Rep (2009) 1.40
Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all. J Mol Biol (2013) 1.39
New generation humanized mice for virus research: comparative aspects and future prospects. Virology (2013) 1.38
Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rgammanull mice. Hum Immunol (2010) 1.35
A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med (2012) 1.27
CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol (2010) 1.27
Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ(-/-) (NSG) BLT mice. Virology (2011) 1.23
Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection. J Reprod Immunol (2011) 1.22
Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice. Sci Transl Med (2012) 1.21
Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs. J Immunol (2010) 1.18
Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice. Trends Microbiol (2012) 1.15
Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes. Retrovirology (2012) 1.14
Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells. Clin Exp Immunol (2013) 1.13
PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads. PLoS One (2013) 1.09
IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice. Mucosal Immunol (2012) 1.09
Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology (2011) 1.08
Generation of improved humanized mouse models for human infectious diseases. J Immunol Methods (2014) 1.08
Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice. J Virol (2012) 1.05
HIV-1 immunopathogenesis in humanized mouse models. Cell Mol Immunol (2012) 1.03
Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice. PLoS One (2012) 1.01
Analysis of the CD1 antigen presenting system in humanized SCID mice. PLoS One (2011) 1.00
BLT humanized mice as a small animal model of HIV infection. Curr Opin Virol (2015) 1.00
Mouse models with human immunity and their application in biomedical research. J Cell Mol Med (2008) 0.99
Humanized hemato-lymphoid system mice. Haematologica (2016) 0.98
Cryptopatches are essential for the development of human GALT. Cell Rep (2013) 0.96
Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther (2013) 0.95
Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci (2010) 0.94
Human natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model. J Immunol (2011) 0.94
Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice. PLoS One (2013) 0.93
Humoral immunity in humanized mice: a work in progress. J Infect Dis (2013) 0.92
Humanized mice for the study of infectious diseases. Curr Opin Immunol (2013) 0.92
Full reconstitution of human platelets in humanized mice after macrophage depletion. Blood (2012) 0.91
Human immune responses and potential for vaccine assessment in humanized mice. Curr Opin Immunol (2013) 0.89
Induction of human T-cell tolerance to pig xenoantigens via thymus transplantation in mice with an established human immune system. Am J Transplant (2009) 0.89
Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans. Hypertension (2016) 0.89
Electron tomography of HIV-1 infection in gut-associated lymphoid tissue. PLoS Pathog (2014) 0.88
Cancer stem cell targeted therapy: progress amid controversies. Oncotarget (2015) 0.88
In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis. Retrovirology (2013) 0.86
Xenotransplantation as a model of integrated, multidisciplinary research. Organogenesis (2009) 0.86
An AAV vector-mediated gene delivery approach facilitates reconstitution of functional human CD8+ T cells in mice. PLoS One (2014) 0.85
Humanized mice for studying human leukocyte integrins in vivo. Methods Mol Biol (2012) 0.85
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. Transpl Immunol (2008) 0.84
BLT humanized mice as model to study HIV vaginal transmission. J Infect Dis (2013) 0.84
Failure of effector function of human CD8+ T Cells in NOD/SCID/JAK3⁻/⁻ immunodeficient mice transplanted with human CD34+ hematopoietic stem cells. PLoS One (2010) 0.84
CD47 in xenograft rejection and tolerance induction. Xenotransplantation (2010) 0.83
Studies of retroviral infection in humanized mice. Virology (2015) 0.83
Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cells. Cell Mol Immunol (2012) 0.82
Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice. Virol J (2011) 0.82
Modeling Human Leukemia Immunotherapy in Humanized Mice. EBioMedicine (2016) 0.82
Production of bone marrow, liver, thymus (BLT) humanized mice on the C57BL/6 Rag2(-/-)γc(-/-)CD47(-/-) background. J Immunol Methods (2014) 0.81
XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer. Oncogene (2015) 0.81
Co-transplantation of fetal bone tissue facilitates the development and reconstitution in human B cells in humanized NOD/SCID/IL-2Rγnull (NSG) mice. J Clin Immunol (2011) 0.81
Recent advances in humanized mice: accelerating the development of an HIV vaccine. J Infect Dis (2013) 0.81
Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice. Oncotarget (2016) 0.81
Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development. Methods Mol Biol (2014) 0.81
Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts. Transplantation (2008) 0.81
Retracted EBV promotes human CD8 NKT cell development. PLoS Pathog (2010) 0.81
Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases. Inflamm Bowel Dis (2015) 0.80
Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency. PLoS One (2014) 0.80
Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice. Viruses (2013) 0.80
In vivo platforms for analysis of HIV persistence and eradication. J Clin Invest (2016) 0.80
Construction of a live-attenuated HIV-1 vaccine through genetic code expansion. Angew Chem Int Ed Engl (2014) 0.80
Modeling EBV infection and pathogenesis in new-generation humanized mice. Exp Mol Med (2015) 0.80
Humanized mouse models of human cytomegalovirus infection. Curr Opin Virol (2015) 0.79
Improved B cell development in humanized NOD-scid IL2Rγ(null) mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3. Immun Inflamm Dis (2016) 0.79
Humanized Mouse Models of Clinical Disease. Annu Rev Pathol (2016) 0.79
In vivo analysis of Nef's role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss. Retrovirology (2015) 0.79
Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells. Methods Mol Biol (2016) 0.78
Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice. Virology (2014) 0.78
APOBEC3G and APOBEC3F Act in Concert To Extinguish HIV-1 Replication. J Virol (2016) 0.78
Humanized Mouse Models for Transplant Immunology. Am J Transplant (2015) 0.78
Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA.A2 transgene using hematopoietic stem cells purified from different sources. J Immunol Methods (2015) 0.78
Increasing hematopoietic stem cell yield to develop mice with human immune systems. Biomed Res Int (2013) 0.78
Humanized mice for HIV and AIDS research. Curr Opin Virol (2016) 0.78
HIV-specific CD8⁺ T-cell immunity in humanized bone marrow-liver-thymus mice. J Infect Dis (2013) 0.77
Conserved and divergent aspects of human T-cell development and migration in humanized mice. Immunol Cell Biol (2015) 0.77
Novel approaches for immune reconstitution and adaptive immune modeling with human pluripotent stem cells. BMC Med (2011) 0.76
Animal models for viral infection and cell exhaustion. Curr Opin HIV AIDS (2014) 0.76
Animal models in HIV cure research. J Virus Erad (2015) 0.76
CD19xCD3 DART protein mediates human B-cell depletion in vivo in humanized BLT mice. Mol Ther Oncolytics (2016) 0.76
Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy. Stem Cells Dev (2016) 0.76
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med (2004) 3.58
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med (2004) 2.91
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol (2009) 2.70
Transcription-coupled events associating with immunoglobulin switch region chromatin. Science (2003) 2.50
Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood (2011) 2.24
GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett (2009) 2.17
Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection. Hum Pathol (2012) 2.16
Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J Biol Chem (2005) 2.10
A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. Int Immunol (2004) 2.02
The balance between Pax5 and Id2 activities is the key to AID gene expression. J Exp Med (2003) 1.96
Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol (2012) 1.95
Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol (2008) 1.92
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol (2004) 1.85
UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. Int J Clin Oncol (2009) 1.82
Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A (2007) 1.80
Essential role of Id2 in negative regulation of IgE class switching. Nat Immunol (2002) 1.71
ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Am J Physiol Renal Physiol (2010) 1.69
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood (2008) 1.60
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells. Proc Natl Acad Sci U S A (2007) 1.58
alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation (2005) 1.56
RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther (2009) 1.55
Isolation and species distribution of staphylococci from animal and human skin. J Vet Med Sci (2002) 1.52
Renoprotective effect of erythropoietin against ischaemia-reperfusion injury in a non-human primate model. Nephrol Dial Transplant (2010) 1.52
Association of metformin use with cancer incidence and mortality: a meta-analysis. Cancer Epidemiol (2013) 1.49
Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J Clin Endocrinol Metab (2005) 1.48
Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation (2003) 1.47
A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs. PLoS Genet (2011) 1.45
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood (2006) 1.44
No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes (2004) 1.35
Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol (2002) 1.35
Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells. J Immunol (2003) 1.34
Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol (2004) 1.29
A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med (2012) 1.27
Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. Nucleic Acids Res (2006) 1.26
Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation (2004) 1.26
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest (2005) 1.24
The spatial and temporal dynamics of rabies in China. PLoS Negl Trop Dis (2012) 1.23
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. J Immunol (2010) 1.22
Method for hemoglobin A(1c) measurement based on peptide analysis by electrospray ionization mass spectrometry with deuterium-labeled synthetic peptides as internal standards. Clin Chem (2003) 1.21
Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood (2004) 1.19
Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs. J Immunol (2010) 1.18
Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010. Clin Exp Nephrol (2013) 1.17
Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine. Blood (2007) 1.14
Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization. Stem Cells (2002) 1.14
An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant (2007) 1.12
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biol (2013) 1.12
Chronic diseases knowledge and related factors among the elderly in Jinan, China. PLoS One (2013) 1.10
Injury and progressive loss of peritubular capillaries in the development of chronic allograft nephropathy. Kidney Int (2005) 1.10
TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice. J Allergy Clin Immunol (2003) 1.09
CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol (2009) 1.09
Comparison of the indocyanine green fluorescence and blue dye methods in detection of sentinel lymph nodes in early-stage breast cancer. Ann Surg Oncol (2013) 1.09
Case of subcutaneous sparganosis: use of imaging in definitive preoperative diagnosis. J Dermatol (2007) 1.09
Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling. J Immunol (2010) 1.08
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem (2011) 1.08
Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal. Stem Cell Res (2011) 1.07
Catalogue of soluble proteins in the human vitreous humor: comparison between diabetic retinopathy and macular hole. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 1.07
Cell delivery: from cell transplantation to organ engineering. Cell Transplant (2010) 1.06
Effects of repeated subculturing and prolonged storage at room temperature of enterohemorrhagic Escherichia coli O157:H7 on pulsed-field gel electrophoresis profiles. J Clin Microbiol (2002) 1.06
Pig islet xenograft rejection in a mouse model with an established human immune system. Xenotransplantation (2008) 1.04
Elimination of porcine hemopoietic cells by macrophages in mice. J Immunol (2002) 1.02
Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety. J Transl Med (2011) 1.02
Neural substrates of human facial expression of pleasant emotion induced by comic films: a PET Study. Neuroimage (2002) 1.02
Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma. Cancer Lett (2008) 1.00
Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis. J Immunol (2003) 1.00
Prevalence and characterization of Staphylococcus aureus and enterotoxigenic Staphylococcus aureus in retail raw chicken meat throughout Japan. J Vet Med Sci (2005) 1.00
Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus. Clin Rheumatol (2009) 0.99
Statin attenuates experimental anti-glomerular basement membrane glomerulonephritis together with the augmentation of alternatively activated macrophages. Am J Pathol (2010) 0.99
Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem (2010) 0.99
GalT-KO pigs: is the cup half empty or half full? Transplantation (2007) 0.99
Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF/KIT protein interactions and the downstream effector, MITF-M. J Pathol (2004) 0.98
Characterization of methicillin-resistant Staphylococcus aureus isolated from retail raw chicken meat in Japan. J Vet Med Sci (2005) 0.98
Surgical treatment of 144 cases of hilar cholangiocarcinoma without liver-related mortality. World J Surg (2014) 0.98
Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model. J Immunol (2008) 0.97
Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy. Lab Invest (2012) 0.97
A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. Int Immunol (2006) 0.96
Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution. Transplantation (2005) 0.96
Inhibition of matrix metalloproteinases reduces ischemia-reperfusion acute kidney injury. Lab Invest (2010) 0.96
CD47 is required for suppression of allograft rejection by donor-specific transfusion. J Immunol (2010) 0.96
Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine. Transplantation (2006) 0.96
The peak height ratio of S-sulfonated transthyretin and other oxidized isoforms as a marker for molybdenum cofactor deficiency, measured by electrospray ionization mass spectrometry. Biochim Biophys Acta (2002) 0.96
IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice. J Immunol (2007) 0.96
Detection of citrullinated proteins in synovial fluids derived from patients with rheumatoid arthritis by proteomics-based analysis. Ann Clin Biochem (2008) 0.95
Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Pathol Int (2011) 0.95
Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun (2007) 0.95
Characterization of Staphylococcus intermedius from pigeons, dogs, foxes, mink, and horses by pulsed-field gel electrophoresis. J Vet Med Sci (2002) 0.95
Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem (2008) 0.94
Current status and issues of C1q nephropathy. Clin Exp Nephrol (2009) 0.94
Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies. J Mol Med (Berl) (2004) 0.94