Published in Immunity on May 31, 2012
Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71
Inflammatory caspases are innate immune receptors for intracellular LPS. Nature (2014) 4.88
Caspase-11 protects against bacteria that escape the vacuole. Science (2013) 4.01
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature (2012) 3.40
Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection. Proc Natl Acad Sci U S A (2015) 1.62
Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host Microbe (2014) 1.50
Inflammasomes in the CNS. Nat Rev Neurosci (2014) 1.44
Pyroptotic cell death defends against intracellular pathogens. Immunol Rev (2015) 1.40
Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol (2013) 1.39
Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. PLoS Pathog (2013) 1.38
Regulation of inflammasome activation. Immunol Rev (2015) 1.28
Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. Curr Opin Microbiol (2013) 1.19
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology. Front Immunol (2013) 1.17
TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis. EMBO J (2012) 1.11
Salmonellae interactions with host processes. Nat Rev Microbiol (2015) 1.11
Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol (2015) 1.10
Regulation where autophagy intersects the inflammasome. Antioxid Redox Signal (2013) 1.09
Cellular microbiology and molecular ecology of Legionella-amoeba interaction. Virulence (2013) 0.99
Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens. Proc Natl Acad Sci U S A (2015) 0.97
Noncanonical inflammasomes: caspase-11 activation and effector mechanisms. PLoS Pathog (2013) 0.97
A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy. Eur J Immunol (2013) 0.95
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection. PLoS Pathog (2014) 0.95
Caspase-11 controls interleukin-1β release through degradation of TRPC1. Cell Rep (2014) 0.93
Caspase-1-dependent and -independent cell death pathways in Burkholderia pseudomallei infection of macrophages. PLoS Pathog (2014) 0.91
Insights into phagocytosis-coupled activation of pattern recognition receptors and inflammasomes. Curr Opin Immunol (2013) 0.91
Inflammasome Complexes: Emerging Mechanisms and Effector Functions. Cell (2016) 0.90
Inflammasome-mediated cell death in response to bacterial pathogens that access the host cell cytosol: lessons from legionella pneumophila. Front Cell Infect Microbiol (2013) 0.90
Hirsutella sinensis mycelium suppresses interleukin-1β and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes. Sci Rep (2013) 0.88
The cytoskeleton in cell-autonomous immunity: structural determinants of host defence. Nat Rev Immunol (2015) 0.86
Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages. Front Cell Infect Microbiol (2013) 0.86
Revisiting caspase-11 function in host defense. Cell Host Microbe (2013) 0.86
Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance. Sci Rep (2015) 0.82
The transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages. PLoS One (2014) 0.82
Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis. PLoS Pathog (2016) 0.81
Complete and ubiquitinated proteome of the Legionella-containing vacuole within human macrophages. J Proteome Res (2014) 0.81
Roles of Caspases in Necrotic Cell Death. Cell (2016) 0.79
Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages. Infect Immun (2016) 0.79
Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice. PLoS One (2013) 0.79
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death. Nat Commun (2016) 0.79
IL-1 signaling inhibits Trichophyton rubrum conidia development and modulates the IL-17 response in vivo. Virulence (2015) 0.78
Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice. Hum Mol Genet (2012) 0.78
The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. PLoS One (2016) 0.77
Microbial modulation of host apoptosis and pyroptosis. Front Cell Infect Microbiol (2014) 0.77
Aging is associated with hypermethylation of autophagy genes in macrophages. Epigenetics (2016) 0.77
Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS. PLoS Pathog (2016) 0.76
Cutting Edge: Caspase-11 Limits the Response of CD8+ T Cells to Low-Abundance and Low-Affinity Antigens. J Immunol (2015) 0.76
Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination. Int J Mol Sci (2015) 0.76
Subversion of Cell-Autonomous Immunity and Cell Migration by Legionella pneumophila Effectors. Front Immunol (2015) 0.76
Novel perspectives on non-canonical inflammasome activation. Immunotargets Ther (2015) 0.75
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev (2017) 0.75
Listeria monocytogenes and the Inflammasome: From Cytosolic Bacteriolysis to Tumor Immunotherapy. Curr Top Microbiol Immunol (2016) 0.75
Differential roles of caspase-1 and caspase-11 in infection and inflammation. Sci Rep (2017) 0.75
Caspase Exploitation by Legionella pneumophila. Front Microbiol (2016) 0.75
Caspase-11 plays a protective role in pulmonary A. baumannii infection. Infect Immun (2017) 0.75
Caspase-11 non-canonical inflammasome: a critical sensor of intracellular LPS in macrophage-mediated inflammatory responses. Immunology (2017) 0.75
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes. J Clin Invest (1980) 12.41
Non-canonical inflammasome activation targets caspase-11. Nature (2011) 8.85
The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J Exp Med (1983) 8.82
Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med (1983) 7.65
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol (2007) 6.36
Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog (2006) 5.17
Cofilin promotes actin polymerization and defines the direction of cell motility. Science (2004) 5.12
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell (1998) 3.62
Inflammasomes: guardians of cytosolic sanctity. Immunol Rev (2009) 3.58
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J Biol Chem (2001) 3.37
Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20
Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release. Proc Natl Acad Sci U S A (2005) 2.82
The caspase-1 inflammasome: a pilot of innate immune responses. Cell Host Microbe (2008) 2.71
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. Immunity (2010) 2.67
Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr Biol (2003) 2.55
Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila. Infect Immun (2009) 2.42
Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles. J Exp Med (2000) 2.40
Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice. Infect Immun (1988) 2.37
Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes. J Biol Chem (2001) 2.34
Caspases at the crossroads of immune-cell life and death. Nat Rev Immunol (2006) 2.17
Molecular characterization of phagosomes. J Biol Chem (1994) 2.07
Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy (2011) 2.06
Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol (2007) 2.01
Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Mol Microbiol (2000) 2.00
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog (2009) 1.99
Cell biology of Legionella pneumophila. Curr Opin Microbiol (1999) 1.97
Pyrin critical to macrophage IL-1beta response to Francisella challenge. J Immunol (2009) 1.73
Properties of the caspases. Biochim Biophys Acta (1998) 1.63
Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires' disease. Am J Pathol (1994) 1.63
NLRC4/IPAF: a CARD carrying member of the NLR family. Clin Immunol (2008) 1.57
Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1. J Immunol (1999) 1.57
Phagosome dynamics and function. Bioessays (2000) 1.47
Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila. Infect Immun (2004) 1.45
Remodelling of the actin cytoskeleton is essential for replication of intravacuolar Salmonella. Cell Microbiol (2001) 1.43
ATP-dependent membrane assembly of F-actin facilitates membrane fusion. Mol Biol Cell (2001) 1.37
Fusion between phagosomes, early and late endosomes: a role for actin in fusion between late, but not early endocytic organelles. Mol Biol Cell (2003) 1.36
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res (1999) 1.36
Caspase assays. Methods Enzymol (2000) 1.35
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ (2002) 1.30
Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation. Infect Immun (2008) 1.30
Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome. Pediatr Res (2007) 1.20
Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis. Infect Immun (2010) 1.17
Roles of ADF/cofilin in actin polymerization and beyond. F1000 Biol Rep (2010) 1.15
Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes. J Biol Chem (2010) 1.15
Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin. Exp Biol Med (Maywood) (2009) 1.09
Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages. Front Microbiol (2011) 1.06
Host-dependent trigger of caspases and apoptosis by Legionella pneumophila. Infect Immun (2007) 1.01
Pathogenic mycobacteria disrupt the macrophage actin filament network. Infect Immun (2000) 1.00
Snapshot: caspases. Cell (2011) 0.99
Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages. J Leukoc Biol (2010) 0.96
Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion. Traffic (2011) 0.92
Differential requirements for actin polymerization, calmodulin, and Ca2+ define distinct stages of lysosome/phagosome targeting. Mol Biol Cell (2006) 0.90
Pyrin Modulates the Intracellular Distribution of PSTPIP1. PLoS One (2009) 0.89
Listeria monocytogenes infection in caspase-11-deficient mice. Infect Immun (2002) 0.87
Apoptosis signal-regulating kinase 1 regulates the expression of caspase-11. FEBS Lett (2009) 0.79
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol (2010) 6.05
AURP: an AUV-aided underwater routing protocol for underwater acoustic sensor networks. Sensors (Basel) (2012) 3.89
Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol (2010) 2.88
Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release. Proc Natl Acad Sci U S A (2005) 2.82
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. Immunity (2010) 2.67
The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J Exp Med (2005) 2.50
A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol (2004) 2.40
Terahertz metamaterials for linear polarization conversion and anomalous refraction. Science (2013) 2.34
Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy (2011) 2.06
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog (2009) 1.99
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med (2010) 1.95
Innate immune gene polymorphisms in tuberculosis. Infect Immun (2012) 1.89
Pyrin critical to macrophage IL-1beta response to Francisella challenge. J Immunol (2009) 1.73
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med (2006) 1.73
Fine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensis. PLoS Pathog (2013) 1.71
Photoinduced handedness switching in terahertz chiral metamolecules. Nat Commun (2012) 1.69
Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages. Infect Immun (2006) 1.68
Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion. PLoS One (2008) 1.67
Activation of estrogen receptor-alpha reduces aortic smooth muscle differentiation. Circ Res (2006) 1.63
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol (2007) 1.63
Active control of electromagnetically induced transparency analogue in terahertz metamaterials. Nat Commun (2012) 1.62
Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci U S A (2011) 1.62
Optimal T cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors. J Immunol (2002) 1.56
Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia. Crit Care Med (2004) 1.56
Failure to recover somatotropic axis function is associated with mortality from pediatric sepsis-induced multiple organ dysfunction syndrome. Pediatr Crit Care Med (2010) 1.55
MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One (2009) 1.55
Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release. J Immunol (2007) 1.54
Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med (2008) 1.52
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host. Tuberculosis (Edinb) (2010) 1.50
Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol (2008) 1.49
Respiratory symptoms among HIV-seropositive individuals. Chest (2003) 1.49
Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia. Crit Care Med (2002) 1.47
Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis. J Leukoc Biol (2007) 1.46
Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death. J Innate Immun (2010) 1.44
Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation. J Biol Chem (2007) 1.43
Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors. J Immunol (2006) 1.41
AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence. Infect Immun (2006) 1.39
Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP. PLoS Pathog (2006) 1.38
Modeling the immune rheostat of macrophages in the lung in response to infection. Proc Natl Acad Sci U S A (2009) 1.38
Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune responses. J Immunol (2010) 1.37
Evasion of complement-mediated lysis and complement C3 deposition are regulated by Francisella tularensis lipopolysaccharide O antigen. J Immunol (2008) 1.36
ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol (2006) 1.31
Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. Am J Respir Crit Care Med (2009) 1.30
The acute respiratory distress syndrome: a role for transforming growth factor-beta 1. Am J Respir Cell Mol Biol (2003) 1.28
Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol (2006) 1.28
Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cells. J Biol Chem (2001) 1.27
Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization. Cell Microbiol (2011) 1.25
Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. J Immunol (2014) 1.25
Francisella tularensis induces IL-23 production in human monocytes. J Immunol (2007) 1.24
Intraphagosomal Mycobacterium tuberculosis acquires iron from both extracellular transferrin and intracellular iron pools. Impact of interferon-gamma and hemochromatosis. J Biol Chem (2002) 1.24
NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell Microbiol (2010) 1.24
Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages. J Immunol (2002) 1.23
Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant. Am J Respir Crit Care Med (2003) 1.22
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem (2011) 1.21
Modeling the Mycobacterium tuberculosis Granuloma - the Critical Battlefield in Host Immunity and Disease. Front Immunol (2013) 1.21
Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome. Pediatr Res (2007) 1.20
Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database. Tuberculosis (Edinb) (2007) 1.19
Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3. J Biol Chem (2005) 1.19
Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP. J Immunol (2004) 1.17
Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes. J Biol Chem (2010) 1.15
ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Rep (2013) 1.14
Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model. J Immunol (2004) 1.14
Regulation of monocytes and macrophages cell fate. Front Biosci (Landmark Ed) (2009) 1.13
Tuning the resonance in high-temperature superconducting terahertz metamaterials. Phys Rev Lett (2010) 1.13
Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages. J Leukoc Biol (2006) 1.13