Published in Proc Natl Acad Sci U S A on December 22, 2005
Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J Exp Med (2007) 4.32
In vivo negative selection screen identifies genes required for Francisella virulence. Proc Natl Acad Sci U S A (2007) 3.73
Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy (2011) 2.06
The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence. Mol Microbiol (2009) 2.02
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog (2009) 1.99
Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages. Infect Immun (2007) 1.98
NALP inflammasomes: a central role in innate immunity. Semin Immunopathol (2007) 1.91
The Jekyll and Hyde functions of caspases. Dev Cell (2009) 1.87
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. Immunity (2012) 1.77
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med (2006) 1.73
Pyrin critical to macrophage IL-1beta response to Francisella challenge. J Immunol (2009) 1.73
Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion. PLoS One (2008) 1.67
Identification of an orphan response regulator required for the virulence of Francisella spp. and transcription of pathogenicity island genes. Infect Immun (2007) 1.66
MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One (2009) 1.55
Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med (2008) 1.52
Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol (2008) 1.49
The inflammasomes. PLoS Pathog (2009) 1.48
Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. PLoS Pathog (2009) 1.47
Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production. Infect Immun (2007) 1.42
Combined deletion of four Francisella novicida acid phosphatases attenuates virulence and macrophage vacuolar escape. Infect Immun (2008) 1.42
Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns. Infect Immun (2008) 1.41
A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge. PLoS One (2008) 1.39
Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP. PLoS Pathog (2006) 1.38
Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9. J Biol Chem (2008) 1.38
Identification of a bile-induced exopolysaccharide required for Salmonella biofilm formation on gallstone surfaces. Infect Immun (2008) 1.34
Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes. Infect Immun (2007) 1.31
Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC. Semin Immunopathol (2007) 1.29
The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling. Front Microbiol (2010) 1.26
Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS. Infect Immun (2009) 1.25
Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. J Immunol (2014) 1.25
NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell Microbiol (2010) 1.24
A novel receptor - ligand pathway for entry of Francisella tularensis in monocyte-like THP-1 cells: interaction between surface nucleolin and bacterial elongation factor Tu. BMC Microbiol (2008) 1.21
MglA regulates Francisella tularensis subsp. novicida (Francisella novicida) response to starvation and oxidative stress. J Bacteriol (2007) 1.17
Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol (2010) 1.17
Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia. Infect Immun (2007) 1.15
Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes. J Biol Chem (2010) 1.15
The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages. Infect Immun (2009) 1.12
Regulation of virulence gene transcripts by the Francisella novicida orphan response regulator PmrA: role of phosphorylation and evidence of MglA/SspA interaction. Infect Immun (2010) 1.11
A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission. Am J Clin Nutr (2011) 1.10
DotU and VgrG, core components of type VI secretion systems, are essential for Francisella LVS pathogenicity. PLoS One (2012) 1.08
Host immune response and acute disease in a zebrafish model of Francisella pathogenesis. Infect Immun (2008) 1.07
Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro. Microb Pathog (2006) 1.07
Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia. J Immunol (2012) 1.07
Francisella tularensis reveals a disparity between human and mouse NLRP3 inflammasome activation. J Biol Chem (2011) 1.07
Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages. Front Microbiol (2011) 1.06
Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair. Mol Ther (2009) 1.05
Exploitation of host cell biology and evasion of immunity by francisella tularensis. Front Microbiol (2011) 1.05
The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk. Mol Immunol (2008) 1.04
IglG and IglI of the Francisella pathogenicity island are important virulence determinants of Francisella tularensis LVS. Infect Immun (2011) 1.02
Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes. Vaccine (2009) 1.01
Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease. J Immunol (2010) 1.01
Mycoplasma suppression of THP-1 Cell TLR responses is corrected with antibiotics. PLoS One (2010) 0.99
Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent. J Biomed Sci (2009) 0.97
Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages. J Leukoc Biol (2010) 0.96
Mutations of Francisella novicida that alter the mechanism of its phagocytosis by murine macrophages. PLoS One (2010) 0.96
IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells. Blood (2011) 0.96
Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway. PLoS One (2009) 0.95
Francisella tularensis regulates autophagy-related host cell signaling pathways. Autophagy (2009) 0.95
Roles of inflammatory caspases during processing of zebrafish interleukin-1β in Francisella noatunensis infection. Infect Immun (2012) 0.94
Regulation of apoptosis and anti-apoptosis signalling by Francisella tularensis. Microbes Infect (2009) 0.94
Immunosuppressive effects of red blood cells on monocytes are related to both storage time and storage solution. Transfusion (2011) 0.92
IgG is transported across the mouse yolk sac independently of FcgammaRIIb. J Reprod Immunol (2009) 0.92
The inflammasomes: molecular effectors of host resistance against bacterial, viral, parasitic, and fungal infections. Front Microbiol (2011) 0.92
Francisella Recognition by Inflammasomes: Differences between Mice and Men. Front Microbiol (2011) 0.90
Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery. J Biol Chem (2012) 0.90
Histoplasma yeast and mycelial transcriptomes reveal pathogenic-phase and lineage-specific gene expression profiles. BMC Genomics (2013) 0.89
Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia. Clin Vaccine Immunol (2008) 0.89
Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt. Front Microbiol (2011) 0.88
Strategies that modulate inflammasomes: insights from host-pathogen interactions. Semin Immunopathol (2007) 0.88
Cadmium-mediated toxicity of lung epithelia is enhanced through NF-κB-mediated transcriptional activation of the human zinc transporter ZIP8. Am J Physiol Lung Cell Mol Physiol (2012) 0.88
Histoplasma capsulatum depends on de novo vitamin biosynthesis for intraphagosomal proliferation. Infect Immun (2013) 0.88
Respiratory syncytial virus represses glucocorticoid receptor-mediated gene activation. Endocrinology (2010) 0.87
Redundant catalases detoxify phagocyte reactive oxygen and facilitate Histoplasma capsulatum pathogenesis. Infect Immun (2013) 0.87
Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. Infect Immun (2012) 0.86
Monocyte/macrophage inflammatory response pathways to combat Francisella infection: possible therapeutic targets? Front Cell Infect Microbiol (2014) 0.84
Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells. Cell Microbiol (2011) 0.83
IFNgamma enhances IL-23 production during Francisella infection of human monocytes. FEBS Lett (2008) 0.82
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity. J Immunol (2015) 0.82
Cathelicidin antimicrobial peptide expression is not induced or required for bacterial clearance during salmonella enterica infection of human monocyte-derived macrophages. Infect Immun (2012) 0.82
Ex vivo stimulation of whole blood as a means to determine glucocorticoid sensitivity. J Inflamm Res (2012) 0.80
IKKβ in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection. PLoS One (2013) 0.80
Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages. J Leukoc Biol (2015) 0.79
Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1β. J Biol Chem (2012) 0.79
Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ΔfopC vaccine strain. Infect Immun (2012) 0.79
FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes. J Leukoc Biol (2016) 0.78
Virulent Type A Francisella tularensis actively suppresses cytokine responses in human monocytes. Front Cell Infect Microbiol (2014) 0.78
A compendium of monocyte transcriptome datasets to foster biomedical knowledge discovery. F1000Res (2016) 0.78
The respiratory syncytial virus (RSV) nonstructural proteins mediate RSV suppression of glucocorticoid receptor transactivation. Virology (2013) 0.78
Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death. PLoS One (2014) 0.78
A mutagenesis-based approach identifies amino acids in the N-terminal part of Francisella tularensis IglE that critically control Type VI system-mediated secretion. Virulence (2016) 0.77
Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination. J Biol Chem (2015) 0.77
Cytokine response in Balb/c mice infected with Francisella tularensis LVS and the Pohang isolate. J Vet Sci (2008) 0.77
A curated compendium of monocyte transcriptome datasets of relevance to human monocyte immunobiology research. F1000Res (2016) 0.77
Fcγ receptor-induced soluble vascular endothelial growth factor receptor-1 (VEGFR-1) production inhibits angiogenesis and enhances efficacy of anti-tumor antibodies. J Biol Chem (2013) 0.77
Effects of vitamin E supplementation on cellular α-tocopherol concentrations of neutrophils in Holstein calves. Can J Vet Res (2013) 0.77
Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. PLoS One (2015) 0.76
A module of human peripheral blood mononuclear cell transcriptional network containing primitive and differentiation markers is related to specific cardiovascular health variables. PLoS One (2014) 0.76
Respiratory syncytial virus (RSV) suppression of glucocorticoid receptor phosphorylation does not account for repression of transactivation. FEBS Open Bio (2013) 0.76
Actin grips: circular actin-rich cytoskeletal structures that mediate the wrapping of polymeric microfibers by endothelial cells. Biomaterials (2015) 0.76
Cadmium attenuates the macrophage response to LPS through inhibition of the NF-κB pathway. Am J Physiol Lung Cell Mol Physiol (2016) 0.76
Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55
Toll-like receptors in the induction of the innate immune response. Nature (2000) 12.23
Tularemia. Clin Microbiol Rev (2002) 8.51
NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem (2005) 6.18
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell (2004) 6.06
NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol (2003) 5.07
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med (2005) 5.00
Nature of protective immunity to Francisella tularensis. Rev Infect Dis (1989) 4.75
An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells. Infect Immun (2003) 4.37
MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival. Proc Natl Acad Sci U S A (2004) 4.14
NLRs join TLRs as innate sensors of pathogens. Trends Immunol (2005) 4.12
NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol (2003) 4.08
Growth of Francisella spp. in rodent macrophages. Infect Immun (1991) 3.81
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ (2006) 3.77
Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann N Y Acad Sci (1998) 3.62
The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm. Cell Microbiol (2005) 3.51
The identification of five genetic loci of Francisella novicida associated with intracellular growth. FEMS Microbiol Lett (2002) 3.36
MglA and MglB are required for the intramacrophage growth of Francisella novicida. Mol Microbiol (1998) 3.29
CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu Rev Immunol (2005) 3.04
Growth of Francisella tularensis LVS in macrophages: the acidic intracellular compartment provides essential iron required for growth. Infect Immun (1995) 2.52
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J Immunol (2003) 2.48
Francisella novicida LPS has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesis. Microbes Infect (2003) 2.31
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J Immunol (2002) 2.18
Toll-like receptors and their ligands. Curr Top Microbiol Immunol (2002) 2.02
The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta. J Biol Chem (1988) 1.95
Inability of the Francisella tularensis lipopolysaccharide to mimic or to antagonize the induction of cell activation by endotoxins. Infect Immun (1996) 1.75
Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta. J Biol Chem (2004) 1.70
Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8. Infect Immun (2001) 1.59
The live vaccine strain of Francisella tularensis replicates in human and murine macrophages but induces only the human cells to secrete proinflammatory cytokines. J Leukoc Biol (2005) 1.56
New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol (2003) 1.54
Toll-like receptors and their role in experimental models of microbial infection. Genes Immun (2003) 1.45
Francisella tularensis selectively induces proinflammatory changes in endothelial cells. J Immunol (2003) 1.45
Characterization of the lipopolysaccharide O-antigen of Francisella novicida (U112). Carbohydr Res (2004) 1.29
IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent. J Immunol (1997) 1.23
Toll-like receptor 4 (TLR4) plays a relatively minor role in murine defense against primary intradermal infection with Francisella tularensis LVS. Immunol Lett (2005) 1.14
Differential regulation of inflammatory cytokine secretion by human dendritic cells upon Chlamydia trachomatis infection. Infect Immun (2004) 1.13
Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci U S A (2004) 1.09
Infectious diseases. An obscure weapon of the cold war edges into the limelight. Science (2003) 0.85
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol (2010) 6.05
Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol (2010) 2.88
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. Immunity (2010) 2.67
A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol (2004) 2.40
Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis (2012) 2.22
Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol (2005) 2.17
Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy (2011) 2.06
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog (2009) 1.99
Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure. Crit Care Med (2008) 1.97
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med (2010) 1.95
Classifying movement behaviour in relation to environmental conditions using hidden Markov models. J Anim Ecol (2009) 1.90
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ. Mol Microbiol (2005) 1.80
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. Immunity (2012) 1.77
Pyrin critical to macrophage IL-1beta response to Francisella challenge. J Immunol (2009) 1.73
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med (2006) 1.73
Comparison of SpO2 to PaO2 based markers of lung disease severity for children with acute lung injury. Crit Care Med (2012) 1.71
The role of different anesthetic techniques in altering the stress response during cardiac surgery in children: a prospective, double-blinded, and randomized study. Pediatr Crit Care Med (2013) 1.70
Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages. Infect Immun (2006) 1.68
Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion. PLoS One (2008) 1.67
Identification of an orphan response regulator required for the virulence of Francisella spp. and transcription of pathogenicity island genes. Infect Immun (2007) 1.66
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol (2007) 1.63
Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia. Crit Care Med (2004) 1.56
Identification and genetic characterization of PmrA-regulated genes and genes involved in polymyxin B resistance in Salmonella enterica serovar typhimurium. Infect Immun (2002) 1.55
Failure to recover somatotropic axis function is associated with mortality from pediatric sepsis-induced multiple organ dysfunction syndrome. Pediatr Crit Care Med (2010) 1.55
MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One (2009) 1.55
Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release. J Immunol (2007) 1.54
Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med (2008) 1.52
Multidisciplinary quality improvement initiative to reduce ventilator-associated tracheobronchitis in the PICU. Pediatr Crit Care Med (2013) 1.51
Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant. Pediatr Crit Care Med (2013) 1.50
Chronic and acute infection of the gall bladder by Salmonella Typhi: understanding the carrier state. Nat Rev Microbiol (2010) 1.50
Respiratory symptoms among HIV-seropositive individuals. Chest (2003) 1.49
Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice. J Immunol (2006) 1.48
Immunoparalysis and adverse outcomes from critical illness. Pediatr Clin North Am (2008) 1.47
Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia. Crit Care Med (2002) 1.47
Combined deletion of four Francisella novicida acid phosphatases attenuates virulence and macrophage vacuolar escape. Infect Immun (2008) 1.42
Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage. Proc Natl Acad Sci U S A (2010) 1.42
A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge. PLoS One (2008) 1.39
AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence. Infect Immun (2006) 1.39
Invasive Mechanical Ventilation and Mortality in Pediatric Hematopoietic Stem Cell Transplantation: A Multicenter Study. Pediatr Crit Care Med (2016) 1.39
Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP. PLoS Pathog (2006) 1.38
Evasion of complement-mediated lysis and complement C3 deposition are regulated by Francisella tularensis lipopolysaccharide O antigen. J Immunol (2008) 1.36
Identification of a bile-induced exopolysaccharide required for Salmonella biofilm formation on gallstone surfaces. Infect Immun (2008) 1.34
ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol (2006) 1.31
Feeding ecology of wild migratory tunas revealed by archival tag records of visceral warming. J Anim Ecol (2008) 1.31
Salmonella enterica serovar typhimurium resistance to bile: identification and characterization of the tolQRA cluster. J Bacteriol (2002) 1.30
Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. Am J Respir Crit Care Med (2009) 1.30
Characterization of the lipopolysaccharide O-antigen of Francisella novicida (U112). Carbohydr Res (2004) 1.29
The acute respiratory distress syndrome: a role for transforming growth factor-beta 1. Am J Respir Cell Mol Biol (2003) 1.28
Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cells. J Biol Chem (2001) 1.27
Predicting feeding success in a migratory predator: integrating telemetry, environment, and modeling techniques. Ecology (2010) 1.27
Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. J Immunol (2014) 1.25
Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant. Am J Respir Crit Care Med (2003) 1.22
Resolvase-in vivo expression technology analysis of the Salmonella enterica serovar Typhimurium PhoP and PmrA regulons in BALB/c mice. J Bacteriol (2005) 1.20
Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome. Pediatr Res (2007) 1.20
Identification and functional analysis of Salmonella enterica serovar Typhimurium PmrA-regulated genes. FEMS Immunol Med Microbiol (2005) 1.19
Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3. J Biol Chem (2005) 1.19
Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP. J Immunol (2004) 1.17
Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes. J Biol Chem (2010) 1.15
ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Rep (2013) 1.14
Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2. Am J Respir Cell Mol Biol (2008) 1.13
Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. PLoS One (2009) 1.13
Regulation of virulence gene transcripts by the Francisella novicida orphan response regulator PmrA: role of phosphorylation and evidence of MglA/SspA interaction. Infect Immun (2010) 1.11
A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission. Am J Clin Nutr (2011) 1.10
Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Crit Care Med (2009) 1.10
Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia. J Immunol (2012) 1.07
Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes. J Immunol (2010) 1.07
Flagellated but not hyperfimbriated Salmonella enterica serovar Typhimurium attaches to and forms biofilms on cholesterol-coated surfaces. J Bacteriol (2010) 1.06
Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages. Front Microbiol (2011) 1.06
Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response. Mol Immunol (2008) 1.04
Regulation of francisella tularensis virulence. Front Microbiol (2011) 1.03
Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection model. Antimicrob Agents Chemother (2009) 1.03
Rapid fluid resuscitation in pediatrics: testing the American College of Critical Care Medicine guideline. Ann Emerg Med (2007) 1.02
Role of Salmonella enterica serovar Typhimurium two-component system PreA/PreB in modulating PmrA-regulated gene transcription. J Bacteriol (2006) 1.01
Genome-wide analysis of the PreA/PreB (QseB/QseC) regulon of Salmonella enterica serovar Typhimurium. BMC Microbiol (2009) 1.01
Protecting against antimicrobial effectors in the phagosome allows SodCII to contribute to virulence in Salmonella enterica serovar Typhimurium. J Bacteriol (2010) 1.00
Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis. Proc Natl Acad Sci U S A (2012) 1.00
Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. J Thorac Cardiovasc Surg (2011) 1.00
Janus kinase 3 down-regulates lipopolysaccharide-induced IL-1 beta-converting enzyme activation by autocrine IL-10. J Immunol (2004) 0.99
Mycoplasma suppression of THP-1 Cell TLR responses is corrected with antibiotics. PLoS One (2010) 0.99
Interaction of Salmonella spp. with the Intestinal Microbiota. Front Microbiol (2011) 0.98
Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent. Antimicrob Agents Chemother (2009) 0.98
Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent. J Biomed Sci (2009) 0.97
A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice. PLoS One (2008) 0.97
Timing of correct parenteral antibiotic initiation and outcomes from severe bacterial community-acquired pneumonia in children. Pediatr Infect Dis J (2011) 0.97
Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages. J Leukoc Biol (2010) 0.96
IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells. Blood (2011) 0.96