Published in J Cell Physiol on January 01, 2013
Adaptive and maladaptive expression of the mRNA regulatory protein HuR. World J Biol Chem (2013) 0.85
TLR9 signaling repressed tumor suppressor miR-7 expression through up-regulation of HuR in human lung cancer cells. Cancer Cell Int (2013) 0.79
Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR. Cell Physiol Biochem (2014) 0.78
Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1. Sci Rep (2016) 0.76
AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin. J Invest Dermatol (2015) 0.75
A HuR/TGF-β1 feedback circuit regulates airway remodeling in airway smooth muscle cells. Respir Res (2016) 0.75
Post-transcriptional regulation of cytokine and growth factor signaling in cancer. Cytokine Growth Factor Rev (2016) 0.75
Cellular survival: a play in three Akts. Genes Dev (1999) 17.05
Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J (1998) 7.62
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (2011) 5.73
Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A (2004) 5.15
HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96
Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem (1998) 4.57
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Mol Cell (2011) 4.29
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol Cell (2011) 4.15
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res (2004) 2.91
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. J Cell Sci (1998) 2.83
Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene (2003) 2.69
Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol (2004) 2.64
miR-519 suppresses tumor growth by reducing HuR levels. Cell Cycle (2010) 2.63
Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci U S A (2003) 2.48
HuR: post-transcriptional paths to malignancy. RNA Biol (2005) 2.38
HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs. Cancer Res (2001) 2.29
Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle (2007) 2.25
The AU-rich transcriptome: more than interferons and cytokines, and its role in disease. J Interferon Cytokine Res (2005) 2.09
Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo. Mol Cell Biol (2007) 2.08
Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock. RNA (2001) 1.99
Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. Cancer Res (2004) 1.79
The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol (2009) 1.78
Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR. J Biol Chem (2002) 1.61
Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest (2009) 1.58
Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition. J Biol Chem (2008) 1.58
Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin Cancer Res (2004) 1.58
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA. J Biol Chem (2002) 1.57
Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature (2011) 1.52
MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol (2009) 1.45
MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms. Prostate (2010) 1.44
Akt is a downstream target of NF-kappa B. J Biol Chem (2002) 1.43
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene (2008) 1.41
Grb10: more than a simple adaptor protein. Front Biosci (2004) 1.38
Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function. Proc Natl Acad Sci U S A (1995) 1.37
Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation. Nucleic Acids Res (2009) 1.35
Ischemic preconditioning provides both acute and delayed protection against renal ischemia and reperfusion injury in mice. J Am Soc Nephrol (2006) 1.30
RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage. Nucleic Acids Res (2011) 1.27
NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis. Gastroenterology (2008) 1.24
Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? Cell Signal (2006) 1.22
Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res (2009) 1.09
AKT can be activated in the nucleus. Cell Signal (2006) 1.05
Protective effect of 17beta-estradiol on ischemic acute renal failure through the PI3K/Akt/eNOS pathway. Kidney Int (2007) 1.01
Changes in apoptosis-related pathways in acute myelocytic leukemia. Cancer Genet Cytogenet (2003) 1.01
The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int (2007) 1.00
Grb10 exceeding the boundaries of a common signaling adapter. Front Biosci (2004) 0.99
Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma. J Cell Biochem (2010) 0.99
Role for the adaptor protein Grb10 in the activation of Akt. Mol Cell Biol (2002) 0.99
The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. J Biol Chem (1995) 0.99
Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int (2003) 0.99
Ischemic postconditioning inhibits apoptosis after renal ischemia/reperfusion injury in rat. Transpl Int (2007) 0.97
Ischemia-reperfusion induces glomerular and tubular activation of proinflammatory and antiapoptotic pathways: differential modulation by rapamycin. J Am Soc Nephrol (2004) 0.96
HuR stabilizes vacuolar H+-translocating ATPase mRNA during cellular energy depletion. J Biol Chem (2005) 0.95
Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells. Am J Physiol Renal Physiol (2006) 0.95
Role of the RNA-binding protein HuR in human renal cell carcinoma. Carcinogenesis (2010) 0.94
Grb10: A new substrate of the insulin-like growth factor I receptor. Cancer Res (1996) 0.91
Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins. J Biol Chem (1998) 0.91
Transcriptional control of human antigen R by bone morphogenetic protein. J Biol Chem (2009) 0.87
Expression of the RNA-stabilizing protein HuR in ischemia-reperfusion injury of rat kidney. Am J Physiol Renal Physiol (2009) 0.86
Grb10 and active Raf-1 kinase promote Bad-dependent cell survival. J Biol Chem (2007) 0.86
Role of PI3-kinase/Akt signalling pathway in renal function and cell proliferation after renal ischaemia/reperfusion injury in mice. Nephrology (Carlton) (2006) 0.84
Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma. Oncol Rep (2005) 0.80
Rapid identification of dysregulated genes in cutaneous malignant melanoma metastases using cDNA technology. Cells Tissues Organs (2004) 0.79
Grb10 interacts with Bim L and inhibits apoptosis. Mol Biol Rep (2010) 0.79
Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans. J Bacteriol (2010) 1.39
The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis. J Bacteriol (2009) 1.35
The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells. Infect Immun (2011) 1.31
Use of polyethyleneimine polymer in cell culture as attachment factor and lipofection enhancer. BMC Biotechnol (2004) 1.17
Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. J Biol Chem (2003) 1.16
Role of Clp proteins in expression of virulence properties of Streptococcus mutans. J Bacteriol (2009) 1.04
Myosin X regulates sealing zone patterning in osteoclasts through linkage of podosomes and microtubules. J Biol Chem (2010) 1.01
Regulated proteolysis of nonmuscle myosin IIA stimulates osteoclast fusion. J Biol Chem (2009) 0.96
Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells. Am J Physiol Renal Physiol (2006) 0.95
Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts. Bone (2006) 0.95
HuR stabilizes vacuolar H+-translocating ATPase mRNA during cellular energy depletion. J Biol Chem (2005) 0.95
Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. J Bone Miner Res (2003) 0.92
Tropomyosin 4 regulates adhesion structures and resorptive capacity in osteoclasts. Exp Cell Res (2007) 0.88
Transcriptional control of human antigen R by bone morphogenetic protein. J Biol Chem (2009) 0.87
Expression of the RNA-stabilizing protein HuR in ischemia-reperfusion injury of rat kidney. Am J Physiol Renal Physiol (2009) 0.86
Adaptive and maladaptive expression of the mRNA regulatory protein HuR. World J Biol Chem (2013) 0.85
High molecular weight tropomyosins regulate osteoclast cytoskeletal morphology. Bone (2008) 0.83
Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities. PLoS One (2012) 0.82
Regulation of enhanced vacuolar H+-ATPase expression in macrophages. J Biol Chem (2002) 0.81
c-Src-mediated phosphorylation of thyroid hormone receptor-interacting protein 6 (TRIP6) promotes osteoclast sealing zone formation. J Biol Chem (2010) 0.79
Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR. Cell Physiol Biochem (2014) 0.78
Mechanosignaling in bone health, trauma and inflammation. Antioxid Redox Signal (2013) 0.76
Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR. Am J Physiol Cell Physiol (2013) 0.76
Characterization of the domains of zRICH, a protein induced during optic nerve regeneration in zebrafish. Brain Res (2006) 0.76
zRICH, a protein induced during optic nerve regeneration in zebrafish, promotes neuritogenesis and interacts with tubulin. Brain Res (2012) 0.75