Published in Hum Mol Genet on June 07, 2012
E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network. Hepatology (2014) 1.03
Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials. ILAR J (2014) 0.88
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells. Genes Dev (2015) 0.87
Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis. Am J Physiol Cell Physiol (2014) 0.86
Emerging links between E2F control and mitochondrial function. Cancer Res (2015) 0.86
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
The muscular dystrophies. Lancet (2002) 6.41
Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol (2004) 5.66
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology. J Cell Biol (2000) 3.34
Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy. Cell (1988) 2.94
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev (2007) 2.79
E2F transcription factor-1 regulates oxidative metabolism. Nat Cell Biol (2011) 1.70
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2005) 1.63
Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest (2004) 1.55
Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol (2003) 1.48
Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. Int J Obes (Lond) (2007) 1.45
Impaired mitochondrial oxidative phosphorylation in skeletal muscle of the dystrophin-deficient mdx mouse. Mol Cell Biochem (1998) 1.41
Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. Proc Natl Acad Sci U S A (2003) 1.20
Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle. Hum Mol Genet (2011) 1.12
Cycling through metabolism. EMBO Mol Med (2010) 1.06
Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events. Am J Physiol Cell Physiol (2001) 1.05
Defective regulation of energy metabolism in mdx-mouse skeletal muscles. Biochem J (1994) 1.05
Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice. Hum Mol Genet (2009) 1.04
Novel approach to meta-analysis of microarray datasets reveals muscle remodeling-related drug targets and biomarkers in Duchenne muscular dystrophy. PLoS Comput Biol (2012) 1.02
Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle. Hum Mol Genet (2006) 0.99
Cell cycle regulators in the control of metabolism. Cell Cycle (2009) 0.91
Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect (2009) 2.57
Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell (2004) 2.31
Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med (2010) 2.17
Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset. Ann Neurol (2004) 2.03
Multiexon skipping leading to an artificial DMD protein lacking amino acids from exons 45 through 55 could rescue up to 63% of patients with Duchenne muscular dystrophy. Hum Mutat (2007) 1.89
Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1. Mol Cell Biol (2007) 1.89
miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PLoS One (2009) 1.84
Sporadic infantile epileptic encephalopathy caused by mutations in PCDH19 resembles Dravet syndrome but mainly affects females. PLoS Genet (2009) 1.81
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab (2009) 1.68
In vitro and in vivo anti-melanoma effects of ciglitazone. J Invest Dermatol (2009) 1.67
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2005) 1.63
Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest (2004) 1.55
Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. J Biol Chem (2003) 1.52
Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. Eur J Pharmacol (2005) 1.50
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc Natl Acad Sci U S A (2007) 1.46
The CDK4-pRB-E2F1 pathway controls insulin secretion. Nat Cell Biol (2009) 1.45
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther (2010) 1.42
Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Mol Cell Biol (2006) 1.37
Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab (2005) 1.31
SIL1 mutations and clinical spectrum in patients with Marinesco-Sjogren syndrome. Brain (2013) 1.29
Targeted inactivation of dystrophin gene product Dp71: phenotypic impact in mouse retina. Hum Mol Genet (2003) 1.27
L-arginine decreases inflammation and modulates the nuclear factor-kappaB/matrix metalloproteinase cascade in mdx muscle fibers. Am J Pathol (2008) 1.25
L-arginine improves dystrophic phenotype in mdx mice. Neurobiol Dis (2005) 1.23
Age-dependent Mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood. J Pediatr (2010) 1.21
The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene. Oncogene (2005) 1.21
Early onset collagen VI myopathies: Genetic and clinical correlations. Ann Neurol (2010) 1.21
PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nat Commun (2012) 1.18
Deleterious mutations in exon 1 of MECP2 in Rett syndrome. Eur J Med Genet (2005) 1.17
Liver receptor homolog 1 controls the expression of carboxyl ester lipase. J Biol Chem (2003) 1.17
Analysis of Dp71 contribution in the severity of mental retardation through comparison of Duchenne and Becker patients differing by mutation consequences on Dp71 expression. Hum Mol Genet (2009) 1.13
A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population. Arterioscler Thromb Vasc Biol (2003) 1.12
Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol Endocrinol (2006) 1.09
Motor and respiratory heterogeneity in Duchenne patients: implication for clinical trials. Eur J Paediatr Neurol (2011) 1.08
Modulation of p38 mitogen-activated protein kinase cascade and metalloproteinase activity in diaphragm muscle in response to free radical scavenger administration in dystrophin-deficient Mdx mice. Am J Pathol (2007) 1.07
Kir4.1 and AQP4 associate with Dp71- and utrophin-DAPs complexes in specific and defined microdomains of Müller retinal glial cell membrane. Glia (2008) 1.06
Cycling through metabolism. EMBO Mol Med (2010) 1.06
Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep (2004) 1.01
Functional muscle impairment in facioscapulohumeral muscular dystrophy is correlated with oxidative stress and mitochondrial dysfunction. Free Radic Biol Med (2012) 0.99
Muscle dystroglycan organizes the postsynapse and regulates presynaptic neurotransmitter release at the Drosophila neuromuscular junction. PLoS One (2008) 0.99
Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response. Proc Natl Acad Sci U S A (2012) 0.99
Modulation of caspase-independent cell death leads to resensitization of imatinib mesylate-resistant cells. Cancer Res (2009) 0.98
Characterization of a novel Dp71 dystrophin-associated protein complex (DAPC) present in the nucleus of HeLa cells: members of the nuclear DAPC associate with the nuclear matrix. Exp Cell Res (2006) 0.97
The human MSH5 (MutSHomolog 5) protein localizes to mitochondria and protects the mitochondrial genome from oxidative damage. Mitochondrion (2012) 0.97
Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype. J Allergy Clin Immunol (2011) 0.97
PPAR-alpha effects on the heart and other vascular tissues. Am J Physiol Heart Circ Physiol (2003) 0.97
Mutation spectrum leading to an attenuated phenotype in dystrophinopathies. Eur J Hum Genet (2005) 0.95
Role of mental retardation-associated dystrophin-gene product Dp71 in excitatory synapse organization, synaptic plasticity and behavioral functions. PLoS One (2008) 0.94
A missense mutation within the fork-head domain of the forkhead box G1 Gene (FOXG1) affects its nuclear localization. Hum Mutat (2010) 0.93
ZZ domain of dystrophin and utrophin: topology and mapping of a beta-dystroglycan interaction site. Biochem J (2007) 0.92
Cyclin G2 regulates adipogenesis through PPAR gamma coactivation. Endocrinology (2010) 0.91
alpha7B integrin changes in mdx mouse muscles after L-arginine administration. FEBS Lett (2005) 0.91
Cell cycle regulators in the control of metabolism. Cell Cycle (2009) 0.91
Ventilation during air breathing and in response to hypercapnia in 5 and 16 month-old mdx and C57 mice. J Muscle Res Cell Motil (2007) 0.91
Ventilatory parameters and maximal respiratory pressure changes with age in Duchenne muscular dystrophy patients. Pediatr Pulmonol (2010) 0.91
Myotonic dystrophy type I in childhood Long-term evolution in patients surviving the neonatal period. Eur J Paediatr Neurol (2007) 0.90
Mutations and deletions in PCDH19 account for various familial or isolated epilepsies in females. Hum Mutat (2011) 0.89
The role of muscle biopsy in analysis of the dystrophin gene in Duchenne muscular dystrophy: experience of a national referral centre. Neuromuscul Disord (2004) 0.89
The RIP140 gene is a transcriptional target of E2F1. PLoS One (2012) 0.89
Absence of Dp71 in mdx3cv mouse spermatozoa alters flagellar morphology and the distribution of ion channels and nNOS. J Cell Sci (2004) 0.89
Benign paroxysmal vertigo of childhood: long-term outcome. Cephalalgia (2010) 0.89
Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis. FASEB J (2011) 0.88
Dystrophin Dp71 in PC12 cell adhesion. Neuroreport (2005) 0.88
PPAR agonists in the treatment of atherosclerosis. Curr Opin Pharmacol (2003) 0.88
Comprehensive oligonucleotide array-comparative genomic hybridization analysis: new insights into the molecular pathology of the DMD gene. Eur J Hum Genet (2012) 0.87
A comparison of gait in spinal muscular atrophy, type II and Duchenne muscular dystrophy. Gait Posture (2005) 0.87
14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements. Eur J Hum Genet (2012) 0.86
Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis. Endocrinology (2008) 0.86
CXCL5 drives obesity to diabetes, and further. Aging (Albany NY) (2009) 0.85
Dystrophin Dp71 is required for neurite outgrowth in PC12 cells. Exp Cell Res (2004) 0.85
Antagonistic functions of LMNA isoforms in energy expenditure and lifespan. EMBO Rep (2014) 0.85
Dose-dependent effect of individualized respiratory muscle training in children with Duchenne muscular dystrophy. Neuromuscul Disord (2002) 0.84
Dystrophin Dp71 is critical for stability of the DAPs in the nucleus of PC12 cells. Neurochem Res (2009) 0.84
A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle. Biochem Biophys Res Commun (2005) 0.84
Ataxia with vitamin E deficiency and severe dystonia: report of a case. Brain Dev (2003) 0.83
Downregulation of protein tyrosine phosphatase PTP-BL represses adipogenesis. Int J Biochem Cell Biol (2009) 0.83
The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice. EMBO J (2009) 0.83
Screening for primary creatine deficiencies in French patients with unexplained neurological symptoms. Orphanet J Rare Dis (2012) 0.82
Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population. Mol Genet Metab (2005) 0.82
Dystrophin isoform Dp7l is present in lamellipodia and focal complexes in human astrocytoma cells U-373 MG. Acta Histochem (2002) 0.82
Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice. Blood (2013) 0.82
The sarcoglycan-sarcospan complex localization in mouse retina is independent from dystrophins. Neurosci Res (2005) 0.81
Functional implication of Dp71 in osmoregulation and vascular permeability of the retina. PLoS One (2009) 0.80
Upregulation of brain utrophin does not rescue behavioral alterations in dystrophin-deficient mice. Hum Mol Genet (2012) 0.80
Biochemical properties of gastrokine-1 purified from chicken gizzard smooth muscle. PLoS One (2008) 0.79