Published in Nat Protoc on June 07, 2012
Microfabrication of human organs-on-chips. Nat Protoc (2013) 1.44
A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. Biomaterials (2013) 1.34
Mechanisms of tumor cell extravasation in an in vitro microvascular network platform. Integr Biol (Camb) (2013) 1.19
Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr Biol (Camb) (2013) 1.17
In vitro model of tumor cell extravasation. PLoS One (2013) 1.16
Multiplexed volumetric bar-chart chip for point-of-care diagnostics. Nat Commun (2012) 1.13
Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation. Proc Natl Acad Sci U S A (2014) 1.13
Formation of microvascular networks in vitro. Nat Protoc (2013) 1.03
Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A (2014) 1.02
Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth. J Clin Invest (2014) 1.00
Probing cell-cell communication with microfluidic devices. Lab Chip (2013) 0.96
From cardiac tissue engineering to heart-on-a-chip: beating challenges. Biomed Mater (2015) 0.94
Three-dimensional microfluidic collagen hydrogels for investigating flow-mediated tumor-endothelial signaling and vascular organization. Tissue Eng Part C Methods (2013) 0.94
Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems. Integr Biol (Camb) (2014) 0.93
Physiologically relevant organs on chips. Biotechnol J (2013) 0.91
In vitro models of the metastatic cascade: from local invasion to extravasation. Drug Discov Today (2013) 0.91
Microfluidic devices for cell cultivation and proliferation. Biomicrofluidics (2013) 0.90
Control of perfusable microvascular network morphology using a multiculture microfluidic system. Tissue Eng Part C Methods (2013) 0.89
Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma. Genome Biol (2016) 0.88
Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade. Cancer Res (2016) 0.87
In vitro models of tumor vessels and matrix: engineering approaches to investigate transport limitations and drug delivery in cancer. Adv Drug Deliv Rev (2013) 0.85
Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform. Small (2015) 0.85
Microfluidics-assisted in vitro drug screening and carrier production. Adv Drug Deliv Rev (2013) 0.84
Simple surface engineering of polydimethylsiloxane with polydopamine for stabilized mesenchymal stem cell adhesion and multipotency. Sci Rep (2015) 0.84
Rapid prototyping of concave microwells for the formation of 3D multicellular cancer aggregates for drug screening. Adv Healthc Mater (2013) 0.84
A microfluidic co-culture system to monitor tumor-stromal interactions on a chip. Biomicrofluidics (2014) 0.83
Inducing chemotactic and haptotactic cues in microfluidic devices for three-dimensional in vitro assays. Biomicrofluidics (2014) 0.83
Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph nodes. Front Immunol (2013) 0.83
Microfluidic isolation of highly pure embryonic stem cells using feeder-separated co-culture system. Sci Rep (2013) 0.82
Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective. Adv Mater (2013) 0.82
Impact of dimensionality and network disruption on microrheology of cancer cells in 3D environments. PLoS Comput Biol (2014) 0.82
A microfluidic model for organ-specific extravasation of circulating tumor cells. Biomicrofluidics (2014) 0.81
Cell Invasion Dynamics into a Three Dimensional Extracellular Matrix Fibre Network. PLoS Comput Biol (2015) 0.81
Engineering a 3D microfluidic culture platform for tumor-treating field application. Sci Rep (2016) 0.80
Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells. Am J Physiol Heart Circ Physiol (2015) 0.80
Characterization of Fibrin and Collagen Gels for Engineering Wound Healing Models. Materials (Basel) (2015) 0.79
Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment. Oncotarget (2015) 0.79
Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units. Sci Adv (2016) 0.78
Microfluidic systems for stem cell-based neural tissue engineering. Lab Chip (2016) 0.78
Flow measurements in a blood-perfused collagen vessel using x-ray micro-particle image velocimetry. PLoS One (2013) 0.78
3D functional and perfusable microvascular networks for organotypic microfluidic models. J Mater Sci Mater Med (2015) 0.77
Fibroblast Migration in 3D is Controlled by Haptotaxis in a Non-muscle Myosin II-Dependent Manner. Ann Biomed Eng (2015) 0.77
Microfluidic perfusion culture system for multilayer artery tissue models. Biomicrofluidics (2014) 0.77
Co-culture of bone marrow stem cells and macrophages indicates intermediate mechanism between local inflammation and innate immune system in diabetic periodontitis. Exp Ther Med (2016) 0.76
Controlled Drug Release and Chemotherapy Response in a Novel Acoustofluidic 3D Tumor Platform. Small (2016) 0.76
Engineering cell-cell signaling. Curr Opin Biotechnol (2013) 0.76
An integrated in vitro imaging platform for characterizing filarial parasite behavior within a multicellular microenvironment. PLoS Negl Trop Dis (2014) 0.76
Fabrication of 3D Controlled in vitro Microenvironments. MethodsX (2014) 0.76
Clonorchis sinensis infestation promotes three-dimensional aggregation and invasion of cholangiocarcinoma cells. PLoS One (2014) 0.76
Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition. JCI Insight (2016) 0.76
Metastasis of circulating tumor cells: Favorable soil or suitable biomechanics, or both? Cell Adh Migr (2015) 0.76
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology (2016) 0.75
Cell-microenvironment interactions and architectures in microvascular systems. Biotechnol Adv (2016) 0.75
MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling. Cell Death Dis (2014) 0.75
Microfluidics 3D gel-island chip for single cell isolation and lineage-dependent drug responses study. Lab Chip (2016) 0.75
Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment. PLoS One (2016) 0.75
Characterization of three-dimensional cancer cell migration in mixed collagen-Matrigel scaffolds using microfluidics and image analysis. PLoS One (2017) 0.75
Droplet-based microtumor model to assess cell-ECM interactions and drug resistance of gastric cancer cells. Sci Rep (2017) 0.75
Constructive remodeling of a synthetic endothelial extracellular matrix. Sci Rep (2015) 0.75
Creating adhesive and soluble gradients for imaging cell migration with fluorescence microscopy. J Vis Exp (2013) 0.75
Vision Marker-Based In Situ Examination of Bacterial Growth in Liquid Culture Media. Sensors (Basel) (2016) 0.75
Angiogenesis in Liquid Tumors: An In Vitro Assay for Leukemic-Cell-Induced Bone Marrow Angiogenesis. Adv Healthc Mater (2016) 0.75
Multiscale microenvironmental perturbation of pluripotent stem cell fate and self-organization. Sci Rep (2017) 0.75
Perspectives in flow-based microfluidic gradient generators for characterizing bacterial chemotaxis. Biomicrofluidics (2016) 0.75
A microfluidics assay to study invasion of human placental trophoblast cells. J R Soc Interface (2017) 0.75
On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics. Nat Protoc (2017) 0.75
Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system. Sci Rep (2016) 0.75
Vasculature-On-A-Chip for In Vitro Disease Models. Bioengineering (Basel) (2017) 0.75
Inherent aggressive character of invasive and non-invasive cells dictates the in vitro migration pattern of multicellular spheroid. Sci Rep (2017) 0.75
Immunomodulatory Effects of Calcium and Strontium Co-Doped Titanium Oxides on Osteogenesis. Front Immunol (2017) 0.75
Microfluidic Platform for the Long-Term On-Chip Cultivation of Mammalian Cells for Lab-On-A-Chip Applications. Sensors (Basel) (2017) 0.75
3D Printing of Organs-On-Chips. Bioengineering (Basel) (2017) 0.75
Testing the Vascular Invasive Ability of Cancer Cells in Zebrafish (Danio Rerio). J Vis Exp (2016) 0.75
Microfluidic on-chip biomimicry for 3D cell culture: a fit-for-purpose investigation from the end user standpoint. Future Sci OA (2017) 0.75
A computational study of VEGF production by patterned retinal epithelial cell colonies as a model for neovascular macular degeneration. J Biol Eng (2017) 0.75
Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol (2006) 8.81
Modeling tissue morphogenesis and cancer in 3D. Cell (2007) 7.49
The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol (2007) 7.38
Soft lithography for micro- and nanoscale patterning. Nat Protoc (2010) 4.82
Cell interactions with three-dimensional matrices. Curr Opin Cell Biol (2002) 4.34
Microfluidic culture platform for neuroscience research. Nat Protoc (2006) 4.02
Cell migration in 3D matrix. Curr Opin Cell Biol (2005) 3.63
Cell migration into scaffolds under co-culture conditions in a microfluidic platform. Lab Chip (2008) 2.70
Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging. Lab Chip (2008) 2.34
Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue Eng (2006) 1.98
Transport-mediated angiogenesis in 3D epithelial coculture. FASEB J (2009) 1.58
Microfluidic platforms for studies of angiogenesis, cell migration, and cell-cell interactions. Sixth International Bio-Fluid Mechanics Symposium and Workshop March 28-30, 2008 Pasadena, California. Ann Biomed Eng (2010) 1.49
A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab Chip (2010) 1.33
Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. Biomicrofluidics (2011) 1.29
In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients. Lab Chip (2011) 1.24
New dimensions in tumor immunology: what does 3D culture reveal? Trends Mol Med (2008) 1.22
Surface-treatment-induced three-dimensional capillary morphogenesis in a microfluidic platform. Adv Mater (2009) 1.17
Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering. Tissue Eng (2004) 1.13
Protocol for the fabrication of enzymatically crosslinked gelatin microchannels for microfluidic cell culture. Nat Protoc (2007) 1.12
Sprouting angiogenesis under a chemical gradient regulated by interactions with an endothelial monolayer in a microfluidic platform. Anal Chem (2011) 1.08
Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling. J Biol Chem (2008) 1.03
Three-dimensional extracellular matrix-mediated neural stem cell differentiation in a microfluidic device. Lab Chip (2012) 0.97
Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system. Ann Biomed Eng (2011) 0.97
Hot embossing for fabrication of a microfluidic 3D cell culture platform. Biomed Microdevices (2011) 0.91
A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices (2010) 0.90
Investigation of bacterial chemotaxis in flow-based microfluidic devices. Nat Protoc (2010) 0.89
Microfluidic assay of endothelial cell migration in 3D interpenetrating polymer semi-network HA-Collagen hydrogel. Biomed Microdevices (2011) 0.86
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A (2006) 7.48
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest (2004) 5.68
Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A (2004) 4.31
Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation (2005) 2.89
Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci U S A (2006) 2.75
Cell migration into scaffolds under co-culture conditions in a microfluidic platform. Lab Chip (2008) 2.70
Mechanotransduction through growth-factor shedding into the extracellular space. Nature (2004) 2.48
Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging. Lab Chip (2008) 2.34
Cell mechanics and mechanotransduction: pathways, probes, and physiology. Am J Physiol Cell Physiol (2004) 2.32
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A (2012) 2.29
Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration. Circulation (2004) 2.11
Computational model for cell migration in three-dimensional matrices. Biophys J (2005) 2.09
Interstitial flow influences direction of tumor cell migration through competing mechanisms. Proc Natl Acad Sci U S A (2011) 1.81
Biomechanics: cell research and applications for the next decade. Ann Biomed Eng (2009) 1.81
Force-induced activation of talin and its possible role in focal adhesion mechanotransduction. J Biomech (2007) 1.69
Measuring molecular rupture forces between single actin filaments and actin-binding proteins. Proc Natl Acad Sci U S A (2008) 1.59
Transport-mediated angiogenesis in 3D epithelial coculture. FASEB J (2009) 1.58
Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence. Biomaterials (2002) 1.52
Kinetic control of dimer structure formation in amyloid fibrillogenesis. Proc Natl Acad Sci U S A (2004) 1.52
Computational modeling of cardiovascular response to orthostatic stress. J Appl Physiol (1985) (2002) 1.52
Microfluidic platforms for studies of angiogenesis, cell migration, and cell-cell interactions. Sixth International Bio-Fluid Mechanics Symposium and Workshop March 28-30, 2008 Pasadena, California. Ann Biomed Eng (2010) 1.49
The relationship between Helicobacter pylori infection and Alzheimer's disease in Japan. J Neurol (2011) 1.44
A three-dimensional viscoelastic model for cell deformation with experimental verification. Biophys J (2003) 1.42
Mechanical deformation of neutrophils into narrow channels induces pseudopod projection and changes in biomechanical properties. J Appl Physiol (1985) (2005) 1.42
Mechanotransduction in cardiac myocytes. Ann N Y Acad Sci (2004) 1.40
A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab Chip (2010) 1.33
Self-assembling short oligopeptides and the promotion of angiogenesis. Biomaterials (2005) 1.33
Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. Biomicrofluidics (2011) 1.29
Formation and optogenetic control of engineered 3D skeletal muscle bioactuators. Lab Chip (2012) 1.28
Microfluidic models of vascular functions. Annu Rev Biomed Eng (2012) 1.25
Poly(dimethylsiloxane)-based protein preconcentration using a nanogap generated by junction gap breakdown. Anal Chem (2007) 1.25
Effects of the mechanical properties of collagen gel on the in vitro formation of microvessel networks by endothelial cells. Tissue Eng (2007) 1.24
In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients. Lab Chip (2011) 1.24
Computational analysis of viscoelastic properties of crosslinked actin networks. PLoS Comput Biol (2009) 1.20
Mechanisms of tumor cell extravasation in an in vitro microvascular network platform. Integr Biol (Camb) (2013) 1.19
Cellular fluid mechanics and mechanotransduction. Ann Biomed Eng (2005) 1.18
Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr Biol (Camb) (2013) 1.17
Surface-treatment-induced three-dimensional capillary morphogenesis in a microfluidic platform. Adv Mater (2009) 1.17
Tumor cell migration in complex microenvironments. Cell Mol Life Sci (2012) 1.16
In vitro model of tumor cell extravasation. PLoS One (2013) 1.16
Generation of core-shell microcapsules with three-dimensional focusing device for efficient formation of cell spheroid. Lab Chip (2010) 1.16
Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow. Exp Cell Res (2005) 1.15
Stress transmission in the lung: pathways from organ to molecule. Annu Rev Physiol (2006) 1.15
Three-dimensional cellular deformation analysis with a two-photon magnetic manipulator workstation. Biophys J (2002) 1.12
A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture under a controlled hypoxic environment. Lab Chip (2012) 1.12
VASP involvement in force-mediated adherens junction strengthening. Biochem Biophys Res Commun (2008) 1.09
Sprouting angiogenesis under a chemical gradient regulated by interactions with an endothelial monolayer in a microfluidic platform. Anal Chem (2011) 1.08
Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial. J Biomater Sci Polym Ed (2002) 1.05
Engineering of in vitro 3D capillary beds by self-directed angiogenic sprouting. PLoS One (2012) 1.04
Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling. J Biol Chem (2008) 1.03
Atomistic simulation approach to a continuum description of self-assembled beta-sheet filaments. Biophys J (2006) 1.03
Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A (2014) 1.02
Cytoskeletal remodeling and cellular activation during deformation of neutrophils into narrow channels. J Appl Physiol (1985) (2005) 1.02
Nuclear mechanics and methods. Methods Cell Biol (2007) 1.01
Functional characterization of OsPPT1, which encodes p-hydroxybenzoate polyprenyltransferase involved in ubiquinone biosynthesis in Oryza sativa. Plant Cell Physiol (2006) 1.01
Neutrophil transit times through pulmonary capillaries: the effects of capillary geometry and fMLP-stimulation. Biophys J (2002) 1.01
Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions. Integr Biol (Camb) (2012) 1.00
Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. Stem Cell Rev (2015) 0.98
Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol (2013) 0.98
Three-dimensional extracellular matrix-mediated neural stem cell differentiation in a microfluidic device. Lab Chip (2012) 0.97
Microfluidic platforms for mechanobiology. Lab Chip (2013) 0.97
Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system. Ann Biomed Eng (2011) 0.97
Intra-aneurysmal hemodynamic alterations by a self-expandable intracranial stent and flow diversion stent: high intra-aneurysmal pressure remains regardless of flow velocity reduction. J Neurointerv Surg (2012) 0.96
Mechanical analysis of atherosclerotic plaques based on optical coherence tomography. Ann Biomed Eng (2004) 0.95
Microfluidic approaches to bacterial biofilm formation. Molecules (2012) 0.95
Dynamic mechanisms of cell rigidity sensing: insights from a computational model of actomyosin networks. PLoS One (2012) 0.95
Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule. Exp Cell Res (2008) 0.95
Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures. PLoS One (2012) 0.94
3D matrix microenvironment for targeted differentiation of embryonic stem cells into neural and glial lineages. Biomaterials (2013) 0.94
Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems. Integr Biol (Camb) (2014) 0.93
Hot embossing for fabrication of a microfluidic 3D cell culture platform. Biomed Microdevices (2011) 0.91