Published in Integr Biol (Camb) on October 01, 2013
Traversing the basement membrane in vivo: a diversity of strategies. J Cell Biol (2014) 1.11
Bioreactor technologies to support liver function in vitro. Adv Drug Deliv Rev (2014) 1.05
In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform. Front Bioeng Biotechnol (2016) 1.04
Microfluidic techniques for development of 3D vascularized tissue. Biomaterials (2014) 1.02
Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems. Integr Biol (Camb) (2014) 0.93
In vitro models of the metastatic cascade: from local invasion to extravasation. Drug Discov Today (2013) 0.91
Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells. Cancer Discov (2016) 0.89
Control of perfusable microvascular network morphology using a multiculture microfluidic system. Tissue Eng Part C Methods (2013) 0.89
Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade. Cancer Res (2016) 0.87
Intravital imaging of mesenchymal stem cell trafficking and association with platelets and neutrophils. Stem Cells (2015) 0.87
A microfluidic platform for quantitative analysis of cancer angiogenesis and intravasation. Biomicrofluidics (2014) 0.86
Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics. J Biomech Eng (2016) 0.85
Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks. Nat Commun (2016) 0.84
Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective. Adv Mater (2013) 0.82
Impact of dimensionality and network disruption on microrheology of cancer cells in 3D environments. PLoS Comput Biol (2014) 0.82
A high-throughput mechanofluidic screening platform for investigating tumor cell adhesion during metastasis. Lab Chip (2015) 0.78
A microchip platform for interrogating tumor-macrophage paracrine signaling at the single-cell level. Lab Chip (2014) 0.78
Numerical simulation of a single cell passing through a narrow slit. Biomech Model Mechanobiol (2016) 0.77
Quantification of Malignant Breast Cancer Cell MDA-MB-231 Transmigration Across Brain and Lung Microvascular Endothelium. Ann Biomed Eng (2015) 0.77
Physical view on migration modes. Cell Adh Migr (2015) 0.77
Microcirculation-on-a-Chip: A Microfluidic Platform for Assaying Blood- and Lymphatic-Vessel Permeability. PLoS One (2015) 0.77
Microfluidic models for adoptive cell-mediated cancer immunotherapies. Drug Discov Today (2016) 0.76
Microfluidics: A new tool for modeling cancer-immune interactions. Trends Cancer (2016) 0.76
Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models. Front Oncol (2015) 0.76
Progress towards understanding heterotypic interactions in multi-culture models of breast cancer. Integr Biol (Camb) (2016) 0.76
Metastasis of circulating tumor cells: Favorable soil or suitable biomechanics, or both? Cell Adh Migr (2015) 0.76
Effects of 3D geometries on cellular gradient sensing and polarization. Phys Biol (2016) 0.76
Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment. Adv Exp Med Biol (2016) 0.75
An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms. Lab Chip (2016) 0.75
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology (2016) 0.75
Three-dimensional cage-like microscaffolds for cell invasion studies. Sci Rep (2015) 0.75
Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels. Adv Healthc Mater (2016) 0.75
A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration. Biophys J (2016) 0.75
Engineered Microvessels for the Study of Human Disease. J Biomech Eng (2016) 0.75
Metastasis as a therapeutic target in prostate cancer: a conceptual framework. Am J Clin Exp Urol (2014) 0.75
On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics. Nat Protoc (2017) 0.75
The Predictive Link between Matrix and Metastasis. Curr Opin Chem Eng (2016) 0.75
Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo. Sci Rep (2015) 0.75
The Mechanics of Single Cell and Collective Migration of Tumor Cells. J Biomech Eng (2016) 0.75
A microfluidic device for isolation and characterization of transendothelial migrating cancer cells. Biomicrofluidics (2017) 0.75
Vasculature-On-A-Chip for In Vitro Disease Models. Bioengineering (Basel) (2017) 0.75
Cancer-related inflammation. Nature (2008) 34.21
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer (2003) 22.78
Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature (2007) 19.33
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature (2005) 6.60
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol (2001) 6.21
Seeding and propagation of untransformed mouse mammary cells in the lung. Science (2008) 5.33
Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol (1998) 4.41
Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med (2000) 4.36
Real-time imaging reveals the single steps of brain metastasis formation. Nat Med (2009) 3.95
Illuminating the metastatic process. Nat Rev Cancer (2007) 3.80
In vitro microvessels for the study of angiogenesis and thrombosis. Proc Natl Acad Sci U S A (2012) 3.61
Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J Cell Biol (2004) 3.47
Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science (2008) 3.39
Formation of perfused, functional microvascular tubes in vitro. Microvasc Res (2006) 2.85
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A (2012) 2.29
High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A (2007) 2.13
Role of the cytoskeleton during leukocyte responses. Nat Rev Immunol (2004) 2.11
Fluid forces control endothelial sprouting. Proc Natl Acad Sci U S A (2011) 2.09
A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction. Cancer Res (2002) 1.97
A simple quantitative assay for studying the invasive potential of high and low human metastatic variants. Cancer Lett (1987) 1.94
Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels. Nat Protoc (2012) 1.89
Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS One (2009) 1.87
Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J Immunol (1996) 1.84
Validation of a model of colon cancer progression. J Pathol (2000) 1.76
Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms. Int J Cancer (2009) 1.72
Stepping out of the flow: capillary extravasation in cancer metastasis. Clin Exp Metastasis (2007) 1.68
Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci (2010) 1.67
Engineering of functional, perfusable 3D microvascular networks on a chip. Lab Chip (2013) 1.64
The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells. Int J Cancer (2009) 1.64
Dormancy of solitary metastatic cells. Cell Cycle (2006) 1.53
CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. PLoS One (2008) 1.36
Morphological study of the interaction of intravascular tumor cells with endothelial cells and subendothelial matrix. Cancer Res (1988) 1.29
Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well. Proc Natl Acad Sci U S A (1996) 1.25
Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth. Cancer Res (1994) 1.23
Mechanisms by which E-selectin regulates diapedesis of colon cancer cells under flow conditions. Cancer Res (2008) 1.19
Full range physiological mass transport control in 3D tissue cultures. Lab Chip (2012) 1.18
In vitro model of tumor cell extravasation. PLoS One (2013) 1.16
Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-α-activated endothelial cells via both leukocyte-like and novel mechanisms. Stem Cells (2012) 1.14
A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime. Lab Chip (2012) 1.12
Non-invasive measurement of solute permeability in cerebral microvessels of the rat. Microvasc Res (2008) 1.12
Metastatic tumor cell interactions with endothelium, basement membrane and tissue. Curr Opin Cell Biol (1989) 1.12
Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device. Lab Chip (2013) 1.10
Cancer cells regulate biomechanical properties of human microvascular endothelial cells. J Biol Chem (2011) 1.09
Permeability of single capillaries to intermediate-sized colored solutes. Am J Physiol (1983) 1.08
Molecular events during leukocyte diapedesis. FEBS J (2006) 1.06
Multi-step microfluidic device for studying cancer metastasis. Lab Chip (2007) 1.00
Realtime visualization of tumor cell/endothelial cell interactions during transmigration across the endothelial barrier. J Cancer Res Clin Oncol (2002) 0.99
Systemic Analysis of Tumor Cell-Induced Endothelial Calcium Signaling and Junction Disassembly. Cell Mol Bioeng (2009) 0.85
Tumor-conditioned medium increases macromolecular permeability of endothelial cell monolayer. Cancer Lett (1995) 0.82
Paracrine VEGF/VE-cadherin action on ovarian cancer permeability. Exp Biol Med (Maywood) (2006) 0.80
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A (2006) 7.48
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest (2004) 5.68
Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A (2004) 4.31
Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation (2005) 2.89
Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci U S A (2006) 2.75
Cell migration into scaffolds under co-culture conditions in a microfluidic platform. Lab Chip (2008) 2.70
Mechanotransduction through growth-factor shedding into the extracellular space. Nature (2004) 2.48
Cell mechanics and mechanotransduction: pathways, probes, and physiology. Am J Physiol Cell Physiol (2004) 2.32
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A (2012) 2.29
Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration. Circulation (2004) 2.11
Computational model for cell migration in three-dimensional matrices. Biophys J (2005) 2.09
Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels. Nat Protoc (2012) 1.89
Interstitial flow influences direction of tumor cell migration through competing mechanisms. Proc Natl Acad Sci U S A (2011) 1.81
Biomechanics: cell research and applications for the next decade. Ann Biomed Eng (2009) 1.81
Force-induced activation of talin and its possible role in focal adhesion mechanotransduction. J Biomech (2007) 1.69
Measuring molecular rupture forces between single actin filaments and actin-binding proteins. Proc Natl Acad Sci U S A (2008) 1.59
Transport-mediated angiogenesis in 3D epithelial coculture. FASEB J (2009) 1.58
Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence. Biomaterials (2002) 1.52
Kinetic control of dimer structure formation in amyloid fibrillogenesis. Proc Natl Acad Sci U S A (2004) 1.52
Computational modeling of cardiovascular response to orthostatic stress. J Appl Physiol (1985) (2002) 1.52
Microfluidic platforms for studies of angiogenesis, cell migration, and cell-cell interactions. Sixth International Bio-Fluid Mechanics Symposium and Workshop March 28-30, 2008 Pasadena, California. Ann Biomed Eng (2010) 1.49
Mechanical deformation of neutrophils into narrow channels induces pseudopod projection and changes in biomechanical properties. J Appl Physiol (1985) (2005) 1.42
A three-dimensional viscoelastic model for cell deformation with experimental verification. Biophys J (2003) 1.42
Mechanotransduction in cardiac myocytes. Ann N Y Acad Sci (2004) 1.40
A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab Chip (2010) 1.33
Self-assembling short oligopeptides and the promotion of angiogenesis. Biomaterials (2005) 1.33
Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. Biomicrofluidics (2011) 1.29
Formation and optogenetic control of engineered 3D skeletal muscle bioactuators. Lab Chip (2012) 1.28
Microfluidic models of vascular functions. Annu Rev Biomed Eng (2012) 1.25
In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients. Lab Chip (2011) 1.24
Computational analysis of viscoelastic properties of crosslinked actin networks. PLoS Comput Biol (2009) 1.20
Cellular fluid mechanics and mechanotransduction. Ann Biomed Eng (2005) 1.18
Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr Biol (Camb) (2013) 1.17
Surface-treatment-induced three-dimensional capillary morphogenesis in a microfluidic platform. Adv Mater (2009) 1.17
Tumor cell migration in complex microenvironments. Cell Mol Life Sci (2012) 1.16
In vitro model of tumor cell extravasation. PLoS One (2013) 1.16
Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow. Exp Cell Res (2005) 1.15
Stress transmission in the lung: pathways from organ to molecule. Annu Rev Physiol (2006) 1.15
Three-dimensional cellular deformation analysis with a two-photon magnetic manipulator workstation. Biophys J (2002) 1.12
A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture under a controlled hypoxic environment. Lab Chip (2012) 1.12
VASP involvement in force-mediated adherens junction strengthening. Biochem Biophys Res Commun (2008) 1.09
Sprouting angiogenesis under a chemical gradient regulated by interactions with an endothelial monolayer in a microfluidic platform. Anal Chem (2011) 1.08
Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial. J Biomater Sci Polym Ed (2002) 1.05
Engineering of in vitro 3D capillary beds by self-directed angiogenic sprouting. PLoS One (2012) 1.04
Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling. J Biol Chem (2008) 1.03
Atomistic simulation approach to a continuum description of self-assembled beta-sheet filaments. Biophys J (2006) 1.03
Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A (2014) 1.02
Cytoskeletal remodeling and cellular activation during deformation of neutrophils into narrow channels. J Appl Physiol (1985) (2005) 1.02
Neutrophil transit times through pulmonary capillaries: the effects of capillary geometry and fMLP-stimulation. Biophys J (2002) 1.01
Nuclear mechanics and methods. Methods Cell Biol (2007) 1.01
Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions. Integr Biol (Camb) (2012) 1.00
Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. Stem Cell Rev (2015) 0.98
Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol (2013) 0.98
Three-dimensional extracellular matrix-mediated neural stem cell differentiation in a microfluidic device. Lab Chip (2012) 0.97
Microfluidic platforms for mechanobiology. Lab Chip (2013) 0.97
Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system. Ann Biomed Eng (2011) 0.97
Mechanical analysis of atherosclerotic plaques based on optical coherence tomography. Ann Biomed Eng (2004) 0.95
Dynamic mechanisms of cell rigidity sensing: insights from a computational model of actomyosin networks. PLoS One (2012) 0.95
Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures. PLoS One (2012) 0.94
3D matrix microenvironment for targeted differentiation of embryonic stem cells into neural and glial lineages. Biomaterials (2013) 0.94
Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems. Integr Biol (Camb) (2014) 0.93
A hybrid continuum-discrete modelling approach to predict and control angiogenesis: analysis of combinatorial growth factor and matrix effects on vessel-sprouting morphology. Philos Trans A Math Phys Eng Sci (2010) 0.91
A microfluidic platform for studying the effects of small temperature gradients in an incubator environment. Biomicrofluidics (2008) 0.91
Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function. Mol Cell Biomech (2010) 0.91
Hot embossing for fabrication of a microfluidic 3D cell culture platform. Biomed Microdevices (2011) 0.91
A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices (2010) 0.90
Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels. Biomaterials (2010) 0.90
Fast fluorescence laser tracking microrheometry, II: quantitative studies of cytoskeletal mechanotransduction. Biophys J (2008) 0.90
Modular aspects of kinesin force generation machinery. Biophys J (2013) 0.90
Fast fluorescence laser tracking microrheometry. I: instrument development. Biophys J (2007) 0.90
Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion. Adv Healthc Mater (2012) 0.89
Control of perfusable microvascular network morphology using a multiculture microfluidic system. Tissue Eng Part C Methods (2013) 0.89
Contrasting effects of vasculogenic induction upon biaxial bioreactor stimulation of mesenchymal stem cells and endothelial progenitor cells cocultures in three-dimensional scaffolds under in vitro and in vivo paradigms for vascularized bone tissue engineering. Tissue Eng Part A (2012) 0.87
Dynamic role of cross-linking proteins in actin rheology. Biophys J (2011) 0.86
Endothelial nitric oxide production during in vitro simulation of external limb compression. Am J Physiol Heart Circ Physiol (2002) 0.86
Integrating focal adhesion dynamics, cytoskeleton remodeling, and actin motor activity for predicting cell migration on 3D curved surfaces of the extracellular matrix. Integr Biol (Camb) (2012) 0.86
A biomechanical model of sagittal tongue bending. J Biomech Eng (2002) 0.85
Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics. J Biomech Eng (2016) 0.85
Spectrally resolved multidepth fluorescence imaging. J Biomed Opt (2011) 0.85
Mucosal folding in biologic vessels. J Biomech Eng (2002) 0.85
Zero-stress state of intra- and extraparenchymal airways from human, pig, rabbit, and sheep lung. J Appl Physiol (1985) (2002) 0.84
A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils. Lab Chip (2012) 0.84
Passive and active microrheology for cross-linked F-actin networks in vitro. Acta Biomater (2009) 0.84
Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells. Stem Cells (2012) 0.84
Rapid prototyping of concave microwells for the formation of 3D multicellular cancer aggregates for drug screening. Adv Healthc Mater (2013) 0.84
Molecular origin of strain softening in cross-linked F-actin networks. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.82
Multiscale impact of nucleotides and cations on the conformational equilibrium, elasticity and rheology of actin filaments and crosslinked networks. Biomech Model Mechanobiol (2015) 0.81
Nascent vessel elongation rate is inversely related to diameter in in vitro angiogenesis. Integr Biol (Camb) (2012) 0.81
Nanointerstice-driven microflow. Small (2009) 0.81
A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs. Lab Chip (2015) 0.81
A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment. Lab Chip (2010) 0.80
Oxygen levels in thermoplastic microfluidic devices during cell culture. Lab Chip (2014) 0.80
Methodological considerations for global analysis of cellular FLIM/FRET measurements. J Biomed Opt (2012) 0.80
Model-based assessment of cardiovascular health from noninvasive measurements. Ann Biomed Eng (2002) 0.80
Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting. Integr Biol (Camb) (2013) 0.79
A coarse-grained model for force-induced protein deformation and kinetics. Biophys J (2006) 0.78