Published in Biochemistry on June 13, 2012
Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease. Biol Psychiatry (2014) 0.90
The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation. J Biol Chem (2012) 0.80
Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence. Sci Rep (2015) 0.77
The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target. Brain Res Bull (2016) 0.75
Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway. J Neurochem (2015) 0.75
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51
The molecular pathology of Alzheimer's disease. Neuron (1991) 8.21
2012 Alzheimer's disease facts and figures. Alzheimers Dement (2012) 5.43
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron (2003) 4.70
A thioredoxin gene fusion expression system that circumvents inclusion body formation in the E. coli cytoplasm. Biotechnology (N Y) (1993) 4.49
Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol (2004) 3.81
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A (2003) 3.36
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature (2010) 2.80
Soluble expression of recombinant proteins in the cytoplasm of Escherichia coli. Microb Cell Fact (2005) 2.67
Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A (2003) 2.44
Prediction of protein secondary structure from circular dichroism using theoretically derived spectra. Proteins (2011) 2.23
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A (2002) 2.16
Solution NMR of membrane proteins: practice and challenges. Magn Reson Chem (2006) 2.01
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? Biochemistry (2008) 1.54
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains. Neuropathol Appl Neurobiol (2012) 0.97
Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase. Science (2009) 2.30
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry (2008) 2.22
The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. Science (2012) 2.06
A sulfilimine bond identified in collagen IV. Science (2009) 1.69
Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins. Prog Nucl Magn Reson Spectrosc (2009) 1.57
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? Biochemistry (2008) 1.54
NMR assignments for a helical 40 kDa membrane protein. J Am Chem Soc (2004) 1.49
Structural models for the KCNQ1 voltage-gated potassium channel. Biochemistry (2007) 1.38
Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome. Biochemistry (2007) 1.35
Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin. Proc Natl Acad Sci U S A (2012) 1.27
DEER EPR measurements for membrane protein structures via bifunctional spin labels and lipodisq nanoparticles. Biochemistry (2013) 1.17
Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships? Biochim Biophys Acta (2010) 1.11
Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein. Biochemistry (2009) 1.11
Prokaryotic diacylglycerol kinase and undecaprenol kinase. Annu Rev Biophys (2011) 1.08
Destabilizing mutations promote membrane protein misfolding. Biochemistry (2004) 1.08
Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein. Biochemistry (2013) 1.07
Comprehensive evaluation of solution nuclear magnetic resonance spectroscopy sample preparation for helical integral membrane proteins. J Struct Funct Genomics (2006) 1.06
Topology and secondary structure of the N-terminal domain of diacylglycerol kinase. Biochemistry (2002) 1.05
Amphipols can support the activity of a membrane enzyme. J Am Chem Soc (2002) 1.04
Solution NMR spectroscopy of the human vasopressin V2 receptor, a G protein-coupled receptor. J Am Chem Soc (2005) 1.03
Cholesterol as a co-solvent and a ligand for membrane proteins. Protein Sci (2013) 0.97
Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp Cell Res (2008) 0.96
Membrane protein preparation for TROSY NMR screening. Methods Enzymol (2005) 0.96
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide. Biochemistry (2011) 0.96
Structural investigation of the transmembrane domain of KCNE1 in proteoliposomes. Biochemistry (2014) 0.95
Oxygen as a paramagnetic probe of membrane protein structure by cysteine mutagenesis and (19)F NMR spectroscopy. J Am Chem Soc (2002) 0.95
CHOBIMALT: a cholesterol-based detergent. Biochemistry (2010) 0.94
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase. J Am Chem Soc (2013) 0.93
Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. J Biol Chem (2010) 0.93
Elucidation of inositol hexaphosphate and heparin interaction sites and conformational changes in arrestin-1 by solution nuclear magnetic resonance. Biochemistry (2010) 0.93
Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environments. Biochemistry (2011) 0.92
A unified hydrophobicity scale for multispan membrane proteins. Proteins (2009) 0.92
Purification and initiation of structural characterization of human peripheral myelin protein 22, an integral membrane protein linked to peripheral neuropathies. Biochemistry (2007) 0.92
Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel. Curr Opin Struct Biol (2011) 0.90
The quiet renaissance of protein nuclear magnetic resonance. Biochemistry (2013) 0.90
The peripheral neuropathy-linked Trembler and Trembler-J mutant forms of peripheral myelin protein 22 are folding-destabilized. Biochemistry (2008) 0.89
Reversible folding of human peripheral myelin protein 22, a tetraspan membrane protein. Biochemistry (2013) 0.89
Lysophospholipid micelles sustain the stability and catalytic activity of diacylglycerol kinase in the absence of lipids. Biochemistry (2010) 0.89
Bicelles at low concentrations. Mol Pharm (2012) 0.88
Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits. J Gen Physiol (2009) 0.87
Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel. Biochemistry (2014) 0.87
The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells. J Biol Chem (2014) 0.86
Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis. J Biol Chem (2012) 0.85
Impact of bilayer lipid composition on the structure and topology of the transmembrane amyloid precursor C99 protein. J Am Chem Soc (2014) 0.85
Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteins. J Am Chem Soc (2011) 0.85
Structural basis for the Trembler-J phenotype of Charcot-Marie-Tooth disease. Structure (2011) 0.84
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1. Mol Pharmacol (2012) 0.84
KCNQ1/KCNE1 assembly, co-translation not required. Channels (Austin) (2010) 0.83
Functional delivery of a membrane protein into oocyte membranes using bicelles. Biochemistry (2010) 0.83
Bolaamphiphile-class surfactants can stabilize and support the function of solubilized integral membrane proteins. Biochemistry (2009) 0.83
Modest effects of lipid modifications on the structure of caveolin-3. Biochemistry (2014) 0.82
β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mol Cell Biol (2012) 0.82
Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices. J Membr Biol (2014) 0.82
Irreversible misfolding of diacylglycerol kinase is independent of aggregation and occurs prior to trimerization and membrane association. Biochemistry (2006) 0.80
The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins. Biochim Biophys Acta (2009) 0.80
Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP). Biochem Biophys Res Commun (2013) 0.80
Tailoring of membrane proteins by alternative splicing of pre-mRNA. Biochemistry (2012) 0.80
Phenotology of disease-linked proteins. Hum Mutat (2005) 0.79
A critical residue in the folding pathway of an integral membrane protein. Biochemistry (2002) 0.78
Analyzing oligomerization of individual transmembrane helices and of entire membrane proteins in E. coli: A hitchhiker's guide to GALLEX. Methods Mol Biol (2013) 0.77
Look and see if it is time to induce protein expression in Escherichia coli cultures. Biochemistry (2010) 0.77
The homology model of PMP22 suggests mutations resulting in peripheral neuropathy disrupt transmembrane helix packing. Biochemistry (2014) 0.77
Conformational Stability and Pathogenic Misfolding of the Integral Membrane Protein PMP22. J Am Chem Soc (2015) 0.76
The rhodopsin-arrestin-1 interaction in bicelles. Methods Mol Biol (2015) 0.75
Evidence for the presence of a critical disulfide bond in the mouse EP3γ receptor. Prostaglandins Other Lipid Mediat (2011) 0.75
Correction to CHOBIMALT: A Cholesterol-Based Detergent. Biochemistry (2013) 0.75