Published in Biochemistry on September 25, 2007
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry (2008) 2.22
Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins. Prog Nucl Magn Reson Spectrosc (2009) 1.57
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? Biochemistry (2008) 1.54
KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains. J Gen Physiol (2008) 1.52
DEER EPR measurements for membrane protein structures via bifunctional spin labels and lipodisq nanoparticles. Biochemistry (2013) 1.17
Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein. Biochemistry (2009) 1.11
Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2. J Biol Chem (2009) 1.10
Dependence of micelle size and shape on detergent alkyl chain length and head group. PLoS One (2013) 1.05
Intracellular domains interactions and gated motions of I(KS) potassium channel subunits. EMBO J (2009) 1.03
Structural investigation of the transmembrane domain of KCNE1 in proteoliposomes. Biochemistry (2014) 0.95
Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits. Biochem J (2010) 0.94
An Examination of KCNE1 Mutations and Common Variants in Chronic Tinnitus. Genes (Basel) (2010) 0.93
Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environments. Biochemistry (2011) 0.92
Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel. Curr Opin Struct Biol (2011) 0.90
The KCNE Tango - How KCNE1 Interacts with Kv7.1. Front Pharmacol (2012) 0.89
Lysophospholipid micelles sustain the stability and catalytic activity of diacylglycerol kinase in the absence of lipids. Biochemistry (2010) 0.89
Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel. Biochemistry (2014) 0.87
Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteins. J Am Chem Soc (2011) 0.85
Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes. BMC Evol Biol (2009) 0.84
KCNQ1/KCNE1 assembly, co-translation not required. Channels (Austin) (2010) 0.83
Functional delivery of a membrane protein into oocyte membranes using bicelles. Biochemistry (2010) 0.83
Biosynthesis and NMR-studies of a double transmembrane domain from the Y4 receptor, a human GPCR. J Biomol NMR (2008) 0.83
Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2. Sci Rep (2014) 0.80
The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins. Biochim Biophys Acta (2009) 0.80
Purification of the cystic fibrosis transmembrane conductance regulator protein expressed in Saccharomyces cerevisiae. J Vis Exp (2014) 0.77
Probing Structural Dynamics and Topology of the KCNE1 Membrane Protein in Lipid Bilayers via Site-Directed Spin Labeling and Electron Paramagnetic Resonance Spectroscopy. Biochemistry (2015) 0.77
Investigation of the utility of selective methyl protonation for determination of membrane protein structures. J Biomol NMR (2008) 0.75
A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit. Sci Rep (2015) 0.75
Development of electron spin echo envelope modulation spectroscopy to probe the secondary structure of recombinant membrane proteins in a lipid bilayer. Protein Sci (2015) 0.75
Characterization of the structure of lipodisq nanoparticles in the presence of KCNE1 by dynamic light scattering and transmission electron microscopy. Chem Phys Lipids (2016) 0.75
Solution NMR of MPS-1 reveals a random coil cytosolic domain structure. PLoS One (2014) 0.75
Probing the interaction of the potassium channel modulating KCNE1 in lipid bilayers via solid-state NMR spectroscopy. Magn Reson Chem (2017) 0.75
Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T). HeartRhythm Case Rep (2016) 0.75
NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94
Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR (1999) 26.99
Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution. Proc Natl Acad Sci U S A (1997) 13.28
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature (1996) 9.77
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature (1996) 8.63
Using NMRView to visualize and analyze the NMR spectra of macromolecules. Methods Mol Biol (2004) 8.02
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet (1996) 7.35
Modulation of A-type potassium channels by a family of calcium sensors. Nature (2000) 5.62
MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell (1999) 5.49
TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins. Proc Natl Acad Sci U S A (1998) 4.79
Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Nature (1994) 4.38
Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nat Genet (1997) 3.90
A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature (2000) 3.75
Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice. JAMA (2005) 3.51
The MinK-related peptides. Neuropharmacology (2004) 2.84
KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther (2001) 2.78
Protein dynamics measurements by TROSY-based NMR experiments. J Magn Reson (2000) 2.12
The KCNQ1 potassium channel: from gene to physiological function. Physiology (Bethesda) (2005) 2.11
KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. Neuron (2004) 2.07
A minK-HERG complex regulates the cardiac potassium current I(Kr). Nature (1997) 2.03
Solution NMR of membrane proteins: practice and challenges. Magn Reson Chem (2006) 2.01
An evaluation of detergents for NMR structural studies of membrane proteins. J Biomol NMR (2004) 1.99
Nuclear magnetic resonance spectroscopy of high-molecular-weight proteins. Annu Rev Biochem (2004) 1.84
Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex. Neuron (2003) 1.80
Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity. J Biol Chem (1997) 1.79
Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol (2005) 1.66
Comparative analysis of amino acid distributions in integral membrane proteins from 107 genomes. Proteins (2005) 1.57
Structural determinants of KvLQT1 control by the KCNE family of proteins. J Biol Chem (2000) 1.54
MinK subdomains that mediate modulation of and association with KvLQT1. J Gen Physiol (2000) 1.54
Incorporation of acetylcholine receptors and Cl- channels in Xenopus oocytes injected with Torpedo electroplaque membranes. Proc Natl Acad Sci U S A (1995) 1.53
A single transmembrane site in the KCNE-encoded proteins controls the specificity of KvLQT1 channel gating. J Biol Chem (2002) 1.48
Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. J Mol Biol (2001) 1.43
Amphipols: polymeric surfactants for membrane biology research. Cell Mol Life Sci (2003) 1.42
Cloning and expression of multiple integral membrane proteins from Mycobacterium tuberculosis in Escherichia coli. Protein Sci (2005) 1.40
Location and orientation of minK within the I(Ks) potassium channel complex. J Biol Chem (2001) 1.40
Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes. Proc Natl Acad Sci U S A (2002) 1.36
KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression. J Biol Chem (2006) 1.36
Functional and molecular aspects of voltage-gated K+ channel beta subunits. Ann N Y Acad Sci (1999) 1.34
Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. FASEB J (2002) 1.29
M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit. FEBS Lett (2000) 1.29
An LQT mutant minK alters KvLQT1 trafficking. Am J Physiol Cell Physiol (2004) 1.24
Cell-free production of G protein-coupled receptors for functional and structural studies. J Struct Biol (2007) 1.24
MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. J Neurosci (2003) 1.21
Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP. J Membr Biol (2003) 1.16
Regulation of ion channel expression by cytoplasmic subunits. Curr Opin Neurobiol (1998) 1.13
Modulation of Kv channel alpha/beta subunit interactions. Trends Cardiovasc Med (1999) 1.10
Structure and dynamics of bacteriophage IKe major coat protein in MPG micelles by solution NMR. Biochemistry (1996) 1.08
French swimwear for membrane proteins. Chembiochem (2004) 1.08
RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies. J Biol Chem (2003) 1.06
Amphipathic polymers: tools to fold integral membrane proteins to their active form. Biochemistry (2006) 1.06
Amphipols can support the activity of a membrane enzyme. J Am Chem Soc (2002) 1.04
Solution NMR spectroscopy of the human vasopressin V2 receptor, a G protein-coupled receptor. J Am Chem Soc (2005) 1.03
Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). Mol Interv (2001) 1.02
Conformation and ion-channeling activity of a 27-residue peptide modeled on the single-transmembrane segment of the IsK (minK) protein. Biochemistry (1998) 0.96
Kinetic study of folding and misfolding of diacylglycerol kinase in model membranes. Biochemistry (2001) 0.95
Lysophosphatidylglycerol: a novel effective detergent for solubilizing and purifying the cystic fibrosis transmembrane conductance regulator. Anal Biochem (1998) 0.95
Synthetic putative transmembrane region of minimal potassium channel protein (minK) adopts an alpha-helical conformation in phospholipid membranes. Biochem J (1997) 0.93
Spectroscopic and functional characterization of the putative transmembrane segment of the minK potassium channel. Biochemistry (1993) 0.93
Do all voltage-gated potassium channels use MiRPs? Circ Res (2001) 0.93
Incorporation of proteins into (Xenopus) oocytes by proteoliposome microinjection: functional characterization of a novel aquaporin. J Cell Sci (1996) 0.93
Use of amphipathic polymers to deliver a membrane protein to lipid bilayers. FEBS Lett (2001) 0.91
Peptides modeled on the transmembrane region of the slow voltage-gated IsK potassium channel: structural characterization of peptide assemblies in the beta-strand conformation. Biochemistry (1996) 0.89
Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy. Chembiochem (2007) 0.89
Solubilization of rat liver vasopressin receptors as a complex with a guanine-nucleotide-binding protein and phosphoinositide-specific phospholipase C. Biochem J (1989) 0.85
Solubilization and reconstitution of vasopressin V1 receptors of rat liver. Mol Pharmacol (1987) 0.81
A single-residue deletion alters the lipid selectivity of a K+ channel-associated peptide in the beta-conformation: spin label electron spin resonance studies. Biophys J (1997) 0.81
Irreversible misfolding of diacylglycerol kinase is independent of aggregation and occurs prior to trimerization and membrane association. Biochemistry (2006) 0.80
The demicellization of alkyltrimethylammonium bromides in 0.1 M sodium chloride solution studied by isothermal titration calorimetry. Colloids Surf B Biointerfaces (2006) 0.80
Solubilization of a guanine nucleotide-sensitive form of vasopressin V2 receptors from porcine kidney. Arch Biochem Biophys (1989) 0.79
Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation (2007) 4.10
PiggyBac transposon-mediated gene transfer in human cells. Mol Ther (2007) 4.07
Molecular basis of an inherited epilepsy. Neuron (2002) 3.77
Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest (2003) 3.00
Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation (2002) 2.98
KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome. Circulation (2005) 2.78
Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation (2013) 2.66
Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation (2008) 2.56
Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study. J Infect Dis (2005) 2.43
Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase. Science (2009) 2.30
Impact of genetics on the clinical management of channelopathies. J Am Coll Cardiol (2013) 2.30
Cardiac sodium channel dysfunction in sudden infant death syndrome. Circulation (2007) 2.28
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry (2008) 2.22
The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. Science (2012) 2.06
Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J Am Soc Nephrol (2008) 2.04
Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women. Pharmacogenetics (2003) 2.03
Long QT syndrome-associated mutations in intrauterine fetal death. JAMA (2013) 2.00
NOS1AP is a genetic modifier of the long-QT syndrome. Circulation (2009) 2.00
Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. J Am Coll Cardiol (2008) 1.91
Cardiac ion channels. Annu Rev Physiol (2002) 1.90
Myotonia congenita. Adv Genet (2008) 1.80
Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J Neurosci (2003) 1.77
Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: characteristic T-U-wave patterns predict the KCNJ2 genotype. Circulation (2005) 1.77
Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks). J Mol Cell Cardiol (2005) 1.70
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest (2008) 1.69
A sulfilimine bond identified in collagen IV. Science (2009) 1.69
Polymorphic ventricular tachycardia and KCNJ2 mutations. Heart Rhythm (2004) 1.68
Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block. Circulation (2002) 1.65
Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. Proc Natl Acad Sci U S A (2004) 1.65
KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes. Am J Hum Genet (2002) 1.60
A KCNH2 branch point mutation causing aberrant splicing contributes to an explanation of genotype-negative long QT syndrome. Heart Rhythm (2008) 1.59
Vagal reflexes following an exercise stress test: a simple clinical tool for gene-specific risk stratification in the long QT syndrome. J Am Coll Cardiol (2012) 1.58
Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins. Prog Nucl Magn Reson Spectrosc (2009) 1.57
Multiplexed transposon-mediated stable gene transfer in human cells. Proc Natl Acad Sci U S A (2010) 1.57
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? Biochemistry (2008) 1.54
Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel. Circ Arrhythm Electrophysiol (2008) 1.53
The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet (2002) 1.51
NMR assignments for a helical 40 kDa membrane protein. J Am Chem Soc (2004) 1.49
Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population. Circulation (2005) 1.48
A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet (2011) 1.48
Structural models for the KCNQ1 voltage-gated potassium channel. Biochemistry (2007) 1.38
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation (2011) 1.38
Functional zinc finger/sleeping beauty transposase chimeras exhibit attenuated overproduction inhibition. FEBS Lett (2005) 1.35
NMR solution structure of the N-terminal domain of hERG and its interaction with the S4-S5 linker. Biochem Biophys Res Commun (2010) 1.34
The genetic basis of variability in drug responses. Nat Rev Drug Discov (2002) 1.34
Possible role of horizontal gene transfer in the colonization of sea ice by algae. PLoS One (2012) 1.31
Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption. Hum Hered (2007) 1.30
Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet (2014) 1.27
Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin. Proc Natl Acad Sci U S A (2012) 1.27
Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27
Improved DNA sequencing quality and efficiency using an optimized fast cycle sequencing protocol. Biotechniques (2007) 1.26
Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice. Kidney Int (2004) 1.24
Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. Brain Res Mol Brain Res (2002) 1.24
Nucleotides and phospholipids compete for binding to the C terminus of KATP channels. Proc Natl Acad Sci U S A (2002) 1.23
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet (2013) 1.23
Divergent biophysical defects caused by mutant sodium channels in dilated cardiomyopathy with arrhythmia. Circ Res (2007) 1.23
Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Clin Infect Dis (2006) 1.18
Strategy for encoding and comparison of gene expression signatures. Genome Biol (2007) 1.18
DEER EPR measurements for membrane protein structures via bifunctional spin labels and lipodisq nanoparticles. Biochemistry (2013) 1.17
Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics (2009) 1.16
Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia. J Am Coll Cardiol (2012) 1.15
Single-channel properties of human NaV1.1 and mechanism of channel dysfunction in SCN1A-associated epilepsy. J Gen Physiol (2006) 1.14
Divergent sodium channel defects in familial hemiplegic migraine. Proc Natl Acad Sci U S A (2008) 1.13
Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures. J Physiol (2005) 1.12
Manipulating piggyBac transposon chromosomal integration site selection in human cells. Mol Ther (2011) 1.12
Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships? Biochim Biophys Acta (2010) 1.11
Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia. Heart Rhythm (2011) 1.11
Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein. Biochemistry (2009) 1.11
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties. Proc Natl Acad Sci U S A (2006) 1.11
Coupled analysis of gene expression and chromosomal location. Genomics (2005) 1.10
KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex. FEBS J (2008) 1.10
Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives. Heart Rhythm (2005) 1.10
Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia (2008) 1.09
Prokaryotic diacylglycerol kinase and undecaprenol kinase. Annu Rev Biophys (2011) 1.08
Destabilizing mutations promote membrane protein misfolding. Biochemistry (2004) 1.08
Nonfunctional SCN1A is common in severe myoclonic epilepsy of infancy. Epilepsia (2006) 1.07
Functional repair of a mutant chloride channel using a trans-splicing ribozyme. J Clin Invest (2002) 1.07
Nav 1.1 dysfunction in genetic epilepsy with febrile seizures-plus or Dravet syndrome. Eur J Neurosci (2011) 1.07
Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells. J Physiol (2002) 1.07
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. Proc Natl Acad Sci U S A (2004) 1.07
Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein. Biochemistry (2013) 1.07
Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. J Neurosci (2006) 1.06
Comprehensive evaluation of solution nuclear magnetic resonance spectroscopy sample preparation for helical integral membrane proteins. J Struct Funct Genomics (2006) 1.06