Published in Cell on June 08, 2012
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature (2013) 4.03
Stress granules as crucibles of ALS pathogenesis. J Cell Biol (2013) 2.80
Intrinsically disordered proteins in cellular signalling and regulation. Nat Rev Mol Cell Biol (2015) 2.69
Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization. Cell (2015) 2.17
Stress granules and cell signaling: more than just a passing phase? Trends Biochem Sci (2013) 2.01
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics. Proc Natl Acad Sci U S A (2015) 1.85
From sequence and forces to structure, function, and evolution of intrinsically disordered proteins. Structure (2013) 1.76
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). Nat Commun (2015) 1.74
Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress. Cell (2015) 1.62
Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers. Nat Mater (2015) 1.56
Phase transitions and size scaling of membrane-less organelles. J Cell Biol (2013) 1.46
Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell (2016) 1.44
Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3. Elife (2016) 1.42
The BEACH Domain Protein SPIRRIG Is Essential for Arabidopsis Salt Stress Tolerance and Functions as a Regulator of Transcript Stabilization and Localization. PLoS Biol (2015) 1.42
Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories. PLoS Pathog (2016) 1.40
Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules. Elife (2015) 1.34
Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. Elife (2014) 1.31
Assemblages: functional units formed by cellular phase separation. J Cell Biol (2014) 1.30
The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes Dev (2013) 1.29
RNA Controls PolyQ Protein Phase Transitions. Mol Cell (2015) 1.28
ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell (2016) 1.26
Inverse size scaling of the nucleolus by a concentration-dependent phase transition. Curr Biol (2015) 1.19
A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells. Nat Cell Biol (2013) 1.19
Processing body and stress granule assembly occur by independent and differentially regulated pathways in Saccharomyces cerevisiae. Genetics (2012) 1.16
Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork. PLoS Biol (2013) 1.14
Coexisting Liquid Phases Underlie Nucleolar Subcompartments. Cell (2016) 1.11
RNA transcription modulates phase transition-driven nuclear body assembly. Proc Natl Acad Sci U S A (2015) 1.09
Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease. Brain Res (2016) 1.08
The "Observer Effect" in genome-wide surveys of protein-RNA interactions. Mol Cell (2013) 1.06
The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion. Annu Rev Biochem (2015) 1.04
Evidence of direct complementary interactions between messenger RNAs and their cognate proteins. Nucleic Acids Res (2013) 1.03
Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin. Proc Natl Acad Sci U S A (2014) 1.03
Regulation of stress granules and P-bodies during RNA virus infection. Wiley Interdiscip Rev RNA (2013) 1.03
Proteome-wide analysis reveals clues of complementary interactions between mRNAs and their cognate proteins as the physicochemical foundation of the genetic code. RNA Biol (2013) 1.02
Biomolecular condensates: organizers of cellular biochemistry. Nat Rev Mol Cell Biol (2017) 1.01
Condensation and localization of the partitioning protein ParB on the bacterial chromosome. Proc Natl Acad Sci U S A (2014) 1.01
Droplet organelles? EMBO J (2016) 1.00
Translation repressors, an RNA helicase, and developmental cues control RNP phase transitions during early development. Dev Cell (2013) 0.99
Enhanced transcription rates in membrane-free protocells formed by coacervation of cell lysate. Proc Natl Acad Sci U S A (2013) 0.97
In vitro reconstitution of a cellular phase-transition process that involves the mRNA decapping machinery. Angew Chem Int Ed Engl (2014) 0.97
Evolution and Biological Roles of Alternative 3'UTRs. Trends Cell Biol (2015) 0.96
A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Genes Dev (2013) 0.94
Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly. Rare Dis (2013) 0.93
Poly(ADP-ribose): an organizer of cellular architecture. J Cell Biol (2014) 0.93
PolyQ-dependent RNA-protein assemblies control symmetry breaking. J Cell Biol (2015) 0.92
Mechanistic insights into mammalian stress granule dynamics. J Cell Biol (2016) 0.91
Alu element-containing RNAs maintain nucleolar structure and function. EMBO J (2015) 0.91
Comprehensive Identification of RNA-Binding Domains in Human Cells. Mol Cell (2016) 0.89
Adaptation to Stressors by Systemic Protein Amyloidogenesis. Dev Cell (2016) 0.89
The physical chemistry of cytoplasm and its influence on cell function: an update. Mol Biol Cell (2013) 0.88
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol (2016) 0.88
Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules. Nucleic Acids Res (2014) 0.88
Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles. Nat Chem (2015) 0.88
Protein kinases are associated with multiple, distinct cytoplasmic granules in quiescent yeast cells. Genetics (2014) 0.87
Novel insights into RNP granules by employing the trypanosome's microtubule skeleton as a molecular sieve. Nucleic Acids Res (2015) 0.84
Compositional Control of Phase-Separated Cellular Bodies. Cell (2016) 0.83
Phase Transitions in Biological Systems with Many Components. Biophys J (2017) 0.83
FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination. J Cell Biol (2017) 0.82
Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling. Chem Rev (2016) 0.82
Beyond the cytoskeleton: mesoscale assemblies and their function in spatial organization. Curr Opin Microbiol (2013) 0.81
Legal but lethal: functional protein aggregation at the verge of toxicity. Front Cell Neurosci (2015) 0.81
Distinct stages in stress granule assembly and disassembly. Elife (2016) 0.80
Cytoplasmic RNA Granules and Viral Infection. Annu Rev Virol (2014) 0.79
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. Cell Rep (2016) 0.79
Nuclear physics (of the cell, not the atom). Mol Biol Cell (2014) 0.79
Modifiers of solid RNP granules control normal RNP dynamics and mRNA activity in early development. J Cell Biol (2015) 0.78
The new (dis)order in RNA regulation. Cell Commun Signal (2016) 0.78
The biology of boundary conditions: cellular reconstitution in one, two, and three dimensions. Curr Opin Cell Biol (2013) 0.77
Amyloid-like assembly of the low complexity domain of yeast Nab3. Prion (2015) 0.77
Bulk and nanoscale polypeptide based polyelectrolyte complexes. Adv Colloid Interface Sci (2016) 0.77
Dysregulated axonal RNA translation in amyotrophic lateral sclerosis. Wiley Interdiscip Rev RNA (2016) 0.77
The Activity-Dependent Regulation of Protein Kinase Stability by the Localization to P-Bodies. Genetics (2016) 0.77
RNA assemblages orchestrate complex cellular processes. Bioessays (2016) 0.76
Protein aggregation as a mechanism of adaptive cellular responses. Curr Genet (2016) 0.76
Triggering signaling pathways using F-actin self-organization. Sci Rep (2016) 0.76
Direct visualization of vaults within intact cells by electron cryo-tomography. Cell Mol Life Sci (2015) 0.76
The cytoplasmic domain of the T-cell receptor zeta subunit does not form disordered dimers. J Mol Biol (2013) 0.76
A Hybrid-Body Containing Constituents of Both P-Bodies and Stress Granules Forms in Response to Hypoosmotic Stress in Saccharomyces cerevisiae. PLoS One (2016) 0.76
Amyloids assemble as part of recognizable structures during oogenesis in Xenopus. Biol Open (2016) 0.76
Microorganisms maintain crowding homeostasis. Nat Rev Microbiol (2017) 0.76
CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets. Elife (2016) 0.76
The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions. Pflugers Arch (2016) 0.76
RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line. G3 (Bethesda) (2016) 0.76
ATPase activity of the DEAD-box protein Dhh1 controls processing body formation. Elife (2016) 0.76
Imaging stress. Cell Stress Chaperones (2015) 0.75
Disentangling a Bad Reputation: Changing Perceptions of Amyloids. Trends Cell Biol (2017) 0.75
Concentrating on the mitotic spindle. J Cell Biol (2015) 0.75
Spatial confinement governs orientational order in patchy particles. Sci Rep (2016) 0.75
Regulation of RNA binding proteins in trypanosomatid protozoan parasites. World J Biol Chem (2016) 0.75
Fast-folding proteins under stress. Cell Mol Life Sci (2015) 0.75
Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2017) 0.75
Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience. Biol Open (2016) 0.75
RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLD. Adv Exp Med Biol (2016) 0.75
The Dark Matter of Biology. Biophys J (2016) 0.75
Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons. Proc Natl Acad Sci U S A (2017) 0.75
Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts. Nucleus (2016) 0.75
Design principles for nonequilibrium self-assembly. Proc Natl Acad Sci U S A (2016) 0.75
Casein Kinase 2 is linked to stress granule dynamics through phosphorylation of the stress granule nucleating protein G3BP1. Mol Cell Biol (2016) 0.75
A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression. Cell Rep (2016) 0.75
Multivalent IDP assemblies: Unique properties of LC8-associated, IDP duplex scaffolds. FEBS Lett (2015) 0.75
The cell as a material. Curr Opin Cell Biol (2006) 2.26
Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos. Curr Biol (2010) 2.23
Chapter 19: Mechanical response of cytoskeletal networks. Methods Cell Biol (2008) 1.40
Spatial organization of the cell cytoplasm by position-dependent phase separation. Phys Rev Lett (2013) 1.22
A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells. Nat Cell Biol (2013) 1.19
A new microrheometric approach reveals individual and cooperative roles for TGF-beta1 and IL-1beta in fibroblast-mediated stiffening of collagen gels. FASEB J (2007) 1.11
Beyond stereospecificity: liquids and mesoscale organization of cytoplasm. Dev Cell (2011) 1.08
Nuclear mechanics: lamin webs and pathological blebs. Nucleus (2013) 0.80