Published in Oncogene on June 11, 2012
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS Biol (2012) 1.06
A critical role for the regulated wnt-myc pathway in naive T cell survival. J Immunol (2014) 0.80
The expression of tumour suppressors and proto-oncogenes in tissues susceptible to their hereditary cancers. Br J Cancer (2015) 0.78
The role of Wnt/β-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: evidences from patients-derived cell lines. Oncotarget (2016) 0.77
Molecular etiology of an indolent lymphoproliferative disorder determined by whole-genome sequencing. Cold Spring Harb Mol Case Stud (2016) 0.75
MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer. Genes Cancer (2016) 0.75
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Wnt signaling and cancer. Genes Dev (2000) 18.53
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science (1990) 9.90
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A (2003) 4.76
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science (1999) 4.08
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology (2004) 3.39
Loss of Apc+ in intestinal adenomas from Min mice. Cancer Res (1994) 3.00
Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development. Nat Immunol (2001) 2.39
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell (2011) 2.18
Deletion of beta-catenin impairs T cell development. Nat Immunol (2003) 2.01
CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest (2007) 1.71
Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J (2001) 1.69
Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol (2005) 1.66
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood (2002) 1.65
Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Immunol (2001) 1.63
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene (2010) 1.54
Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression. Mol Cell Biol (1999) 1.49
Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood (2007) 1.48
Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo. Neoplasia (2010) 1.35
beta-Catenin expression enhances generation of mature thymocytes. Int Immunol (2003) 1.31
The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes. Blood (1995) 1.29
Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. Proc Natl Acad Sci U S A (2010) 1.28
A survival guide to early T cell development. Immunol Res (2006) 1.24
Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene (2005) 1.23
Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol (2007) 1.21
Loss of expression of the WNT/beta-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor-1 (TCF-1) in a subset of peripheral T cell lymphomas. Am J Pathol (2003) 1.18
Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells. Int Immunol (1999) 1.17
Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis. Blood (2003) 1.14
Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse. Cancer Biol Ther (2006) 1.14
Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia. Leukemia (2006) 1.07
TCF1 and beta-catenin regulate T cell development and function. Immunol Res (2010) 1.06
B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proc Natl Acad Sci U S A (2008) 1.06
Signaling pathways involved in the development of T-cell acute lymphoblastic leukemia. Haematologica (2008) 1.00
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer (2008) 0.97
Beta-catenin expression in thymocytes accelerates thymic involution. Eur J Immunol (2003) 0.93
Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies. Cancer Res (2008) 0.92
Aberrant expression of beta-catenin discriminates acute myeloid leukaemia from acute lymphoblastic leukaemia. Br J Haematol (2004) 0.92
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Mol Med (2010) 0.91
Pre-TCR-induced beta-catenin facilitates traversal through beta-selection. J Immunol (2009) 0.91
Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development. J Immunol (2009) 0.91
Frequent beta-catenin overexpression without exon 3 mutation in cutaneous lymphomas. Mod Pathol (2004) 0.87
Expression of cadherin-catenin complexes in human leukemia cell lines. J Biochem (1996) 0.85
Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic beta-catenin in Min mice. Int J Cancer (2003) 0.85
Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription. Mol Cancer Ther (2008) 0.81