Published in Cell Stem Cell on June 14, 2012
Cerebral organoids model human brain development and microcephaly. Nature (2013) 9.07
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nat Biotechnol (2013) 2.06
Cytosystems dynamics in self-organization of tissue architecture. Nature (2013) 1.74
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun (2014) 1.68
Stem cells in retinal regeneration: past, present and future. Development (2013) 1.59
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. Proc Natl Acad Sci U S A (2013) 1.53
Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature (2013) 1.46
Three-dimensional organotypic culture: experimental models of mammalian biology and disease. Nat Rev Mol Cell Biol (2014) 1.43
Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa. Elife (2013) 1.33
In vitro generation of human pluripotent stem cell derived lung organoids. Elife (2015) 1.30
Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium. Stem Cells Transl Med (2013) 1.27
Generation of cerebral organoids from human pluripotent stem cells. Nat Protoc (2014) 1.25
Human pluripotent stem cells: an emerging model in developmental biology. Development (2013) 1.22
Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells. Development (2014) 1.20
The transcriptional regulation of pluripotency. Cell Res (2012) 1.15
Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics. Cell Stem Cell (2014) 1.10
Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease. Stem Cells Transl Med (2015) 1.08
Biology and therapy of inherited retinal degenerative disease: insights from mouse models. Dis Model Mech (2015) 1.05
From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. Proc Natl Acad Sci U S A (2014) 1.04
Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium. PLoS One (2013) 1.01
Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups. Cell Stem Cell (2016) 1.01
Cell replacement and visual restoration by retinal sheet transplants. Prog Retin Eye Res (2012) 1.01
Using human induced pluripotent stem cells to treat retinal disease. Prog Retin Eye Res (2013) 1.00
Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases. Curr Gene Ther (2013) 1.00
Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2. Stem Cells (2014) 0.99
Stem cell treatment of degenerative eye disease. Stem Cell Res (2015) 0.99
Derivation of traceable and transplantable photoreceptors from mouse embryonic stem cells. Stem Cell Reports (2014) 0.97
Induced pluripotent stem cells as custom therapeutics for retinal repair: progress and rationale. Exp Eye Res (2014) 0.97
RPGR: Its role in photoreceptor physiology, human disease, and future therapies. Exp Eye Res (2015) 0.97
The billion cell construct: will three-dimensional printing get us there? PLoS Biol (2014) 0.96
3D mouse embryonic stem cell culture for generating inner ear organoids. Nat Protoc (2014) 0.96
Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors. Protein Cell (2014) 0.96
Stem cells for investigation and treatment of inherited retinal disease. Hum Mol Genet (2014) 0.94
Engineering three-dimensional stem cell morphogenesis for the development of tissue models and scalable regenerative therapeutics. Ann Biomed Eng (2013) 0.94
Precocious acquisition of neuroepithelial character in the eye field underlies the onset of eye morphogenesis. Dev Cell (2013) 0.93
3D reconstitution of the patterned neural tube from embryonic stem cells. Stem Cell Reports (2014) 0.93
The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. Nat Protoc (2014) 0.93
Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nat Commun (2015) 0.92
Co-ordinated ocular development from human iPS cells and recovery of corneal function. Nature (2016) 0.92
Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells. Sci Rep (2015) 0.92
Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell-Derived Self-Forming Retina. Stem Cells (2015) 0.91
Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells. Cell Res (2013) 0.91
Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells. J Neurogenet (2014) 0.91
Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism. Stem Cells (2016) 0.91
Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proc Natl Acad Sci U S A (2015) 0.90
Subretinal transplantation of MACS purified photoreceptor precursor cells into the adult mouse retina. J Vis Exp (2014) 0.90
Vision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and disease. Prog Retin Eye Res (2015) 0.90
Bioengineered stem cells in neural development and neurodegeneration research. Ageing Res Rev (2013) 0.89
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sci Rep (2015) 0.89
Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine. Curr Med Chem (2015) 0.89
Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell (2015) 0.89
Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium. Invest Ophthalmol Vis Sci (2015) 0.88
Analysis of cell surface markers specific for transplantable rod photoreceptors. Mol Vis (2013) 0.88
Concise review: microfluidic technology platforms: poised to accelerate development and translation of stem cell-derived therapies. Stem Cells Transl Med (2013) 0.88
Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis. Stem Cell Reports (2016) 0.87
Modeling the blood-brain barrier using stem cell sources. Fluids Barriers CNS (2013) 0.86
Modeling physiological and pathological human neurogenesis in the dish. Front Neurosci (2014) 0.86
Ophthalmologic stem cell transplantation therapies. Regen Med (2012) 0.86
A review of therapeutic prospects of non-viral gene therapy in the retinal pigment epithelium. Biomaterials (2013) 0.85
Photoreceptor cell fate specification in vertebrates. Development (2015) 0.85
Organoids and the genetically encoded self-assembly of embryonic stem cells. Bioessays (2015) 0.85
IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells. Stem Cells (2015) 0.85
Stem cells, retinal ganglion cells and glaucoma. Dev Ophthalmol (2014) 0.84
On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology. Biomaterials (2015) 0.84
Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice. Sci Rep (2016) 0.84
Engineering efficient retinal pigment epithelium differentiation from human pluripotent stem cells. Stem Cells Transl Med (2014) 0.84
Modeling retinal dystrophies using patient-derived induced pluripotent stem cells. Adv Exp Med Biol (2014) 0.83
Multiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/β-catenin signalling in the anterior neural patterning of adherent human embryonic stem cell cultures. Open Biol (2013) 0.83
Topological and electrical control of cardiac differentiation and assembly. Stem Cell Res Ther (2013) 0.83
Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells. Curr Protoc Stem Cell Biol (2015) 0.83
Advances in retinal stem cell biology. J Ophthalmic Vis Res (2013) 0.83
Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Trends Biotechnol (2012) 0.83
Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation. Hum Mol Genet (2014) 0.83
Modeling retinal degenerative diseases with human iPS-derived cells: current status and future implications. Expert Rev Ophthalmol (2013) 0.83
Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration. Stem Cell Res Ther (2015) 0.83
Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration. Stem Cells (2016) 0.82
Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells. Transl Vis Sci Technol (2014) 0.82
Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish. Front Neurosci (2014) 0.82
Cellular models and therapies for age-related macular degeneration. Dis Model Mech (2015) 0.82
The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs. Int J Mol Sci (2015) 0.82
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness. Sci Rep (2016) 0.81
Tissue engineering: The brainmaker. Nature (2012) 0.81
A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies. Front Cell Neurosci (2013) 0.81
iPS Cells for Modelling and Treatment of Retinal Diseases. J Clin Med (2014) 0.81
Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. Nat Commun (2016) 0.81
Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement. J Ocul Pharmacol Ther (2016) 0.81
The Potential of Human Stem Cells for the Study and Treatment of Glaucoma. Invest Ophthalmol Vis Sci (2016) 0.81
Using Stem Cells to Model Diseases of the Outer Retina. Comput Struct Biotechnol J (2015) 0.81
The development of anatomy: from macroscopic body dissections to stem cell-derived organoids. Histochem Cell Biol (2016) 0.80
On the road to bioartificial organs. Pflugers Arch (2014) 0.80
Shaping the eye from embryonic stem cells: Biological and medical implications. World J Stem Cells (2012) 0.80
Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol Cell Biol (2015) 0.79
Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration. Cells (2012) 0.79
What is it about 'eye of newt'? Genome Biol (2013) 0.79
Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells Toward a Retinal Lineage. Stem Cells Transl Med (2016) 0.79
Probing disorders of the nervous system using reprogramming approaches. EMBO J (2015) 0.79
The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells. Stem Cells (2015) 0.79
Let There Be Light: Gene and Cell Therapy for Blindness. Hum Gene Ther (2016) 0.79
A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol (2007) 13.56
Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature (2011) 6.51
Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell (2008) 5.40
Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol (2008) 4.50
Directed differentiation of telencephalic precursors from embryonic stem cells. Nat Neurosci (2005) 4.34
A simplified laminin nomenclature. Matrix Biol (2005) 3.81
Differentiation of embryonic stem cells is induced by GATA factors. Genes Dev (2002) 3.12
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet (2002) 3.06
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell (2010) 3.05
Hippo pathway regulation by cell morphology and stress fibers. Development (2011) 2.94
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell (2008) 2.89
Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell (2013) 2.74
Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. Dev Cell (2006) 2.47
In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci (2009) 2.46
Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J Cell Sci (2005) 2.37
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci U S A (2002) 2.34
Self-formation of functional adenohypophysis in three-dimensional culture. Nature (2011) 2.34
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci U S A (2005) 2.31
Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Nature (2011) 2.29
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest (2005) 2.25
Cdc42 and mDia3 regulate microtubule attachment to kinetochores. Nature (2004) 2.15
Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation. Cell (2008) 2.11
Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells (2006) 2.07
Risk factors for chronic kidney disease after chemotherapy for testicular cancer. Int J Urol (2012) 2.03
Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.93
Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation. Exp Cell Res (2006) 1.91
Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm. Development (2005) 1.89
Stepwise differentiation of pluripotent stem cells into retinal cells. Nat Protoc (2009) 1.88
The basement membrane of hair follicle stem cells is a muscle cell niche. Cell (2011) 1.88
Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci U S A (2008) 1.87
Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins. Matrix Biol (2006) 1.82
Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals. J Neurosci (2011) 1.73
Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals. Cell (2013) 1.71
Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex. EMBO J (2003) 1.70
Functional anatomy of the basal ganglia in X-linked recessive dystonia-parkinsonism. Ann Neurol (2005) 1.70
Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells. Nat Commun (2012) 1.70
HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J (2004) 1.69
Ectodermal factor restricts mesoderm differentiation by inhibiting p53. Cell (2008) 1.64
Retraction: Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature (2014) 1.62
Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism. Am J Hum Genet (2007) 1.62
Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells. Biochem Biophys Res Commun (2008) 1.55
The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements. Nat Cell Biol (2004) 1.54
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. Proc Natl Acad Sci U S A (2013) 1.53
Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. Environ Health Perspect (2008) 1.52
In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells. Invest Ophthalmol Vis Sci (2004) 1.52
Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells. Mol Biol Cell (2006) 1.51
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development (2006) 1.50
Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients. Clin Gastroenterol Hepatol (2005) 1.47
Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci (2009) 1.45
Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151. Proc Natl Acad Sci U S A (2005) 1.44
Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. J Biol Chem (2004) 1.44
Improved survival time with combined early blood transfusion and fluid administration in uncontrolled hemorrhagic shock in rats. J Trauma (2010) 1.43
Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell (2005) 1.43
Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice. J Clin Invest (2008) 1.43
Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells (2005) 1.42
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev (2008) 1.41
Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's disease. Stem Cells (2012) 1.41
E-cadherin is required for gastrulation cell movements in zebrafish. Mech Dev (2005) 1.38
Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues. Nat Protoc (2011) 1.38
Electron tomography reveals diverse conformations of integrin alphaIIbbeta3 in the active state. J Struct Biol (2005) 1.37
Whole genome association study of rheumatoid arthritis using 27 039 microsatellites. Hum Mol Genet (2005) 1.36
Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Proc Natl Acad Sci U S A (2006) 1.36
Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Mol Cell Biol (2004) 1.34
Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol Cell Biol (2004) 1.31
Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A (2008) 1.31
Rapid accumulation of nucleostemin in nucleolus during newt regeneration. Dev Dyn (2007) 1.30
NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry. Curr Biol (2013) 1.29
Molecular dissection of the alpha-dystroglycan- and integrin-binding sites within the globular domain of human laminin-10. J Biol Chem (2003) 1.26
CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization. J Cell Biol (2003) 1.26
Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci (2010) 1.26
Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. PLoS Genet (2010) 1.25
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol (2008) 1.24
Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation. Mol Biol Cell (2008) 1.24
Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development (2006) 1.20
Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development (2007) 1.20