Published in Proc Natl Acad Sci U S A on August 12, 2008
Self-formation of functional adenohypophysis in three-dimensional culture. Nature (2011) 2.34
Stepwise differentiation of pluripotent stem cells into retinal cells. Nat Protoc (2009) 1.88
Deriving excitatory neurons of the neocortex from pluripotent stem cells. Neuron (2011) 1.62
Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells (2012) 1.52
Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation. Cell Stem Cell (2010) 1.42
Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues. Nat Protoc (2011) 1.38
Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat Neurosci (2013) 1.38
Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci (2010) 1.26
Adult neural stem cells in distinct microdomains generate previously unknown interneuron types. Nat Neurosci (2013) 1.23
Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Reports (2014) 1.22
Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells. Development (2014) 1.20
Programming embryonic stem cells to neuronal subtypes. Curr Opin Neurobiol (2010) 1.06
Wnt/β-catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells. Development (2014) 1.00
Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture. PLoS One (2012) 0.98
Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development (2015) 0.93
Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest (2015) 0.93
Pluripotent stem cells for the study of CNS development. Front Mol Neurosci (2011) 0.92
Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS One (2013) 0.91
Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci (2013) 0.90
Relaxation-expansion model for self-driven retinal morphogenesis: a hypothesis from the perspective of biosystems dynamics at the multi-cellular level. Bioessays (2011) 0.90
A modular gain-of-function approach to generate cortical interneuron subtypes from ES cells. Neuron (2013) 0.88
Patient-specific pluripotent stem cells in neurological diseases. Stem Cells Int (2011) 0.88
Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity. Curr Opin Neurobiol (2014) 0.87
The positional identity of mouse ES cell-generated neurons is affected by BMP signaling. Cell Mol Life Sci (2012) 0.86
Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media. PLoS One (2014) 0.86
An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells. Biol Open (2014) 0.86
Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem (2013) 0.85
Genetic regulation of murine pituitary development. J Mol Endocrinol (2015) 0.84
Impact of induced pluripotent stem cells on the study of central nervous system disease. Curr Opin Genet Dev (2011) 0.84
In vitro differentiation of mouse embryonic stem cells into neurons of the dorsal forebrain. Cell Mol Neurobiol (2011) 0.84
Mechanistic insight into the pathology of polyalanine expansion disorders revealed by a mouse model for X linked hypopituitarism. PLoS Genet (2013) 0.84
Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons. Sci Rep (2015) 0.84
Activation of Wnt/ß-catenin signaling in ESC promotes rostral forebrain differentiation in vitro. In Vitro Cell Dev Biol Anim (2015) 0.82
Dishing out mini-brains: Current progress and future prospects in brain organoid research. Dev Biol (2016) 0.81
Human periodontal ligament fibroblasts are the optimal cell source for induced pluripotent stem cells. Histochem Cell Biol (2012) 0.81
Tissue engineering: The brainmaker. Nature (2012) 0.81
Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. Nat Commun (2016) 0.81
Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus. Mol Metab (2014) 0.80
Neurodevelopmental origin and adult neurogenesis of the neuroendocrine hypothalamus. Front Cell Neurosci (2015) 0.80
Neural differentiation from embryonic stem cells in vitro: An overview of the signaling pathways. World J Stem Cells (2015) 0.79
Polycomb binding precedes early-life stress responsive DNA methylation at the Avp enhancer. PLoS One (2014) 0.79
From pluripotency to forebrain patterning: an in vitro journey astride embryonic stem cells. Cell Mol Life Sci (2014) 0.77
Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells. Curr Protoc Hum Genet (2016) 0.77
Establishment of a radial glia-like mouse fetal hypothalamic neural stem cell line (AC1) able to differentiate into neuroendocrine cells. Neurogenesis (Austin) (2014) 0.77
Making a pituitary gland in a dish. Cell Stem Cell (2011) 0.77
Regenerative Medicine: Organ recital in a dish. Nature (2011) 0.77
Generation and clonal isolation of retinal stem cells from human embryonic stem cells. Eur J Neurosci (2012) 0.77
High glucose suppresses embryonic stem cell differentiation into cardiomyocytes : High glucose inhibits ES cell cardiogenesis. Stem Cell Res Ther (2016) 0.77
Comparative, transcriptome analysis of self-organizing optic tissues. Sci Data (2015) 0.76
Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS One (2016) 0.75
Brain-Derived Neurotrophic Factor Loaded PS80 PBCA Nanocarrier for In Vitro Neural Differentiation of Mouse Induced Pluripotent Stem Cells. Int J Mol Sci (2017) 0.75
Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. Development (2017) 0.75
Molecular profiling of human iPS-derived hypothalamic neurons provides developmental insights to genetic loci for body weight regulation. J Neuroendocrinol (2017) 0.75
Organoid technologies meet genome engineering. EMBO Rep (2017) 0.75
Data describing Rax positive optic-vesicle generation from mouse embryonic stem cells in vitro. Data Brief (2016) 0.75
Activin/Nodal Signaling Supports Retinal Progenitor Specification in a Narrow Time Window during Pluripotent Stem Cell Neuralization. Stem Cell Reports (2015) 0.75
Human embryonic and induced pluripotent stem cells maintain phenotype but alter their metabolism after exposure to ROCK inhibitor. Sci Rep (2017) 0.75
Sorting of Sox1-GFP Mouse Embryonic Stem Cells Enhances Neuronal Identity Acquisition upon Factor-Free Monolayer Differentiation. Biores Open Access (2014) 0.75
A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol (2007) 13.56
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Directed differentiation of embryonic stem cells into motor neurons. Cell (2002) 9.76
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol (2003) 9.41
Directed differentiation of telencephalic precursors from embryonic stem cells. Nat Neurosci (2005) 4.34
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90
Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci (2003) 3.64
Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol (2005) 3.49
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron (2001) 3.42
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab (2007) 3.02
Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron (1992) 2.79
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev (2003) 2.59
Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution. Cell (2007) 2.36
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci U S A (2005) 2.31
rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina. Proc Natl Acad Sci U S A (1997) 2.29
Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene (2001) 2.25
Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol (1995) 2.12
Progressive induction of caudal neural character by graded Wnt signaling. Nat Neurosci (2002) 2.02
Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.93
Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development (2004) 1.79
Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes Dev (1999) 1.61
Regionalization of the prosencephalic neural plate. Annu Rev Neurosci (1998) 1.59
Parsing the prosencephalon. Nat Rev Neurosci (2002) 1.57
Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells. Stem Cells (2007) 1.38
Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes. J Comp Neurol (2000) 1.29
The organization of tubero-hypophyseal and reticulo-infundibular catecholamine neuron systems in the rat brain. Brain Res (1973) 1.25
Development of the neuroendocrine hypothalamus. Front Neuroendocrinol (2002) 1.23
Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. Genesis (2000) 1.20
Directed differentiation of neural cells to hypothalamic dopaminergic neurons. Development (2005) 1.13
The role of Otx and Otp genes in brain development. Int J Dev Biol (2000) 0.97
Human embryonic stem cells: culture, differentiation, and genetic modification for regenerative medicine applications. Cancer J (2002) 0.92
Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus. Development (2000) 0.91
Hedgehog signaling is required for the differentiation of ES cells into neurectoderm. Dev Biol (2004) 0.89
Distribution and morphology of vasopressin-, neurophysin II-, and oxytocin-immunoreactive cell bodies in the forebrain of the cat. J Comp Neurol (1987) 0.84
Galanin influences vasopressin and oxytocin release from the hypothalamo-neurohypophysial system of salt loaded rats. J Physiol Pharmacol (2005) 0.79
A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol (2007) 13.56
A more efficient method to generate integration-free human iPS cells. Nat Methods (2011) 7.39
Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature (2011) 6.51
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74
The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med (2012) 5.57
Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell (2008) 5.40
Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol (2008) 4.50
Directed differentiation of telencephalic precursors from embryonic stem cells. Nat Neurosci (2005) 4.34
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett (2004) 4.02
Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell (2012) 3.85
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell (2010) 3.05
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol Cell (2005) 2.88
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
Generation of retinal cells from mouse and human induced pluripotent stem cells. Neurosci Lett (2009) 2.75
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell (2013) 2.74
alpha-Klotho as a regulator of calcium homeostasis. Science (2007) 2.71
Prognostic stratification of patients with vasospastic angina: a comprehensive clinical risk score developed by the Japanese Coronary Spasm Association. J Am Coll Cardiol (2013) 2.51
In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci (2009) 2.46
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci U S A (2002) 2.34
Self-formation of functional adenohypophysis in three-dimensional culture. Nature (2011) 2.34
The Great East Japan Earthquake Disaster and cardiovascular diseases. Eur Heart J (2012) 2.32
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci U S A (2005) 2.31
Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Nature (2011) 2.29
Long-term outcome in patients harboring intracranial ependymoma. J Neurosurg (2005) 2.28
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest (2005) 2.25
Effects of extracranial-intracranial bypass for patients with hemorrhagic moyamoya disease: results of the Japan Adult Moyamoya Trial. Stroke (2014) 2.12
Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation. Cell (2008) 2.11
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in pigs in vivo. J Am Coll Cardiol (2009) 2.10
Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells (2006) 2.07
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res (2005) 2.05
Risk factors for chronic kidney disease after chemotherapy for testicular cancer. Int J Urol (2012) 2.03
Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One (2011) 2.01
Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development (2007) 2.01
Radiological findings, clinical course, and outcome in asymptomatic moyamoya disease: results of multicenter survey in Japan. Stroke (2007) 2.00
Evidence for brain activation in patients with takotsubo cardiomyopathy. Circ J (2013) 1.98
Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.93
Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm. Development (2005) 1.89
Stepwise differentiation of pluripotent stem cells into retinal cells. Nat Protoc (2009) 1.88
Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome. Hum Mutat (2010) 1.83
Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals. J Neurosci (2011) 1.73
Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals. Cell (2013) 1.71
Functional anatomy of the basal ganglia in X-linked recessive dystonia-parkinsonism. Ann Neurol (2005) 1.70
Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J Neurosci Res (2008) 1.70
Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: multicentre registry study of the Japanese Coronary Spasm Association. Eur Heart J (2012) 1.68
Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats. Stroke (2008) 1.67
Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients surviving out-of-hospital cardiac arrest. Circ J (2009) 1.66
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke (2008) 1.64
Ectodermal factor restricts mesoderm differentiation by inhibiting p53. Cell (2008) 1.64
Retraction: Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature (2014) 1.62
Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism. Am J Hum Genet (2007) 1.62
Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment. J Am Coll Cardiol (2011) 1.62
Long-term results of computer-assisted posterior occipitocervical reconstruction. World Neurosurg (2010) 1.61
Plasma cyclophilin A is a novel biomarker for coronary artery disease. Circ J (2012) 1.59
Clinical outcome and survival after palliative surgery for spinal metastases: palliative surgery in spinal metastases. Cancer (2003) 1.59
Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J Cell Biol (2003) 1.58
Survival and differentiation of neural progenitor cells derived from embryonic stem cells and transplanted into ischemic brain. J Neurosurg (2005) 1.57
Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Stroke (2006) 1.56
The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements. Nat Cell Biol (2004) 1.54
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. Proc Natl Acad Sci U S A (2013) 1.53
In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells. Invest Ophthalmol Vis Sci (2004) 1.52
Prognostic Impact of Anemia in Patients With Chronic Heart Failure- With Special Reference to Clinical Background: Report From the CHART-2 Study. Circ J (2015) 1.51
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development (2006) 1.50
Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate. Stem Cell Reports (2013) 1.48
Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients. Clin Gastroenterol Hepatol (2005) 1.47