Published in Science on December 14, 1990
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide. Proc Natl Acad Sci U S A (1996) 3.57
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A (1993) 2.95
Atomic scale structure and functional models of voltage-gated potassium channels. Biophys J (1992) 2.80
Functional dissection of the Moloney murine leukemia virus envelope protein gp70. J Virol (1997) 2.24
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The cation-π interaction. Acc Chem Res (2012) 1.94
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Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center. EMBO J (1992) 1.43
Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine. Proc Natl Acad Sci U S A (1993) 1.42
Analysis of the murine ecotropic leukemia virus receptor reveals a common biochemical determinant on diverse cell surface receptors that is essential to retrovirus entry. J Virol (1996) 1.39
Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC. PLoS Biol (2011) 1.37
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Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residues. J Physiol (2001) 1.32
Cation-pi (Na+-Trp) interactions in the crystal structure of tetragonal lysozyme. Protein Sci (1998) 1.31
The geometry and efficacy of cation-pi interactions in a diagonal position of a designed beta-hairpin. Protein Sci (2003) 1.27
Acetylcholinesterase: from 3D structure to function. Chem Biol Interact (2010) 1.22
Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proc Natl Acad Sci U S A (2010) 1.18
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Escherichia coli TehB requires S-adenosylmethionine as a cofactor to mediate tellurite resistance. J Bacteriol (2000) 1.08
Long-range coupling in an allosteric receptor revealed by mutant cycle analysis. Biophys J (2009) 1.07
Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin. J Biol Inorg Chem (2010) 1.03
A structural motif for the voltage-gated potassium channel pore. Proc Natl Acad Sci U S A (1995) 1.02
Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1994) 1.00
Affinity purification of multifunctional polymer nanoparticles. J Am Chem Soc (2010) 0.99
Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analogues. J Med Chem (2008) 0.97
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Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase. Cell Chem Biol (2016) 0.94
Structural answers and persistent questions about how nicotinic receptors work. Front Biosci (2008) 0.93
The nature of cation-pi binding: interactions between tetramethylammonium ion and benzene in aqueous solution. Biophys J (1993) 0.92
In vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic tool. Chembiochem (2014) 0.90
Evidence for a boroxinate based Brønsted acid derivative of VAPOL as the active catalyst in the catalytic asymmetric aziridination reaction. J Am Chem Soc (2009) 0.88
Noncovalent keystone interactions controlling biomembrane structure. Chemistry (2008) 0.88
Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground. J Med Chem (2014) 0.86
Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution. Proc Natl Acad Sci U S A (1996) 0.86
Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom. Proc Natl Acad Sci U S A (1991) 0.86
The immunomodulation of acetylcholinesterase in zhikong scallop Chlamys farreri. PLoS One (2012) 0.85
Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PLoS One (2011) 0.84
Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6 antigen (Psa) fimbriae of Yersinia pestis. Proc Natl Acad Sci U S A (2012) 0.84
A modular treatment of molecular traffic through the active site of cholinesterase. Biophys J (1999) 0.82
Principles of agonist recognition in Cys-loop receptors. Front Physiol (2014) 0.82
pKa determination of histidine residues in α-conotoxin MII peptides by 1H NMR and constant pH molecular dynamics simulation. J Phys Chem B (2013) 0.81
Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy. Biophys J (1992) 0.81
Structural evidence for a programmed general base in the active site of a catalytic antibody. Proc Natl Acad Sci U S A (2000) 0.81
Gas-phase reactions of hydrated alkaline earth metal ions, M2+ (H2O)n (M = Mg, Ca, Sr, Ba and n = 4-7), with benzene. J Am Soc Mass Spectrom (2001) 0.80
Structure of tick anticoagulant peptide at 1.6 A resolution complexed with bovine pancreatic trypsin inhibitor. Protein Sci (2000) 0.80
Ionophores and receptors using cation-pi interactions: collarenes. Proc Natl Acad Sci U S A (1998) 0.80
Residues in human arsenic (+3 oxidation state) methyltransferase forming potential hydrogen bond network around S-adenosylmethionine. PLoS One (2013) 0.79
Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis. Chemistry (2015) 0.79
Antagonism by lipophilic quaternary ions of the K+ channel opener, levcromakalim, in vascular smooth muscle. Br J Pharmacol (1994) 0.78
Cation-π interactions of methylated ammonium ions: a quantum mechanical study. Proteins (2014) 0.77
Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. J Med Chem (2014) 0.77
Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday. Protein Sci (1999) 0.77
Multiple tyrosine residues at the GABA binding pocket influence surface expression and mediate kinetics of the GABAA receptor. J Neurochem (2012) 0.76
Influence of cation-pi interactions to the structural stability of prokaryotic and eukaryotic translation elongation factors. Protoplasma (2009) 0.76
Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box. Nat Commun (2017) 0.75
Efficient conformational sampling of multiconformational cyclic molecules: application to 1,4,7,10,13-Pentaoxacyclopentadecane. J Mol Model (2009) 0.75
A computational model of the nicotinic acetylcholine binding site. J Comput Aided Mol Des (1999) 0.75
Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science (1992) 5.61
Unknown identification using reference mass spectra. Quality evaluation of databases. J Am Soc Mass Spectrom (1999) 0.89