Published in Front Physiol on April 24, 2014
Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. J Biol Chem (2014) 0.83
Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels. Sci Rep (2015) 0.79
Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What? Front Mol Neurosci (2016) 0.77
EPR Studies of Gating Mechanisms in Ion Channels. Methods Enzymol (2015) 0.76
Selective potentiation of alpha 1 glycine receptors by ginkgolic acid. Front Mol Neurosci (2015) 0.76
The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site. J Biol Chem (2017) 0.75
Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid. Front Mol Neurosci (2017) 0.75
Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47
Tetramisole (R 8299), a new, potent broad spectrum anthelmintic. Nature (1966) 30.39
Refined structure of the nicotinic acetylcholine receptor at 4A resolution. J Mol Biol (2005) 12.16
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature (2001) 11.78
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron (2004) 7.48
Cation-pi interactions in structural biology. Proc Natl Acad Sci U S A (1999) 6.88
X-ray structure of a prokaryotic pentameric ligand-gated ion channel. Nature (2008) 6.02
Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature (2011) 5.93
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature (2008) 5.77
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J (2005) 5.55
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. Nature (2008) 5.09
Molecular and neuronal substrate for the selective attenuation of anxiety. Science (2000) 5.07
International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev (2008) 4.49
Observations on the physiological action of extracts of the supra-renal bodies. J Physiol (1901) 4.44
Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature (1999) 4.36
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
Acetylcholine binding by a synthetic receptor: implications for biological recognition. Science (1990) 3.92
A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature (2001) 3.69
Neonicotinoid insecticide toxicology: mechanisms of selective action. Annu Rev Pharmacol Toxicol (2005) 3.57
GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. Nature (1993) 3.49
Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities. J Gen Physiol (1990) 3.05
A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature (2006) 3.04
A new class of anthelmintics effective against drug-resistant nematodes. Nature (2008) 2.98
A nomenclature for ligand-gated ion channels. Neuropharmacology (2008) 2.93
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature (1994) 2.92
Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature (2003) 2.89
Kinetics of unliganded acetylcholine receptor channel gating. Biophys J (1986) 2.83
A point mutation in a Drosophila GABA receptor confers insecticide resistance. Nature (1993) 2.75
The beta subunit determines the ligand binding properties of synaptic glycine receptors. Neuron (2005) 2.42
Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes. J Pharmacol Exp Ther (1997) 2.30
Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. Biochemistry (2002) 2.22
Binding, activation and modulation of Cys-loop receptors. Trends Pharmacol Sci (2010) 2.22
Nicotine binding to brain receptors requires a strong cation-pi interaction. Nature (2009) 2.21
Native glycine receptor subtypes and their physiological roles. Neuropharmacology (2008) 2.06
Structure, function, and modulation of GABA(A) receptors. J Biol Chem (2012) 1.91
Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron (2005) 1.89
A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J Biol Chem (1992) 1.88
Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor. Biophys J (1991) 1.86
Nicotinic receptor subtypes and cognitive function. J Neurobiol (2002) 1.86
Unliganded gating of acetylcholine receptor channels. Proc Natl Acad Sci U S A (2008) 1.80
Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site. Biochemistry (1988) 1.80
High tolerance for ionizable residues in the hydrophobic interior of proteins. Proc Natl Acad Sci U S A (2008) 1.78
Anxiety over GABA(A) receptor structure relieved by AChBP. Trends Biochem Sci (2002) 1.74
Cys-loop neuroreceptors: structure to the rescue? Chem Rev (2008) 1.70
Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists. J Biol Chem (1994) 1.67
Large shifts in pKa values of lysine residues buried inside a protein. Proc Natl Acad Sci U S A (2011) 1.67
The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins. ACS Chem Biol (2009) 1.65
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans. Nature (2000) 1.62
Molecular tuning of fast gating in pentameric ligand-gated ion channels. Proc Natl Acad Sci U S A (2005) 1.58
Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. J Physiol (2010) 1.58
Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors. J Neurosci (2011) 1.56
Homomeric rho 1 GABA channels: activation properties and domains. Receptors Channels (1994) 1.55
A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor. Chem Biol (2005) 1.53
Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation. J Neurosci (2001) 1.53
Kinetic properties of the glycine receptor main- and sub-conductance states of mouse spinal cord neurones in culture. J Physiol (1991) 1.50
Evolution of amino acid frequencies in proteins over deep time: inferred order of introduction of amino acids into the genetic code. Mol Biol Evol (2002) 1.46
A nicotinic acetylcholine receptor mutation conferring target-site resistance to imidacloprid in Nilaparvata lugens (brown planthopper). Proc Natl Acad Sci U S A (2005) 1.46
Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. J Neurosci (2007) 1.45
Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors. J Neurosci (2009) 1.41
Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye. J Biol Chem (2001) 1.41
Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC. PLoS Biol (2011) 1.37
Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci U S A (2008) 1.36
Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis. J Neurosci (2004) 1.35
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proc Natl Acad Sci U S A (2013) 1.32
Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Science (2009) 1.30
Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions. Biochemistry (2006) 1.28
Nicotinic acetylcholine receptors: targets for commercially important insecticides. Invert Neurosci (2007) 1.28
A novel class of ligand-gated ion channel is activated by Zn2+. J Biol Chem (2002) 1.28
Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel. FEBS Lett (2002) 1.25
Invariant aspartic Acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding. J Gen Physiol (2004) 1.25
Distinct agonist- and antagonist-binding sites on the glycine receptor. Neuron (1992) 1.24
A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans. J Biol Chem (2004) 1.23
Arginine residues at internal positions in a protein are always charged. Proc Natl Acad Sci U S A (2011) 1.23
Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating. J Gen Physiol (2002) 1.23
The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating. J Biol Chem (2003) 1.22
Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound. J Gen Physiol (2002) 1.22
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A (2012) 1.22
Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge? J Am Chem Soc (2003) 1.19
Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor. J Biol Chem (1992) 1.19
An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors. EMBO J (2003) 1.19
A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. J Neurosci (2008) 1.18
Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans. J Mol Biol (1996) 1.17
GABA(A) receptor subtypes as targets for neuropsychiatric drug development. Pharmacol Ther (2005) 1.16
Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor. J Biol Chem (1995) 1.16
The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain. J Biol Chem (2000) 1.15
Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance. Br J Pharmacol (2011) 1.15
The human muscle nicotinic acetylcholine receptor alpha-subunit exist as two isoforms: a novel exon. EMBO J (1990) 1.15
The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits. PLoS Pathog (2009) 1.13
Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor. Biochemistry (2007) 1.12
5-HT(3) receptors. J Biol Chem (2012) 1.11
Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model. J Biol Chem (2004) 1.08
Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes. J Biol Chem (2011) 1.08
Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans. Neuroscience (2000) 1.08
Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain. J Biol Chem (2009) 1.08
Structural insights into Cys-loop receptor function and ligand recognition. Biochem Pharmacol (2013) 1.04
Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop. J Biol Chem (2006) 1.03
Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation. Biophys J (2009) 1.03
A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites. PLoS One (2013) 1.02
Stoichiometry for activation of neuronal α7 nicotinic receptors. Proc Natl Acad Sci U S A (2013) 1.01