PubRank

Brian K Kobilka

Author PubWeight™ 177.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007 20.32
2 Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature 2007 14.06
3 Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature 2011 13.92
4 GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science 2007 11.74
5 Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature 2011 9.61
6 The structure and function of G-protein-coupled receptors. Nature 2009 8.08
7 Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature 2012 6.18
8 Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature 2011 5.35
9 betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 2002 4.47
10 The dynamic process of β(2)-adrenergic receptor activation. Cell 2013 4.09
11 Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature 2012 3.83
12 Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature 2012 3.83
13 Structure of the δ-opioid receptor bound to naltrindole. Nature 2012 3.69
14 Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature 2010 3.19
15 Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest 2003 3.15
16 Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. J Biol Chem 2003 2.68
17 Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 2013 2.49
18 Structure-based discovery of beta2-adrenergic receptor ligands. Proc Natl Acad Sci U S A 2009 2.48
19 High-resolution crystal structure of human protease-activated receptor 1. Nature 2012 2.44
20 Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature 2011 2.43
21 Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature 2013 2.14
22 Energy landscapes as a tool to integrate GPCR structure, dynamics, and function. Physiology (Bethesda) 2010 2.05
23 Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A 2011 2.03
24 Counting low-copy number proteins in a single cell. Science 2007 2.01
25 Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. J Clin Invest 2003 1.87
26 Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. EMBO J 2009 1.86
27 Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor. Structure 2012 1.85
28 Myocyte adrenoceptor signaling pathways. Science 2003 1.81
29 Nanobody stabilization of G protein-coupled receptor conformational states. Curr Opin Struct Biol 2011 1.75
30 Structure-based drug screening for G-protein-coupled receptors. Trends Pharmacol Sci 2012 1.72
31 A monoclonal antibody for G protein-coupled receptor crystallography. Nat Methods 2007 1.60
32 Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J 2006 1.56
33 Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature 2016 1.55
34 The role of ligands on the equilibria between functional states of a G protein-coupled receptor. J Am Chem Soc 2013 1.48
35 Structural insights into G-protein-coupled receptor activation. Curr Opin Struct Biol 2008 1.22
36 Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes. Am J Physiol Heart Circ Physiol 2005 1.21
37 Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the beta2-adrenergic receptor. Muscle Nerve 2002 1.20
38 Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol 2007 1.19
39 Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. J Neurosci 2002 1.18
40 A fluorescent probe designed for studying protein conformational change. Proc Natl Acad Sci U S A 2005 1.17
41 N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One 2012 1.17
42 Role of detergents in conformational exchange of a G protein-coupled receptor. J Biol Chem 2012 1.10
43 Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor. Proc Natl Acad Sci U S A 2012 1.09
44 N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. Mol Pharmacol 2007 1.06
45 Conformational dynamics of single G protein-coupled receptors in solution. J Phys Chem B 2011 1.06
46 Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Anesthesiology 2002 1.04
47 Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proc Natl Acad Sci U S A 2002 0.99
48 Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. Mol Pharmacol 2013 0.98
49 A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry 2012 0.96
50 Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability. Am J Physiol Heart Circ Physiol 2005 0.96
51 Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature 2016 0.92
52 Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. Mol Pharmacol 2013 0.87
53 Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein immobilization. Lab Chip 2006 0.84
54 Analysis of biomolecular interactions using a miniaturized surface plasmon resonance sensor. Anal Chem 2002 0.84
55 Functional immobilization of a ligand-activated G-protein-coupled receptor. Chembiochem 2002 0.83
56 Identification of GPCR-interacting cytosolic proteins using HDL particles and mass spectrometry-based proteomic approach. PLoS One 2013 0.83
57 Novel tripod amphiphiles for membrane protein analysis. Chemistry 2013 0.81
58 The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor. Mol Pharmacol 2003 0.80
59 Efficient adenylyl cyclase activation by a beta2-adrenoceptor-G(i)alpha2 fusion protein. Biochem Biophys Res Commun 2002 0.78
60 Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr 2013 0.77
61 A device for separated and reversible co-culture of cardiomyocytes. Biotechnol Prog 2010 0.76
62 Novel insights into M3 muscarinic acetylcholine receptor physiology and structure. J Mol Neurosci 2013 0.75
63 New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. Analyst 2017 0.75