Published in Genes Dev on July 03, 2012
Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice. Blood (2014) 1.43
C/EBPα in normal and malignant myelopoiesis. Int J Hematol (2015) 1.06
Posttranslational modifications of RUNX1 as potential anticancer targets. Oncogene (2014) 1.00
Regulation of transcription factor activity by interconnected post-translational modifications. Trends Pharmacol Sci (2013) 0.95
Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells. PLoS One (2014) 0.89
Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition. Leukemia (2015) 0.88
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis. Nat Commun (2015) 0.85
RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation. Blood (2015) 0.84
Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. J Biol Chem (2014) 0.81
Tyrosyl phosphorylation toggles a Runx1 switch. Genes Dev (2012) 0.78
Blocking initial infiltration of pioneer CD8(+) T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice. Br J Pharmacol (2014) 0.78
A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer. Oncotarget (2016) 0.77
Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis. J Biol Chem (2015) 0.76
RUNX1 cooperates with FLT3-ITD to induce leukemia. J Exp Med (2017) 0.75
Charged Amino Acid-rich Leucine Zipper-1 (Crlz-1) as a Target of Wnt Signaling Pathway Controls Pre-B Cell Proliferation by Affecting Runx/CBFβ-targeted VpreB and λ5 Genes. J Biol Chem (2016) 0.75
Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis. Br J Haematol (2015) 0.75
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol (2001) 31.56
Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95
Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med (2011) 9.90
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell (1996) 9.74
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet (1999) 6.61
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A (1996) 6.29
Forcing cells to change lineages. Nature (2009) 5.99
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature (2009) 5.34
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell (2010) 5.05
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development (1999) 4.21
Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity (2002) 4.15
Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature (2010) 4.14
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med (2004) 4.00
Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology (1993) 3.37
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood (2005) 3.32
Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer (2002) 3.18
Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development (2004) 2.88
Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood (2006) 2.88
New mutations and pathogenesis of myeloproliferative neoplasms. Blood (2011) 2.53
Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell (2005) 2.51
Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell (2011) 2.30
RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Blood (2003) 2.21
Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J (2004) 2.12
Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo. Immunity (2000) 2.10
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages. EMBO J (2010) 1.82
Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit. Mol Cell Biol (1998) 1.80
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy. Blood (2008) 1.65
Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2. Mol Cell Biol (2000) 1.62
Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood (2011) 1.54
The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol Rev (2003) 1.52
Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors. Blood (2004) 1.35
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol (2009) 1.31
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. Blood (2005) 1.29
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. Exp Hematol (2010) 1.28
Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood (2009) 1.23
Identification and activation of Src family kinases in primary megakaryocytes. Exp Hematol (2003) 1.22
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med (2007) 1.19
Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models. Blood (2010) 1.18
Increased megakaryocytopoiesis in Lyn-deficient mice. Oncogene (2006) 1.15
Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. J Immunol (2006) 1.10
Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Res (2002) 1.10
Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells. J Immunol (2000) 1.09
Activation of SHP2 protein-tyrosine phosphatase increases HoxA10-induced repression of the genes encoding gp91(PHOX) and p67(PHOX). J Biol Chem (2006) 1.07
Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma. Blood (2005) 1.04
The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region. Dev Biol (2000) 1.04
Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation. Blood (2011) 1.04
Immature Megakaryocytes in the Mouse: Morphology and quantitation by acetylcholinesterase staining. Blood (1981) 1.04
Biological and biochemical characteristics of murine megakaryoblastic cell line L8057. Exp Hematol (1993) 1.01
The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes. J Cell Physiol (2010) 1.01
Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage. J Immunol (2001) 1.01
Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656. Blood (2005) 0.95
Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute myeloblastic leukaemia and myelodysplastic syndrome. Br J Haematol (2004) 0.90
Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response. J Biol Chem (2003) 0.89
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. J Biol Chem (2010) 0.88
Regulation of RUNX1 transcriptional function by GATA-1. Crit Rev Eukaryot Gene Expr (2007) 0.81
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics (2002) 30.58
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
Directed proteomic analysis of the human nucleolus. Curr Biol (2002) 7.04
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (2008) 6.66
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell (2010) 6.00
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med (2002) 5.07
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome. Trends Biotechnol (2002) 3.85
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell (2009) 3.05
The efficacy and safety of pain management before and after implementation of hospital-wide pain management standards: is patient safety compromised by treatment based solely on numerical pain ratings? Anesth Analg (2005) 2.83
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell (2011) 2.46
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A (2004) 2.36
TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell (2010) 2.33
Pulmonary embolism after major abdominal surgery in gynecologic oncology. Obstet Gynecol (2006) 2.31
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood (2006) 2.28
Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A (2004) 2.25
Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Mol Cell Proteomics (2009) 2.16
Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology (2011) 2.13
GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Immunity (2003) 2.05
Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO J (2003) 2.03
Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A (2004) 1.99
Discovery of distinct protein profiles specific for lung tumors and pre-malignant lung lesions by SELDI mass spectrometry. Lung Cancer (2003) 1.96
Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc (2009) 1.94
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell (2012) 1.89
Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiol Biomarkers Prev (2004) 1.87
Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding. Wiley Interdiscip Rev Syst Biol Med (2012) 1.81
Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med (2008) 1.79
Comparative outcomes analysis of procedures performed in physician offices and ambulatory surgery centers. Arch Surg (2003) 1.78
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A (2002) 1.77
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. Proc Natl Acad Sci U S A (2010) 1.67
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood (2012) 1.63
p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology (2012) 1.59
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun (2012) 1.58
PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J (2008) 1.58
Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol Cell Biol (2004) 1.55
Indirect economic effects of long-term breast cancer survival. Cancer Pract (2002) 1.55
Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood (2011) 1.54
Prediction of radiation sensitivity using a gene expression classifier. Cancer Res (2005) 1.53
Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis. Arterioscler Thromb Vasc Biol (2011) 1.49
Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol (2007) 1.48
NITPICK: peak identification for mass spectrometry data. BMC Bioinformatics (2008) 1.47
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J Biol Chem (2002) 1.44
Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood (2012) 1.42
A randomized controlled trial to increase cancer screening among attendees of community health centers. Ann Fam Med (2004) 1.37
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Ann Neurol (2013) 1.37
Efficacy and cost-effectiveness of a minimal intervention to prevent smoking relapse: dismantling the effects of amount of content versus contact. J Consult Clin Psychol (2004) 1.36
Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol (2006) 1.36
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood (2003) 1.36
Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development. Mol Cell Biol (2008) 1.36
Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Ann Emerg Med (2009) 1.35
Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc Natl Acad Sci U S A (2008) 1.34
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med (2005) 1.32
Robust prediction of the MASCOT score for an improved quality assessment in mass spectrometric proteomics. J Proteome Res (2008) 1.31
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol (2009) 1.31
Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology (2012) 1.30
Protein profiling with cleavable isotope-coded affinity tag (cICAT) reagents: the yeast salinity stress response. Mol Cell Proteomics (2003) 1.29
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. Blood (2005) 1.29
Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development (2007) 1.27
Selective hepatic artery embolization for treatment of patients with metastatic carcinoid and pancreatic endocrine tumors. Cancer Control (2006) 1.27
Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure. Sci Transl Med (2013) 1.25
When less can yield more - Computational preprocessing of MS/MS spectra for peptide identification. Proteomics (2009) 1.24
Urine proteomics for profiling of human disease using high accuracy mass spectrometry. Proteomics Clin Appl (2009) 1.24
Identification of Shp-2 as a Stat5A phosphatase. J Biol Chem (2003) 1.23
Deuteration distribution estimation with improved sequence coverage for HX/MS experiments. Bioinformatics (2010) 1.22
Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function. Blood (2007) 1.21
p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways. Hepatology (2010) 1.21
Optimizing sample handling for urinary proteomics. J Proteome Res (2008) 1.18
Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Mol Cell Biol (2002) 1.18
Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics (2009) 1.18
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. J Clin Invest (2014) 1.17
Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proc Natl Acad Sci U S A (2011) 1.17
mz5: space- and time-efficient storage of mass spectrometry data sets. Mol Cell Proteomics (2011) 1.16
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (2009) 1.15
FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res (2009) 1.15
A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells. Proteomics (2005) 1.15
Proteomic analysis of palmitoylated platelet proteins. Blood (2011) 1.14
Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation. Biol Blood Marrow Transplant (2010) 1.13
Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development (2010) 1.13
Protein sulfation analysis--A primer. Biochim Biophys Acta (2006) 1.11
Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. J Immunol (2006) 1.10
A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. PLoS One (2009) 1.08
Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol (2008) 1.08
Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. J Neurosci (2010) 1.08
Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J Biol Chem (2006) 1.05
GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem (2003) 1.05