Published in Development on June 01, 1999
Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature (2009) 5.34
Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell (2008) 4.17
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature (2010) 4.16
Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol (2008) 4.04
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood (2005) 3.32
Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo. EMBO J (2000) 3.10
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell (2008) 3.09
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J (2002) 2.99
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc Natl Acad Sci U S A (2003) 2.85
Hematopoietic stem cell development is dependent on blood flow. Cell (2009) 2.77
Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell (2013) 2.71
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med (2012) 2.69
Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J (2002) 2.40
Decoding the regulatory network of early blood development from single-cell gene expression measurements. Nat Biotechnol (2015) 2.30
Integrative analysis of RUNX1 downstream pathways and target genes. BMC Genomics (2008) 2.14
Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta. Proc Natl Acad Sci U S A (2007) 1.93
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci U S A (2005) 1.83
Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood (2007) 1.82
Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos. Development (2010) 1.81
A Serrate-expressing signaling center controls Drosophila hematopoiesis. Genes Dev (2003) 1.79
Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet (2010) 1.76
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. Cell Stem Cell (2011) 1.76
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification. Blood (2008) 1.67
The effects of hemodynamic force on embryonic development. Microcirculation (2010) 1.66
Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2. Mol Cell Biol (2000) 1.62
Origin and differentiation of microglia. Front Cell Neurosci (2013) 1.58
Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1). Mol Cell Biol (2000) 1.58
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region. J Exp Med (2011) 1.48
Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci U S A (2002) 1.47
VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines. Blood (2011) 1.46
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46
Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential. Proc Natl Acad Sci U S A (2007) 1.46
A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis. Proc Natl Acad Sci U S A (2008) 1.44
Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms. Mol Cell Biol (2000) 1.42
Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5. Proc Natl Acad Sci U S A (2003) 1.40
The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep (2005) 1.38
RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. Front Biosci (Landmark Ed) (2012) 1.37
Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. Cancer Res (2009) 1.37
Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun (2013) 1.36
The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity. Proc Natl Acad Sci U S A (2007) 1.36
Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level. Nat Commun (2013) 1.35
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol (2009) 1.31
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. Exp Hematol (2010) 1.28
A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood (2009) 1.27
Factors regulating microglia activation. Front Cell Neurosci (2013) 1.26
Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer. EMBO J (2012) 1.25
Runx1 function in hematopoiesis is required in cells that express Tek. Blood (2005) 1.25
Megakaryocyte biology and related disorders. J Clin Invest (2005) 1.23
Signalling pathways that control vertebrate haematopoietic stem cell specification. Nat Rev Immunol (2013) 1.21
Regulation of endothelial cell differentiation and specification. Circ Res (2013) 1.20
Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J (2006) 1.20
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med (2007) 1.19
Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells. Blood (2011) 1.18
Cell cycle and developmental control of hematopoiesis by Runx1. J Cell Physiol (2009) 1.16
RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making. Crit Rev Oncog (2011) 1.15
Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells. Blood (2013) 1.14
Epigenetic consequences of AML1-ETO action at the human c-FMS locus. EMBO J (2003) 1.14
HoxA3 is an apical regulator of haemogenic endothelium. Nat Cell Biol (2010) 1.13
Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis. Dev Cell (2013) 1.13
Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis. Cell Stem Cell (2012) 1.11
Hematopoietic stem cell emergence in the conceptus and the role of Runx1. Int J Dev Biol (2010) 1.11
Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood (2013) 1.10
Runx3 knockouts and stomach cancer. EMBO Rep (2003) 1.09
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs. Blood (2013) 1.07
Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control. Dev Cell (2013) 1.07
A short history of hemogenic endothelium. Blood Cells Mol Dis (2013) 1.05
Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma. Blood (2005) 1.04
Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development. Development (2009) 1.04
Three-dimensional imaging of whole midgestation murine embryos shows an intravascular localization for all hematopoietic clusters. Blood (2011) 1.04
Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype. Proc Natl Acad Sci U S A (2005) 1.01
The biochemistry of hematopoietic stem cell development. Biochim Biophys Acta (2012) 1.01
Common features of megakaryocytes and hematopoietic stem cells: what's the connection? J Cell Biochem (2009) 0.99
Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol (2011) 0.99
Molecular and developmental biology of the hemangioblast. Dev Dyn (2008) 0.99
Core binding factor at the crossroads: determining the fate of the HSC. J Cell Physiol (2010) 0.98
Conditional Cre/LoxP strategies for the study of hematopoietic stem cell formation. Blood Cells Mol Dis (2009) 0.97
Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation. J Exp Med (2014) 0.97
Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun (2015) 0.97
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest (2015) 0.97
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev (2012) 0.96
Filamin A-bound PEBP2beta/CBFbeta is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factor. Mol Cell Biol (2005) 0.96
Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis. BMC Dev Biol (2007) 0.95
Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol Med (2011) 0.95
Genetically engineered mouse models for skin research: taking the next step. J Dermatol Sci (2008) 0.94
Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development. Blood (2007) 0.94
Core-binding factor influences the disease specificity of Moloney murine leukemia virus. J Virol (1999) 0.93
Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet (2009) 0.93
Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity. Stem Cells (2015) 0.92
Resolving early mesoderm diversification through single-cell expression profiling. Nature (2016) 0.92
AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons. Proc Natl Acad Sci U S A (2004) 0.91
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nat Cell Biol (2015) 0.91
RUNX1: A microRNA hub in normal and malignant hematopoiesis. Int J Mol Sci (2013) 0.91
Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection. Stem Cells Dev (2014) 0.89
Oceans of opportunity: exploring vertebrate hematopoiesis in zebrafish. Exp Hematol (2014) 0.89
Embryonic vasculogenesis and hematopoietic specification. Organogenesis (2008) 0.89
A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells. Mol Cell Biol (2012) 0.88
The Ribosomal Database Project: improved alignments and new tools for rRNA analysis. Nucleic Acids Res (2008) 52.43
The Ribosomal Database Project (RDP-II): sequences and tools for high-throughput rRNA analysis. Nucleic Acids Res (2005) 24.85
The Ribosomal Database Project (RDP-II): previewing a new autoaligner that allows regular updates and the new prokaryotic taxonomy. Nucleic Acids Res (2003) 18.64
The ribosomal database project (RDP-II): introducing myRDP space and quality controlled public data. Nucleic Acids Res (2006) 16.26
Effect of computer-based alerts on the treatment and outcomes of hospitalized patients. Arch Intern Med (1994) 8.20
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature (1998) 7.26
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet (1999) 6.61
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A (1996) 6.29
Characteristics and physiological role of the Ca(2+)-activated Cl- conductance in smooth muscle. Am J Physiol (1996) 4.44
Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis. Diabet Med (2011) 4.04
Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer. Mol Cell Biol (1987) 4.02
Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care (1996) 3.96
Purification on renografin density gradients of Chlamydia trachomatis grown in the yolk sac of eggs. Appl Microbiol (1974) 3.64
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell (1996) 3.55
Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site. Mol Cell Biol (1991) 3.54
Diagnostic accuracy of dermoscopy. Lancet Oncol (2002) 3.14
Identification of intact peanut lectin in peripheral venous blood. Lancet (1998) 3.11
Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo. EMBO J (2000) 3.10
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08
Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol (1993) 3.07
A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA (2000) 3.06
The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci (1995) 2.99
Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation (2000) 2.95
Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet (1996) 2.87
The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle. J Cell Biol (1999) 2.82
Frequency and characteristics of enlarging common melanocytic nevi. Arch Dermatol (2000) 2.75
Complications following the use of the Combitube, tracheal tube and laryngeal mask airway. Anaesthesia (1999) 2.72
Confirmatory assay increases specificity of the chlamydiazyme test for Chlamydia trachomatis infection of the cervix. J Clin Microbiol (1990) 2.65
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet (1997) 2.64
Alternaria redefined. Stud Mycol (2013) 2.56
Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron (2000) 2.50
Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem (2000) 2.44
Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest (1984) 2.43
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2. Mol Cell Biol (1998) 2.39
Secular trends in the prevalence of general and abdominal obesity among Chinese adults, 1993-2009. Obes Rev (2011) 2.36
Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem (1998) 2.35
Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc Natl Acad Sci U S A (1997) 2.35
Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design. J Virol (1990) 2.34
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci U S A (2001) 2.33
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors. J Biol Chem (2000) 2.33
Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circ Res (1996) 2.29
Characteristics of chloride currents activated by noradrenaline in rabbit ear artery cells. J Physiol (1990) 2.29
PCR and blood culture for detection of Escherichia coli bacteremia in rats. J Clin Microbiol (1999) 2.28
Cooperative binding of Ets-1 and core binding factor to DNA. Mol Cell Biol (1994) 2.27
Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet (1996) 2.26
Lactation is associated with greater maternal bone size and bone strength later in life. Osteoporos Int (2011) 2.19
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18
Three 4-coumarate:coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms. Plant J (1999) 2.14
MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components. J Immunol (2001) 2.12
Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines. J Psychopharmacol (2008) 2.11
Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Mol Cell Biol (1992) 2.10
Atomistic free-volume zones and inelastic deformation of metallic glasses. Nat Mater (2010) 2.08
Detection of exon deletions and duplications of the mismatch repair genes in hereditary nonpolyposis colorectal cancer families using multiplex polymerase chain reaction of short fluorescent fragments. Cancer Res (2000) 2.06
A polypeptide bacteriophage receptor: modified cell wall protein subunits in bacteriophage-resistant mutants of Bacillus sphaericus strain P-1. J Bacteriol (1973) 2.00
Noninvasive assessment of cardiac output in critically ill patients by analysis of the finger blood pressure waveform. Crit Care Med (1997) 2.00
CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am J Pathol (1997) 2.00
Review of clinical budgeting and costing experiments. Br Med J (Clin Res Ed) (1983) 2.00
The relationship between opsin overexpression and photoreceptor degeneration. Invest Ophthalmol Vis Sci (2001) 1.98
Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. J Med Genet (2004) 1.94
Recombinant antigens to detect Toxoplasma gondii-specific immunoglobulin G and immunoglobulin M in human sera by enzyme immunoassay. J Clin Microbiol (2000) 1.92
Hypertension and retinopathy, arteriolar narrowing, and arteriovenous nicking in a population. Arch Ophthalmol (1994) 1.91
KCNE1 mutations cause jervell and Lange-Nielsen syndrome. Nat Genet (1997) 1.90
A consensus sequence for binding of Lrp to DNA. J Bacteriol (1995) 1.88
The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration. Neuron (2000) 1.88
Two independent peroxisomal targeting signals in catalase A of Saccharomyces cerevisiae. J Cell Biol (1993) 1.86
Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell (1996) 1.84
Risks and benefits of sequential imaging of melanocytic skin lesions in patients with multiple atypical nevi. Arch Dermatol (2001) 1.84
Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative Group. J Clin Oncol (1998) 1.82
Comparing three-class diagnostic tests by three-way ROC analysis. Med Decis Making (2000) 1.80
Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins. J Virol (1995) 1.80
Administrative registers in psychiatric research: a systematic review of validity studies. Acta Psychiatr Scand (2005) 1.79
The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol (2001) 1.77
Treatment of focal hyperhidrosis with botulinum toxin type A: long-term follow-up in 61 patients. Br J Dermatol (2001) 1.77
Coloidal gold, ferritin and peroxidase as markers for electron microscopic double labeling lectin techniques. J Histochem Cytochem (1978) 1.77
Chromosome movement in mitosis requires microtubule anchorage at spindle poles. J Cell Biol (2001) 1.76
Action of niflumic acid on evoked and spontaneous calcium-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein. Br J Pharmacol (1994) 1.73
Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. Int J Cancer (1996) 1.71
Automated melanoma recognition. IEEE Trans Med Imaging (2001) 1.71
Mutational spectrum of the TSC1 gene in a cohort of 225 tuberous sclerosis complex patients: no evidence for genotype-phenotype correlation. J Med Genet (1999) 1.71
Barriers to compliance with screening guidelines for diabetic retinopathy. Ophthalmic Epidemiol (1999) 1.69
Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology (2003) 1.69
Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome. Proc Natl Acad Sci U S A (1988) 1.69
Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1. J Biol Chem (2001) 1.67
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J Biol Chem (2001) 1.66
Randomized clinical trial to compare the effects of preoperative oral carbohydrate versus placebo on insulin resistance after colorectal surgery. Br J Surg (2010) 1.65
Sucrose transport into barley seeds: molecular characterization of two transporters and implications for seed development and starch accumulation. Plant J (2000) 1.64
Sequence specificity of the core-binding factor. J Virol (1993) 1.63