Published in Cell Stress Chaperones on July 10, 2012
An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes. Front Mol Neurosci (2014) 1.01
Basal and stress-inducible expression of HSPA6 in human keratinocytes is regulated by negative and positive promoter regions. Cell Stress Chaperones (2014) 0.85
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster. Neurobiol Dis (2015) 0.82
The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease. J Huntingtons Dis (2013) 0.81
Ataxin-3 expression correlates with the clinicopathologic features of gastric cancer. Int J Clin Exp Med (2014) 0.76
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. Nat Microbiol (2017) 0.75
The heat-shock proteins. Annu Rev Genet (1988) 22.28
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (2002) 19.36
Molecular chaperones in the cytosol: from nascent chain to folded protein. Science (2002) 15.09
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature (2002) 10.81
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev (1998) 8.13
Molecular chaperones and protein quality control. Cell (2006) 7.74
The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. Annu Rev Genet (1993) 7.60
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Nat Genet (1994) 7.07
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev (2008) 6.18
Heat shock transcription factors: structure and regulation. Annu Rev Cell Dev Biol (1995) 6.16
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet (1999) 4.93
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (2009) 4.80
DAF-16 target genes that control C. elegans life-span and metabolism. Science (2003) 4.57
Conformational disease. Lancet (1997) 4.53
Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron (2001) 4.43
Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci U S A (1986) 3.27
A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem Sci (2001) 3.24
The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev (1992) 3.04
The consequences of expressing hsp70 in Drosophila cells at normal temperatures. Genes Dev (1992) 3.00
Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci U S A (1986) 2.83
Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem (2011) 2.80
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature (2003) 2.60
Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J Cell Sci (2002) 2.58
Molecular chaperones in protein folding: the art of avoiding sticky situations. Trends Biochem Sci (1994) 2.44
Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Mol Cell Biol (1987) 2.17
The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity. Hum Mol Genet (2003) 2.13
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem (2008) 2.09
Stress management - heat shock protein-70 and the regulation of apoptosis. Trends Cell Biol (2001) 2.02
Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3. J Cell Biol (2006) 2.00
Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae. Cell Stress Chaperones (1997) 1.96
Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo. EMBO J (1998) 1.85
Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. Mol Cell (2005) 1.84
E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Mol Cell Biol (1989) 1.83
Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem (2000) 1.83
Multiple basal elements of a human hsp70 promoter function differently in human and rodent cell lines. Mol Cell Biol (1987) 1.77
The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70. Mol Cell Biol (1993) 1.76
The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review. Gerontology (2009) 1.69
Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis. Mol Cell Biol (2003) 1.68
Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo. Mol Cell Biol (1994) 1.68
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet (2006) 1.66
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation. Proc Natl Acad Sci U S A (2005) 1.60
Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Mol Cell Biol (1990) 1.48
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3. EMBO J (2009) 1.46
Oncogenic potential of Hsp72. Oncogene (1999) 1.42
Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. Hum Mol Genet (2000) 1.38
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Mol Cell (2011) 1.37
Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics. Hum Mol Genet (2003) 1.36
Cell cycle-dependent association of HSP70 with specific cellular proteins. J Cell Biol (1989) 1.25
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. Biochem Biophys Res Commun (2007) 1.24
Transduction of the stress signal and mechanisms of transcriptional regulation of heat shock/stress protein gene expression in higher eukaryotes. Crit Rev Eukaryot Gene Expr (1994) 1.22
Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities. J Biol Chem (2002) 1.21
The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability. Hum Mol Genet (2010) 1.21
Hsp70B' regulation and function. Cell Stress Chaperones (2007) 1.19
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. J Neurosci (2006) 1.19
Cadmium and cellular signaling cascades: to be or not to be? Toxicol Appl Pharmacol (2009) 1.17
A developmentally regulated GAGA box-binding factor and Sp1 are required for transcription of the hsp70.1 gene at the onset of mouse zygotic genome activation. Development (2000) 1.15
Tissue-specific differences in heat shock protein hsc70 and hsp70 in the control and hyperthermic rabbit. J Cell Physiol (1997) 1.12
Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini. J Biol Chem (2011) 1.11
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol (2011) 1.08
Constitutive expression of heat shock proteins Hsp90, Hsc70, Hsp70 and Hsp60 in neural and non-neural tissues of the rat during postnatal development. Cell Stress Chaperones (1998) 1.05
Heat shock proteins and Drosophila aging. Exp Gerontol (2010) 1.05
Evidence for the involvement of mouse heat shock factor 1 in the atypical expression of the HSP70.1 heat shock gene during mouse zygotic genome activation. Mol Cell Biol (1997) 1.05
Proteotoxic stress increases nuclear localization of ataxin-3. Hum Mol Genet (2009) 1.02
Basal and inducible levels of Hsp70 in patients with acute heat illness induced during training. Cell Stress Chaperones (2003) 1.01
Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. J Biol Chem (1999) 1.01
Inducible isoform of HSP70 is constitutively expressed in a muscle fiber type specific pattern. Am J Physiol (1991) 1.00
A transcription cofactor required for the heat-shock response. EMBO Rep (2008) 0.99
Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease. Prog Neurobiol (2011) 0.98
Higher levels of heat shock proteins in longer-lived mammals and birds. Mech Ageing Dev (2011) 0.97
Heat shock proteins HSP25, HSP60, HSP72, HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney. Pflugers Arch (1996) 0.97
Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis. J Biol Chem (2004) 0.96
Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3. FASEB J (2007) 0.95
HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes. J Biol Chem (2001) 0.93
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3. Hum Mol Genet (2011) 0.91
Developmental activation of an episomic hsp70 gene promoter in two-cell mouse embryos by transcription factor Sp1. Nucleic Acids Res (1997) 0.89
Heat shock proteins chaperoning life and death. Cell Stress Chaperones (1998) 0.89
In vivo and in vitro osmotic regulation of HSP-70 and prostaglandin synthase gene expression in kidney cells. Am J Physiol (1995) 0.87
Firefly luciferase terminally degraded by mild heat exposure: implications for reporter assays. J Immunol Methods (2006) 0.81
Constitutive expression of inducible Hsp70 is linked to natural shifts in skeletal muscle phenotype. Acta Physiol Scand (2004) 0.79
Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats. Neurosci Lett (2010) 0.78
Absence of ataxin-3 leads to enhanced stress response in C. elegans. PLoS One (2011) 0.78
MicroRNA pathways modulate polyglutamine-induced neurodegeneration. Mol Cell (2006) 2.55
The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity. Hum Mol Genet (2003) 2.13
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res (2010) 1.82
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet (2006) 1.66
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation. Proc Natl Acad Sci U S A (2005) 1.60
Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities. J Biol Chem (2002) 1.21
Proteotoxic stress increases nuclear localization of ataxin-3. Hum Mol Genet (2009) 1.02
Rho kinase regulates fragmentation and phagocytosis of apoptotic cells. Exp Cell Res (2005) 0.99
Rho kinase regulates phagocytosis, surface expression of GlcNAc, and Golgi fragmentation of apoptotic PC12 cells. Exp Cell Res (2006) 0.89
Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death. Exp Neurol (2003) 0.85