Published in Oncogene on June 17, 1999
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones (2005) 5.22
CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70. Nature (2006) 2.90
The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol (2000) 2.69
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev (2005) 2.67
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc Natl Acad Sci U S A (2000) 2.10
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest (2005) 2.06
The HSP70 family and cancer. Carcinogenesis (2013) 2.06
Hsp70 interactions with the p53 tumour suppressor protein. EMBO J (2001) 1.62
Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene. Mol Cell Biol (2001) 1.50
Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia. Leuk Res (2008) 1.45
Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells. J Cell Mol Med (2011) 1.42
Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones (2005) 1.41
KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem (2010) 1.18
Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol (2003) 1.18
Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo. BMC Cancer (2010) 1.13
Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2. PLoS One (2012) 1.11
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorg Med Chem (2007) 1.09
Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr (2011) 1.08
Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia. Blood Cancer J (2011) 0.96
Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis. J Hematol Oncol (2009) 0.89
Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. J Proteome Res (2010) 0.88
Heat shock protein 70 modulates influenza A virus polymerase activity. J Biol Chem (2014) 0.87
The complex function of hsp70 in metastatic cancer. Cancers (Basel) (2013) 0.87
Influence of in vitro IL-2 or IL-15 alone or in combination with Hsp-70-derived 14-mer peptide (TKD) on the expression of NK cell activatory and inhibitory receptors. Mediators Inflamm (2013) 0.85
Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry (2014) 0.84
Basal and stress-induced Hsp70 are modulated by ataxin-3. Cell Stress Chaperones (2012) 0.83
Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer. Genes Cancer (2013) 0.83
Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70. Lasers Surg Med (2011) 0.82
Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human esophageal squamous cell carcinoma. Clin Dev Immunol (2010) 0.82
Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma. Genes Cancer (2015) 0.80
Heat shock protein 70 and the acute respiratory distress syndrome. J Anesth (2005) 0.79
Attenuation of okadaic acid-induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms. Cell Stress Chaperones (2004) 0.76
Upregulation of heat shock protein 70 and the differential protein expression induced by tumor necrosis factor-alpha enhances migration and inhibits apoptosis of hepatocellular carcinoma cell HepG2. Int J Med Sci (2017) 0.75
A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens. Sci Rep (2015) 0.75
Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach. Int J Mol Sci (2017) 0.75
The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol (2000) 2.69
Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J Biol Chem (1997) 2.31
Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol (1999) 1.75
Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.69
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis. J Biol Chem (1998) 1.67
Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett (1998) 1.57
Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene (2010) 1.45
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol (2000) 1.42
The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol Cell Biol (1996) 1.30
Role of molecular chaperones in neurodegenerative disorders. Int J Hyperthermia (2005) 1.16
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene (2011) 1.06
The function of HSP72 in suppression of c-Jun N-terminal kinase activation can be dissociated from its role in prevention of protein damage. J Biol Chem (1999) 1.05
Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation. HSP72 alleviates the stewss-induced inhibition of JNK dephosphorylation. J Biol Chem (2000) 1.02
The molecular chaperone DnaJ is required for the degradation of a soluble abnormal protein in Escherichia coli. J Biol Chem (2000) 1.01
Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1. J Cell Biol (2001) 1.00
Reduced thermotolerance in aged cells results from a loss of an hsp72-mediated control of JNK signaling pathway. Cell Stress Chaperones (1998) 0.97
ATPase activity of the heat shock protein hsp72 is dispensable for its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosis. FEBS Lett (1999) 0.93
HSP72 can protect cells from heat-induced apoptosis by accelerating the inactivation of stress kinase JNK. Cell Stress Chaperones (2000) 0.92
Adjuvant potential of aggregate-forming polyglutamine domains. Vaccine (2008) 0.92
HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling. Oncogene (2010) 0.91
Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme. Int J Hyperthermia (2002) 0.81
Interrelation between taxis and sporulation systems. FEBS Lett (1982) 0.75