Published in Science on March 08, 2002
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Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res (2005) 2.72
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The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. Mol Cell Biol (2003) 2.36
Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series. EMBO Rep (2004) 2.35
Hepatitis B virus replication. World J Gastroenterol (2007) 2.30
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The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci (2008) 2.10
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The relationship of protein conservation and sequence length. BMC Evol Biol (2002) 1.95
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol (2010) 1.95
Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes. Nat Struct Mol Biol (2006) 1.94
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis (2007) 1.90
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Embryo stability and vulnerability in an always changing world. Proc Natl Acad Sci U S A (2007) 1.84
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The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. J Biol Chem (2008) 1.82
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The cauliflower Or gene encodes a DnaJ cysteine-rich domain-containing protein that mediates high levels of beta-carotene accumulation. Plant Cell (2006) 1.80
Role of the gamma-phosphate of ATP in triggering protein folding by GroEL-GroES: function, structure and energetics. EMBO J (2003) 1.78
MecA, an adaptor protein necessary for ClpC chaperone activity. Proc Natl Acad Sci U S A (2003) 1.76
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Mol Syst Biol (2009) 1.75
Cellular strategies of protein quality control. Cold Spring Harb Perspect Biol (2011) 1.74
Bimodal protein solubility distribution revealed by an aggregation analysis of the entire ensemble of Escherichia coli proteins. Proc Natl Acad Sci U S A (2009) 1.73
The 1.6-A crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad. Proc Natl Acad Sci U S A (2003) 1.72
Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins. J Cell Biol (2008) 1.71
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol (2003) 1.71
Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. Structure (2011) 1.71
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nat Rev Drug Discov (2011) 1.71
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CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J Cell Biol (2002) 1.69
Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr Med Chem (2008) 1.68
From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein. Biopolymers (2007) 1.67
The disulfide relay system of mitochondria is connected to the respiratory chain. J Cell Biol (2007) 1.66
Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease. Neuropsychopharmacology (2011) 1.66
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity. Proc Natl Acad Sci U S A (2002) 1.65
Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev (2009) 1.65
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Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response. Mol Cell Biol (2005) 1.64
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The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex. Mol Cell Biol (2003) 1.62
The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell (2006) 1.61
Network of general and specialty J protein chaperones of the yeast cytosol. Proc Natl Acad Sci U S A (2007) 1.61
Simultaneous application of heat, drought, and virus to Arabidopsis plants reveals significant shifts in signaling networks. Plant Physiol (2013) 1.61
A dual function for chaperones SSB-RAC and the NAC nascent polypeptide-associated complex on ribosomes. J Cell Biol (2010) 1.61
The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase. Nat Chem Biol (2010) 1.59
SIZ1 small ubiquitin-like modifier E3 ligase facilitates basal thermotolerance in Arabidopsis independent of salicylic acid. Plant Physiol (2006) 1.58
Target cell cyclophilins facilitate human papillomavirus type 16 infection. PLoS Pathog (2009) 1.57
Chaperone-mediated in vitro assembly of Polyomavirus capsids. Proc Natl Acad Sci U S A (2003) 1.56
J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A (2003) 1.55
Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate binding. Mol Cell Biol (2004) 1.55
Mechanics of Hsp70 chaperones enables differential interaction with client proteins. Nat Struct Mol Biol (2011) 1.54
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease. EMBO Mol Med (2009) 1.53
Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev (2002) 1.53
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. Pharmacol Rev (2013) 1.52
Topologies of a substrate protein bound to the chaperonin GroEL. Mol Cell (2007) 1.52
The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell (2004) 1.52
Allostery in the Hsp70 chaperone proteins. Top Curr Chem (2013) 1.52
Retracted L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle. EMBO Rep (2006) 1.51
GroEL-mediated protein folding: making the impossible, possible. Crit Rev Biochem Mol Biol (2006) 1.51
Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nat Struct Mol Biol (2008) 1.51
The ribosome modulates nascent protein folding. Science (2011) 1.51
Mba1, a membrane-associated ribosome receptor in mitochondria. EMBO J (2006) 1.50
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) (2010) 1.50
Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins. Mol Cell (2006) 1.49
Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy. Am J Hum Genet (2008) 1.49
Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system. Microbiol Mol Biol Rev (2012) 1.48
Exchangeable chaperone modules contribute to specification of type I and type II Hsp40 cellular function. Mol Biol Cell (2003) 1.48
Direct NMR observation of a substrate protein bound to the chaperonin GroEL. Proc Natl Acad Sci U S A (2005) 1.47
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem (2008) 1.47
Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding. Proc Natl Acad Sci U S A (2009) 1.46
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Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell (2005) 4.78
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell (2011) 3.98
Molecular chaperone functions in protein folding and proteostasis. Annu Rev Biochem (2013) 3.56
Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein. Cell (2006) 3.45
Real-time observation of trigger factor function on translating ribosomes. Nature (2006) 2.23
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol Cell (2004) 2.19
Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco. Cell (2007) 2.11
Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed. Cell (2004) 1.85
PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone. Cell (2013) 1.76
Protein folding in the cytoplasm and the heat shock response. Cold Spring Harb Perspect Biol (2010) 1.71
Coupled chaperone action in folding and assembly of hexadecameric Rubisco. Nature (2010) 1.63
DnaK functions as a central hub in the E. coli chaperone network. Cell Rep (2012) 1.52
Monitoring protein conformation along the pathway of chaperonin-assisted folding. Cell (2008) 1.45
Chaperonin-catalyzed rescue of kinetically trapped states in protein folding. Cell (2010) 1.36
Essential role of the chaperonin folding compartment in vivo. EMBO J (2008) 1.29
Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Nature (2011) 1.20
The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation. EMBO J (2002) 1.06
SnapShot: molecular chaperones, Part I. Cell (2007) 1.05
Structure of green-type Rubisco activase from tobacco. Nat Struct Mol Biol (2011) 1.05
Structural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studies. J Biol Chem (2002) 0.98
Crystal structure of a chaperone-bound assembly intermediate of form I Rubisco. Nat Struct Mol Biol (2011) 0.95
SnapShot: molecular chaperones, Part II. Cell (2007) 0.93
Differential substrate specificity of group I and group II chaperonins in the archaeon Methanosarcina mazei. Mol Microbiol (2009) 0.93
Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei. J Biol Chem (2003) 0.93
Chaperonin cofactors, Cpn10 and Cpn20, of green algae and plants function as hetero-oligomeric ring complexes. J Biol Chem (2012) 0.87
A mobile loop order-disorder transition modulates the speed of chaperonin cycling. Protein Sci (2004) 0.82
Structural basis for subunit assembly in UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae. J Mol Biol (2006) 0.81
Functional characterization of an archaeal GroEL/GroES chaperonin system: significance of substrate encapsulation. J Biol Chem (2003) 0.78
How to orient the functional GroEL-SR1 mutant for atomic force microscopy investigations. Biochem Biophys Res Commun (2005) 0.78
The first chaperonin. Nat Rev Mol Cell Biol (2013) 0.75