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An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways. Pain (2013) 0.98

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Defining modulatory inputs into CNS neuronal subclasses by functional pharmacological profiling. Proc Natl Acad Sci U S A (2014) 0.84

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Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc Natl Acad Sci U S A (2015) 0.82

Constellation pharmacology: a new paradigm for drug discovery. Annu Rev Pharmacol Toxicol (2015) 0.81

Metabolic model for diversity-generating biosynthesis. Proc Natl Acad Sci U S A (2016) 0.81

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A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons. Pflugers Arch (2007) 0.95

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Conotoxins down under. Toxicon (2006) 1.58

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Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem (2007) 1.48

Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors. Proc Natl Acad Sci U S A (2006) 1.42

Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors. J Biol Chem (2004) 1.40

Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actions. J Neurosci (2004) 1.40

Venomous auger snail Hastula (Impages) hectica (Linnaeus, 1758): molecular phylogeny, foregut anatomy and comparative toxinology. J Exp Zool B Mol Dev Evol (2007) 1.39

Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors. J Neurosci (2003) 1.34

Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2. J Pharmacol Exp Ther (2002) 1.33

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels. Biochemistry (2005) 1.31

The A-superfamily of conotoxins: structural and functional divergence. J Biol Chem (2003) 1.31

Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons. Biochemistry (2002) 1.30

μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A (2011) 1.30

Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics (2011) 1.29

Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR. Biochemistry (2006) 1.28

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J Biol Chem (2005) 1.27

Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuropsychopharmacology (2006) 1.27

A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors. J Biol Chem (2005) 1.26

Microhabitats within venomous cone snails contain diverse actinobacteria. Appl Environ Microbiol (2009) 1.23

Functional profiling of neurons through cellular neuropharmacology. Proc Natl Acad Sci U S A (2012) 1.23

Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning. Development (2008) 1.22

Accessing novel conoidean venoms: Biodiverse lumun-lumun marine communities, an untapped biological and toxinological resource. Toxicon (2009) 1.22

gamma -Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates. Proc Natl Acad Sci U S A (2002) 1.22

Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon (2008) 1.19

Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors. Endocrinology (2003) 1.19

Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. Biochemistry (2005) 1.18

Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist. Biochemistry (2007) 1.18

Oxidative folding of conotoxins sharing an identical disulfide bridging framework. FEBS J (2005) 1.18

The augertoxins: biochemical characterization of venom components from the toxoglossate gastropod Terebra subulata. Toxicon (2003) 1.18

Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J Biol Chem (2007) 1.18

Amyloid as a depot for the formulation of long-acting drugs. PLoS Biol (2008) 1.17

Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry (2006) 1.17

Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. BMC Genomics (2012) 1.16

The mitochondrial genome of Conus textile, coxI-coxII intergenic sequences and Conoidean evolution. Mol Phylogenet Evol (2007) 1.16

Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites. J Biol Chem (2002) 1.15

Genes expressed in a turrid venom duct: divergence and similarity to conotoxins. J Mol Evol (2006) 1.15

Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin. J Neurophysiol (2010) 1.14

A novel structural class of toxins: the methionine-rich peptides from the venoms of turrid marine snails (Mollusca, Conoidea). Toxicon (2004) 1.14

Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry (2004) 1.13

Folding of conotoxins: formation of the native disulfide bridges during chemical synthesis and biosynthesis of Conus peptides. Antioxid Redox Signal (2008) 1.12

A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry (2006) 1.12

Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors. J Biol Chem (2006) 1.12

Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors. J Biol Chem (2002) 1.12

A rapidly diverging superfamily of peptide toxins in venomous Gemmula species. Toxicon (2007) 1.11

Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels (Austin) (2009) 1.11

Phylogeny of the genus Turris: correlating molecular data with radular anatomy and shell morphology. Mol Phylogenet Evol (2011) 1.10

Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads. Curr Opin Drug Discov Devel (2009) 1.09

A bacterial source for mollusk pyrone polyketides. Chem Biol (2013) 1.09

Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry (2008) 1.09

Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting. J Med Chem (2008) 1.09

Integrated oxidative folding of cysteine/selenocysteine containing peptides: improving chemical synthesis of conotoxins. Angew Chem Int Ed Engl (2009) 1.08

Molecular interaction of delta-conotoxins with voltage-gated sodium channels. FEBS Lett (2005) 1.08

A soluble mouse brain splice variant of type 2alpha corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity. Proc Natl Acad Sci U S A (2005) 1.08

A soluble form of the first extracellular domain of mouse type 2beta corticotropin-releasing factor receptor reveals differential ligand specificity. J Biol Chem (2003) 1.06

Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels. Biochemistry (2006) 1.05

Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. J Nat Prod (2010) 1.05

Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide. J Biol Chem (2004) 1.05

Efficient oxidative folding of conotoxins and the radiation of venomous cone snails. Proc Natl Acad Sci U S A (2003) 1.04

Alpha-conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon (2008) 1.04

Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem (2009) 1.04

Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry (2009) 1.04

Complete mitochondrial DNA sequence of a Conoidean gastropod, Lophiotoma (Xenuroturris) cerithiformis: gene order and gastropod phylogeny. Toxicon (2006) 1.03

Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem Pharmacol (2008) 1.03

Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. J Mol Biol (2008) 1.02

Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. J Med Chem (2011) 1.02

Common and divergent structural features of a series of corticotropin releasing factor-related peptides. J Am Chem Soc (2007) 1.02

Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol Phylogenet Evol (2010) 1.02

Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity. Chem Biol (2007) 1.01

CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α. PLoS One (2012) 1.01

Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: degarelix. J Pharmacol Exp Ther (2002) 1.01

Novel excitatory Conus peptides define a new conotoxin superfamily. J Neurochem (2003) 1.01

Conantokin-P, an unusual conantokin with a long disulfide loop. Toxicon (2008) 1.01

muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2. Channels (Austin) (2007) 1.00

Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass. Proc Natl Acad Sci U S A (2014) 1.00

μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels. Biochemistry (2010) 0.99

Propeptide does not act as an intramolecular chaperone but facilitates protein disulfide isomerase-assisted folding of a conotoxin precursor. Biochemistry (2004) 0.99

Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome. Mar Genomics (2012) 0.99

Norcystine, a new tool for the study of the structure-activity relationship of peptides. Org Lett (2006) 0.98

Evolution of Conus peptide genes: duplication and positive selection in the A-superfamily. J Mol Evol (2010) 0.98

Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA. J Biol Chem (2003) 0.97

NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist. J Biol Chem (2010) 0.97

Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. J Pharmacol Exp Ther (2004) 0.97

Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. Biochemistry (2007) 0.96

Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem (2010) 0.96

Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys. Neuropsychopharmacology (2004) 0.96

Role of hydroxyprolines in the in vitro oxidative folding and biological activity of conotoxins. Biochemistry (2008) 0.96

Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. J Biol Chem (2012) 0.96

Natural products and ion channel pharmacology. Future Med Chem (2010) 0.96

NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA. J Am Chem Soc (2008) 0.95

Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity. J Med Chem (2008) 0.95

Prolongation of evoked and spontaneous synaptic currents at the neuromuscular junction after activity blockade is caused by the upregulation of fetal acetylcholine receptors. J Neurosci (2006) 0.95