Published in Nature on January 07, 2004
Dissecting the Heterogeneity of Oral Cancer Pain | NCT05024383
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TRPV1-lineage neurons are required for thermal sensation. EMBO J (2010) 1.77
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A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci (2008) 1.71
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst (2008) 1.70
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TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci (2011) 1.67
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TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A (2009) 1.52
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Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47
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Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain (2009) 1.42
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The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci U S A (2006) 1.39
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Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol (2010) 1.36
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Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. FASEB J (2011) 1.33
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01
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Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature (2002) 8.94
The menthol receptor TRPM8 is the principal detector of environmental cold. Nature (2007) 6.16
Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature (2013) 5.75
TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A (2006) 5.41
TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A (2007) 5.27
The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci (2006) 4.93
Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell (2002) 4.57
Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A (2005) 4.20
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TRPV1 structures in distinct conformations reveal activation mechanisms. Nature (2013) 3.62
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TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci (2011) 3.05
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Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci (2011) 2.90
Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature (2006) 2.47
Molecular basis of infrared detection by snakes. Nature (2010) 2.40
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol (2007) 2.21
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron (2004) 2.19
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The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem (2008) 2.03
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A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature (2011) 1.84
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci (2005) 1.83
The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci (2002) 1.82
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A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell (2010) 1.82
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron (2008) 1.79
TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron (2013) 1.73
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell (2013) 1.71
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Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature (2011) 1.49
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47
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TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol. Nat Commun (2011) 1.43
The ion channel TRPA1 is required for chronic itch. J Neurosci (2013) 1.41
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Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS One (2011) 1.34
Coiled coils direct assembly of a cold-activated TRP channel. Neuron (2006) 1.33
TRPV1 in brain is involved in acetaminophen-induced antinociception. PLoS One (2010) 1.25
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Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain. J Neurosci (2013) 0.88