Published in Channels (Austin) on July 01, 2012
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1. Proc Natl Acad Sci U S A (2013) 1.86
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels. Nat Commun (2013) 1.60
Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. Sci Signal (2015) 1.56
Mechanosensing is critical for axon growth in the developing brain. Nat Neurosci (2016) 1.46
Piezo1 plays a role in erythrocyte volume homeostasis. Haematologica (2013) 1.29
Human PIEZO1: removing inactivation. Biophys J (2013) 1.07
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A (2014) 1.03
Calcium in red blood cells-a perilous balance. Int J Mol Sci (2013) 1.02
Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures. J Biol Chem (2014) 1.01
Sensory mechanotransduction at membrane-matrix interfaces. Pflugers Arch (2014) 0.87
Piezo1 regulates mechanotransductive release of ATP from human RBCs. Proc Natl Acad Sci U S A (2015) 0.86
Mechanochemitry: a molecular biomechanics view of mechanosensing. Ann Biomed Eng (2013) 0.82
Protonation of the human PIEZO1 ion channel stabilizes inactivation. J Biol Chem (2015) 0.81
Physiological and pathological functions of mechanosensitive ion channels. Mol Neurobiol (2014) 0.80
Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes. Elife (2017) 0.80
Mechanosensitive ion channels: an evolutionary and scientific tour de force in mechanobiology. Channels (Austin) (2012) 0.77
The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in decerebrate rats. J Physiol (2016) 0.76
Mechanosensitive channels: feeling tension in a world under pressure. Front Plant Sci (2014) 0.76
Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability. Oncotarget (2016) 0.75
TRPV4 participates in pressure-induced inhibition of renin secretion by juxtaglomerular cells. J Physiol (2016) 0.75
Channelizing the red blood cell: molecular biology competes with patch-clamp. Front Mol Biosci (2015) 0.75
Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Mechanosensitive Piezo Channels in the Gastrointestinal Tract. Curr Top Membr (2017) 0.75
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (2010) 6.29
Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. Science (2002) 5.82
Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol (1984) 5.57
Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science (1989) 4.80
Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Nature (2002) 4.42
Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL. J Gen Physiol (1999) 4.10
TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol (2005) 3.92
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature (2012) 3.81
Piezo proteins are pore-forming subunits of mechanically activated channels. Nature (2012) 3.54
Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci U S A (2008) 3.04
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science (2012) 2.94
The role of Drosophila Piezo in mechanical nociception. Nature (2012) 2.72
Structural models of the MscL gating mechanism. Biophys J (2001) 2.58
Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax. Biochemistry (1994) 2.21
Assessment of potential stimuli for mechano-dependent gating of MscL: effects of pressure, tension, and lipid headgroups. Biochemistry (2005) 2.16
Biophysics and structure of the patch and the gigaseal. Biophys J (2009) 2.15
Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol (2000) 2.09
Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proc Natl Acad Sci U S A (2008) 2.07
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry (2011) 1.93
Stretch-activated ion channels: what are they? Physiology (Bethesda) (2010) 1.85
Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch (2007) 1.81
Single channel properties of P2X2 purinoceptors. J Gen Physiol (1999) 1.78
Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood (2012) 1.76
Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci U S A (2006) 1.65
Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol (2010) 1.58
High-speed pressure clamp. Pflugers Arch (2002) 1.56
Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes. J Physiol (2007) 1.55
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum. J Cell Sci (2010) 1.45
Nav channel mechanosensitivity: activation and inactivation accelerate reversibly with stretch. Biophys J (2007) 1.44
Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording. Channels (Austin) (2012) 1.43
Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry (2004) 1.42
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. EMBO Rep (2005) 1.41
Atomic force microscopy analysis of cell volume regulation. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 1.37
Dynamic regulation of mechanosensitive channels: capacitance used to monitor patch tension in real time. Phys Biol (2004) 1.35
Solution structure of peptide toxins that block mechanosensitive ion channels. J Biol Chem (2002) 1.34
Structure and function of the bacterial mechanosensitive channel of large conductance. Protein Sci (1999) 1.19
Bacterial mechanosensitive channels as a paradigm for mechanosensory transduction. Cell Physiol Biochem (2011) 1.18
On the discrepancy between whole-cell and membrane patch mechanosensitivity in Xenopus oocytes. J Physiol (2000) 1.14
G protein-mediated stretch reception. Am J Physiol Heart Circ Physiol (2012) 1.13
Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers? Biophys J (2007) 1.10
The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons. J Neurosci (2011) 1.10
Mechanosensitive channel MscS in the open state: modeling of the transition, explicit simulations, and experimental measurements of conductance. J Gen Physiol (2008) 1.09
Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One (2010) 1.09
A mechanosensitive ion channel regulating cell volume. Am J Physiol Cell Physiol (2010) 1.06
Hydration properties of mechanosensitive channel pores define the energetics of gating. J Phys Condens Matter (2010) 1.01
Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch (2007) 0.99
Whole-cell mechanosensitive currents in rat ventricular myocytes activated by direct stimulation. J Membr Biol (2000) 0.98
Biophysics of mechanoreception. Membr Biochem (1986) 0.95
Mechanoprotection of the plasma membrane in neurons and other non-erythroid cells by the spectrin-based membrane skeleton. Cell Mol Biol Lett (2001) 0.94
Calcium-, voltage- and osmotic stress-sensitive currents in Xenopus oocytes and their relationship to single mechanically gated channels. J Physiol (2000) 0.89
Modeling ion channels in the gigaseal. Biophys J (2011) 0.89
Mechanogated channels in Xenopus oocytes: different gating modes enable a channel to switch from a phasic to a tonic mechanotransducer. Biol Bull (1997) 0.87
Polycystin-1 and -2 dosage regulates pressure sensing. Cell (2009) 3.36
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature (2004) 3.12
Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophys J (2005) 2.18
Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse. J Physiol (2004) 2.17
Biophysics and structure of the patch and the gigaseal. Biophys J (2009) 2.15
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry (2011) 1.93
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1. Proc Natl Acad Sci U S A (2013) 1.86
Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch (2007) 1.81
Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci U S A (2006) 1.65
Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol (2010) 1.58
High-speed pressure clamp. Pflugers Arch (2002) 1.56
Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes. J Physiol (2007) 1.55
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49
A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J (2008) 1.49
Connexins are mechanosensitive. Am J Physiol Cell Physiol (2004) 1.46
A simple automated stimulator of mechanically induced arrhythmias in the isolated rat heart. Exp Physiol (2009) 1.44
Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording. Channels (Austin) (2012) 1.43
Atomic force microscopy analysis of cell volume regulation. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 1.37
Maximum likelihood estimation of molecular motor kinetics from staircase dwell-time sequences. Biophys J (2006) 1.35
Dynamic regulation of mechanosensitive channels: capacitance used to monitor patch tension in real time. Phys Biol (2004) 1.35
Solution structure of peptide toxins that block mechanosensitive ion channels. J Biol Chem (2002) 1.34
Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J Cell Sci (2010) 1.30
Molecular force transduction by ion channels: diversity and unifying principles. J Cell Sci (2012) 1.28
Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. J Neurosci (2006) 1.25
cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels. Toxicon (2003) 1.25
Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice. Neuromuscul Disord (2006) 1.25
Extracting dwell time sequences from processive molecular motor data. Biophys J (2006) 1.16
Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers? Biophys J (2007) 1.10
Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One (2010) 1.09
Mechanosensation and endothelin in astrocytes--hypothetical roles in CNS pathophysiology. Brain Res Brain Res Rev (2004) 1.09
Microfluidic actuation using electrochemically generated bubbles. Anal Chem (2002) 1.08
Orientation-based FRET sensor for real-time imaging of cellular forces. J Cell Sci (2012) 1.08
Human PIEZO1: removing inactivation. Biophys J (2013) 1.07
A mechanosensitive ion channel regulating cell volume. Am J Physiol Cell Physiol (2010) 1.06
Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts. Biophys J (2010) 1.06
Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes. BMC Neurosci (2002) 1.04
Dynamic properties of stretch-activated K+ channels in adult rat atrial myocytes. Prog Biophys Mol Biol (2003) 1.04
Mechanosensitive ion channels as drug targets. Curr Drug Targets CNS Neurol Disord (2004) 1.01
Electromechanical coupling in the membranes of Shaker-transfected HEK cells. Proc Natl Acad Sci U S A (2009) 1.01
Volume cytometry: microfluidic sensor for high-throughput screening in real time. Anal Chem (2005) 0.99
Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch (2007) 0.99
Real Time FRET Based Detection of Mechanical Stress in Cytoskeletal and Extracellular Matrix Proteins. Cell Mol Bioeng (2011) 0.97
The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms. Prog Biophys Mol Biol (2008) 0.97
Genetically encoded force sensors for measuring mechanical forces in proteins. Commun Integr Biol (2011) 0.96
Drift-free atomic force microscopy measurements of cell height and mechanical properties. Rev Sci Instrum (2007) 0.91
Stretch-activated potassium channels in hypotonically induced blebs of atrial myocytes. J Membr Biol (2008) 0.90
Microfluidic chip to produce temperature jumps for electrophysiology. Anal Chem (2008) 0.90
Dynamic effects of Hg2+-induced changes in cell volume. Cell Biochem Biophys (2008) 0.90
Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs). Biochem Biophys Res Commun (2011) 0.89
Modeling ion channels in the gigaseal. Biophys J (2011) 0.89
Caveolae regulation of mechanosensitive channel function in myotubes. PLoS One (2013) 0.87
Shear-induced volume decrease in MDCK cells. Cell Physiol Biochem (2012) 0.87
Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium. Cardiovasc Res (2008) 0.86
Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. Cell Rep (2012) 0.86
Fluorescence-based force/tension sensors: a novel tool to visualize mechanical forces in structural proteins in live cells. Antioxid Redox Signal (2014) 0.85
High throughput assay of diffusion through Cx43 gap junction channels with a microfluidic chip. Anal Chem (2010) 0.84
Interplay between cytoskeletal stresses and cell adaptation under chronic flow. PLoS One (2012) 0.84
Microfabricated torsion levers optimized for low force and high-frequency operation in fluids. Ultramicroscopy (2006) 0.83
Hereditary xerocytosis revisited. Am J Hematol (2014) 0.82
Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy. Bioconjug Chem (2014) 0.81
Gigaseal mechanics: creep of the gigaseal under the action of pressure, adhesion, and voltage. J Phys Chem B (2014) 0.81
Probing the double layer: effect of image forces on AFM. Biophys J (2006) 0.80
Cell biology: The sensation of stretch. Nature (2012) 0.79
Flexoelectricity and elasticity of asymmetric biomembranes. Phys Rev E Stat Nonlin Soft Matter Phys (2002) 0.79
Neurite outgrowth from PC12 cells is enhanced by an inhibitor of mechanical channels. Neurosci Lett (2010) 0.79
Retaining your identity under stress. Nat Struct Biol (2002) 0.77
Cholesterol depletion facilitates recovery from hypotonic cell swelling in CHO cells. Cell Physiol Biochem (2011) 0.77
Mechanical effects on KATP channel gating in rat ventricular myocytes. PLoS One (2013) 0.77
A microfluidic platform for measuring electrical activity across cells. Biomicrofluidics (2012) 0.75