Published in Nature on July 08, 2004
Emerging roles for lipids in shaping membrane-protein function. Nature (2009) 4.14
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A (2006) 2.30
Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse. J Physiol (2004) 2.17
Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci (2011) 2.12
Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proc Natl Acad Sci U S A (2008) 2.07
A phospholipid sensor controls mechanogating of the K+ channel TREK-1. EMBO J (2004) 1.98
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry (2011) 1.93
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1. Proc Natl Acad Sci U S A (2013) 1.86
Stretch-activated ion channels: what are they? Physiology (Bethesda) (2010) 1.85
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. J R Soc Interface (2009) 1.77
Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling. Am J Physiol Renal Physiol (2006) 1.72
Tarantula toxins interacting with voltage sensors in potassium channels. Toxicon (2006) 1.69
On the role of VDAC in apoptosis: fact and fiction. J Bioenerg Biomembr (2005) 1.68
Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci U S A (2006) 1.65
Molecular dynamics simulations of model trans-membrane peptides in lipid bilayers: a systematic investigation of hydrophobic mismatch. Biophys J (2006) 1.65
VDAC regulation: role of cytosolic proteins and mitochondrial lipids. J Bioenerg Biomembr (2008) 1.60
Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther (2007) 1.60
Tarantula toxins interact with voltage sensors within lipid membranes. J Gen Physiol (2007) 1.58
The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity. J Gen Physiol (2005) 1.57
Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes. J Physiol (2007) 1.55
Microtubules underlie dysfunction in duchenne muscular dystrophy. Sci Signal (2012) 1.54
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49
A simple automated stimulator of mechanically induced arrhythmias in the isolated rat heart. Exp Physiol (2009) 1.44
Spider-venom peptides as therapeutics. Toxins (Basel) (2010) 1.44
Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording. Channels (Austin) (2012) 1.43
Canonical TRP channels and mechanotransduction: from physiology to disease states. Pflugers Arch (2010) 1.38
Molecular force transduction by ion channels: diversity and unifying principles. J Cell Sci (2012) 1.28
Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine. Br J Pharmacol (2005) 1.27
Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids. Biophys J (2008) 1.26
Twenty odd years of stretch-sensitive channels. Pflugers Arch (2006) 1.26
Amphiphile regulation of ion channel function by changes in the bilayer spring constant. Proc Natl Acad Sci U S A (2010) 1.26
Stim, ORAI and TRPC channels in the control of calcium entry signals in smooth muscle. Clin Exp Pharmacol Physiol (2008) 1.25
TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch (2008) 1.24
Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb) (2010) 1.23
The sticky issue of neurosteroids and GABA(A) receptors. Trends Neurosci (2010) 1.21
A finite element framework for studying the mechanical response of macromolecules: application to the gating of the mechanosensitive channel MscL. Biophys J (2006) 1.20
D-amino acids modulate the cellular response of enzymatic-instructed supramolecular nanofibers of small peptides. Biomacromolecules (2014) 1.14
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A (2014) 1.11
Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol (2008) 1.10
Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers? Biophys J (2007) 1.10
Curvature forces in membrane lipid-protein interactions. Biochemistry (2012) 1.09
Spatially resolved shear distribution in microfluidic chip for studying force transduction mechanisms in cells. Lab Chip (2009) 1.08
A mechanosensitive ion channel regulating cell volume. Am J Physiol Cell Physiol (2010) 1.06
Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts. Biophys J (2010) 1.06
Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants. J Gen Physiol (2014) 1.06
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A (2014) 1.03
Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells. EMBO Rep (2013) 1.02
Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures. J Biol Chem (2014) 1.01
Piezo proteins: regulators of mechanosensation and other cellular processes. J Biol Chem (2014) 1.01
Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch (2007) 0.99
Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. J Neurosci (2009) 0.98
Quenching-enhanced fluorescence titration protocol for accurate determination of free energy of membrane binding. Anal Biochem (2006) 0.98
Lipid bilayer mechanics in a pipette with glass-bilayer adhesion. Biophys J (2011) 0.97
Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor. PLoS One (2010) 0.95
Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci (2013) 0.95
Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proc Natl Acad Sci U S A (2014) 0.94
Molecular dynamics simulations of a stretch-activated channel inhibitor GsMTx4 with lipid membranes: two binding modes and effects of lipid structure. Biophys J (2007) 0.94
Heterologously expressed fungal transient receptor potential channels retain mechanosensitivity in vitro and osmotic response in vivo. Eur Biophys J (2005) 0.94
Voltage-gated channel mechanosensitivity: fact or friction? Front Physiol (2011) 0.93
Structure and orientation of a voltage-sensor toxin in lipid membranes. Biophys J (2010) 0.91
The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology (2009) 0.91
Molecular candidates for cardiac stretch-activated ion channels. Glob Cardiol Sci Pract (2014) 0.90
Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs). Biochem Biophys Res Commun (2011) 0.89
Slower Piezo1 inactivation in dehydrated hereditary stomatocytosis (xerocytosis). Biophys J (2013) 0.89
Mechanical and biochemical modeling of cortical oscillations in spreading cells. Biophys J (2008) 0.88
Ion channels: gate expectations. Nature (2004) 0.87
Role of chirality in peptide-induced formation of cholesterol-rich domains. Biochem J (2005) 0.86
D-Maurocalcine, a pharmacologically inert efficient cell-penetrating peptide analogue. J Biol Chem (2010) 0.86
The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating. FASEB J (2014) 0.85
Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback. J Biomech Eng (2014) 0.85
Concentration dependent effect of GsMTx4 on mechanosensitive channels of small conductance in E. coli spheroplasts. Eur Biophys J (2009) 0.85
Hemodynamic forces regulate developmental patterning of atrial conduction. PLoS One (2014) 0.85
Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology. Trends Pharmacol Sci (2015) 0.84
Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels . Biochemistry (2010) 0.84
Structural interactions of a voltage sensor toxin with lipid membranes. Proc Natl Acad Sci U S A (2014) 0.84
Sites and functional consequence of VDAC-alkylphenol anesthetic interactions. FEBS Lett (2014) 0.84
Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife (2015) 0.83
Interfacial polar interactions affect gramicidin channel kinetics. Biophys J (2007) 0.83
Cardiac Mechano-Gated Ion Channels and Arrhythmias. Circ Res (2016) 0.82
Effect of structural transition of the host assembly on dynamics of an ion channel peptide: a fluorescence approach. Biophys J (2005) 0.82
Effect of gating modifier toxins on membrane thickness: implications for toxin effect on gramicidin and mechanosensitive channels. Toxins (Basel) (2013) 0.82
Protonation of the human PIEZO1 ion channel stabilizes inactivation. J Biol Chem (2015) 0.81
Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore. J Cardiovasc Pharmacol (2009) 0.81
A Threshold Shear Force for Calcium Influx in an Astrocyte Model of Traumatic Brain Injury. J Neurotrauma (2015) 0.80
Neurite outgrowth from PC12 cells is enhanced by an inhibitor of mechanical channels. Neurosci Lett (2010) 0.79
Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties. J Gen Physiol (2014) 0.78
The salty and burning taste of capsaicin. J Gen Physiol (2005) 0.78
Indole and other aromatic compounds activate the yeast TRPY1 channel. FEBS Lett (2008) 0.78
Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations. Biochim Biophys Acta (2015) 0.77
Mechanosensitive Ca(2+) permeant cation channels in human prostate tumor cells. Channels (Austin) (2012) 0.77
The Water Permeability and Pore Entrance Structure of Aquaporin-4 Depend on Lipid Bilayer Thickness. Biophys J (2016) 0.76
Mechanosensitive channels: feeling tension in a world under pressure. Front Plant Sci (2014) 0.76
Computational Studies of Venom Peptides Targeting Potassium Channels. Toxins (Basel) (2015) 0.76
GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion. J Mol Cell Cardiol (2016) 0.76
The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in decerebrate rats. J Physiol (2016) 0.76
Effects of tarantula toxin GsMTx4 on the membrane motor of outer hair cells. Neurosci Lett (2006) 0.76
The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in rats with ligated femoral arteries. Am J Physiol Heart Circ Physiol (2016) 0.75
Mechanical transduction by ion channels: A cautionary tale. World J Neurol (2015) 0.75
Transient Receptor Potential Canonical 1 (TRPC1) Channels as Regulators of Sphingolipid and VEGF Receptor Expression: IMPLICATIONS FOR THYROID CANCER CELL MIGRATION AND PROLIFERATION. J Biol Chem (2015) 0.75
GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J (2017) 0.75
Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs. Acad Med (2010) 6.51
Bilayer thickness and membrane protein function: an energetic perspective. Annu Rev Biophys Biomol Struct (2007) 3.52
Polycystin-1 and -2 dosage regulates pressure sensing. Cell (2009) 3.36
Energetics of ion conduction through the gramicidin channel. Proc Natl Acad Sci U S A (2003) 2.67
Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophys J (2005) 2.18
Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse. J Physiol (2004) 2.17
Biophysics and structure of the patch and the gigaseal. Biophys J (2009) 2.15
Geometry and intrinsic tilt of a tryptophan-anchored transmembrane alpha-helix determined by (2)H NMR. Biophys J (2002) 2.01
Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR. Biophys J (2004) 1.98
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry (2011) 1.93
Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactions. Biochemistry (2003) 1.92
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1. Proc Natl Acad Sci U S A (2013) 1.86
Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. J Gen Physiol (2004) 1.83
Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch (2007) 1.81
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. J R Soc Interface (2009) 1.77
Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity. Mol Pharmacol (2005) 1.70
Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci U S A (2006) 1.65
Structure of gramicidin a in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data. J Am Chem Soc (2003) 1.61
Ion permeation through a narrow channel: using gramicidin to ascertain all-atom molecular dynamics potential of mean force methodology and biomolecular force fields. Biophys J (2006) 1.61
Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol (2010) 1.58
Molecular dynamics - potential of mean force calculations as a tool for understanding ion permeation and selectivity in narrow channels. Biophys Chem (2006) 1.57
High-speed pressure clamp. Pflugers Arch (2002) 1.56
Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics. Biochemistry (2003) 1.55
Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes. J Physiol (2007) 1.55
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode. Chem Biol (2012) 1.49
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49
A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J (2008) 1.49
Docosahexaenoic acid alters bilayer elastic properties. Proc Natl Acad Sci U S A (2007) 1.48
Connexins are mechanosensitive. Am J Physiol Cell Physiol (2004) 1.46
A simple automated stimulator of mechanically induced arrhythmias in the isolated rat heart. Exp Physiol (2009) 1.44
Models and mechanistic insight. J Gen Physiol (2008) 1.44
Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording. Channels (Austin) (2012) 1.43
The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer Res (2007) 1.42
Changes in transmembrane helix alignment by arginine residues revealed by solid-state NMR experiments and coarse-grained MD simulations. J Am Chem Soc (2010) 1.41
Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol (2014) 1.39
Atomic force microscopy analysis of cell volume regulation. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 1.37
Maximum likelihood estimation of molecular motor kinetics from staircase dwell-time sequences. Biophys J (2006) 1.35
Dynamic regulation of mechanosensitive channels: capacitance used to monitor patch tension in real time. Phys Biol (2004) 1.35
Solution structure of peptide toxins that block mechanosensitive ion channels. J Biol Chem (2002) 1.34
Curcumin is a modulator of bilayer material properties. Biochemistry (2007) 1.34
Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J Cell Sci (2010) 1.30
Molecular force transduction by ion channels: diversity and unifying principles. J Cell Sci (2012) 1.28
Hydrophobic mismatch between helices and lipid bilayers. Biophys J (2003) 1.28
Amphiphile regulation of ion channel function by changes in the bilayer spring constant. Proc Natl Acad Sci U S A (2010) 1.26
Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. J Neurosci (2006) 1.25
Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice. Neuromuscul Disord (2006) 1.25
cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels. Toxicon (2003) 1.25
Comparison of "Polarization inversion with spin exchange at magic angle" and "geometric analysis of labeled alanines" methods for transmembrane helix alignment. J Am Chem Soc (2008) 1.24
Hydrophobic coupling of lipid bilayer energetics to channel function. J Gen Physiol (2003) 1.20
Charged or aromatic anchor residue dependence of transmembrane peptide tilt. J Biol Chem (2010) 1.20
Orientation and motion of tryptophan interfacial anchors in membrane-spanning peptides. Biochemistry (2007) 1.20
Piezo1: properties of a cation selective mechanical channel. Channels (Austin) (2012) 1.16
Extracting dwell time sequences from processive molecular motor data. Biophys J (2006) 1.16
Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophys J (2011) 1.15
Influence of hydrophobic mismatch on structures and dynamics of gramicidin a and lipid bilayers. Biophys J (2012) 1.15
The preference of tryptophan for membrane interfaces: insights from N-methylation of tryptophans in gramicidin channels. J Biol Chem (2008) 1.14
Gramicidin channels. IEEE Trans Nanobioscience (2005) 1.12
Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers? Biophys J (2007) 1.10
Mechanosensation and endothelin in astrocytes--hypothetical roles in CNS pathophysiology. Brain Res Brain Res Rev (2004) 1.09
Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One (2010) 1.09
Screening for small molecules' bilayer-modifying potential using a gramicidin-based fluorescence assay. Assay Drug Dev Technol (2010) 1.08
Orientation-based FRET sensor for real-time imaging of cellular forces. J Cell Sci (2012) 1.08
Microfluidic actuation using electrochemically generated bubbles. Anal Chem (2002) 1.08
Human PIEZO1: removing inactivation. Biophys J (2013) 1.07
A mechanosensitive ion channel regulating cell volume. Am J Physiol Cell Physiol (2010) 1.06
Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts. Biophys J (2010) 1.06
Binding of the priming nucleotide in the initiation of transcription by T7 RNA polymerase. J Biol Chem (2002) 1.06
Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes. BMC Neurosci (2002) 1.04
Dynamic properties of stretch-activated K+ channels in adult rat atrial myocytes. Prog Biophys Mol Biol (2003) 1.04
Single-molecule methods for monitoring changes in bilayer elastic properties. Methods Mol Biol (2007) 1.01
Mechanosensitive ion channels as drug targets. Curr Drug Targets CNS Neurol Disord (2004) 1.01
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. PLoS One (2013) 1.01
Electromechanical coupling in the membranes of Shaker-transfected HEK cells. Proc Natl Acad Sci U S A (2009) 1.01
On the combined analysis of ²H and ¹⁵N/¹H solid-state NMR data for determination of transmembrane peptide orientation and dynamics. Biophys J (2011) 1.00
Volume cytometry: microfluidic sensor for high-throughput screening in real time. Anal Chem (2005) 0.99
Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch (2007) 0.99
Alcohol's effects on lipid bilayer properties. Biophys J (2011) 0.99
Tyrosine replacing tryptophan as an anchor in GWALP peptides. Biochemistry (2012) 0.99
2,3-butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylation-independent mechanisms: the role of bilayer material properties. Mol Pharmacol (2006) 0.99