Connexins are mechanosensitive.

Connexin channel permeability to cytoplasmic molecules. Prog Biophys Mol Biol (2007) 2.73

The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J (2006) 2.24

Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta (2005) 2.16

Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear. Proc Natl Acad Sci U S A (2005) 1.84

Intracellular calcium changes trigger connexin 32 hemichannel opening. EMBO J (2005) 1.69

Gap junctions. Compr Physiol (2012) 1.59

Biological role of connexin intercellular channels and hemichannels. Arch Biochem Biophys (2012) 1.45

Connexins, pannexins, innexins: novel roles of "hemi-channels". Pflugers Arch (2008) 1.45

Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis. J Am Soc Nephrol (2009) 1.37

Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors. J Neurosci (2010) 1.37

Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain. J Biol Chem (2008) 1.36

The role of connexins in ear and skin physiology - functional insights from disease-associated mutations. Biochim Biophys Acta (2012) 1.34

Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart. Proc Natl Acad Sci U S A (2006) 1.32

Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor. Mol Biol Cell (2006) 1.30

Paracrine signaling through plasma membrane hemichannels. Biochim Biophys Acta (2012) 1.28

Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. Nat Cell Biol (2015) 1.17

Regulation of connexin hemichannels by monovalent cations. J Gen Physiol (2006) 1.17

Connexins and the kidney. Am J Physiol Regul Integr Comp Physiol (2010) 1.15

Connexin mutants and cataracts. Front Pharmacol (2013) 1.11

Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels. Biophys J (2006) 1.11

Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50. J Cell Sci (2010) 1.07

Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. J Cell Physiol (2012) 1.06

Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium? J Anat (2009) 1.06

Ultra-low-level laser therapy. Lasers Med Sci (2010) 1.05

Innexins form two types of channels. FEBS Lett (2007) 1.05

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol (2013) 1.02

Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow. Am J Physiol Cell Physiol (2010) 1.02

Connexin43-dependent mechanism modulates renin secretion and hypertension. J Clin Invest (2006) 1.00

Voltage-dependent conformational changes in connexin channels. Biochim Biophys Acta (2011) 0.99

Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner. J Cell Sci (2009) 0.96

ATP as a multi-target danger signal in the brain. Front Neurosci (2015) 0.94

Mechanisms of ATP release, the enabling step in purinergic dynamics. Cell Physiol Biochem (2011) 0.92

Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells. Am J Physiol Cell Physiol (2009) 0.92

Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels. FEBS Lett (2007) 0.92

Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. PLoS One (2013) 0.91

Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J Membr Biol (2007) 0.90

ATP releasing connexin 30 hemichannels mediate flow-induced calcium signaling in the collecting duct. Front Physiol (2013) 0.89

Phosphorylation of connexin 50 by protein kinase A enhances gap junction and hemichannel function. J Biol Chem (2011) 0.88

Protein-mediated interactions of pancreatic islet cells. Scientifica (Cairo) (2013) 0.85

Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2011) 0.84

Emerging functions of pannexin 1 in the eye. Front Cell Neurosci (2014) 0.81

Physiological and pathological functions of mechanosensitive ion channels. Mol Neurobiol (2014) 0.80

The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches. Front Physiol (2016) 0.76

The role of gap junctions in inflammatory and neoplastic disorders (Review). Int J Mol Med (2017) 0.76

Shear stress induces a longitudinal Ca(2+) wave via autocrine activation of P2Y1 purinergic signalling in rat atrial myocytes. J Physiol (2015) 0.76

Focus on lens connexins. BMC Cell Biol (2017) 0.75

Pannexin channel and connexin hemichannel expression in vascular function and inflammation. BMC Cell Biol (2017) 0.75

Complementary expression and phosphorylation of Cx46 and Cx50 during development and following gene deletion in mouse and in normal and orchitic mink testes. Am J Physiol Regul Integr Comp Physiol (2015) 0.75

Connexin23 deletion does not affect lens transparency. Exp Eye Res (2016) 0.75

Concurrent hyperbaric oxygen therapy and intratympanic steroid application as salvage therapy after severe sudden sensorineural hearing loss. Clin Case Rep (2016) 0.75

Connexin Hemichannels: Methods for Dye Uptake and Leakage. J Membr Biol (2016) 0.75

Connexin channel and its role in diabetic retinopathy. Prog Retin Eye Res (2017) 0.75

Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73

Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A (2006) 4.03

Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett (2005) 3.89

Polycystin-1 and -2 dosage regulates pressure sensing. Cell (2009) 3.36

Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett (2007) 3.19

Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature (2004) 3.12

The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90

Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol (2008) 2.79

Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci (2009) 2.48

Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophys J (2005) 2.18

Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse. J Physiol (2004) 2.17

Biophysics and structure of the patch and the gigaseal. Biophys J (2009) 2.15

Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. J Biol Chem (2007) 2.05

The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry (2011) 1.93

Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol (2009) 1.89

Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1. Proc Natl Acad Sci U S A (2013) 1.86

Connexin and pannexin mediated cell-cell communication. Neuron Glia Biol (2007) 1.86

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol (2008) 1.86

Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84

Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch (2007) 1.81

Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci U S A (2006) 1.65

Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol (2007) 1.60

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol (2010) 1.58

High-speed pressure clamp. Pflugers Arch (2002) 1.56

Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes. J Physiol (2007) 1.55

Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49

A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J (2008) 1.49

A simple automated stimulator of mechanically induced arrhythmias in the isolated rat heart. Exp Physiol (2009) 1.44

Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording. Channels (Austin) (2012) 1.43

Function of the voltage gate of gap junction channels: selective exclusion of molecules. Proc Natl Acad Sci U S A (2002) 1.40

Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other. J Biol Chem (2010) 1.39

Atomic force microscopy analysis of cell volume regulation. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 1.37

Maximum likelihood estimation of molecular motor kinetics from staircase dwell-time sequences. Biophys J (2006) 1.35

Dynamic regulation of mechanosensitive channels: capacitance used to monitor patch tension in real time. Phys Biol (2004) 1.35

Solution structure of peptide toxins that block mechanosensitive ion channels. J Biol Chem (2002) 1.34

Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J Cell Sci (2010) 1.30

Molecular force transduction by ion channels: diversity and unifying principles. J Cell Sci (2012) 1.28

Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. J Neurosci (2006) 1.25

SCAM analysis of Panx1 suggests a peculiar pore structure. J Gen Physiol (2010) 1.25

cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels. Toxicon (2003) 1.25

Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice. Neuromuscul Disord (2006) 1.25

ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes. Glia (2012) 1.22

Trafficking dynamics of glycosylated pannexin 1 proteins. Cell Commun Adhes (2008) 1.20

Piezo1: properties of a cation selective mechanical channel. Channels (Austin) (2012) 1.16

Extracting dwell time sequences from processive molecular motor data. Biophys J (2006) 1.16

Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers? Biophys J (2007) 1.10

Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One (2010) 1.09

Mechanosensation and endothelin in astrocytes--hypothetical roles in CNS pathophysiology. Brain Res Brain Res Rev (2004) 1.09

Orientation-based FRET sensor for real-time imaging of cellular forces. J Cell Sci (2012) 1.08

Microfluidic actuation using electrochemically generated bubbles. Anal Chem (2002) 1.08

Human PIEZO1: removing inactivation. Biophys J (2013) 1.07

The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J (2009) 1.07

A mechanosensitive ion channel regulating cell volume. Am J Physiol Cell Physiol (2010) 1.06

Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts. Biophys J (2010) 1.06

Innexins form two types of channels. FEBS Lett (2007) 1.05

Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes. BMC Neurosci (2002) 1.04

Dynamic properties of stretch-activated K+ channels in adult rat atrial myocytes. Prog Biophys Mol Biol (2003) 1.04

Mechanosensitive ion channels as drug targets. Curr Drug Targets CNS Neurol Disord (2004) 1.01

The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. J Gen Physiol (2013) 1.01

Electromechanical coupling in the membranes of Shaker-transfected HEK cells. Proc Natl Acad Sci U S A (2009) 1.01

Conductance of connexin hemichannels segregates with the first transmembrane segment. Biophys J (2005) 1.00

Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett (2011) 1.00

Volume cytometry: microfluidic sensor for high-throughput screening in real time. Anal Chem (2005) 0.99

Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch (2007) 0.99

Real Time FRET Based Detection of Mechanical Stress in Cytoskeletal and Extracellular Matrix Proteins. Cell Mol Bioeng (2011) 0.97

The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms. Prog Biophys Mol Biol (2008) 0.97

Genetically encoded force sensors for measuring mechanical forces in proteins. Commun Integr Biol (2011) 0.96

Neuroglial ATP release through innexin channels controls microglial cell movement to a nerve injury. J Gen Physiol (2010) 0.95

Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity. Purinergic Signal (2011) 0.93

Drift-free atomic force microscopy measurements of cell height and mechanical properties. Rev Sci Instrum (2007) 0.91

Microfluidic chip to produce temperature jumps for electrophysiology. Anal Chem (2008) 0.90

Stretch-activated potassium channels in hypotonically induced blebs of atrial myocytes. J Membr Biol (2008) 0.90

Dynamic effects of Hg2+-induced changes in cell volume. Cell Biochem Biophys (2008) 0.90

Modeling ion channels in the gigaseal. Biophys J (2011) 0.89

Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs). Biochem Biophys Res Commun (2011) 0.89

Cosegregation of permeability and single-channel conductance in chimeric connexins. Biophys J (2005) 0.88

Caveolae regulation of mechanosensitive channel function in myotubes. PLoS One (2013) 0.87

Shear-induced volume decrease in MDCK cells. Cell Physiol Biochem (2012) 0.87

Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium. Cardiovasc Res (2008) 0.86

Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. Cell Rep (2012) 0.86

Fluorescence-based force/tension sensors: a novel tool to visualize mechanical forces in structural proteins in live cells. Antioxid Redox Signal (2014) 0.85

Accessibility of cx46 hemichannels for uncharged molecules and its modulation by voltage. Biophys J (2004) 0.84

High throughput assay of diffusion through Cx43 gap junction channels with a microfluidic chip. Anal Chem (2010) 0.84

Interplay between cytoskeletal stresses and cell adaptation under chronic flow. PLoS One (2012) 0.84

Microfabricated torsion levers optimized for low force and high-frequency operation in fluids. Ultramicroscopy (2006) 0.83

Hereditary xerocytosis revisited. Am J Hematol (2014) 0.82

Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy. Bioconjug Chem (2014) 0.81

Gigaseal mechanics: creep of the gigaseal under the action of pressure, adhesion, and voltage. J Phys Chem B (2014) 0.81

Probing the double layer: effect of image forces on AFM. Biophys J (2006) 0.80

Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury. Dev Neurobiol (2013) 0.80

Cell biology: The sensation of stretch. Nature (2012) 0.79

Flexoelectricity and elasticity of asymmetric biomembranes. Phys Rev E Stat Nonlin Soft Matter Phys (2002) 0.79

Neurite outgrowth from PC12 cells is enhanced by an inhibitor of mechanical channels. Neurosci Lett (2010) 0.79

Assessing a potential role of host Pannexin 1 during Chlamydia trachomatis infection. PLoS One (2013) 0.78

Retaining your identity under stress. Nat Struct Biol (2002) 0.77

Cholesterol depletion facilitates recovery from hypotonic cell swelling in CHO cells. Cell Physiol Biochem (2011) 0.77

Mechanical effects on KATP channel gating in rat ventricular myocytes. PLoS One (2013) 0.77

A microfluidic platform for measuring electrical activity across cells. Biomicrofluidics (2012) 0.75