Published in Carcinogenesis on July 12, 2012
O-GlcNAcylation regulates EZH2 protein stability and function. Proc Natl Acad Sci U S A (2014) 1.09
O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins. Front Endocrinol (Lausanne) (2014) 0.93
Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APC(min/+) Mouse Models of Experimental Colon Cancer. Phytother Res (2016) 0.75
Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol (2000) 128.08
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A (1992) 35.45
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A (1999) 10.75
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA (2010) 8.21
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol (2005) 8.08
Statistical analysis of real-time PCR data. BMC Bioinformatics (2006) 7.31
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol (2007) 7.20
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science (2005) 5.68
Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer (2008) 4.30
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell (2012) 3.91
Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res (1998) 3.79
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med (2002) 3.47
Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem (2007) 2.81
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A (2002) 2.65
The role of the EGFR signaling in tumor microenvironment. J Cell Physiol (2008) 2.34
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res (2001) 2.29
Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clin Cancer Res (2009) 2.27
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization. Mol Cell Biol (1991) 2.27
HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol (2010) 2.24
Stromal myofibroblasts predict disease recurrence for colorectal cancer. Clin Cancer Res (2007) 2.19
Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment. J Transl Med (2006) 1.98
Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res (2000) 1.82
Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology (1995) 1.74
The role of interleukin 1 in growth and metastasis of human cancer xenografts. Clin Cancer Res (2006) 1.68
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res (2005) 1.68
Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr Relat Cancer (2003) 1.67
Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology (2005) 1.58
Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma. J Clin Invest (2011) 1.52
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem (2008) 1.31
Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics (2004) 1.28
Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. Clin Cancer Res (2008) 1.21
Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells. J Pathol (2005) 1.20
EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators. Mol Cancer Res (2011) 1.18
Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels. Mol Cancer Ther (2006) 1.18
Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family. Biochem J (1997) 1.16
Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm Genome (2004) 1.16
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res (2007) 1.07
Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells. Mol Cancer Res (2006) 1.05
Construction and characterization of multiple human colon cancer cell lines for inducibly regulated gene expression. J Cell Biochem (2005) 1.04
Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. Oncogene (2006) 1.04
Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. Clin Cancer Res (2004) 1.04
Cancer-associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs. Mol Cancer Res (2010) 1.02
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors. Neoplasia (2008) 1.02
Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts. Int J Mol Med (2006) 1.02
Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1. Cancer Res (2000) 0.97
Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer. Exp Oncol (2008) 0.95
Regulation of Caco-2 cell proliferation by basolateral membrane epidermal growth factor receptors. Am J Physiol (1994) 0.95
Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. Int J Oncol (2010) 0.89
Direct inhibition of EGF receptor activation in vascular endothelial cells by gefitinib ('Iressa', ZD1839). Cancer Sci (2004) 0.89
Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2. Clin Cancer Res (2009) 0.88
Cytokine-mediated PGE2 expression in human colonic fibroblasts. Am J Physiol (1998) 0.83
Cyclooxygenase-2 expression and prostanoid biogenesis reflect clinical phenotype in human colorectal fibroblast strains. Cancer Res (2003) 0.79
Cetuximab in colon cancer. Int J Biol Markers (2007) 0.77
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet (2007) 5.09
Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer. J Clin Oncol (2011) 4.72
Averting biodiversity collapse in tropical forest protected areas. Nature (2012) 4.46
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
Safety and immunogenicity of 2009 pandemic influenza A H1N1 vaccines in China: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet (2009) 3.97
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A (2009) 3.82
Forest elephant crisis in the Congo Basin. PLoS Biol (2007) 3.74
Quantification of C-reactive protein in the serum of patients with rheumatoid arthritis using multiple reaction monitoring mass spectrometry and 13C-labeled peptide standards. Proteomics (2004) 3.57
Estimating genome conservation between crop and model legume species. Proc Natl Acad Sci U S A (2004) 3.55
Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. J Clin Oncol (2012) 3.51
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J Clin Oncol (2011) 3.33
Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res (2011) 3.25
Distinct prefrontal cortex activity associated with item memory and source memory for visual shapes. Brain Res Cogn Brain Res (2003) 3.14
Investigation of the cause of death in a gene-therapy trial. N Engl J Med (2009) 3.02
Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med (2010) 2.94
Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches. J Thorac Oncol (2012) 2.81
Circulating tumor cells as a window on metastasis biology in lung cancer. Am J Pathol (2011) 2.76
Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. Gastroenterology (2012) 2.68
Complete Barrett's eradication endoscopic mucosal resection: an effective treatment modality for high-grade dysplasia and intramucosal carcinoma--an American single-center experience. Am J Gastroenterol (2009) 2.66
Conservation. Elephants, ivory, and trade. Science (2010) 2.51
Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol (2007) 2.45
Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem (2008) 2.40
Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe (2008) 2.30
Surface area congruence of atlas superior articulating facets and occipital condyles. J Chiropr Med (2008) 2.29
Devastating decline of forest elephants in central Africa. PLoS One (2013) 2.28
Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer. Clin Cancer Res (2012) 2.26
The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1). J Gen Physiol (2006) 2.18
Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatics (2007) 2.17
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature (2011) 2.11
R gene-controlled host specificity in the legume-rhizobia symbiosis. Proc Natl Acad Sci U S A (2010) 2.10
Identification and characterization of nucleotide-binding site-leucine-rich repeat genes in the model plant Medicago truncatula. Plant Physiol (2007) 2.01
Gastric mucosal necrosis with vascular degeneration induced by doxycycline. Am J Surg Pathol (2013) 1.99
Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study. Lancet Neurol (2008) 1.98
The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell (2013) 1.96
Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy. Am J Pathol (2009) 1.95
Biomarker utility of circulating tumor cells in metastatic cutaneous melanoma. J Invest Dermatol (2012) 1.91
Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation. Cancer Res (2005) 1.90
The influence of carbon dioxide on brain activity and metabolism in conscious humans. J Cereb Blood Flow Metab (2010) 1.88
Depressive symptoms and white matter dysfunction in retired NFL players with concussion history. Neurology (2013) 1.87
Inhibition of FGFR2 and FGFR1 increases cisplatin sensitivity in ovarian cancer. Cancer Biol Ther (2010) 1.85
Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis. Arthritis Rheum (2004) 1.82
1.3-μm InAs/GaAs quantum-dot lasers monolithically grown on Si substrates using InAlAs/GaAs dislocation filter layers. Opt Express (2014) 1.82
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol (2004) 1.77
Diversity, distribution, and ancient taxonomic relationships within the TIR and non-TIR NBS-LRR resistance gene subfamilies. J Mol Evol (2002) 1.77
Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome. Theor Appl Genet (2010) 1.76
First assessment of needle-based confocal laser endomicroscopy during EUS-FNA procedures of the pancreas (with videos). Gastrointest Endosc (2011) 1.72
In vivo tumor targeting of tumor necrosis factor-alpha-loaded stealth nanoparticles: effect of MePEG molecular weight and particle size. Eur J Pharm Sci (2005) 1.72
Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol (2010) 1.66
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66
Bowel necrosis associated with early jejunal tube feeding: A complication of postoperative enteral nutrition. Arch Surg (2006) 1.65
Brain activity in adolescent major depressive disorder before and after fluoxetine treatment. Am J Psychiatry (2012) 1.61
Role of 4-1BB in allograft rejection mediated by CD8+ T cells. Am J Transplant (2003) 1.61
Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer. Breast Cancer Res Treat (2010) 1.59
Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions. Blood (2011) 1.55
Origins of 1/f noise in nanostructure inclusion polymorphous silicon films. Nanoscale Res Lett (2011) 1.54
Oxidative injury and hepatocyte apoptosis in total parenteral nutrition-associated liver dysfunction. J Pediatr Surg (2006) 1.53
A case of adult hepatic toxocariasis. Nat Clin Pract Gastroenterol Hepatol (2008) 1.51
Surveillance of macrolide-resistant Mycoplasma pneumoniae in Beijing, China, from 2008 to 2012. Antimicrob Agents Chemother (2012) 1.51
InvertNet: a new paradigm for digital access to invertebrate collections. Zookeys (2012) 1.50
Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev (2004) 1.46
Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci U S A (2009) 1.45
What if a patient with atrial fibrillation and anticoagulant treatment is suffering from acute ischemia stroke? Cerebrovasc Dis (2013) 1.45
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res (2009) 1.43
A pilot study of in vivo identification of pancreatic cystic neoplasms with needle-based confocal laser endomicroscopy under endosonographic guidance. Endoscopy (2013) 1.42
Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J Biol Chem (2010) 1.42
Natural history of mucinous ductal ectasia of the pancreas: a case report and review of the literature. Am J Gastroenterol (2002) 1.42
Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene (2004) 1.41
Identification of unknown residue 55 in bovine folate binding protein: fingerprint matching and sequencing of a doubly tagged peptide fragment by ion trap mass spectrometry. Rapid Commun Mass Spectrom (2003) 1.41
Long-term functional results after ileal pouch anal restorative proctocolectomy for ulcerative colitis: a prospective observational study. Ann Surg (2003) 1.40
Anti-tumor necrosis factor-α monoclonal antibody alleviates parenteral nutrition-associated liver disease in mice. JPEN J Parenter Enteral Nutr (2012) 1.39
Intravenous regional anesthesia administered by the operating plastic surgeon: is it safe and efficient? Experience of a medical center. Plast Reconstr Surg (2007) 1.38
Enhanced magnetic resonance imaging of Guillain-Barré syndrome. J Paediatr Child Health (2011) 1.38
Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin Invest (2013) 1.38
InGaAs Quantum Well Grown on High-Index Surfaces for Superluminescent Diode Applications. Nanoscale Res Lett (2010) 1.37
Multiplexed assays for detection of mutations in PIK3CA. Clin Chem (2008) 1.36
Origin of nanohole formation by etching based on droplet epitaxy. Nanoscale (2014) 1.34
Chemical regulation of epigenetic modifications: opportunities for new cancer therapy. Med Res Rev (2008) 1.32
Field emission from in situ-grown vertically aligned SnO2 nanowire arrays. Nanoscale Res Lett (2012) 1.31
MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J (2011) 1.29
Influence of ethnicity on histological differences in non-alcoholic fatty liver disease. J Hepatol (2009) 1.29
Circulating tumour cells: their utility in cancer management and predicting outcomes. Ther Adv Med Oncol (2010) 1.29
Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor (GIST). Int J Colorectal Dis (2006) 1.28
Mitochondrial membrane permeabilisation by Bax/Bak. Biochem Biophys Res Commun (2003) 1.27
Analytical validation of whole exome and whole genome sequencing for clinical applications. BMC Med Genomics (2014) 1.27
Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer. Neoplasia (2008) 1.25
External quality assurance of circulating tumor cell enumeration using the CellSearch(®) system: a feasibility study. Cytometry B Clin Cytom (2010) 1.24
Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology (2006) 1.24
Roles of T helper 17 cells and interleukin-17 in neuroautoimmune diseases with emphasis on multiple sclerosis and Guillain-Barré syndrome as well as their animal models. J Neurosci Res (2013) 1.21
Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. Clin Cancer Res (2008) 1.21
Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther (2004) 1.21
miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes. Inflamm Bowel Dis (2011) 1.20