Published in J Cell Sci on July 13, 2012
Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration. J Cell Biol (2015) 0.90
The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids. Elife (2016) 0.78
Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers. Open Biol (2014) 0.77
Ubc13: the Lys63 ubiquitin chain building machine. Oncotarget (2016) 0.76
Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol (2006) 10.67
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75
Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol (2009) 5.41
Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ (2009) 5.28
Crystal structure of the sodium-potassium pump. Nature (2007) 5.12
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation. Nat Struct Mol Biol (2006) 3.71
Crystal structure of the sodium-potassium pump at 2.4 A resolution. Nature (2009) 3.49
A myristoyl/phosphotyrosine switch regulates c-Abl. Cell (2003) 3.48
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A (2010) 2.28
The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. J Cell Biochem (2006) 2.03
Calcium-myristoyl protein switch. Proc Natl Acad Sci U S A (1992) 1.98
Identification of protein phosphorylation sites by a combination of mass spectrometry and solid phase Edman sequencing. J Biomol Tech (2002) 1.97
Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain. Proc Natl Acad Sci U S A (2009) 1.96
Assay of protein kinases using radiolabeled ATP: a protocol. Nat Protoc (2006) 1.94
Phosphorylation-dependent interactions between enzymes of plant metabolism and 14-3-3 proteins. Plant J (1999) 1.92
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res (2009) 1.68
Automated identification and quantification of protein phosphorylation sites by LC/MS on a hybrid triple quadrupole linear ion trap mass spectrometer. Mol Cell Proteomics (2005) 1.62
The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase. Annu Rev Physiol (2010) 1.58
A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps. Nat Rev Mol Cell Biol (2011) 1.52
FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase. Sci STKE (2003) 1.50
Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. Biochem J (2008) 1.50
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol (2009) 1.43
Hormonal regulation of the Na(+)-K(+)-ATPase: mechanisms underlying rapid and sustained changes in pump activity. Am J Physiol (1995) 1.42
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Biol (2011) 1.39
Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism. Kidney Int (2004) 1.37
Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signaling. Mol Cell Proteomics (2009) 1.35
Significance of SGK1 in the regulation of neuronal function. J Physiol (2010) 1.32
Mapping insulin/GLUT4 circuitry. Traffic (2011) 1.26
FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. Am J Physiol Cell Physiol (2009) 1.20
Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. J Biol Chem (2007) 1.18
Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast. J Biol Chem (2011) 1.05
N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor. J Biol Chem (2009) 1.04
Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation. J Neurosci (2010) 1.00
Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. J Biol Chem (2001) 0.99
Phosphorylation of the Na+,K+-ATPase and the H+,K+-ATPase. FEBS Lett (2010) 0.98
Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt. J Cell Sci (2010) 0.93
ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. J Neurosci (2003) 0.93
Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells. J Cell Sci (2008) 0.93
Na+,K+-ATPase trafficking in skeletal muscle: insulin stimulates translocation of both alpha 1- and alpha 2-subunit isoforms. FEBS Lett (2003) 0.91
Role of insulin in regulation of Na+-/K+-dependent ATPase activity and pump function in corneal endothelial cells. Invest Ophthalmol Vis Sci (2010) 0.90
Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase. Am J Physiol Cell Physiol (2010) 0.87
ZNRF1 interacts with tubulin and regulates cell morphogenesis. Biochem Biophys Res Commun (2009) 0.84
The unusual UBZ domain of Saccharomyces cerevisiae polymerase η. DNA Repair (Amst) (2010) 0.79
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J (2004) 10.82
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem J (2007) 3.89
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J (2003) 3.77
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. Biochem J (2004) 3.60
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol (2012) 3.42
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochem J (2004) 3.39
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science (2004) 3.08
Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci (2008) 3.07
Essential role of PDK1 in regulating cell size and development in mice. EMBO J (2002) 2.93
Molecular mechanisms of kinetochore capture by spindle microtubules. Nature (2005) 2.90
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J (2010) 2.82
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem (2007) 2.50
Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. EMBO J (2003) 2.47
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization. Biochem J (2010) 2.43
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol (2008) 2.37
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J (2004) 2.11
Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J (2008) 2.09
The influence of peripheral iridotomy on the intraocular pressure course in patients with pigmentary glaucoma. J Glaucoma (2005) 2.05
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab (2005) 2.04
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. Biochem J (2007) 1.92
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J (2002) 1.83
Inhibition of autophagy in mitotic animal cells. Traffic (2002) 1.81
Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. FEBS Lett (2005) 1.79
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J (2002) 1.78
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J (2004) 1.77
Functional analysis of a DNA-shuffled movement protein reveals that microtubules are dispensable for the cell-to-cell movement of tobacco mosaic virus. Plant Cell (2002) 1.74
Bioinformatic and experimental survey of 14-3-3-binding sites. Biochem J (2010) 1.73
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. BMC Cell Biol (2006) 1.72
MSK1 activity is controlled by multiple phosphorylation sites. Biochem J (2005) 1.72
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. J Cell Biol (2006) 1.68
Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci (2004) 1.65
Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast. Mol Cell Biol (2007) 1.61
Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4. Proc Natl Acad Sci U S A (2009) 1.57
Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell (2013) 1.57
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci (2011) 1.55
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J Cell Sci (2008) 1.52
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. J Cell Biol (2007) 1.49
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res (2004) 1.49
Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Res (2007) 1.48
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. Cell Metab (2011) 1.47
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. J Cell Sci (2005) 1.46
Proof that Burkholderia strains form effective symbioses with legumes: a study of novel Mimosa-nodulating strains from South America. Appl Environ Microbiol (2005) 1.44
BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm. Proc Natl Acad Sci U S A (2013) 1.44
Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo. J Cell Sci (2003) 1.44
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal (2010) 1.43
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem J (2004) 1.43
The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells. J Cell Biol (2002) 1.43
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med (2011) 1.42
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biol (2011) 1.42
Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J (2002) 1.35
The C terminus of lens aquaporin 0 interacts with the cytoskeletal proteins filensin and CP49. Invest Ophthalmol Vis Sci (2006) 1.35
PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J Immunol (2012) 1.35
Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signaling. Mol Cell Proteomics (2009) 1.35
Loss of iron triggers PINK1/Parkin-independent mitophagy. EMBO Rep (2013) 1.34
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy (2011) 1.31
Nodulation of Mimosa spp. by the beta-proteobacterium Ralstonia taiwanensis. Mol Plant Microbe Interact (2003) 1.31
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol (2013) 1.30
The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number. J Biol Chem (2005) 1.30
The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. Biochem J (2006) 1.27
Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract. Exp Eye Res (2003) 1.26
Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction. Autophagy (2011) 1.24
Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains. J Biol Chem (2004) 1.24
Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells. Biochem J (2002) 1.24
Desmin aggregate formation by R120G alphaB-crystallin is caused by altered filament interactions and is dependent upon network status in cells. Mol Biol Cell (2004) 1.23
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. EMBO J (2011) 1.23
Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem (2011) 1.23
Activation of necroptosis in multiple sclerosis. Cell Rep (2015) 1.21
Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell (2010) 1.21
Displacement affinity chromatography of protein phosphatase one (PP1) complexes. BMC Biochem (2008) 1.21
14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase. EMBO J (2003) 1.19
ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa. Biochem J (2011) 1.17
Burkholderia phymatum is a highly effective nitrogen-fixing symbiont of Mimosa spp. and fixes nitrogen ex planta. New Phytol (2007) 1.17
O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. EMBO J (2012) 1.16
Fin development in a cartilaginous fish and the origin of vertebrate limbs. Nature (2002) 1.16
Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry. J Cell Sci (2010) 1.16
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J (2008) 1.15
Differential redox regulation within the PTP superfamily. Cell Signal (2007) 1.15
Total knee replacement in the morbidly obese: a literature review. ANZ J Surg (2010) 1.14
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL. Biochem J (2004) 1.14
The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. Am J Hum Genet (2006) 1.13
Metabolic enzymes as targets for 14-3-3 proteins. Plant Mol Biol (2002) 1.12