Published in Proc Natl Acad Sci U S A on October 25, 2010
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev (2011) 5.26
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
The ancient drug salicylate directly activates AMP-activated protein kinase. Science (2012) 3.77
Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature (2012) 1.88
AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol (2011) 1.85
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol (2012) 1.75
Structural basis of AMPK regulation by small molecule activators. Nat Commun (2013) 1.58
A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metab (2011) 1.55
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metab (2013) 1.40
ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase. Cell Metab (2011) 1.37
AMP-activated protein kinase regulation and biological actions in the heart. Circ Res (2012) 1.33
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat Struct Mol Biol (2012) 1.30
AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin Sci (Lond) (2012) 1.29
AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway. Cancer Biol Ther (2013) 1.28
Conserved regulatory elements in AMPK. Nature (2013) 1.11
AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases. J Lipid Res (2012) 1.10
Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res (2014) 1.03
Characterization of the CaMKKβ-AMPK signaling complex. Cell Signal (2011) 1.03
Proteomic analysis of protein palmitoylation in adipocytes. Adipocyte (2013) 1.02
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Front Plant Sci (2014) 0.98
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. Trends Pharmacol Sci (2015) 0.96
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. Biochem J (2014) 0.96
AMPK at the crossroads of circadian clocks and metabolism. Mol Cell Endocrinol (2012) 0.94
Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol. J Biol Chem (2014) 0.92
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662. Am J Physiol Endocrinol Metab (2014) 0.91
Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators. Cell Rep (2015) 0.91
Heterotrimer-independent regulation of activation-loop phosphorylation of Snf1 protein kinase involves two protein phosphatases. Proc Natl Acad Sci U S A (2012) 0.91
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure (2013) 0.91
Function of the master energy regulator adenosine monophosphate-activated protein kinase in stroke. J Neurosci Res (2013) 0.88
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. FEBS J (2016) 0.87
LKB1 Tumor Suppressor: Therapeutic Opportunities Knock when LKB1 Is Inactivated. Genes Dis (2014) 0.87
Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro. PLoS One (2013) 0.87
Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nat Commun (2015) 0.86
LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells. Oncogene (2015) 0.85
Chemoproteomic analysis of intertissue and interspecies isoform diversity of AMP-activated protein kinase (AMPK). J Biol Chem (2013) 0.85
Alterations at dispersed sites cause phosphorylation and activation of SNF1 protein kinase during growth on high glucose. J Biol Chem (2011) 0.85
Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms. Biochem J (2015) 0.85
Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases. J Med Chem (2014) 0.84
AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain. Exp Neurobiol (2012) 0.84
Ligand binding to the AMP-activated protein kinase active site mediates protection of the activation loop from dephosphorylation. J Biol Chem (2012) 0.84
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature (2017) 0.83
Regulation of AMP-activated protein kinase by natural and synthetic activators. Acta Pharm Sin B (2015) 0.81
AMP kinase regulates K-ATP currents evoked by NMDA receptor stimulation in rat subthalamic nucleus neurons. Neuroscience (2014) 0.80
Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Sci Rep (2014) 0.80
Regulation and function of AMPK in physiology and diseases. Exp Mol Med (2016) 0.80
ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J Cell Sci (2012) 0.79
Neuropharmacological Actions of Metformin in Stroke. Curr Neuropharmacol (2015) 0.77
AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes. PLoS One (2016) 0.77
The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation. J Biol Chem (2015) 0.77
SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling. Nat Commun (2015) 0.77
Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials. Oncotarget (2017) 0.76
AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. Mol Cell (2017) 0.76
Polyplex Evolution: Understanding Biology, Optimizing Performance. Mol Ther (2017) 0.76
Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nat Commun (2016) 0.76
Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators. Pharmacol Ther (2014) 0.76
Oxidative Stress Attenuates Lipid Synthesis and Increases Mitochondrial Fatty Acid Oxidation in Hepatoma Cells Infected with Hepatitis C Virus. J Biol Chem (2015) 0.76
LKB1/AMPK pathway mediates resistin-induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes. Biomed Rep (2016) 0.76
AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy. Cardiovasc Pharm Open Access (2015) 0.76
Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity. Dis Model Mech (2016) 0.76
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing. J Biol Chem (2017) 0.76
β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase. Sci Rep (2016) 0.75
N-cadherin coordinates AMP kinase-mediated lung vascular repair. Am J Physiol Lung Cell Mol Physiol (2015) 0.75
A High Throughput Assay for Discovery of Small Molecules that Bind AMP-activated Protein Kinase (AMPK). Curr Chem Genom Transl Med (2013) 0.75
AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons. Neuroscience (2016) 0.75
The N-myristoylome of Trypanosoma cruzi. Sci Rep (2016) 0.75
The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes. FEBS Open Bio (2014) 0.75
AMP-activated protein kinase and energy balance in breast cancer. Am J Transl Res (2017) 0.75
Molecular characterization and expression analysis of AMPK α subunit isoform genes from Scophthalmus maximus responding to salinity stress. Fish Physiol Biochem (2016) 0.75
SnRK1 activates autophagy via the TOR signaling pathway in Arabidopsis thaliana. PLoS One (2017) 0.75
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System. Circ Res (2017) 0.75
AMPK: a novel target for treating hepatic fibrosis. Oncotarget (2017) 0.75
AMP-activated protein kinase - not just an energy sensor. F1000Res (2017) 0.75
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs. Nat Commun (2017) 0.75
Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6 independent manner. Mol Oncol (2017) 0.75
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem (1996) 7.23
AMPK in Health and Disease. Physiol Rev (2009) 6.38
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J Clin Invest (2004) 5.36
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J (2007) 4.48
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. J Biol Chem (1998) 3.53
Molecular mechanics of calcium-myristoyl switches. Nature (1997) 3.36
Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem (2006) 3.31
Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature (2007) 3.26
Entropic switch regulates myristate exposure in the HIV-1 matrix protein. Proc Natl Acad Sci U S A (2003) 3.20
Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science (2007) 2.87
Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. Proc Natl Acad Sci U S A (1990) 2.61
Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles. J Cell Biol (1993) 2.51
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. J Biol Chem (2003) 2.45
Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci (1993) 2.44
Structural insight into AMPK regulation: ADP comes into play. Structure (2007) 2.32
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature (2009) 2.25
Calcium-myristoyl protein switch. Proc Natl Acad Sci U S A (1992) 1.98
Two distinct populations of ARF bound to Golgi membranes. J Cell Biol (1993) 1.78
Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. Biochem J (2001) 1.69
Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit. J Biol Chem (1997) 1.49
Role of the acylated amino terminus of recoverin in Ca(2+)-dependent membrane interaction. Science (1993) 1.41
Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing. J Biol Chem (2003) 1.39
AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). J Biol Chem (2005) 1.39
C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest. J Biol Chem (2008) 1.17
AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267. J Biol Chem (2007) 1.01
AMPK in Health and Disease. Physiol Rev (2009) 6.38
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem (2005) 6.27
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. Lancet Neurol (2013) 5.73
Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett (2003) 5.22
AMP-activated protein kinase--development of the energy sensor concept. J Physiol (2006) 4.93
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
The ancient drug salicylate directly activates AMP-activated protein kinase. Science (2012) 3.77
AMPK is a direct adenylate charge-regulated protein kinase. Science (2011) 3.58
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med (2006) 3.11
Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab (2008) 3.04
Blood-based protein biomarkers for diagnosis of Alzheimer disease. Arch Neurol (2012) 3.03
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol (2006) 2.94
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes (2006) 2.80
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells (2003) 2.62
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest (2011) 2.34
AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes (2008) 2.13
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation (2009) 2.00
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem (2003) 1.98
AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A (2011) 1.96
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem (2006) 1.93
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol (2008) 1.93
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med (2013) 1.91
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab (2007) 1.69
Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci (2004) 1.65
Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci (2005) 1.59
Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes (2003) 1.58
Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635. J Biol Chem (2002) 1.56
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol (2002) 1.56
Prediction of myocardial infarction by N-terminal-pro-B-type natriuretic peptide, C-reactive protein, and renin in subjects with cerebrovascular disease. Circulation (2005) 1.55
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Am J Hum Genet (2005) 1.51
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem (2001) 1.51
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.51
Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (2005) 1.50
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem (2009) 1.49
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab (2005) 1.48
Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. J Clin Endocrinol Metab (2005) 1.45
AMPK functions as an adenylate charge-regulated protein kinase. Trends Endocrinol Metab (2012) 1.44
Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol (2002) 1.43
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci (2004) 1.41
Exercise increases nuclear AMPK alpha2 in human skeletal muscle. Diabetes (2003) 1.40
Effect of iodine on mercury concentrations in dental-unit wastewater. Dent Mater (2005) 1.40
Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase. Mol Endocrinol (2006) 1.39
AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). J Biol Chem (2005) 1.39
Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes (2007) 1.32
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit. Biochem Biophys Res Commun (2002) 1.29
Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. J Physiol (2005) 1.26
Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen. J Physiol (2005) 1.25
Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle. Am J Physiol Endocrinol Metab (2004) 1.25
Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP-activated protein kinase (AMPK). Biochem J (2007) 1.24
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J Physiol (2008) 1.23
High-density lipoprotein and apolipoprotein AI increase endothelial NO synthase activity by protein association and multisite phosphorylation. Proc Natl Acad Sci U S A (2004) 1.23
AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem (2006) 1.23
Incidence immunoassay for distinguishing recent from established HIV-1 infection in therapy-naive populations. AIDS (2004) 1.22
High-density SNP genotyping of tomato (Solanum lycopersicum L.) reveals patterns of genetic variation due to breeding. PLoS One (2012) 1.22
Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem (2002) 1.21
The Tomato Yellow Leaf Curl Virus resistance genes Ty-1 and Ty-3 are allelic and code for DFDGD-class RNA-dependent RNA polymerases. PLoS Genet (2013) 1.20
Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83. J Biol Chem (2005) 1.20
Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Transl Psychiatry (2013) 1.19
Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free Radic Biol Med (2003) 1.16
Walking, running and the evolution of short toes in humans. J Exp Biol (2009) 1.15
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes (2003) 1.15
Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality. Am J Physiol Renal Physiol (2004) 1.13
AMPK structure and regulation from three angles. Structure (2007) 1.13
The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. J Clin Endocrinol Metab (2006) 1.13
Predicting Alzheimer disease with β-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing. Ann Neurol (2013) 1.13
Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J Physiol (2006) 1.13
Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling. FASEB J (2004) 1.09
5-aminoimidazole-4-carboxamide ribonucleoside and AMP-activated protein kinase inhibit signalling through NF-κB. Immunol Cell Biol (2010) 1.09
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology (2009) 1.09
Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177. Am J Physiol Renal Physiol (2005) 1.08
Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke (2005) 1.07
Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites. BMC Bioinformatics (2008) 1.07