Published in Traffic on December 01, 2002
Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99
Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol (2005) 5.84
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol (2011) 3.45
Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell (2004) 2.29
Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis. J Am Soc Nephrol (2009) 1.86
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer (2010) 1.78
Autophagy in cellular growth control. FEBS Lett (2010) 1.74
Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat Cell Biol (2008) 1.70
Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1. J Virol (2005) 1.33
mVps34 is activated following high-resistance contractions. J Physiol (2008) 1.32
Acetylated microtubules are required for fusion of autophagosomes with lysosomes. BMC Cell Biol (2010) 1.24
ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy (2011) 1.17
Autophagosome formation in mammalian cells. Semin Immunopathol (2010) 1.16
Autophagy and cell growth--the yin and yang of nutrient responses. J Cell Sci (2012) 1.14
RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Mol Biol Cell (2008) 1.10
mTOR controls ovarian follicle growth by regulating granulosa cell proliferation. PLoS One (2011) 1.00
Robust autophagy/mitophagy persists during mitosis. Cell Cycle (2009) 1.00
AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat Cell Biol (2015) 0.99
Regulation of autophagy by amino acids and MTOR-dependent signal transduction. Amino Acids (2014) 0.97
The role of autophagy in genome stability through suppression of abnormal mitosis under starvation. PLoS Genet (2013) 0.94
A beta-tubulin mutation selectively uncouples nuclear division and cytokinesis in Tetrahymena thermophila. Eukaryot Cell (2004) 0.93
Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex. EMBO J (2006) 0.93
Tanshinone IIA potentiates the efficacy of 5-FU in Colo205 colon cancer cells in vivo through downregulation of P-gp and LC3-II. Exp Ther Med (2011) 0.86
Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis. Biochim Biophys Acta (2015) 0.85
CD98 increases renal epithelial cell proliferation by activating MAPKs. PLoS One (2012) 0.83
Autophagy and immunity - insights from human herpesviruses. Front Immunol (2012) 0.82
Proton-shuttling lichen compound usnic acid affects mitochondrial and lysosomal function in cancer cells. PLoS One (2012) 0.79
A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis. PLoS Genet (2015) 0.79
Bacillus sphaericus binary toxin elicits host cell autophagy as a response to intoxication. PLoS One (2011) 0.79
Autophagy and the Cell Cycle: A Complex Landscape. Front Oncol (2017) 0.77
Autophagy SEPArates germline and somatic cells. Cell (2009) 0.77
Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. Cell Death Dis (2015) 0.77
Interplay between cell cycle and autophagy induced by boswellic acid analog. Sci Rep (2016) 0.77
Chaperone-mediated autophagy in the kidney: the road more traveled. Semin Nephrol (2013) 0.76
GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes. Autophagy (2014) 0.76
SNARE-mediated membrane fusion in autophagy. Semin Cell Dev Biol (2016) 0.76
BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy (2017) 0.75
Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency. Am J Physiol Cell Physiol (2016) 0.75
Autophagic flux is highly active in early mitosis and differentially regulated throughout the cell cycle. Oncotarget (2016) 0.75
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy (2017) 0.75
A simple method to estimate the number of autophagic elements by electron microscopic morphometry in real cellular dimensions. Biomed Res Int (2014) 0.75
Euptox A Induces G1 Arrest and Autophagy via p38 MAPK- and PI3K/Akt/mTOR-Mediated Pathways in Mouse Splenocytes. J Histochem Cytochem (2017) 0.75
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21
Risk factors for suicide in China: a national case-control psychological autopsy study. Lancet (2002) 7.00
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem (2005) 5.22
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science (2007) 5.19
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res (2005) 5.07
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol (2004) 4.85
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell (2009) 4.47
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Validation of verbal autopsy procedures for adult deaths in China. Int J Epidemiol (2005) 4.20
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J (2003) 3.77
Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation. Nature (2003) 3.38
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37
Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling. Science (2004) 3.08
A mitochondrial remnant in the microsporidian Trachipleistophora hominis. Nature (2002) 2.98
Essential role of PDK1 in regulating cell size and development in mice. EMBO J (2002) 2.93
Molecular mechanisms of kinetochore capture by spindle microtubules. Nature (2005) 2.90
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J (2010) 2.82
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol (2004) 2.55
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2001) 2.49
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J Cell Biol (2007) 2.48
Discovery of chemically induced mutations in rice by TILLING. BMC Plant Biol (2007) 2.46
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization. Biochem J (2010) 2.43
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol (2002) 2.42
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol (2007) 2.26
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal (2008) 2.19
Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J (2002) 2.16
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J (2003) 2.11
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J (2004) 2.11
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab (2005) 2.04
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. J Biol Chem (2002) 1.97
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J Cell Biol (2003) 1.91
Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder. Am J Psychiatry (2002) 1.87
Probing phosphoinositide functions in signaling and membrane trafficking. Trends Cell Biol (2005) 1.87
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J (2002) 1.83
The late endosome is essential for mTORC1 signaling. Mol Biol Cell (2010) 1.79
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J (2004) 1.77
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. J Cell Biol (2008) 1.73
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr Biol (2003) 1.71
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. J Cell Biol (2006) 1.68
A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi. Nature (2008) 1.66
Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci (2004) 1.65
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol (2008) 1.63
hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. Biochem J (2009) 1.61
Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit. J Biol Chem (2005) 1.57
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. Mol Cancer Ther (2014) 1.56
Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Mol Cell (2006) 1.55
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci (2011) 1.55
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J Clin Invest (2008) 1.53
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J Cell Sci (2008) 1.52
Contamination assessment of copper, lead, zinc, manganese and nickel in street dust of Baoji, NW China. J Hazard Mater (2008) 1.51
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res (2004) 1.49
Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Mol Biol Cell (2008) 1.48
Construction of a high-density genetic map for grape using next generation restriction-site associated DNA sequencing. BMC Plant Biol (2012) 1.47
Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Proc Natl Acad Sci U S A (2009) 1.46
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. J Cell Sci (2005) 1.46
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Res (2009) 1.45
Proof that Burkholderia strains form effective symbioses with legumes: a study of novel Mimosa-nodulating strains from South America. Appl Environ Microbiol (2005) 1.44
BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm. Proc Natl Acad Sci U S A (2013) 1.44
Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo. J Cell Sci (2003) 1.44
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal (2010) 1.43
Hypoxia-inducible factor-1α expression indicates poor prognosis in myelodysplastic syndromes. Leuk Lymphoma (2012) 1.43
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem J (2004) 1.43
The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells. J Cell Biol (2002) 1.43
Mandating nurse staffing in Pennsylvania: more than a numbers game. J Nurs Adm (2009) 1.42
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. J Cell Sci (2003) 1.40
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Sci Signal (2012) 1.38
p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol (2009) 1.36
Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem (2003) 1.36
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic (2002) 1.35
Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J (2002) 1.35
Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Mol Endocrinol (2003) 1.35
The C terminus of lens aquaporin 0 interacts with the cytoskeletal proteins filensin and CP49. Invest Ophthalmol Vis Sci (2006) 1.35
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. J Cell Sci (2007) 1.34
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem (2003) 1.31
Nodulation of Mimosa spp. by the beta-proteobacterium Ralstonia taiwanensis. Mol Plant Microbe Interact (2003) 1.31
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol (2011) 1.31
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol (2013) 1.30
Inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes transdifferentiation of mouse myoblasts into myofibroblasts. PLoS One (2012) 1.30
The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number. J Biol Chem (2005) 1.30
Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic (2007) 1.29
How amelogenin orchestrates the organization of hierarchical elongated microstructures of apatite. J Phys Chem B (2010) 1.29
The genome of the hydatid tapeworm Echinococcus granulosus. Nat Genet (2013) 1.29
A biocompatible fluorescent ink based on water-soluble luminescent carbon nanodots. Angew Chem Int Ed Engl (2012) 1.29
Tuning reactivity and chemoselectivity in electron transfer initiated cyclization reactions: applications to carbon-carbon bond formation. J Am Chem Soc (2003) 1.27
Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature. Asian Pac J Cancer Prev (2011) 1.27
The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. Biochem J (2006) 1.27
Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract. Exp Eye Res (2003) 1.26
Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res (2004) 1.25
Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains. J Biol Chem (2004) 1.24
A Novel YY1-miR-1 regulatory circuit in skeletal myogenesis revealed by genome-wide prediction of YY1-miRNA network. PLoS One (2012) 1.23
Desmin aggregate formation by R120G alphaB-crystallin is caused by altered filament interactions and is dependent upon network status in cells. Mol Biol Cell (2004) 1.23
A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2010) 1.23
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22
Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis. J Biol Chem (2002) 1.22
Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. J Immunol (2008) 1.22
Scalable recombinant adeno-associated virus production using recombinant herpes simplex virus type 1 coinfection of suspension-adapted mammalian cells. Hum Gene Ther (2009) 1.21