Published in Hum Mol Genet on July 27, 2012
Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness? Exp Neurol (2012) 1.50
It's a cell-eat-cell world: autophagy and phagocytosis. Am J Pathol (2013) 0.95
Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities. Antioxid Redox Signal (2013) 0.94
The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy (2014) 0.88
Autophagic activity in neuronal cell death. Neurosci Bull (2015) 0.86
QSOX1 inhibits autophagic flux in breast cancer cells. PLoS One (2014) 0.85
Compartmentalized Regulation of Parkin-Mediated Mitochondrial Quality Control in the Drosophila Nervous System In Vivo. J Neurosci (2016) 0.82
Parkinson's disease: an update on pathogenesis and treatment. J Neurol (2013) 0.81
Loss of Mitochondrial Function Impairs Lysosomes. J Biol Chem (2016) 0.80
Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons. Oxid Med Cell Longev (2014) 0.79
Iron in neurodegenerative disorders of protein misfolding: a case of prion disorders and Parkinson's disease. Antioxid Redox Signal (2014) 0.78
Diversity of mitochondrial pathology in a mouse model of axonal degeneration in synucleinopathies. Oxid Med Cell Longev (2013) 0.77
The pallidopyramidal syndromes: nosology, aetiology and pathogenesis. Curr Opin Neurol (2013) 0.76
A cybrid cell model for the assessment of the link between mitochondrial deficits and sporadic Parkinson's disease. Methods Mol Biol (2015) 0.76
Back to the tubule: microtubule dynamics in Parkinson's disease. Cell Mol Life Sci (2016) 0.75
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
A guided tour into subcellular colocalization analysis in light microscopy. J Microsc (2006) 16.73
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science (2004) 8.71
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol (2005) 6.16
Mitochondrial complex I deficiency in Parkinson's disease. Lancet (1989) 5.72
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature (2011) 5.27
Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci (2004) 5.19
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90
Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72
Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord (2003) 4.56
Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol (1996) 4.54
In search of an "autophagomometer". Autophagy (2009) 4.31
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. Trends Cell Biol (2010) 4.15
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol (1997) 3.80
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron (2009) 3.49
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest (2008) 3.23
The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic (2008) 3.18
Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol (1989) 3.11
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem (2008) 2.86
Cybrids in Alzheimer's disease: a cellular model of the disease? Neurology (1997) 2.85
Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci (2007) 2.84
Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem (2006) 2.51
Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes. Cell Struct Funct (2008) 2.47
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A (2010) 2.45
Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol (1996) 2.22
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci (2011) 2.09
Experimental models of Parkinson's disease. Nat Rev Neurosci (2001) 2.06
Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum Mol Genet (2010) 1.99
NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell. J Neurosci Res (1993) 1.97
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One (2009) 1.88
Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. Am J Physiol Cell Physiol (2005) 1.82
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy (2008) 1.74
Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J Neurosci (1999) 1.66
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol (2003) 1.66
Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells. J Cell Biol (1985) 1.50
Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency. Am J Physiol Cell Physiol (2005) 1.49
Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid. J Cell Biol (1994) 1.37
Functional mitochondria are required for amyloid beta-mediated neurotoxicity. FASEB J (2001) 1.29
Energy dependence of different steps in the autophagic-lysosomal pathway. J Biol Chem (1989) 1.22
Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids. Antioxid Redox Signal (2009) 1.08
Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background. Mitochondrion (2008) 1.07
Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells. J Biol Chem (1994) 1.07
Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides. Eur J Neurosci (2003) 1.02
Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture. Neurobiol Dis (2004) 1.01
Energy dependence of autophagic protein degradation in isolated rat hepatocytes. Eur J Biochem (1987) 1.01
Surface oxidase and oxidative stress propagation in aging. J Exp Biol (2000) 0.99
Regulation of the intracellular distribution of cytoplasmic dynein by serum factors and calcium. J Cell Sci (1993) 0.98
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology. Neurobiol Dis (2009) 0.97
Toxin models of mitochondrial dysfunction in Parkinson's disease. Antioxid Redox Signal (2011) 0.97
Hepatic autophagy and intracellular ATP. A morphometric study. Exp Cell Res (1988) 0.97
Live-cell imaging of autophagy induction and autophagosome-lysosome fusion in primary cultured neurons. Methods Enzymol (2009) 0.97
Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease. Neurochem Int (2009) 0.96
Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer. J Neurochem (2010) 0.96
Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy. Mol Neurodegener (2009) 0.95
Turning teratocarcinoma cells into neurons: rapid differentiation of NT-2 cells in floating spheres. Brain Res Dev Brain Res (2003) 0.94
As you like it, Part 3: A critique and historical review of calcification as seen with the electron microscope. Ultrastruct Pathol (2001) 0.93
Microtubule depolymerization potentiates alpha-synuclein oligomerization. Front Aging Neurosci (2010) 0.92
ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells. BMB Rep (2009) 0.91
Apoptotic molecules and MPTP-induced cell death. Neurotoxicol Teratol (2002) 0.91
Disrupted mitochondrial electron transport function increases expression of anti-apoptotic bcl-2 and bcl-X(L) proteins in SH-SY5Y neuroblastoma and in Parkinson disease cybrid cells through oxidative stress. J Neurosci Res (2000) 0.89
Identification of functional dopamine receptors in human teratocarcinoma NT2 cells. Brain Res Mol Brain Res (2002) 0.89
Mitochondrial metabolism modulation: a new therapeutic approach for Parkinson's disease. CNS Neurol Disord Drug Targets (2010) 0.86
The mitochondrial cascade hypothesis for Parkinson's disease. Curr Pharm Des (2011) 0.86
Does mitochondrial DNA play a role in Parkinson's disease? A review of cybrid and other supportive evidence. Antioxid Redox Signal (2011) 0.83
Energy depletion and autophagy. Cytochemical and biochemical studies in isolated rat hepatocytes. Histochem J (1991) 0.80
Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases. Curr Pharm Des (2011) 0.76
Introduction. Autophagy dysregulation in neuropathology. Brain Pathol (2012) 0.76
Biology and pathology of the mitochondrion. Ultrastruct Pathol (1999) 0.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell (2011) 3.71
Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nat Genet (2011) 2.76
Functional interaction between autophagy and ciliogenesis. Nature (2013) 2.21
Macroautophagy regulates energy metabolism during effector T cell activation. J Immunol (2010) 1.71
Complex I deficiency in Parkinson's disease frontal cortex. Brain Res (2007) 1.61
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity. J Neurochem (2004) 1.58
DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination. Mitochondrion (2009) 1.50
Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness? Exp Neurol (2012) 1.50
Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Diabetes (2008) 1.47
Reduced lean mass in early Alzheimer disease and its association with brain atrophy. Arch Neurol (2010) 1.47
Mitochondrial haplotypes associated with biomarkers for Alzheimer's disease. PLoS One (2013) 1.47
Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochem Res (2003) 1.34
Insulin in central nervous system: more than just a peripheral hormone. J Aging Res (2012) 1.33
The lipid kinase PI4KIIIβ preserves lysosomal identity. EMBO J (2012) 1.32
Cytochrome c oxidase is decreased in Alzheimer's disease platelets. Neurobiol Aging (2004) 1.30
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. J Neurosci (2005) 1.29
Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease. Neurology (2011) 1.23
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. J Neurosci (2009) 1.23
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. J Neurosci (2006) 1.19
Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci (2005) 1.19
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis (2007) 1.19
Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol (2007) 1.18
The thiazolidinedione pioglitazone alters mitochondrial function in human neuron-like cells. Mol Pharmacol (2007) 1.18
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. Neurobiol Dis (2006) 1.17
MRI characteristics and scoring in HDLS due to CSF1R gene mutations. Neurology (2012) 1.17
CXCL12/CXCR4 promotes motility and proliferation of glioma cells. Cancer Biol Ther (2010) 1.17
Regulation of neuron mitochondrial biogenesis and relevance to brain health. Biochim Biophys Acta (2009) 1.17
Alzheimer disease and the role of free radicals in the pathogenesis of the disease. CNS Neurol Disord Drug Targets (2008) 1.15
Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner. Mol Biol Cell (2012) 1.15
Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy (2007) 1.14
Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes. Hum Genomics (2010) 1.12
Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. J Neurochem (2005) 1.11
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Brain Res Rev (2008) 1.11
Metformin promotes isolated rat liver mitochondria impairment. Mol Cell Biochem (2007) 1.10
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol Dis (2008) 1.09
Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene. J Autism Dev Disord (2006) 1.09
An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease. J Alzheimers Dis (2009) 1.08
Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets. Cell Biol Toxicol (2008) 1.08
Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids. Antioxid Redox Signal (2009) 1.08
Hyperglycemia alters the schwann cell mitochondrial proteome and decreases coupled respiration in the absence of superoxide production. J Proteome Res (2010) 1.08
Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background. Mitochondrion (2008) 1.07
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. J Neurol Sci (2007) 1.07
Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview. Mini Rev Med Chem (2008) 1.07
Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. Eur J Neurosci (2003) 1.06
Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. Brain Res (2006) 1.05
Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: trapping early oligomers of non-expanded ataxin-3. J Mol Biol (2005) 1.05
Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years. Neurobiol Aging (2011) 1.05
Right orbitofrontal tumor with pedophilia symptom and constructional apraxia sign. Arch Neurol (2003) 1.05
Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure. J Biol Chem (2006) 1.05
Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress. Diabetes (2006) 1.04
Overactivation of calcineurin induced by amyloid-beta and prion proteins. Neurochem Int (2008) 1.04
Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation. Brain Res (2012) 1.04
Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease. J Alzheimers Dis (2011) 1.04
Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging. Biochim Biophys Acta (2011) 1.03
Cholesterol and statins in Alzheimer's disease: current controversies. Exp Neurol (2009) 1.03
Alzheimer's disease: a lesson from mitochondrial dysfunction. Antioxid Redox Signal (2007) 1.02
Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations. Parkinsonism Relat Disord (2013) 1.02
Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture. Neurobiol Dis (2004) 1.01
Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia. J Biol Chem (2010) 1.01
Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes. Med Chem (2008) 1.01
Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet. Scand J Gastroenterol (2008) 0.99
Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis. Free Radic Biol Med (2003) 0.99
NEDD8: a new ataxin-3 interactor. Biochim Biophys Acta (2007) 0.98
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radic Biol Med (2005) 0.98
Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure. Diabetes (2003) 0.98
Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria. Brain Res (2002) 0.98
Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide. J Neurosci Res (2004) 0.98
Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. Neurobiol Dis (2007) 0.97
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology. Neurobiol Dis (2009) 0.97
Mitochondria in neurodegeneration. Adv Exp Med Biol (2012) 0.97
Cell and animal models of mtDNA biology: progress and prospects. Am J Physiol Cell Physiol (2006) 0.96
Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease. Neurochem Int (2009) 0.96
Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines. Hum Mol Genet (2013) 0.96
Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer. J Neurochem (2010) 0.96
Epigenetics in neurodegeneration: a new layer of complexity. Prog Neuropsychopharmacol Biol Psychiatry (2010) 0.96
Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus. Brain Res (2003) 0.96
Adenosine A3 receptors are located in neurons of the rat hippocampus. Neuroreport (2003) 0.95
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A (2012) 0.95
FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures. Neurobiol Dis (2004) 0.94
Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5. Aging Cell (2009) 0.94
Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides. Cell Cycle (2009) 0.94
The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells. J Neurosci (2010) 0.93
Role of mitochondrial homeostasis and dynamics in Alzheimer's disease. Neurobiol Dis (2012) 0.93