Published in Cell on September 23, 2005
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78
Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46
Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol (2007) 6.45
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ (2011) 5.95
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17
NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol (2009) 4.95
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet (2008) 4.93
Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72
Endogenous HMGB1 regulates autophagy. J Cell Biol (2010) 4.71
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (2008) 4.71
Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res (2009) 4.53
Toll-like receptors control autophagy. EMBO J (2008) 4.50
Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. Trends Cell Biol (2010) 4.15
The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy (2010) 3.99
Autophagy: cellular and molecular mechanisms. J Pathol (2010) 3.96
Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol (2007) 3.86
Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe (2009) 3.79
Identification of a candidate therapeutic autophagy-inducing peptide. Nature (2013) 3.76
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol (2009) 3.71
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep (2009) 3.69
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene (2008) 3.63
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell (2010) 3.63
Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol (2014) 3.38
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37
Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell (2007) 3.37
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest (2006) 3.34
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol (2007) 3.29
Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev (2007) 3.18
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol (2010) 3.17
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol (2007) 3.10
ER stress-induced cell death mechanisms. Biochim Biophys Acta (2013) 3.07
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J (2011) 3.06
The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol (2013) 3.04
Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration. Nat Med (2010) 3.01
The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ (2009) 2.93
HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene (2010) 2.91
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ (2009) 2.85
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol (2009) 2.81
Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev (2007) 2.80
Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74
A method to measure cardiac autophagic flux in vivo. Autophagy (2008) 2.72
Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe (2013) 2.71
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One (2008) 2.67
Autophagy in malignant transformation and cancer progression. EMBO J (2015) 2.67
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell (2013) 2.66
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J Biol Chem (2008) 2.63
To be or not to be? How selective autophagy and cell death govern cell fate. Cell (2014) 2.63
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy (2010) 2.62
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis (2010) 2.61
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58
Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57
Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis (2008) 2.56
The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ (2008) 2.53
Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation. PLoS One (2010) 2.45
The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood (2009) 2.39
Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res (2012) 2.38
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell (2009) 2.32
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. J Biol Chem (2008) 2.30
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol (2010) 2.29
Autophagy in ischemic heart disease. Circ Res (2009) 2.20
High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal (2011) 2.19
A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1. J Biol Chem (2009) 2.19
Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol (2006) 2.17
Eating the enemy within: autophagy in infectious diseases. Cell Death Differ (2008) 2.17
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
eTBLAST: a web server to identify expert reviewers, appropriate journals and similar publications. Nucleic Acids Res (2007) 2.10
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 2.10
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Methods in mammalian autophagy research. Cell (2010) 20.08
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Cardiac resynchronization in chronic heart failure. N Engl J Med (2002) 17.52
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med (2014) 11.77
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
Autophagy in immunity and inflammation. Nature (2011) 11.16
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science (2003) 9.17
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med (2007) 8.82
Autophagy in human health and disease. N Engl J Med (2013) 8.71
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res (2007) 8.44
Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87
Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65
HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe (2007) 7.34
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation (2006) 6.58
Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell (2007) 6.39
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99
A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell (2007) 5.85
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A (2001) 5.59
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet (2013) 4.71
Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science (2003) 4.56
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A (2005) 4.56
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem (2005) 4.56
Cell biology: autophagy and cancer. Nature (2007) 4.40
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell (2012) 4.40
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest (2005) 4.25
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
Autophagy regulates programmed cell death during the plant innate immune response. Cell (2005) 4.18
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe (2008) 4.16
The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature (2002) 4.10
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy (2005) 4.08
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy (2005) 4.02
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy (2010) 3.99
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A (2007) 3.98
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy (2007) 3.91
Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe (2010) 3.79
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem (2006) 3.77
Autophagy genes in immunity. Nat Immunol (2009) 3.76
Identification of a candidate therapeutic autophagy-inducing peptide. Nature (2013) 3.76
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial. Lancet (2012) 3.66
Autophagy is essential for preimplantation development of mouse embryos. Science (2008) 3.55
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest (2006) 3.54
Sizing up the heart: development redux in disease. Genes Dev (2003) 3.52
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2006) 3.49
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J Biol Chem (2007) 3.45
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem (2009) 3.41
Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL). Circulation (2004) 3.30
Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science (2012) 3.24
Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest (2006) 3.22
In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity (2010) 3.19
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. J Virol (2005) 3.10
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature (2008) 3.09
Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol (2004) 3.04
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A (2002) 2.99
PKR-dependent autophagic degradation of herpes simplex virus type 1. Autophagy (2006) 2.97
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A (2010) 2.95
Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor. Circulation (2007) 2.93
Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial. JAMA (2007) 2.90
Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med (2002) 2.82
A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol (2011) 2.81