Published in J Am Chem Soc on August 15, 2012
Physical and structural basis for polymorphism in amyloid fibrils. Protein Sci (2014) 0.99
Amyloid polymorphism: structural basis and neurobiological relevance. Neuron (2015) 0.95
The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush. Proc Natl Acad Sci U S A (2012) 0.94
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nat Commun (2015) 0.91
Conformational features of tau fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant protein. Biochemistry (2013) 0.88
Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity. J Biol Chem (2014) 0.86
β-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR. Proc Natl Acad Sci U S A (2014) 0.84
Structural Insight into Tau Protein's Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation. J Phys Chem Lett (2014) 0.82
NMR Meets Tau: Insights into Its Function and Pathology. Biomolecules (2016) 0.81
Cellular factors modulating the mechanism of tau protein aggregation. Cell Mol Life Sci (2015) 0.79
Progress towards structural understanding of infectious sheep PrP-amyloid. Prion (2014) 0.78
Structure and mechanism of action of tau aggregation inhibitors. Curr Alzheimer Res (2014) 0.77
Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3. J Phys Chem B (2015) 0.77
Alternative conformations of the Tau repeat domain in complex with an engineered binding protein. J Biol Chem (2014) 0.77
Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR. Biochemistry (2016) 0.77
Hyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble. PLoS One (2015) 0.76
PET Radioligands for Imaging of Tau Pathology: Current Status. Nucl Med Mol Imaging (2015) 0.76
Fracture and Growth Are Competing Forces Determining the Fate of Conformers in Tau Fibril Populations. J Biol Chem (2016) 0.76
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Sci (2016) 0.75
Formation, release, and internalization of stable tau oligomers in cells. J Neurochem (2016) 0.75
Solid-State NMR Studies Reveal Native-like β-Sheet Structures in Transthyretin Amyloid. Biochemistry (2016) 0.75
Structural biology of supramolecular assemblies by magic-angle spinning NMR spectroscopy. Q Rev Biophys (2017) 0.75
A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nat Chem (2017) 0.75
Non-equilibrium hydrogen exchange for determination of H-bond strength and water accessibility in solid proteins. J Biomol NMR (2017) 0.75
Amyloidogenesis of Tau protein. Protein Sci (2017) 0.75
Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions. PLoS One (2017) 0.75
Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science (2008) 8.04
Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core. Science (2008) 5.55
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci U S A (2005) 3.48
Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc Natl Acad Sci U S A (2005) 3.37
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet (2009) 2.69
Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci (2010) 2.66
Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med (2012) 2.39
VDAC, a multi-functional mitochondrial protein regulating cell life and death. Mol Aspects Med (2010) 2.36
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR. Nature (2006) 2.34
Mars -- robust automatic backbone assignment of proteins. J Biomol NMR (2004) 2.22
β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Ann Neurol (2013) 2.10
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J (2009) 2.09
Structural and functional characterization of two alpha-synuclein strains. Nat Commun (2013) 2.05
NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. Proc Natl Acad Sci U S A (2006) 2.05
Atomic model of the type III secretion system needle. Nature (2012) 2.02
Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy. J Am Chem Soc (2005) 2.02
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. J Biol Chem (2008) 1.94
Single-molecule investigation of the interference between kinesin, tau and MAP2c. EMBO J (2002) 1.91
Proton assisted recoupling and protein structure determination. J Chem Phys (2008) 1.83
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs. J Biol Chem (2005) 1.79
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci (2008) 1.78
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell (2002) 1.76
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. J Am Chem Soc (2005) 1.75
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J (2003) 1.75
Atomic-resolution three-dimensional structure of HET-s(218-289) amyloid fibrils by solid-state NMR spectroscopy. J Am Chem Soc (2010) 1.69
Global hairpin folding of tau in solution. Biochemistry (2006) 1.69
Structural constraints from proton-mediated rare-spin correlation spectroscopy in rotating solids. J Am Chem Soc (2002) 1.68
Model-free analysis of protein backbone motion from residual dipolar couplings. J Am Chem Soc (2002) 1.65
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J Biol Chem (2004) 1.62
A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol (2008) 1.61
Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61
Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem (2009) 1.57
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci (2011) 1.57
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem (2005) 1.54
Secondary structure, dynamics, and topology of a seven-helix receptor in native membranes, studied by solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2007) 1.54
A concept for rapid protein-structure determination by solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2005) 1.53
Dissociation of amyloid fibrils of alpha-synuclein in supercooled water. Angew Chem Int Ed Engl (2008) 1.51
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 1.50
"Lest we forget you--methylene blue...". Neurobiol Aging (2011) 1.50
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J Cell Biol (2004) 1.49
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. J Am Chem Soc (2007) 1.49
Tau protein and tau aggregation inhibitors. Neuropharmacology (2010) 1.48
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. EMBO J (2002) 1.48
The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem (2003) 1.48
Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J Neurosci (2007) 1.47
Tau aggregation is driven by a transition from random coil to beta sheet structure. Biochim Biophys Acta (2004) 1.47
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
3D structure determination of the Crh protein from highly ambiguous solid-state NMR restraints. J Am Chem Soc (2008) 1.46
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci (2010) 1.46
Weak long-range correlated motions in a surface patch of ubiquitin involved in molecular recognition. J Am Chem Soc (2011) 1.45
NMR characterization of long-range order in intrinsically disordered proteins. J Am Chem Soc (2010) 1.43
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity. Proc Natl Acad Sci U S A (2010) 1.42
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO J (2004) 1.41
Solid-state NMR spectroscopy on complex biomolecules. Angew Chem Int Ed Engl (2010) 1.39
The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Mol Cell Biol (2005) 1.39
Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin. Angew Chem Int Ed Engl (2009) 1.38
Characterization of different water pools in solid-state NMR protein samples. J Biomol NMR (2009) 1.38
The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem (2007) 1.37
Structural properties of pore-forming oligomers of alpha-synuclein. J Am Chem Soc (2009) 1.36
A structural link between inactivation and block of a K+ channel. Nat Struct Mol Biol (2008) 1.36
Protein refolding is required for assembly of the type three secretion needle. Nat Struct Mol Biol (2010) 1.36
Modulation of kinesin binding by the C-termini of tubulin. EMBO J (2004) 1.35
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. J Biol Chem (2008) 1.34