Regulation of mRNA translation by signaling pathways.

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (2013) 2.79

Translational control in cancer etiology. Cold Spring Harb Perspect Biol (2013) 1.71

Principles of translational control: an overview. Cold Spring Harb Perspect Biol (2012) 1.51

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Genes Dev (2014) 1.22

Tinkering with translation: protein synthesis in virus-infected cells. Cold Spring Harb Perspect Biol (2013) 1.21

Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling. Curr Genet (2015) 1.16

mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle (2015) 1.11

Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale. J Vis Exp (2014) 1.06

Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction. RNA (2013) 0.90

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. Nat Commun (2016) 0.86

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res (2016) 0.86

Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems. Nat Struct Mol Biol (2014) 0.84

Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins. Biochimie (2015) 0.81

Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes. Fly (Austin) (2014) 0.81

Guardian of Genetic Messenger-RNA-Binding Proteins. Biomolecules (2016) 0.80

Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis). Trans Am Ophthalmol Soc (2014) 0.79

The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem (2016) 0.78

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res (2015) 0.76

Regulation of global and specific mRNA translation by the mTOR signaling pathway. Translation (Austin) (2015) 0.76

Waterpipe smoking induces epigenetic changes in the small airway epithelium. PLoS One (2017) 0.75

Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation. Proc Natl Acad Sci U S A (2015) 0.75

Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway. Med Sci Monit (2016) 0.75

Phosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase. Oncogene (2016) 0.75

Sarcopenia in alcoholic liver disease: clinical and molecular advances. Alcohol Clin Exp Res (2017) 0.75

Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development. Front Oncol (2017) 0.75

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity. Nat Commun (2017) 0.75

Targeting EIF4F complex in non-small cell lung cancer cells. Oncotarget (2017) 0.75

Targeting RNA helicases in cancer: The translation trap. Biochim Biophys Acta (2017) 0.75

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99

TOR signaling in growth and metabolism. Cell (2006) 35.29

The phosphoinositide 3-kinase pathway. Science (2002) 24.72

Global quantification of mammalian gene expression control. Nature (2011) 22.36

Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63

Upstream and downstream of mTOR. Genes Dev (2004) 21.61

mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell (2006) 18.36

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 17.36

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet (2006) 17.19

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83

AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem (1999) 14.59

Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell (2009) 14.51

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91

Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24

Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature (2006) 12.13

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65

The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol (2010) 11.19

Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A (2004) 10.78

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev (2004) 9.54

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem (1998) 9.37

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature (1994) 9.30

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev (1999) 9.02

Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92

mTOR signaling at a glance. J Cell Sci (2009) 8.66

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell (1992) 8.51

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol (2007) 8.07

The renaissance of GSK3. Nat Rev Mol Cell Biol (2001) 7.99

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene (2004) 7.92

The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell (2004) 7.77

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell (2005) 7.75

Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans (2006) 7.69

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol (2004) 7.69

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (2011) 7.55

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev (2004) 7.51

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J (2008) 7.18

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science (1997) 7.07

The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol (2010) 6.91

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A (2008) 6.84

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell (2003) 6.76

Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell (2005) 6.71

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol (2004) 6.00

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell (2009) 5.97

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science (2006) 5.94

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J (1993) 5.60

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J (1997) 5.49

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res (2007) 5.45

Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37

The pharmacology of mTOR inhibition. Sci Signal (2009) 5.36

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J (1998) 5.34

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A (2004) 5.16

eIF-4E expression and its role in malignancies and metastases. Oncogene (2004) 5.10

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol (2006) 5.06

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev (2011) 5.02

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev (2004) 5.00

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (2010) 4.81

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell (1997) 4.75

MAP kinases. Chem Rev (2001) 4.70

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65

Translational control in cancer. Nat Rev Cancer (2010) 4.59

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev (2008) 4.52

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem (2007) 4.45

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev (2005) 4.41

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J (2001) 4.40

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J (1997) 4.39

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc Natl Acad Sci U S A (1994) 4.16

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol (2003) 4.01

The Vam6 GEF controls TORC1 by activating the EGO complex. Mol Cell (2009) 4.01

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet (2005) 3.94

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol (2003) 3.90

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A (1995) 3.87

Identification of a conserved motif required for mTOR signaling. Curr Biol (2002) 3.78

mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J (1992) 3.66

The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J (2006) 3.57

Dissecting eIF4E action in tumorigenesis. Genes Dev (2007) 3.53

The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci U S A (2005) 3.49

p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol Cell (2011) 3.46

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell (2008) 3.43

Activation of mTORC2 by association with the ribosome. Cell (2011) 3.38

Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell (2010) 3.33

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J (2004) 3.29

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol (2004) 3.28

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene (2006) 3.18

Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A (2010) 3.13

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem (2007) 3.09

Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J (2007) 3.08

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (2010) 4.81

Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta (2009) 2.89

Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci U S A (2004) 2.32

Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe (2011) 2.01

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91

eIF4E is a central node of an RNA regulon that governs cellular proliferation. J Cell Biol (2006) 1.90

S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer Res (2012) 1.62

Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E. Cell Cycle (2007) 1.53

p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell (2009) 1.51

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR. J Cell Biol (2005) 1.49

Distinct perturbation of the translatome by the antidiabetic drug metformin. Proc Natl Acad Sci U S A (2012) 1.43

Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B. Mol Cell Biol (2010) 1.41

Regulation of p53 localization and activity by Ubc13. Mol Cell Biol (2006) 1.26

Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands. EMBO J (2006) 1.21

Further evidence that ribavirin interacts with eIF4E. RNA (2005) 1.13

mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle (2015) 1.11

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol (2012) 1.09

Carbon source and myc expression influence the antiproliferative actions of metformin. Cancer Res (2012) 1.07

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. J Biol Chem (2010) 1.01

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio. Oncotarget (2012) 0.93

The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus. J Virol (2005) 0.92

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. PLoS Biol (2013) 0.91

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex. Mol Cell Biol (2013) 0.90

Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds. J Gen Virol (2006) 0.86

Distinct translational control in CD4+ T cell subsets. PLoS Genet (2013) 0.84

The eukaryotic translation initiation factor 4E (eIF4E) and HuR RNA operons collaboratively regulate the expression of survival and proliferative genes. Cell Cycle (2009) 0.80

A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH. Mol Cell Biochem (2009) 0.79

Cell biology. Trans-HSF1 express. Science (2013) 0.75

4E-BPs at the crossroads of oncogenic MAPK and AKT signaling. Pigment Cell Melanoma Res (2010) 0.75