Published in Gene on August 04, 2012
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature (2008) 10.11
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature (2004) 7.42
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev (2008) 5.58
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev (2006) 4.97
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell (2006) 4.61
Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet (2010) 4.27
Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nat Genet (2011) 3.99
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. J Cell Biol (2005) 3.54
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A (2003) 3.28
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum Mol Genet (2007) 3.27
Epigenetic control of rDNA loci in response to intracellular energy status. Cell (2008) 3.22
Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature (2005) 3.09
Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol (2005) 3.05
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol (2004) 3.03
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev (2008) 2.99
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell (2009) 2.96
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A (2005) 2.82
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes (2003) 2.59
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol Cell (2008) 2.58
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. Curr Biol (2002) 2.44
Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes. Development (2011) 2.28
Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science (2011) 2.17
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol (2007) 2.15
SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol (2004) 2.09
Identification and functional analysis of endothelial tip cell-enriched genes. Blood (2010) 2.02
Unregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses. J Biol Chem (2002) 2.01
Tsix silences Xist through modification of chromatin structure. Dev Cell (2005) 1.97
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem (2001) 1.96
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers. J Exp Med (2009) 1.95
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev Cell (2011) 1.94
Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J Biol Chem (2004) 1.94
Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem (2004) 1.91
Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J Biol Chem (2004) 1.90
CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A (2008) 1.90
Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal (2011) 1.88
MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev (2010) 1.84
A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res (2010) 1.83
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell Signal (2006) 1.80
Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. PLoS Genet (2007) 1.79
Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients. Hum Mol Genet (2007) 1.79
Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev (2003) 1.76
Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest (2008) 1.70
Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. J Cell Biol (2005) 1.69
Association of sarcopenia with functional decline in community-dwelling elderly subjects in Japan. Geriatr Gerontol Int (2013) 1.67
The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J Clin Invest (2006) 1.62
Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J (2007) 1.59
An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. EMBO J (2002) 1.57
Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases. PLoS Genet (2013) 1.57
Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules. Am J Pathol (2004) 1.56
Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis. J Mol Med (Berl) (2002) 1.54
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest (2012) 1.54
Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. Endocrinology (2005) 1.54
Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice. Hypertension (2005) 1.53
Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell (2010) 1.51
De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes. Genesis (2008) 1.51
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab (2012) 1.51
Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification. Development (2007) 1.50
Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential. J Cell Sci (2004) 1.50
Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc Natl Acad Sci U S A (2010) 1.49
Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J Biol Chem (2002) 1.48
Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia. J Cell Biol (2004) 1.47
LSR defines cell corners for tricellular tight junction formation in epithelial cells. J Cell Sci (2011) 1.47
Relationship between self-reported periodontal status and skeletal bone mineral density in Japanese postmenopausal women. Menopause (2005) 1.46
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J (2006) 1.45
Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor. J Biol Chem (2007) 1.43
Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. Int J Mol Med (2003) 1.41
A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding. J Biol Chem (2008) 1.41
Loss of occludin affects tricellular localization of tricellulin. Mol Biol Cell (2008) 1.40
Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression. Hum Mol Genet (2011) 1.39
De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation. Development (2004) 1.39
An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev (2012) 1.38
Regulation of FoxO transcription factors by acetylation and protein-protein interactions. Biochim Biophys Acta (2011) 1.38
A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse. Development (2008) 1.35
Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming. Cell Res (2011) 1.33
Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest (2004) 1.31
Musculin/MyoR is expressed in kidney side population cells and can regulate their function. J Cell Biol (2005) 1.31
Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells. Mol Cell Biol (2003) 1.30
Essential role of synoviolin in embryogenesis. J Biol Chem (2004) 1.28
Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucleic Acids Res (2010) 1.27
Megaintestine in claudin-15-deficient mice. Gastroenterology (2007) 1.25
Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem (2003) 1.25
Stochastic imprinting in the progeny of Dnmt3L-/- females. Hum Mol Genet (2006) 1.24
(Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation. Diabetes (2009) 1.24
Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth. Carcinogenesis (2005) 1.24
Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A (2011) 1.22
Developing 100 ps-resolved X-ray structural analysis capabilities on beamline NW14A at the Photon Factory Advanced Ring. J Synchrotron Radiat (2007) 1.22
Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells. Mol Reprod Dev (2006) 1.21
Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription. J Biol Chem (2002) 1.21