Published in Nutr Metab (Lond) on August 14, 2012
The complex role of branched chain amino acids in diabetes and cancer. Metabolites (2013) 0.98
Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Exp Dermatol (2013) 0.95
Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr J (2013) 0.95
Cutting through the complexities of mTOR for the treatment of stroke. Curr Neurovasc Res (2014) 0.86
Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. J Transl Med (2015) 0.85
Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation. Int J Mol Sci (2015) 0.80
The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus. Curr Diabetes Rev (2015) 0.80
Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status. Nutr Metab (Lond) (2013) 0.79
Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa. Open Heart (2016) 0.78
Obesity and insulin resistance: an abridged molecular correlation. Lipid Insights (2013) 0.78
Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer. Nutr Metab (Lond) (2017) 0.75
Milk's Role as an Epigenetic Regulator in Health and Disease. Diseases (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Integrative genomic profiling of human prostate cancer. Cancer Cell (2010) 23.61
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 13.98
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med (2004) 13.57
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature (2006) 12.13
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem (1998) 9.37
Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet (2004) 8.77
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14
Pten dose dictates cancer progression in the prostate. PLoS Biol (2003) 7.62
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev (2004) 7.51
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell (2011) 7.32
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21
Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr (2005) 6.50
A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44
The two TORCs and Akt. Dev Cell (2007) 6.17
Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat Genet (2001) 5.92
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene (2008) 5.85
The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61
Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol (2007) 5.13
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab (2006) 4.98
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A (2002) 4.93
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell (2011) 4.70
mTOR, translation initiation and cancer. Oncogene (2006) 4.68
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev (2008) 4.52
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci U S A (1998) 4.40
Plasma amino acid levels and insulin secretion in obesity. N Engl J Med (1969) 4.18
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev (2006) 4.02
High school dietary dairy intake and teenage acne. J Am Acad Dermatol (2005) 4.00
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell (2009) 3.78
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med (2007) 3.66
Role of autophagy in cancer: management of metabolic stress. Autophagy (2007) 3.40
Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. Diabetes Metab Res Rev (2009) 3.37
Akt-regulated pathways in prostate cancer. Oncogene (2005) 3.35
Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab (2007) 3.30
Paleolithic nutrition. A consideration of its nature and current implications. N Engl J Med (1985) 3.29
Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst (1995) 3.24
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A (2010) 3.13
mTOR and cancer therapy. Oncogene (2006) 3.07
Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab (2008) 3.03
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) (2009) 2.94
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell (2008) 2.87
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes Dev (2006) 2.76
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem (2005) 2.70
Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study. Am J Clin Nutr (2001) 2.64
regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes (2004) 2.64
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res (2010) 2.60
Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev (2005) 2.56
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes (2005) 2.55
Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis. J Natl Cancer Inst (2005) 2.54
Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins. Cancer Res (2006) 2.46
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol Endocrinol Metab (2007) 2.46
Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr (2006) 2.38
The mTOR signalling pathway in human cancer. Int J Mol Sci (2012) 2.38
Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study. J Natl Cancer Inst (2000) 2.34
Milk consumption and acne in teenaged boys. J Am Acad Dermatol (2008) 2.33
Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival. Diabetes Care (2012) 2.32
Role of diet in prostate cancer development and progression. J Clin Oncol (2005) 2.29
Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab (2008) 2.27
Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res (2006) 2.21
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Lett (2007) 2.15
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell (2010) 2.11
The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes (2007) 2.09
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN. Br J Cancer (1998) 2.06
Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE (2005) 2.04
Body mass index and incidence of localized and advanced prostate cancer--a dose-response meta-analysis of prospective studies. Ann Oncol (2012) 1.97
Obesity and prostate cancer: making sense out of apparently conflicting data. Epidemiol Rev (2007) 1.97
Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomarkers Prev (2000) 1.96
Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. Biochem Soc Trans (2009) 1.91
Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol (2009) 1.88
Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks. Am J Clin Nutr (2007) 1.86
Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J Biol Chem (1998) 1.85
Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr (2005) 1.83
Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem (2010) 1.80
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem (2006) 1.78
Milk consumption and acne in adolescent girls. Dermatol Online J (2006) 1.77
Molecular interactions of the IGF system. Cytokine Growth Factor Rev (2005) 1.75
S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74
International comparisons of prostate cancer mortality rates with dietary practices and sunlight levels. Urol Oncol (2006) 1.72
Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab (2007) 1.71
Androgen receptor and growth factor signaling cross-talk in prostate cancer cells. Endocr Relat Cancer (2008) 1.70
Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle. Cell Metab (2011) 1.67
Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway. Curr Cancer Drug Targets (2009) 1.66
Cow's milk and linear growth in industrialized and developing countries. Annu Rev Nutr (2006) 1.65
Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p. J Biol Chem (2006) 1.63
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk. Nat Rev Endocrinol (2010) 1.61
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev (2008) 1.61
Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. J Am Coll Cardiol (2004) 4.07
Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer. Mayo Clin Proc (2004) 1.84
Evolutionary health promotion. Prev Med (2002) 1.41
Evolutionary health promotion: a consideration of common counterarguments. Prev Med (2002) 1.21
African hominin stable isotopic data do not necessarily indicate grass consumption. Proc Natl Acad Sci U S A (2013) 1.16
Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet. Br J Nutr (2010) 1.11
Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk. Br J Nutr (2005) 1.08
Beyond the Paleolithic prescription: commentary. Nutr Rev (2014) 1.07
Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr J (2013) 0.95
Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy? J Transl Med (2014) 0.94
Exercise like a hunter-gatherer: a prescription for organic physical fitness. Prog Cardiovasc Dis (2011) 0.91
Site variations in susceptibility to SLS. Contact Dermatitis (2007) 0.91
Achieving hunter-gatherer fitness in the 21(st) century: back to the future. Am J Med (2010) 0.90
Acetaminophen use: a risk for asthma? Curr Allergy Asthma Rep (2009) 0.89
Diet-dependent acid load, Paleolithic [corrected] nutrition, and evolutionary health promotion. Am J Clin Nutr (2009) 0.89
Evolution, body composition, insulin receptor competition, and insulin resistance. Prev Med (2009) 0.83
Decreasing incidence of occupational contact urticaria caused by natural rubber latex allergy in German health care workers. J Allergy Clin Immunol (2004) 0.82
Anxiety, depression and impaired health-related quality of life in patients with occupational hand eczema. Contact Dermatitis (2012) 0.82
Dietary fat quality and coronary heart disease prevention: a unified theory based on evolutionary, historical, global, and modern perspectives. Curr Treat Options Cardiovasc Med (2009) 0.82
Ultraviolet radiation represents an evolutionary selective pressure for the south-to-north gradient of the MTHFR 677TT genotype. Am J Clin Nutr (2006) 0.81
Acne: risk indicator for increased body mass index and insulin resistance. Acta Derm Venereol (2013) 0.80
Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status. Nutr Metab (Lond) (2013) 0.79
Long-term effectiveness of secondary prevention in geriatric nurses with occupational hand eczema: the challenge of a controlled study design. Contact Dermatitis (2011) 0.79
Ratio of irritant contact dermatitis to allergic contact dermatitis in occupational skin disease. J Am Acad Dermatol (2003) 0.78
Skin cancer induced by natural UV-radiation as an occupational disease—requirements for its notification and recognition. J Dtsch Dermatol Ges (2014) 0.77
Coronary artery disease prognosis and C-reactive protein levels improve in proportion to percent lowering of low-density lipoprotein. Am J Cardiol (2006) 0.77
Osnabrueck hand eczema severity index--a study of the interobserver reliability of a scoring system assessing skin diseases of the hands. Contact Dermatitis (2006) 0.77
10 years quality assurance of the dermatologist's procedure. ABD review board part II: 2003-2009. J Dtsch Dermatol Ges (2010) 0.77
Comment on acne and glycemic index. J Am Acad Dermatol (2008) 0.77
Cooperation between the occupational health insurance and physicians practicing occupational dermatology: optimization potential in quality assurance. J Dtsch Dermatol Ges (2014) 0.77
First results from the multicentre study rehabilitation of occupational skin diseases--optimization and quality assurance of inpatient management (ROQ). Contact Dermatitis (2011) 0.77
Multicenter study "Medical-Occupational Rehabilitation Procedure Skin--optimizing and quality assurance of inpatient-management (ROQ)". J Dtsch Dermatol Ges (2008) 0.77
Contact allergy to ingredients of hair cosmetics - a comparison of female hairdressers and clients based on IVDK 2007-2012 data. Contact Dermatitis (2014) 0.76
Organic fitness: physical activity consistent with our hunter-gatherer heritage. Phys Sportsmed (2010) 0.76
Short- and long-term effects of single and repetitive glove occlusion on the epidermal barrier. Arch Dermatol Res (2009) 0.76
Skin protection for hairdressers. Curr Probl Dermatol (2007) 0.75
Adipogenic and insulin resistance- promoting effects of milk consumption. Mol Nutr Food Res (2014) 0.75
Allergic contact dermatitis caused by the blue pigment VINAMON® Blue BX FW - a phthalocyanine blue in a vinyl glove. J Dtsch Dermatol Ges (2010) 0.75
[New occupational disease of solar skin cancer and parallel improvements in UV GOÄ 2013]. J Dtsch Dermatol Ges (2013) 0.75
Secondary prevention of occupational dermatoses: first systematic evaluation of optimized dermatologist's procedure and hierarchical multi-step intervention. J Dtsch Dermatol Ges (2013) 0.75
[Occupational skin cancer due to sun: the new occupational disease 5103 is instituted]. J Dtsch Dermatol Ges (2014) 0.75
Development of a standardized testing procedure for assessing the irritation potential of occupational skin cleansers. Contact Dermatitis (2013) 0.75
Psoriasis predisposition and occupational triggering factors in the appraisal of occupational medical expertises. J Dtsch Dermatol Ges (2014) 0.75
Occupational airborne contact allergy to tetrazepam in a geriatric nurse. J Dtsch Dermatol Ges (2009) 0.75
[Through prevention, better living...]. J Dtsch Dermatol Ges (2007) 0.75
Antibacterial effects of a chitosan-containing spray: results of a pilot study. J Drugs Dermatol (2010) 0.75
[Positive patch test reaction without clinical contact dermatitis--what is the best approach in medico-legal evaluation?]. J Dtsch Dermatol Ges (2008) 0.75
Topical ophthalmic agents as allergens in periorbital dermatitis. Br J Ophthalmol (2013) 0.75
Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. Acta Biomed (2012) 0.75
Safety, effectiveness and comparability of professional skin cleansers. J Dtsch Dermatol Ges (2010) 0.75
Semipermeable glove membranes--effects on skin barrier repair following SLS irritation. Contact Dermatitis (2009) 0.75
[Current trends in occupational dermatology]. Hautarzt (2014) 0.75
No remarkable differences in rates of sensitization to common type I and IV allergens between FLG loss-of-function mutation carriers and wild-type subjects. Contact Dermatitis (2013) 0.75
Intestinal immune-potentiation by a purified alkylglycerols compound. Acta Biomed (2012) 0.75
Psoriasis predisposition and occupational triggering factors in the appraisal of occupational medical expertises. J Dtsch Dermatol Ges (2014) 0.75
Evaluation of structured patient education in occupational skin diseases: a systematic assessment of the disease-specific knowledge. Int Arch Occup Environ Health (2014) 0.75
Patch test characteristics of patients referred for suspected contact allergy of the feet--retrospective 10-year cross-sectional study of the IVDK data. Contact Dermatitis (2012) 0.75
[Inflammation of the fingertips with naildystrophy. Allergic contact dermatitis to (meth-)acrylates in a nail designer]. J Dtsch Dermatol Ges (2009) 0.75
Occupational allergic contact dermatitis caused by (R)-3-(2-chloro-1-hydroxyethyl)-phenol. Contact Dermatitis (2012) 0.75