Published in Sci STKE on January 25, 2005
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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell (2008) 3.91
Role of mitochondrial dysfunction in insulin resistance. Circ Res (2008) 3.45
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A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med (2007) 1.17
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Macrophages, meta-inflammation, and immuno-metabolism. ScientificWorldJournal (2011) 1.10
IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. Int J Mol Med (2008) 1.07
The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication. Am J Transl Res (2010) 1.03
Elevated PI3K signaling drives multiple breast cancer subtypes. Oncotarget (2011) 1.03
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma. Proc Natl Acad Sci U S A (2007) 0.98
The complex role of branched chain amino acids in diabetes and cancer. Metabolites (2013) 0.98
Molecular mechanisms of insulin resistance in chronic hepatitis C. World J Gastroenterol (2009) 0.98
Leucine signaling in the pathogenesis of type 2 diabetes and obesity. World J Diabetes (2012) 0.98
Diabetic cardiomyopathy: signaling defects and therapeutic approaches. Expert Rev Cardiovasc Ther (2010) 0.97
Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Exp Dermatol (2013) 0.95
Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord (2015) 0.94
C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1. Circ Res (2009) 0.93
Nutritional interventions to alleviate the negative consequences of heat stress. Adv Nutr (2013) 0.93
Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle. Diabetologia (2011) 0.93
A dynamic analysis of IRS-PKR signaling in liver cells: a discrete modeling approach. PLoS One (2009) 0.93
Global IRS-1 phosphorylation analysis in insulin resistance. Diabetologia (2011) 0.93
Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem (2014) 0.92
Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet. Dermatoendocrinol (2012) 0.92
Metabolomics and diabetes: analytical and computational approaches. Diabetes (2015) 0.90
Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signalling in monocytes from obese subjects. Cell Stress Chaperones (2012) 0.90
Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Brain Res (2008) 0.90
Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy. Exp Diabetes Res (2011) 0.89
Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS One (2010) 0.89
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta (2014) 0.88
Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum. J Clin Endocrinol Metab (2011) 0.88
The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells. Mol Biol Cell (2010) 0.86
Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress. Diabetes (2010) 0.84
Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase. Mol Endocrinol (2010) 0.84
Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity. J Obes (2012) 0.83
Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. Am J Physiol Endocrinol Metab (2014) 0.83
Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes. Heart Fail Rev (2016) 0.82
Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation. BMC Cell Biol (2010) 0.82
Tissue-specific insulin signaling in the regulation of metabolism and aging. IUBMB Life (2014) 0.82
The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer. Nutr Metab (Lond) (2012) 0.81
Burn injury-induced IRS-1 degradation in mouse skeletal muscle. Int J Burns Trauma (2013) 0.81
Computational modelling of the regulation of Insulin signalling by oxidative stress. BMC Syst Biol (2013) 0.80
Effect of insulin levels on the phosphorylation of specific amino acid residues in IRS-1: implications for burn-induced insulin resistance. Int J Mol Med (2009) 0.80
Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474. Cancer Sci (2015) 0.79
O-GlcNAc: A Bittersweet Switch in Liver. Front Endocrinol (Lausanne) (2014) 0.79
Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573. PLoS One (2012) 0.79
Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells. Biochem Pharmacol (2009) 0.79
Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest (2017) 0.79
Insulin resistance in euglycemic cirrhosis. Ann Gastroenterol (2014) 0.78
Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes. J Biol Chem (2015) 0.78
Primary cilia in energy balance signaling and metabolic disorder. BMB Rep (2015) 0.78
Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice. Aging Cell (2016) 0.77
Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer. Cancer Sci (2015) 0.77
Alternate Phosphorylation/O-GlcNAc Modification on Human Insulin IRSs: A Road towards Impaired Insulin Signaling in Alzheimer and Diabetes. Adv Bioinformatics (2014) 0.77
Endoplasmic reticulum stress impairs insulin receptor signaling in the brains of obese rats. PLoS One (2015) 0.77
Will targeting PI3K/Akt/mTOR signaling work in hematopoietic malignancies? Stem Cell Investig (2016) 0.77
Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. FEBS J (2013) 0.77
Adipose tissue insulin sensitivity and macrophage recruitment: Does PI3K pick the pathway? Adipocyte (2013) 0.77
Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation-Mediated Degenerative Diseases. Oxid Med Cell Longev (2016) 0.76
HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis. Oxid Med Cell Longev (2016) 0.75
Nitric oxide agents impair insulin-mediated signal transduction in rat skeletal muscle. BMC Biochem (2006) 0.75
Positive Correlation between Enhanced Expression of TLR4/MyD88/NF-κB with Insulin Resistance in Placentae of Gestational Diabetes Mellitus. PLoS One (2016) 0.75
The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2. J Biol Chem (2016) 0.75
Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol (2017) 0.75