Published in Am J Pathol on September 01, 2012
Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. Am J Pathol (2013) 0.98
The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy. PLoS One (2013) 0.82
Vascular endothelial growth factor acts primarily via platelet-derived growth factor receptor α to promote proliferative vitreoretinopathy. Am J Pathol (2014) 0.80
Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin. PLoS One (2013) 0.80
Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Invest Ophthalmol Vis Sci (2016) 0.77
MicroRNA-182 Suppresses HGF/SF-Induced Increases in Retinal Pigment Epithelial Cell Proliferation and Migration through Targeting c-Met. PLoS One (2016) 0.75
Notch signaling modulates proliferative vitreoretinopathy via regulating retinal pigment epithelial-to-mesenchymal transition. Histochem Cell Biol (2016) 0.75
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med (2001) 24.51
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
The p53 tumour suppressor gene. Nature (1991) 14.49
Signaling to p53: breaking the MDM2-p53 circuit. Cell (1998) 8.63
The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol (2001) 5.82
p53 and human cancer: the first ten thousand mutations. Adv Cancer Res (2000) 4.71
Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem (2002) 3.01
Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy : Results from a randomized, double-blind, controlled clinical trial. Ophthalmology (2001) 2.83
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene (2002) 2.50
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell (2008) 2.46
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev (2006) 2.35
mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation. Mol Cell Biol (2003) 2.32
Epidemiology of retinal detachment. Arch Ophthalmol (1982) 2.15
Pathogenic mechanisms in proliferative vitreoretinopathy. Arch Ophthalmol (1997) 1.58
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (1999) 1.49
A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2007) 1.41
Recent advances in the therapeutic perspectives of Nutlin-3. Curr Pharm Des (2011) 1.35
Platelet-derived growth factor ligands and receptors immunolocalized in proliferative retinal diseases. Invest Ophthalmol Vis Sci (1994) 1.34
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem (2009) 1.31
The incidence of retinal detachment in Rochester, Minnesota, 1970-1978. Am J Ophthalmol (1982) 1.29
Adjunctive daunorubicin in the treatment of proliferative vitreoretinopathy: results of a multicenter clinical trial. Daunomycin Study Group. Am J Ophthalmol (1998) 1.27
Ultrastructural and electron-immunocytochemical characterization of cells in epiretinal membranes. Invest Ophthalmol Vis Sci (1990) 1.26
Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. Cancer Res (2011) 1.21
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis. J Biol Chem (1999) 1.14
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol (2010) 1.11
Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor. Invest Ophthalmol Vis Sci (2000) 1.11
Clinical risk factors for proliferative vitreoretinopathy after retinal detachment surgery. Retina (1994) 1.10
Immunohistologic study of epiretinal membranes in proliferative vitreoretinopathy. Am J Ophthalmol (1990) 1.07
Prevalence and risk factors for proliferative vitreoretinopathy in eyes with rhegmatogenous retinal detachment but no previous vitreoretinal surgery. Am J Ophthalmol (2004) 1.06
An in vivo gene therapy approach for experimental proliferative vitreoretinopathy using the truncated platelet-derived growth factor alpha receptor. Invest Ophthalmol Vis Sci (2002) 1.06
FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction. Invest Ophthalmol Vis Sci (2008) 1.06
Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol (2011) 1.06
PDGF receptors are activated in human epiretinal membranes. Exp Eye Res (2008) 1.06
Collagen gel contraction by ARPE-19 cells is mediated by a FAK-Src dependent pathway. Exp Eye Res (2007) 1.03
Onset and recurrence of proliferative vitreoretinopathy in various vitreoretinal disease. Br J Ophthalmol (1995) 1.02
A comparison of different cellular inocula in an experimental model of massive periretinal proliferation. Am J Ophthalmol (1982) 1.01
Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest. Mol Cell Biol (2007) 1.01
A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. Am J Pathol (2011) 0.99
Growth factors outside the PDGF family drive experimental PVR. Invest Ophthalmol Vis Sci (2009) 0.99
Growth factors in proliferative vitreoretinopathy. Br J Ophthalmol (1998) 0.93
Comparative study of clinical factors predisposing patients to proliferative vitreoretinopathy. Retina (1989) 0.91
The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol (1982) 0.91
Induction of proliferative vitreoretinopathy by a unique line of human retinal pigment epithelial cells. Can J Ophthalmol (2002) 0.90
Interaction between surgical procedure for repairing retinal detachment and clinical risk factors for proliferative vitreoretinopathy. Curr Eye Res (2005) 0.89
Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2). Invest Ophthalmol Vis Sci (2009) 0.89
Down-regulation of fibronectin gene expression by the p53 tumor suppressor protein. Cell Growth Differ (1996) 0.88
Safety and efficacy assessment of chimeric ribozyme to proliferating cell nuclear antigen to prevent recurrence of proliferative vitreoretinopathy. Arch Ophthalmol (2007) 0.86
Comparative study of clinical factors that predispose patients to proliferative vitreoretinopathy in aphakia. Retina (1991) 0.86
Epithelial membrane protein-2 (EMP2) and experimental proliferative vitreoretinopathy (PVR). Curr Eye Res (2011) 0.82
Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin. Mol Cell Biochem (2011) 0.79
Rewiring integrin-mediated signaling and cellular response with the peripheral myelin protein 22 and epithelial membrane protein 2 components of the tetraspan web. Invest Ophthalmol Vis Sci (2011) 0.76
[Clinical risk factors for proliferative vitreoretinopathy after retinal detachment surgery]. Arch Soc Esp Oftalmol (2000) 0.76
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07
Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med (2006) 4.46
Oral fluoroquinolones and the risk of retinal detachment. JAMA (2012) 4.43
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52
Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Rheumatology (Oxford) (2009) 3.33
Schistosoma haematobium infection in workers returning from Africa to China. J Travel Med (2013) 3.14
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol (2009) 2.95
Simple, inexpensive technique for high-quality smartphone fundus photography in human and animal eyes. J Ophthalmol (2013) 2.60
PDGF signaling in cells and mice. Cytokine Growth Factor Rev (2004) 2.57
Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet (2010) 2.41
Teleophthalmology screening for diabetic retinopathy through mobile imaging units within Canada. Can J Ophthalmol (2008) 2.30
Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Invest Ophthalmol Vis Sci (2008) 1.70
Maternal influence on blood pressure suggests involvement of mitochondrial DNA in the pathogenesis of hypertension: the Framingham Heart Study. J Hypertens (2007) 1.67
Use of topiramate and risk of glaucoma: a case-control study. Am J Ophthalmol (2012) 1.66
miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev (2011) 1.66
Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circ Res (2007) 1.64
Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study. Arthritis Res Ther (2011) 1.55
Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk. Ann Rheum Dis (2010) 1.53
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nat Cell Biol (2003) 1.53
Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study. Rheumatology (Oxford) (2010) 1.53
Case records of the Massachusetts General Hospital. Case 5-2006. An 11-year-old girl with loss of vision in the right eye. N Engl J Med (2006) 1.51
Power and type I error rate of false discovery rate approaches in genome-wide association studies. BMC Genet (2005) 1.50
Platelet-derived growth factor receptor-mediated signal transduction from endosomes. J Biol Chem (2003) 1.49
Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells. Cancer Res (2007) 1.49
Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J (2007) 1.46
Smartphone photography safety. Ophthalmology (2012) 1.44
A randomized controlled trial of an internal family systems-based psychotherapeutic intervention on outcomes in rheumatoid arthritis: a proof-of-concept study. J Rheumatol (2013) 1.43
Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls. Arthritis Rheum (2013) 1.43
A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2007) 1.41
Isolated vitreoretinal amyloidosis in the absence of transthyretin mutations. Arch Ophthalmol (2004) 1.40
Visual outcomes of vitreoretinal surgery in eyes with severe open-globe injury presenting with no-light-perception vision. Graefes Arch Clin Exp Ophthalmol (2009) 1.39
Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J (2012) 1.38
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Mol Biol Cell (2005) 1.35
The correlation between height of macular detachment and visual outcome in macula-off retinal detachments of < or = 7 days' duration. Ophthalmology (2005) 1.33
Predictors of visual outcome and choroidal neovascular membrane formation after traumatic choroidal rupture. Arch Ophthalmol (2006) 1.32
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem (2009) 1.31
IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Cancer Biol Ther (2007) 1.30
A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration. J Cell Sci (2004) 1.30
Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum (2010) 1.25
Wnt signaling in bone formation and its therapeutic potential for bone diseases. Ther Adv Musculoskelet Dis (2013) 1.25
Sustained rheumatoid arthritis remission is uncommon in clinical practice. Arthritis Res Ther (2012) 1.22
Pericytes and ocular diseases. Exp Eye Res (2007) 1.21
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. J Biol Chem (2007) 1.18
Characterization of mammographic masses based on level set segmentation with new image features and patient information. Med Phys (2008) 1.18
Association of NEDD4L ubiquitin ligase with essential hypertension. Hypertension (2005) 1.17
Sensitivity and optimization of artificial digestion in the inspection of meat for Trichinella spiralis. Foodborne Pathog Dis (2010) 1.17
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. J Clin Invest (2011) 1.16
Complement-associated deposits in the human retina. Invest Ophthalmol Vis Sci (2008) 1.15
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Mol Cell Biol (2004) 1.14
Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. J Biol Chem (2003) 1.12
IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1. J Zhejiang Univ Sci B (2006) 1.12
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol (2010) 1.11
Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential. PLoS One (2012) 1.11
Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2008) 1.10
PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. PLoS Pathog (2012) 1.10
Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis. Ann Rheum Dis (2012) 1.10
Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy. Cancer (2013) 1.10
Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ Res (2004) 1.09
Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis. Arthritis Rheum (2010) 1.08
Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells. J Bone Miner Res (2012) 1.08
Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery. Int J Pharm (2009) 1.08
An in vivo gene therapy approach for experimental proliferative vitreoretinopathy using the truncated platelet-derived growth factor alpha receptor. Invest Ophthalmol Vis Sci (2002) 1.06
Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset. PLoS One (2011) 1.06
PDGF receptors are activated in human epiretinal membranes. Exp Eye Res (2008) 1.06
Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol (2011) 1.06
Cloning, expression and characterization of a Trichinella spiralis serine protease gene encoding a 35.5 kDa protein. Exp Parasitol (2013) 1.05
Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway. J Biol Chem (2007) 1.04
Mitochondrial genome mutations in hypertensive individuals. Am J Hypertens (2004) 1.02
Clinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning. Head Neck (2014) 1.02
Regulating angiogenesis at the level of PtdIns-4,5-P2. EMBO J (2006) 1.00
A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. Am J Pathol (2011) 0.99
Molecular characterization of Trichinella spiralis aminopeptidase and its potential as a novel vaccine candidate antigen against trichinellosis in BALB/c mice. Parasit Vectors (2013) 0.99
BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells. J Cell Sci (2012) 0.99
Growth factors outside the PDGF family drive experimental PVR. Invest Ophthalmol Vis Sci (2009) 0.99
Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis. J Biol Chem (2013) 0.99
Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. Am J Pathol (2013) 0.98
Cooperation between Rb and Arf in suppressing mouse retinoblastoma. J Clin Invest (2012) 0.98
Proteomic analysis of Trichinella spiralis proteins in intestinal epithelial cells after culture with their larvae by shotgun LC-MS/MS approach. J Proteomics (2012) 0.98
Genetic analyses of longitudinal phenotype data: a comparison of univariate methods and a multivariate approach. BMC Genet (2003) 0.98
Reactivation of IGFBP7 by DNA demethylation inhibits human colon cancer cell growth in vitro. Cancer Biol Ther (2008) 0.97
The role of cathepsins in ocular physiology and pathology. Exp Eye Res (2006) 0.97