Published in Circ Res on July 05, 2007
The renin-angiotensin system and diabetes: an update. Vasc Health Risk Manag (2008) 1.30
Genetic basis of atherosclerosis: insights from mice and humans. Circ Res (2012) 1.14
ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS One (2012) 0.94
Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J (2011) 0.92
Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS One (2010) 0.89
The role of profilin-1 in endothelial cell injury induced by advanced glycation end products (AGEs). Cardiovasc Diabetol (2013) 0.82
In vivo MR and Fluorescence Dual-modality Imaging of Atherosclerosis Characteristics in Mice Using Profilin-1 Targeted Magnetic Nanoparticles. Theranostics (2016) 0.80
Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis. Diabetes (2013) 0.80
Cytoskeleton disruption in J774 macrophages: consequences for lipid droplet formation and cholesterol flux. Biochim Biophys Acta (2011) 0.78
Rosuvastatin Modulates the Post-Translational Acetylome in Endothelial Cells. Zhonghua Minguo Xin Zang Xue Hui Za Zhi (2014) 0.77
Profilin-1: an unexpected molecule linking vascular inflammation to the actin cytoskeleton. Circ Res (2007) 0.77
Profilin1 biology and its mutation, actin(g) in disease. Cell Mol Life Sci (2016) 0.76
Lipopolysaccharides Promote S-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophages in Vivo. J Biol Chem (2015) 0.76
Proteomics reveals potential non-neuronal cholinergic receptor-effectors in endothelial cells. Acta Pharmacol Sin (2014) 0.75
Profilin-1 promotes the development of hypertension-induced artery remodeling. J Histochem Cytochem (2014) 0.75
Macrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis. Circ Res (2017) 0.75
Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med (2006) 4.46
PDGF signaling in cells and mice. Cytokine Growth Factor Rev (2004) 2.57
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nat Cell Biol (2003) 1.53
Platelet-derived growth factor receptor-mediated signal transduction from endosomes. J Biol Chem (2003) 1.49
Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells. Cancer Res (2007) 1.49
A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2007) 1.41
Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J (2012) 1.38
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Mol Biol Cell (2005) 1.35
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem (2009) 1.31
A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration. J Cell Sci (2004) 1.30
Pericytes and ocular diseases. Exp Eye Res (2007) 1.21
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. J Biol Chem (2007) 1.18
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. J Clin Invest (2011) 1.16
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Mol Cell Biol (2004) 1.14
Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. J Biol Chem (2003) 1.12
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol (2010) 1.11
PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. PLoS Pathog (2012) 1.10
Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2008) 1.10
Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK. Arterioscler Thromb Vasc Biol (2009) 1.10
Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ Res (2004) 1.09
An in vivo gene therapy approach for experimental proliferative vitreoretinopathy using the truncated platelet-derived growth factor alpha receptor. Invest Ophthalmol Vis Sci (2002) 1.06
PDGF receptors are activated in human epiretinal membranes. Exp Eye Res (2008) 1.06
Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol (2011) 1.06
Adipose tissue growth and regression are regulated by angiopoietin-1. Biochem Biophys Res Commun (2003) 1.05
Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway. J Biol Chem (2007) 1.04
E-selectin is required for the antiangiogenic activity of endostatin. Proc Natl Acad Sci U S A (2004) 1.01
Regulating angiogenesis at the level of PtdIns-4,5-P2. EMBO J (2006) 1.00
A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. Am J Pathol (2011) 0.99
Growth factors outside the PDGF family drive experimental PVR. Invest Ophthalmol Vis Sci (2009) 0.99
Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis. J Biol Chem (2013) 0.99
Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. Am J Pathol (2013) 0.98
The role of cathepsins in ocular physiology and pathology. Exp Eye Res (2006) 0.97
Expression of PDGFRα is a determinant of the PVR potential of ARPE19 cells. Invest Ophthalmol Vis Sci (2011) 0.96
TGFbeta1-dependent contraction of fibroblasts is mediated by the PDGFalpha receptor. Invest Ophthalmol Vis Sci (2002) 0.96
Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Mol Cell Biol (2010) 0.96
Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses. Mol Cell Biol (2012) 0.95
Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci (2004) 0.94
Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One (2010) 0.94
New insights regarding vessel regression. Cell Cycle (2006) 0.91
Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS One (2010) 0.89
Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications. Biomed Opt Express (2012) 0.89
The role of c-Src in platelet-derived growth factor alpha receptor internalization. Exp Cell Res (2003) 0.88
A novel function of p53: a gatekeeper of retinal detachment. Am J Pathol (2012) 0.87
Urinary matrix metalloproteinase activities: biomarkers for plaque angiogenesis and nephropathy in diabetes. Am J Physiol Renal Physiol (2011) 0.87
PI3K and PLCgamma play a central role in experimental PVR. Invest Ophthalmol Vis Sci (2002) 0.87
Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity. J Cell Sci (2005) 0.87
Corneal endothelial cells are protected from apoptosis by gene therapy. Hum Gene Ther (2011) 0.87
Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis. Proc Natl Acad Sci U S A (2005) 0.86
Focus on molecules: platelet-derived growth factor C, PDGF-C. Exp Eye Res (2007) 0.86
Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem (2008) 0.85
Ex vivo adenovirus-mediated gene transfer to corneal graft endothelial cells in mice. Invest Ophthalmol Vis Sci (2004) 0.85
Diabetes disrupts the response of retinal endothelial cells to the angiomodulator lysophosphatidic acid. Diabetes (2012) 0.85
Regulation of Ras signaling by the cell cycle. Curr Opin Genet Dev (2002) 0.84
Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis. Am J Pathol (2002) 0.84
The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms. Cancer Res (2010) 0.84
A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Mol Cell Biol (2013) 0.84
Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol (2013) 0.83
Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis. J Lipid Res (2005) 0.83
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol (2008) 0.82
Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction. FASEB J (2004) 0.82
Primary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA). Biosci Rep (2012) 0.82
Retinal Pigment Epithelium and Müller Progenitor Cell Interaction Increase Müller Progenitor Cell Expression of PDGFRα and Ability to Induce Proliferative Vitreoretinopathy in a Rabbit Model. Stem Cells Int (2012) 0.81
VE-cadherin increases the half-life of VEGF receptor 2. Exp Cell Res (2004) 0.81
VEGF-A engages at least three tyrosine kinases to activate PI3K/Akt. Cell Cycle (2012) 0.80
SU9518 inhibits proliferative vitreoretinopathy in fibroblast and genetically modified Müller cell-induced rabbit models. Invest Ophthalmol Vis Sci (2013) 0.79
Keratocyte apoptosis and failure of corneal allografts. Transplantation (2006) 0.78
Focus on molecules: Akt (PKB). Exp Eye Res (2010) 0.78
Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS One (2011) 0.77
PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis. Expert Opin Ther Targets (2007) 0.76
The timing and extent of activation of diacylglycerol-responsive protein kinase-cs determines their ability to inhibit or promote platelet-derived growth factor-dependent DNA synthesis. Exp Cell Res (2002) 0.75
Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion. Adv Exp Med Biol (2002) 0.75
A phage display-based approach to investigate abnormal neovessels of the retina. Invest Ophthalmol Vis Sci (2012) 0.75
Focus on molecules: HtrA1 and neovascular AMD. Exp Eye Res (2010) 0.75
Detection of H2O2-mediated phosphorylation of kinase-inactive PDGFRα. Methods Enzymol (2013) 0.75