The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors.

MSP-RON signalling in cancer: pathogenesis and therapeutic potential. Nat Rev Cancer (2013) 1.17

Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential. Leukemia (2013) 1.06

Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction. J Biomed Res (2013) 0.84

The Hepatocyte Growth Factor (HGF)/Met Axis: A Neglected Target in the Treatment of Chronic Myeloproliferative Neoplasms? Cancers (Basel) (2014) 0.77

Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics. Oncotarget (2016) 0.75

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science (2003) 19.77

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia (2003) 13.41

Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program. Leukemia (2003) 4.31

Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia (1999) 4.09

New insights to the MLL recombinome of acute leukemias. Leukemia (2009) 4.07

Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet (2000) 3.47

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J (1994) 3.39

The MLL recombinome of acute leukemias in 2013. Leukemia (2013) 2.55

A role for phosphoinositide 3-kinase in bacterial invasion. Science (1996) 2.46

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia (2011) 2.12

Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease. Age Ageing (1992) 2.12

Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Molecular Cytogenetic Diagnosis in Haematological Malignancies". Blood (2000) 1.99

Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. Hum Mol Genet (2000) 1.92

Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C. Mol Biol Cell (2000) 1.86

Microsatellite markers for typing Aspergillus fumigatus isolates. J Clin Microbiol (1998) 1.82

Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology (1998) 1.71

A robust xenotransplantation model for acute myeloid leukemia. Leukemia (2009) 1.67

SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias. Leukemia (2013) 1.65

Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol (1997) 1.64

Tracking of airborne radionuclides from the damaged Fukushima Dai-ichi nuclear reactors by European networks. Environ Sci Technol (2011) 1.61

CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes. Leukemia (2005) 1.59

Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia (2006) 1.58

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase. J Cell Biol (1995) 1.57

Specific small nucleolar RNA expression profiles in acute leukemia. Leukemia (2012) 1.56

The Listeria monocytogenes protein InlB is an agonist of mammalian phosphoinositide 3-kinase. J Biol Chem (1999) 1.56

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. J Biol Chem (2000) 1.56

Src and Ras are involved in separate pathways in epithelial cell scattering. EMBO J (1997) 1.53

Interaction of myristoylated alanine-rich protein kinase C substrate (MARCKS) with membrane phospholipids. J Biol Chem (1993) 1.51

The MLL recombinome of acute leukemias. Leukemia (2006) 1.51

Colonic mast cells in controls and slow transit constipation patients. Aliment Pharmacol Ther (2011) 1.46

Multicentric evaluation of the MDR phenotype in leukemia. French Network of the Drug Resistance Intergroup, and Drug Resistance Network of Assistance Publique-Hôpitaux de Paris. Leukemia (1997) 1.41

Interaction between the epidermal growth factor receptor and phosphoinositide kinases. J Biol Chem (1991) 1.40

A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Blood (1999) 1.40

[Preoperative cardiac-risk assessment for non-cardiac surgery: The French RICARDO survey]. Ann Fr Anesth Reanim (2013) 1.39

The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia. Leukemia (2009) 1.38

A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia. Oncogene (2006) 1.37

Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia. Leukemia (2009) 1.33

A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene (2000) 1.30

Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS. Neurology (1989) 1.29

Idiopathic IgA mesangial nephropathy. Clinical and histological study of 374 patients. Medicine (Baltimore) (1985) 1.23

Distinction between coeliac disease and refractory sprue: a simple immunohistochemical method. Histopathology (2000) 1.22

Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem (2001) 1.19

The 213-amino-acid leucine-rich repeat region of the listeria monocytogenes InlB protein is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling. Mol Microbiol (1999) 1.18

Sequential chemotherapy by CHOP and DHAP regimens followed by high-dose therapy with stem cell transplantation induces a high rate of complete response and improves event-free survival in mantle cell lymphoma: a prospective study. Leukemia (2002) 1.18

The detection of monocytes in human glomerulonephritis. Kidney Int (1985) 1.17

Epidermal growth factor induces rapid and transient association of phospholipase C-gamma 1 with EGF-receptor and filamentous actin at membrane ruffles of A431 cells. J Cell Sci (1995) 1.17

Spontaneous hypoglycemia in patients with cystic fibrosis. Eur J Endocrinol (2007) 1.15

Prognostic indicators in idiopathic IgA mesangial nephropathy. Q J Med (1986) 1.15

Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation. J Biol Chem (1998) 1.15

Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. J Biol Chem (2000) 1.14

PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study. Leukemia (2009) 1.14

Flavonoids and the inhibition of PKC and PI 3-kinase. Gen Pharmacol (1999) 1.12

Body composition assessment in spinal cord injury subjects. Acta Diabetol (2003) 1.11

The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells. Oncogene (2007) 1.11

Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis. Ann Rheum Dis (2007) 1.10

Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells. Leukemia (2013) 1.10

Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets. J Biol Chem (1998) 1.10

Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome. J Thromb Haemost (2011) 1.08

Rituximab versus observation after high-dose consolidative first-line chemotherapy with autologous stem-cell transplantation in patients with poor-risk diffuse large B-cell lymphoma. Ann Oncol (2009) 1.07

Internalization of microparticles by endothelial cells promotes platelet/endothelial cell interaction under flow. J Thromb Haemost (2010) 1.06

An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid. J Biol Chem (1999) 1.05

A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets. Biochem J (1999) 1.05

Production of phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid in platelet rafts: evidence for a critical role of cholesterol-enriched domains in human platelet activation. Biochemistry (2001) 1.05

Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas. Oncogene (2007) 1.04

The Src SH3 domain is required for DNA synthesis induced by platelet-derived growth factor and epidermal growth factor. J Biol Chem (1996) 1.04

Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. Leukemia (1995) 1.04

The myristoyl moiety of myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein is embedded in the membrane. J Biol Chem (1995) 1.03

The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells. J Biol Chem (2001) 1.03

Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets. FEBS Lett (2001) 1.02

Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. Mol Psychiatry (2006) 1.01

Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes. Mol Cell Biol (2000) 1.01

A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse. Leukemia (2013) 1.01

Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization. Oncogene (2009) 1.01

The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene (2001) 1.00

Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets. J Biol Chem (1997) 1.00

Chromosomal abnormalities in couples undergoing intracytoplasmic sperm injection. A study of 370 couples and review of the literature. Int J Androl (2004) 1.00

Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: results of the GRAALL AFR09 study. Leukemia (2006) 0.99

A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation. J Thromb Haemost (2005) 0.99

A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J Cell Biol (2001) 0.98

G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells. FEBS Lett (1998) 0.97

Src family tyrosine kinase regulates intracellular pH in cardiomyocytes. J Cell Biol (1998) 0.97

Myristoylated alanine-rich C kinase substrate (MARCKS), a major protein kinase C substrate, is an in vivo substrate of proline-directed protein kinase(s). A mass spectroscopic analysis of the post-translational modifications. J Biol Chem (1994) 0.95

Differential expression of G1 cyclins and cyclin-dependent kinase inhibitors in normal and transformed melanocytes. Invest Ophthalmol Vis Sci (1998) 0.94

Thrombopoietin potentiates collagen receptor signaling in platelets through a phosphatidylinositol 3-kinase-dependent pathway. Blood (2000) 0.94

G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress. Oncogene (2008) 0.94

Differentiation of transitional zone prostate cancer from benign hyperplasia nodules: evaluation of discriminant criteria at multiparametric MRI. Clin Radiol (2013) 0.94