PubRank

William A Catterall

Author PubWeight™ 165.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The crystal structure of a voltage-gated sodium channel. Nature 2011 7.82
2 Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci 2006 5.02
3 IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Res 2008 3.76
4 Gating pore current in an inherited ion channelopathy. Nature 2007 3.41
5 Overview of the voltage-gated sodium channel family. Genome Biol 2003 3.10
6 The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis. Sci STKE 2004 3.09
7 The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol 2013 3.03
8 Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc Natl Acad Sci U S A 2006 2.81
9 Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. Nature 2012 2.78
10 Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev 2005 2.73
11 Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J Neurosci 2003 2.58
12 The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol 2013 2.48
13 An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A 2002 2.48
14 Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature 2012 2.46
15 Regulation of presynaptic Ca(V)2.1 channels by Ca2+ sensor proteins mediates short-term synaptic plasticity. Neuron 2008 2.30
16 Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci Signal 2010 2.25
17 Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation 2004 2.15
18 Overview of the Alliance for Cellular Signaling. Nature 2002 2.15
19 Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Proc Natl Acad Sci U S A 2003 2.09
20 A gating hinge in Na+ channels; a molecular switch for electrical signaling. Neuron 2004 2.08
21 Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci U S A 2008 2.02
22 Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block. J Biol Chem 2002 1.95
23 Ion permeation through a voltage- sensitive gating pore in brain sodium channels having voltage sensor mutations. Neuron 2005 1.95
24 The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy. Hum Mol Genet 2007 1.95
25 Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J Physiol 2006 1.92
26 Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 2004 1.92
27 Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. J Neurosci 2007 1.92
28 Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP. Nature 2005 1.89
29 An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc Natl Acad Sci U S A 2003 1.86
30 Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci 2002 1.86
31 Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy. Proc Natl Acad Sci U S A 2009 1.85
32 Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci U S A 2009 1.79
33 Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation. Proc Natl Acad Sci U S A 2006 1.73
34 An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol 2012 1.72
35 Sites of proteolytic processing and noncovalent association of the distal C-terminal domain of CaV1.1 channels in skeletal muscle. Proc Natl Acad Sci U S A 2005 1.68
36 Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc Natl Acad Sci U S A 2011 1.68
37 Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A 2012 1.65
38 Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels. Circ Res 2010 1.59
39 Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. J Biol Chem 2006 1.58
40 A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function. J Biol Chem 2001 1.57
41 Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis. Proc Natl Acad Sci U S A 2008 1.52
42 Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A 2002 1.52
43 Molecular determinants of Ca(2+)/calmodulin-dependent regulation of Ca(v)2.1 channels. Proc Natl Acad Sci U S A 2003 1.52
44 Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity. Neuron 2003 1.51
45 Functional properties and differential neuromodulation of Na(v)1.6 channels. Mol Cell Neurosci 2008 1.47
46 Sudden unexpected death in a mouse model of Dravet syndrome. J Clin Invest 2013 1.45
47 Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment. Proc Natl Acad Sci U S A 2004 1.44
48 Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proc Natl Acad Sci U S A 2011 1.40
49 Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C. Neuron 2006 1.38
50 Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II. Mol Pharmacol 2007 1.36
51 Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor. Proc Natl Acad Sci U S A 2011 1.36
52 Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain. Proc Natl Acad Sci U S A 2007 1.33
53 A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis 2009 1.32
54 The extracellular matrix molecule hyaluronic acid regulates hippocampal synaptic plasticity by modulating postsynaptic L-type Ca(2+) channels. Neuron 2010 1.31
55 Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2. J Neurosci 2005 1.30
56 Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle. Am J Physiol Heart Circ Physiol 2007 1.28
57 Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proc Natl Acad Sci U S A 2012 1.21
58 Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations. J Gen Physiol 2010 1.20
59 Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels. Proc Natl Acad Sci U S A 2003 1.17
60 Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo. J Biol Chem 2011 1.16
61 Molecular determinants for modulation of persistent sodium current by G-protein betagamma subunits. J Neurosci 2005 1.15
62 Differential regulation of CaV2.1 channels by calcium-binding protein 1 and visinin-like protein-2 requires N-terminal myristoylation. J Neurosci 2005 1.12
63 Insights into pathophysiology and therapy from a mouse model of Dravet syndrome. Epilepsia 2011 1.10
64 Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15. Mol Cell Neurosci 2002 1.10
65 Catalysis of Na+ permeation in the bacterial sodium channel Na(V)Ab. Proc Natl Acad Sci U S A 2013 1.09
66 Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice. J Clin Invest 2011 1.09
67 Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150. J Gen Physiol 2014 1.08
68 Convergent regulation of skeletal muscle Ca2+ channels by dystrophin, the actin cytoskeleton, and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 2005 1.07
69 Subtype-selective reconstitution of synaptic transmission in sympathetic ganglion neurons by expression of exogenous calcium channels. Proc Natl Acad Sci U S A 2003 1.05
70 Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels. J Biol Chem 2011 1.05
71 Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon. J Neurosci 2005 1.04
72 Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels. J Biol Chem 2011 1.00
73 Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels. J Biol Chem 2012 0.99
74 Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation. Proc Natl Acad Sci U S A 2012 0.98
75 Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response. Proc Natl Acad Sci U S A 2010 0.98
76 Sites and molecular mechanisms of modulation of Na(v)1.2 channels by Fyn tyrosine kinase. J Neurosci 2007 0.98
77 Cooperative regulation of Ca(v)1.2 channels by intracellular Mg(2+), the proximal C-terminal EF-hand, and the distal C-terminal domain. J Gen Physiol 2009 0.96
78 Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons. J Biol Chem 2011 0.95
79 Regulation of Na(v)1.2 channels by brain-derived neurotrophic factor, TrkB, and associated Fyn kinase. J Neurosci 2007 0.94
80 Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response. Proc Natl Acad Sci U S A 2013 0.93
81 Functional role of a C-terminal Gbetagamma-binding domain of Ca(v)2.2 channels. Mol Pharmacol 2004 0.92
82 Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins. J Biol Chem 2009 0.92
83 Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site. Mol Cell Neurosci 2005 0.92
84 Fine-tuning synaptic plasticity by modulation of Ca(V)2.1 channels with Ca2+ sensor proteins. Proc Natl Acad Sci U S A 2012 0.92
85 Protective effect of the ketogenic diet in Scn1a mutant mice. Epilepsia 2011 0.92
86 Modulation of CaV1.2 channels by Mg2+ acting at an EF-hand motif in the COOH-terminal domain. J Gen Physiol 2005 0.91
87 Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases. Circulation 2012 0.91
88 Regulation of cardiac ion channels by signaling complexes: role of modified leucine zipper motifs. J Mol Cell Cardiol 2004 0.91
89 A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb. J Gen Physiol 2013 0.89
90 Molecular determinants of CaV2.1 channel regulation by calcium-binding protein-1. J Biol Chem 2011 0.89
91 Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol 2015 0.88
92 Bidirectional modulation of transmitter release by calcium channel/syntaxin interactions in vivo. J Neurosci 2007 0.88
93 Distribution of high-voltage-activated calcium channels in cultured gamma-aminobutyric acidergic neurons from mouse cerebral cortex. J Neurosci Res 2002 0.87
94 Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry. J Mol Cell Cardiol 2013 0.86
95 Dopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15 and PKA by a modified leucine zipper motif. Proc Natl Acad Sci U S A 2007 0.86
96 Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation. Mol Cell Neurosci 2014 0.85
97 Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore. Mol Pharmacol 2006 0.85
98 Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol 2012 0.85
99 Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A 2012 0.84
100 Partial agonist and antagonist activities of a mutant scorpion beta-toxin on sodium channels. J Biol Chem 2010 0.83
101 Molecular determinants of modulation of CaV2.1 channels by visinin-like protein 2. J Biol Chem 2011 0.82
102 Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome. J Pharmacol Exp Ther 2013 0.82
103 Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels. J Biol Chem 2012 0.81
104 Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src. Cell Mol Life Sci 2013 0.81
105 PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes. J Cell Sci 2014 0.79
106 Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes. Cardiovasc Res 2013 0.79
107 Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse. Mol Cell Neurosci 2011 0.77