Published in Proc Natl Acad Sci U S A on March 25, 2005
Voltage-gated calcium channels. Cold Spring Harb Perspect Biol (2011) 3.36
The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor. Cell (2006) 2.86
Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev (2009) 2.53
Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci Signal (2010) 2.25
Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J Physiol (2006) 1.92
Age-related homeostatic midchannel proteolysis of neuronal L-type voltage-gated Ca²⁺ channels. Neuron (2014) 1.68
L-type calcium channel C terminus autoregulates transcription. Circ Res (2009) 1.38
Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels. J Biol Chem (2011) 1.37
Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain. Proc Natl Acad Sci U S A (2006) 1.37
Signaling complexes of voltage-gated sodium and calcium channels. Neurosci Lett (2010) 1.34
Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain. J Biol Chem (2008) 1.32
Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo. J Biol Chem (2011) 1.16
Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150. J Gen Physiol (2014) 1.08
L-type Ca(2+) channels in heart and brain. Wiley Interdiscip Rev Membr Transp Signal (2014) 1.06
Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response. Proc Natl Acad Sci U S A (2010) 0.98
Cooperative regulation of Ca(v)1.2 channels by intracellular Mg(2+), the proximal C-terminal EF-hand, and the distal C-terminal domain. J Gen Physiol (2009) 0.96
Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons. J Biol Chem (2011) 0.95
The carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells. Acta Neuropathol (2009) 0.95
β-adrenergic regulation of the L-type Ca2+ channel does not require phosphorylation of α1C Ser1700. Circ Res (2013) 0.93
Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response. Proc Natl Acad Sci U S A (2013) 0.93
The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium. Am J Physiol Heart Circ Physiol (2012) 0.92
Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth. J Biol Chem (2011) 0.91
Ca(V)1.1: The atypical prototypical voltage-gated Ca²⁺ channel. Biochim Biophys Acta (2012) 0.88
Ca2+-dependent transcriptional control of Ca2+ homeostasis. J Biol Chem (2012) 0.88
Multilayered regulation of cardiac ion channels. Biochim Biophys Acta (2012) 0.87
Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators. Nat Commun (2014) 0.87
Accessibility of targeted DHPR sites to streptavidin and functional effects of binding on EC coupling. J Gen Physiol (2007) 0.87
Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700. Proc Natl Acad Sci U S A (2014) 0.87
Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis. Protein Sci (2012) 0.86
Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol (2012) 0.85
Sequence differences in the IQ motifs of CaV1.1 and CaV1.2 strongly impact calmodulin binding and calcium-dependent inactivation. J Biol Chem (2008) 0.84
Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A (2012) 0.84
A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT. PLoS One (2013) 0.84
Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel. J Biol Chem (2010) 0.83
Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem (2014) 0.82
L-type calcium channel auto-regulation of transcription. Cell Calcium (2011) 0.81
Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain. Front Cell Neurosci (2015) 0.81
Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization. Cell Commun Adhes (2014) 0.80
A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function. J Biol Chem (2015) 0.79
Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response. Curr Mol Pharmacol (2015) 0.79
Distal C terminus of CaV1.2 channels plays a crucial role in the neural differentiation of dental pulp stem cells. PLoS One (2013) 0.79
Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2. Biochim Biophys Acta (2014) 0.77
The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart. J Biol Chem (2014) 0.76
Apparent lack of physical or functional interaction between CaV1.1 and its distal C terminus. J Gen Physiol (2015) 0.76
Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure. Proc Natl Acad Sci U S A (2016) 0.76
Phosphorylation sites in the Hook domain of CaVβ subunits differentially modulate CaV1.2 channel function. J Mol Cell Cardiol (2015) 0.76
Regulation of voltage-gated calcium channels by proteolysis. Sheng Li Xue Bao (2012) 0.76
Cooperative and acute inhibitionby multiple C-terminal motifs of L-type Ca(2+) channels. Elife (2017) 0.75
3D Structure of the Dihydropyridine Receptor of Skeletal Muscle. Eur J Transl Myol (2015) 0.75
Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit. J Physiol (2017) 0.75
Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor α1S Subunit Reveals Conformational Differences Induced by Binding of the β1a Subunit. J Biol Chem (2016) 0.75
Cannabinoid signalling inhibits sarcoplasmic Ca(2+) release and regulates excitation-contraction coupling in mammalian skeletal muscle. J Physiol (2016) 0.75
Voltage sensor of excitation-contraction coupling in skeletal muscle. Physiol Rev (1991) 4.66
Probability-based evaluation of peptide and protein identifications from tandem mass spectrometry and SEQUEST analysis: the human proteome. J Proteome Res (2005) 4.13
Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. Science (1988) 3.38
Dihydropyridine receptors in muscle are voltage-dependent but most are not functional calcium channels. Nature (1985) 2.65
Packed capillary reversed-phase liquid chromatography with high-performance electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for proteomics. Anal Chem (2001) 2.39
Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules. Biochemistry (1984) 2.36
Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3',5'-cyclic monophosphate-dependent protein kinase. Biochemistry (1996) 2.24
On the sequential determinants of calpain cleavage. J Biol Chem (2004) 2.13
Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Proc Natl Acad Sci U S A (2003) 2.09
Voltage-dependent potentiation of L-type Ca2+ channels due to phosphorylation by cAMP-dependent protein kinase. Nature (1993) 2.06
Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit. J Biol Chem (1994) 1.85
Subunits of purified calcium channels: a 212-kDa form of alpha 1 and partial amino acid sequence of a phosphorylation site of an independent beta subunit. Proc Natl Acad Sci U S A (1989) 1.74
Characterization of the two size forms of the alpha 1 subunit of skeletal muscle L-type calcium channels. Proc Natl Acad Sci U S A (1991) 1.70
N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons. Proc Natl Acad Sci U S A (1996) 1.62
C-terminal fragments of the alpha 1C (CaV1.2) subunit associate with and regulate L-type calcium channels containing C-terminal-truncated alpha 1C subunits. J Biol Chem (2001) 1.59
Calmodulin-binding proteins as calpain substrates. Biochem J (1989) 1.58
A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function. J Biol Chem (2001) 1.57
Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel alpha 1 subunit. J Biol Chem (1993) 1.53
Primary structure and function of an A kinase anchoring protein associated with calcium channels. Neuron (1998) 1.51
Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1994) 1.48
Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes. J Biol Chem (1997) 1.39
Excitation-contraction coupling in vertebrate skeletal muscle: a tale of two calcium channels. Cell (1991) 1.39
Modulation of calcium channels of twitch skeletal muscle fibres of the frog by adrenaline and cyclic adenosine monophosphate. J Physiol (1987) 1.27
Modulation of the cloned skeletal muscle L-type Ca2+ channel by anchored cAMP-dependent protein kinase. J Neurosci (1997) 1.23
Cyclic AMP-dependent phosphorylation of two size forms of alpha 1 subunits of L-type calcium channels in rat skeletal muscle cells. J Biol Chem (1990) 1.16
Relation between isometric force and stimulus rate in cat's hindlimb motor units of different twitch contraction time. Exp Brain Res (1983) 1.13
Convergent regulation of skeletal muscle Ca2+ channels by dystrophin, the actin cytoskeleton, and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (2005) 1.07
Differential proteolysis of the full-length form of the L-type calcium channel alpha 1 subunit by calpain. J Neurochem (1994) 1.07
Muscular dysgenesis in mice: a model system for studying excitation-contraction coupling. FASEB J (1990) 1.05
Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different. J Biol Chem (1988) 1.01
Excessive repolarization-dependent calcium currents induced by strong depolarizations in rat skeletal myoballs. J Physiol (1995) 1.00
Identification of two distinct proteins that are immunologically related to the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel. J Biol Chem (1992) 0.93
The bovine cardiac receptor for calcium channel blockers is a 195-kDa protein. Eur J Biochem (1988) 0.93
COOH-terminal truncated alpha(1S) subunits conduct current better than full-length dihydropyridine receptors. J Gen Physiol (2000) 0.88
Purification and reconstitution of skeletal muscle calcium channels. Methods Enzymol (1992) 0.85
The crystal structure of a voltage-gated sodium channel. Nature (2011) 7.82
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci (2006) 5.02
Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol (2004) 4.30
Probability-based evaluation of peptide and protein identifications from tandem mass spectrometry and SEQUEST analysis: the human proteome. J Proteome Res (2005) 4.13
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Res (2008) 3.76
DAnTE: a statistical tool for quantitative analysis of -omics data. Bioinformatics (2008) 3.51
Gating pore current in an inherited ion channelopathy. Nature (2007) 3.41
Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23
Overview of the voltage-gated sodium channel family. Genome Biol (2003) 3.10
The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis. Sci STKE (2004) 3.09
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc Natl Acad Sci U S A (2006) 2.81
Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. Nature (2012) 2.78
Voltage-gated ion channels and gating modifier toxins. Toxicon (2006) 2.77
Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev (2005) 2.73
Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J Neurosci (2003) 2.58
Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics (2005) 2.50
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A (2002) 2.48
Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog (2010) 2.48
Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature (2012) 2.46
Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. Proteomics (2011) 2.44
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res (2005) 2.35
Integrative analysis of the mitochondrial proteome in yeast. PLoS Biol (2004) 2.31
Regulation of presynaptic Ca(V)2.1 channels by Ca2+ sensor proteins mediates short-term synaptic plasticity. Neuron (2008) 2.30
High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics (2006) 2.25
Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci Signal (2010) 2.25
Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation (2004) 2.15
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Advances and challenges in liquid chromatography-mass spectrometry-based proteomics profiling for clinical applications. Mol Cell Proteomics (2006) 2.14
Evaluation of multiprotein immunoaffinity subtraction for plasma proteomics and candidate biomarker discovery using mass spectrometry. Mol Cell Proteomics (2006) 2.11
Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Proc Natl Acad Sci U S A (2003) 2.09
A gating hinge in Na+ channels; a molecular switch for electrical signaling. Neuron (2004) 2.08
Enhanced detection of low abundance human plasma proteins using a tandem IgY12-SuperMix immunoaffinity separation strategy. Mol Cell Proteomics (2008) 2.08
Development and evaluation of a micro- and nanoscale proteomic sample preparation method. J Proteome Res (2005) 2.06
Clinical microfluidics for neutrophil genomics and proteomics. Nat Med (2010) 2.02
Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci U S A (2008) 2.02
Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome. Anal Chem (2004) 2.00
High-throughput comparative proteome analysis using a quantitative cysteinyl-peptide enrichment technology. Anal Chem (2004) 1.99
Head-to-head comparison of serum fractionation techniques. J Proteome Res (2007) 1.98
Utilizing human blood plasma for proteomic biomarker discovery. J Proteome Res (2005) 1.96
Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block. J Biol Chem (2002) 1.95
Ion permeation through a voltage- sensitive gating pore in brain sodium channels having voltage sensor mutations. Neuron (2005) 1.95
The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy. Hum Mol Genet (2007) 1.95
Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry. Proteomics (2005) 1.94
High throughput quantitative analysis of serum proteins using glycopeptide capture and liquid chromatography mass spectrometry. Mol Cell Proteomics (2004) 1.94
Characterization of the mouse brain proteome using global proteomic analysis complemented with cysteinyl-peptide enrichment. J Proteome Res (2006) 1.93
Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J Physiol (2006) 1.92
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci (2004) 1.92
Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. J Neurosci (2007) 1.92
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP. Nature (2005) 1.89
An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc Natl Acad Sci U S A (2003) 1.86
Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci (2002) 1.86
Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy. Proc Natl Acad Sci U S A (2009) 1.85
Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation. Hepatology (2012) 1.82
Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci U S A (2009) 1.79
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75
Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation. Proc Natl Acad Sci U S A (2006) 1.73
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol (2012) 1.72
Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc Natl Acad Sci U S A (2011) 1.68
Ultrasensitive proteomics using high-efficiency on-line micro-SPE-nanoLC-nanoESI MS and MS/MS. Anal Chem (2004) 1.66
Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A (2012) 1.65
Improved peptide elution time prediction for reversed-phase liquid chromatography-MS by incorporating peptide sequence information. Anal Chem (2006) 1.59
Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels. Circ Res (2010) 1.59
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. J Biol Chem (2006) 1.58
A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function. J Biol Chem (2001) 1.57
Application of peptide LC retention time information in a discriminant function for peptide identification by tandem mass spectrometry. J Proteome Res (2004) 1.56
Establishing the proteome of normal human cerebrospinal fluid. PLoS One (2010) 1.53
Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serum. Proc Natl Acad Sci U S A (2012) 1.52
Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis. Proc Natl Acad Sci U S A (2008) 1.52
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A (2002) 1.52
Molecular determinants of Ca(2+)/calmodulin-dependent regulation of Ca(v)2.1 channels. Proc Natl Acad Sci U S A (2003) 1.52
Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity. Neuron (2003) 1.51
Functional properties and differential neuromodulation of Na(v)1.6 channels. Mol Cell Neurosci (2008) 1.47
Spatial mapping of protein abundances in the mouse brain by voxelation integrated with high-throughput liquid chromatography-mass spectrometry. Genome Res (2007) 1.46
Sudden unexpected death in a mouse model of Dravet syndrome. J Clin Invest (2013) 1.45
Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment. Proc Natl Acad Sci U S A (2004) 1.44
Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A (2007) 1.40
Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proc Natl Acad Sci U S A (2011) 1.40
Sensitive immunoassays of nitrated fibrinogen in human biofluids. Talanta (2010) 1.40
Phosphoprotein isotope-coded solid-phase tag approach for enrichment and quantitative analysis of phosphopeptides from complex mixtures. Anal Chem (2003) 1.39
Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C. Neuron (2006) 1.38
Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II. Mol Pharmacol (2007) 1.36
Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor. Proc Natl Acad Sci U S A (2011) 1.36
High-pH reversed-phase chromatography with fraction concatenation for 2D proteomic analysis. Expert Rev Proteomics (2012) 1.35
Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33
Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain. Proc Natl Acad Sci U S A (2007) 1.33
Improved proteome coverage by using high efficiency cysteinyl peptide enrichment: the human mammary epithelial cell proteome. Proteomics (2005) 1.33