Published in Mol Biol Cell on August 23, 2012
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature (2015) 1.23
Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria. Mol Biol Cell (2013) 1.04
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci U S A (2013) 0.98
The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins. Mol Cell Biol (2013) 0.95
Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells. Mol Biol Cell (2013) 0.93
Retro-translocation of mitochondrial intermembrane space proteins. Proc Natl Acad Sci U S A (2015) 0.88
The mitochondrial disulfide relay system: roles in oxidative protein folding and beyond. Int J Cell Biol (2013) 0.88
Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space. Mol Biol Cell (2014) 0.87
The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly. Sci Rep (2016) 0.84
Role of membrane contact sites in protein import into mitochondria. Protein Sci (2015) 0.84
A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Mol Biol Cell (2014) 0.81
Mitochondrial translocation of APE1 relies on the MIA pathway. Nucleic Acids Res (2015) 0.80
How lipids modulate mitochondrial protein import. J Bioenerg Biomembr (2016) 0.79
Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System. J Biol Chem (2015) 0.78
Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway. J Biol Chem (2015) 0.78
The MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis. Acc Chem Res (2015) 0.77
The Oxidation Status of Mic19 Regulates MICOS Assembly. Mol Cell Biol (2015) 0.76
Enzymatic improvement of mitochondrial thiol oxidase Erv1 for oxidized glutathione fermentation by Saccharomyces cerevisiae. Microb Cell Fact (2017) 0.75
Oxidative folding in the mitochondrial intermembrane space in human health and disease. Int J Mol Sci (2013) 0.75
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
Translocation of proteins into mitochondria. Annu Rev Biochem (2007) 7.53
Importing mitochondrial proteins: machineries and mechanisms. Cell (2009) 5.46
A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Cell (2005) 4.41
Evolution of the molecular machines for protein import into mitochondria. Science (2006) 3.03
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell (2011) 2.52
Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Mol Cell (2006) 2.46
Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J (2004) 2.43
Disulfide formation in the ER and mitochondria: two solutions to a common process. Science (2009) 1.97
Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding. Structure (2005) 1.81
Systematic analysis of the twin cx(9)c protein family. J Mol Biol (2009) 1.75
Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space. J Biol Chem (2004) 1.69
MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria. Nat Struct Mol Biol (2009) 1.60
Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions. FEBS Lett (2005) 1.59
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. J Mol Biol (2006) 1.53
Multiple ways to make disulfides. Trends Biochem Sci (2011) 1.52
Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria. Mol Biol Cell (2009) 1.41
Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione. Mol Cell (2010) 1.38
Functional characterization of Mia40p, the central component of the disulfide relay system of the mitochondrial intermembrane space. J Biol Chem (2007) 1.35
How proteins form disulfide bonds. Antioxid Redox Signal (2011) 1.35
The small Tim proteins and the twin Cx3C motif. Trends Biochem Sci (2004) 1.34
Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase. J Cell Biol (2008) 1.28
The Erv1-Mia40 disulfide relay system in the intermembrane space of mitochondria. Biochim Biophys Acta (2007) 1.27
A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding. J Cell Biol (2009) 1.26
Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Mol Biol Cell (1999) 1.25
Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10. J Biol Chem (2006) 1.24
Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J Cell Biol (2007) 1.22
Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space. Mol Biol Cell (2007) 1.22
Oxidative protein folding in the mitochondrial intermembrane space. Antioxid Redox Signal (2010) 1.19
Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import. Proc Natl Acad Sci U S A (2010) 1.16
Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. Proc Natl Acad Sci U S A (2011) 1.14
Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria. J Biol Chem (2008) 1.13
Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space. Proc Natl Acad Sci U S A (2009) 1.12
Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space. Biochemistry (2009) 1.12
Import of small Tim proteins into the mitochondrial intermembrane space. EMBO J (2003) 1.12
Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins. Mol Biol Cell (2009) 1.05
The MIA system for protein import into the mitochondrial intermembrane space. Biochim Biophys Acta (2007) 1.05
Disulfide bond formation network in the three biological kingdoms, bacteria, fungi and mammals. FEBS J (2012) 1.01
Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40. J Biol Chem (2008) 1.01
Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. Mol Biol Cell (2008) 0.95
Function and redox state of mitochondrial localized cysteine-rich proteins important in the assembly of cytochrome c oxidase. Biochim Biophys Acta (2007) 0.94
Importing mitochondrial proteins: machineries and mechanisms. Cell (2009) 5.46
Function of mitochondrial Stat3 in cellular respiration. Science (2009) 5.13
The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A (2003) 5.13
Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature (2003) 3.46
Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell (2008) 2.97
L23 protein functions as a chaperone docking site on the ribosome. Nature (2002) 2.68
An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J Biol Chem (2003) 2.59
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell (2011) 2.52
Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell (2005) 2.49
Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J (2004) 2.43
Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem (2009) 2.11
Isolation of yeast mitochondria. Methods Mol Biol (2006) 2.09
The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell (2004) 1.98
The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell (2002) 1.95
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet (2012) 1.94
Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J (2005) 1.92
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J (2011) 1.89
Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science (2003) 1.89
Trigger Factor and DnaK possess overlapping substrate pools and binding specificities. Mol Microbiol (2003) 1.77
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell (2006) 1.75
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol (2003) 1.71
Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat Cell Biol (2007) 1.64
Pam16 has an essential role in the mitochondrial protein import motor. Nat Struct Mol Biol (2004) 1.63
The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J (2007) 1.58
Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway. J Biol Chem (2004) 1.55
Tim50 maintains the permeability barrier of the mitochondrial inner membrane. Science (2006) 1.55
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. J Mol Biol (2006) 1.53
Impaired folding of the mitochondrial small TIM chaperones induces clearance by the i-AAA protease. J Mol Biol (2012) 1.51
Regulation of mitochondrial protein import by cytosolic kinases. Cell (2011) 1.42
Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria. Mol Biol Cell (2009) 1.41
The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins. J Mol Biol (2005) 1.40
Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. J Biol Chem (2004) 1.37
Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol Cell Biol (2005) 1.34
Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol (2014) 1.34
The presequence translocase-associated protein import motor of mitochondria. Pam16 functions in an antagonistic manner to Pam18. J Biol Chem (2004) 1.34
The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J Cell Biol (2008) 1.32
A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria. Curr Biol (2006) 1.32
Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase. J Cell Biol (2008) 1.28
Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40. J Biol Chem (2007) 1.27
Cooperation of translocase complexes in mitochondrial protein import. J Cell Biol (2007) 1.26
Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10. J Biol Chem (2006) 1.24
Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. J Biol Chem (2002) 1.23
Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J Cell Biol (2007) 1.22
Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space. Mol Biol Cell (2007) 1.22
Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J (2003) 1.21
Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex. Mol Cell Biol (2002) 1.19
Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol (2006) 1.19
Composition and topology of the endoplasmic reticulum-mitochondria encounter structure. J Mol Biol (2011) 1.17
The MIA pathway: a tight bond between protein transport and oxidative folding in mitochondria. Biochim Biophys Acta (2012) 1.17
Inactivation of the mitochondrial heat shock protein zim17 leads to aggregation of matrix hsp70s followed by pleiotropic effects on morphology and protein biogenesis. J Mol Biol (2005) 1.16
Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J Biol Chem (2007) 1.15
Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli. EMBO J (2009) 1.14
Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space. Mol Cell Biol (2003) 1.14
Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol Cell (2011) 1.14
Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell (2013) 1.11
Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel. Mol Cell (2002) 1.11
Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol Cell Biol (2010) 1.11
Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS. EMBO Rep (2009) 1.10
Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics (2012) 1.09