Published in EMBO J on September 09, 2004
Importing mitochondrial proteins: machineries and mechanisms. Cell (2009) 5.46
Mitochondrial protein import: from proteomics to functional mechanisms. Nat Rev Mol Cell Biol (2010) 2.87
Copper metallochaperones. Annu Rev Biochem (2010) 2.27
Multiple pathways for sorting mitochondrial precursor proteins. EMBO Rep (2008) 2.19
Dynamic subcompartmentalization of the mitochondrial inner membrane. J Cell Biol (2006) 1.98
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell (2006) 1.75
The disulfide relay system of mitochondria is connected to the respiratory chain. J Cell Biol (2007) 1.66
MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria. Nat Struct Mol Biol (2009) 1.60
The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J (2007) 1.58
Catch me if you can! Oxidative protein trapping in the intermembrane space of mitochondria. J Cell Biol (2007) 1.44
A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1. EMBO J (2007) 1.41
Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria. Mol Biol Cell (2009) 1.41
The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis. Mitochondrion (2011) 1.40
Origin of mitochondria by intracellular enslavement of a photosynthetic purple bacterium. Proc Biol Sci (2006) 1.31
Mitochondria-associated yeast mRNAs and the biogenesis of molecular complexes. Mol Biol Cell (2006) 1.28
Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase. J Cell Biol (2008) 1.28
Cooperation of translocase complexes in mitochondrial protein import. J Cell Biol (2007) 1.26
A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding. J Cell Biol (2009) 1.26
Mitochondrial disulfide relay: redox-regulated protein import into the intermembrane space. J Biol Chem (2011) 1.24
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature (2015) 1.23
Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space. Mol Biol Cell (2007) 1.22
Mitochondrial protein synthesis, import, and assembly. Genetics (2012) 1.17
The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency. Am J Hum Genet (2009) 1.16
Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import. Proc Natl Acad Sci U S A (2010) 1.16
Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. Proc Natl Acad Sci U S A (2011) 1.14
Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state. EMBO J (2012) 1.14
The iron-sulfur cluster assembly machineries in plants: current knowledge and open questions. Front Plant Sci (2013) 1.13
Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space. Biochemistry (2009) 1.12
Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space. Proc Natl Acad Sci U S A (2009) 1.12
Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics (2012) 1.09
The basal flux of Akt in the mitochondria is mediated by heat shock protein 90. J Neurochem (2009) 1.06
The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40. EMBO Rep (2008) 1.06
Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins. Mol Biol Cell (2009) 1.05
Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria. Mol Biol Cell (2013) 1.04
Redox regulation of protein folding in the mitochondrial intermembrane space. Biochim Biophys Acta (2008) 1.04
Mitochondrial protein import and human health and disease. Biochim Biophys Acta (2006) 1.04
Mitochondrial copper metabolism and delivery to cytochrome c oxidase. IUBMB Life (2008) 1.02
In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins. Mol Biol Cell (2012) 1.02
Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40. J Biol Chem (2008) 1.01
Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria. EMBO J (2012) 0.97
Oxidative switches in functioning of mammalian copper chaperone Cox17. Biochem J (2007) 0.97
Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane. Mol Biol Cell (2012) 0.96
Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. Mol Biol Cell (2008) 0.95
The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins. Mol Cell Biol (2013) 0.95
A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy. Am J Hum Genet (2011) 0.95
Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. J Clin Invest (2012) 0.94
Function and redox state of mitochondrial localized cysteine-rich proteins important in the assembly of cytochrome c oxidase. Biochim Biophys Acta (2007) 0.94
Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes. J Biol Chem (2010) 0.93
Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells. Mol Biol Cell (2013) 0.93
Zinc can play chaperone-like and inhibitor roles during import of mitochondrial small Tim proteins. J Biol Chem (2008) 0.92
A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell (2013) 0.91
Mechanisms of protein sorting in mitochondria. Cold Spring Harb Perspect Biol (2012) 0.91
Loss of apoptosis-inducing factor critically affects MIA40 function. Cell Death Dis (2015) 0.90
Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system. Mol Biol Cell (2011) 0.90
DMR1 (CCM1/YGR150C) of Saccharomyces cerevisiae encodes an RNA-binding protein from the pentatricopeptide repeat family required for the maintenance of the mitochondrial 15S ribosomal RNA. Genetics (2010) 0.89
The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases. Mol Cell Biol (2008) 0.89
Retro-translocation of mitochondrial intermembrane space proteins. Proc Natl Acad Sci U S A (2015) 0.88
CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation. Cell Death Differ (2014) 0.87
Acquisition, conservation, and loss of dual-targeted proteins in land plants. Plant Physiol (2012) 0.85
Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae. Eukaryot Cell (2008) 0.85
Role of membrane contact sites in protein import into mitochondria. Protein Sci (2015) 0.84
Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase. EMBO Rep (2008) 0.84
Mitochondrial protein quality control in health and disease. Br J Pharmacol (2014) 0.84
Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Antioxid Redox Signal (2013) 0.84
Structure of yeast sulfhydryl oxidase erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space. J Biol Chem (2012) 0.84
The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly. Sci Rep (2016) 0.84
Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1. J Biol Chem (2012) 0.83
Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase. Mol Biol Cell (2015) 0.83
The essential function of Tim12 in vivo is ensured by the assembly interactions of its C-terminal domain. J Biol Chem (2008) 0.82
Oxidative protein-folding systems in plant cells. Int J Cell Biol (2013) 0.82
Revisiting trends on mitochondrial mega-channels for the import of proteins and nucleic acids. J Bioenerg Biomembr (2016) 0.82
A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Mol Biol Cell (2014) 0.81
Folding and biogenesis of mitochondrial small Tim proteins. Int J Mol Sci (2013) 0.81
A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import. J Cell Biol (2016) 0.81
Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding. Elife (2016) 0.81
Redox and reactive oxygen species regulation of mitochondrial cytochrome C oxidase biogenesis. Antioxid Redox Signal (2012) 0.80
Human augmenter of liver regeneration: probing the catalytic mechanism of a flavin-dependent sulfhydryl oxidase. Biochemistry (2013) 0.80
Redox-regulation of protein import into chloroplasts and mitochondria: similarities and differences. Plant Signal Behav (2010) 0.80
Mitochondrial translocation of APE1 relies on the MIA pathway. Nucleic Acids Res (2015) 0.80
Mitochondria, cholesterol and cancer cell metabolism. Clin Transl Med (2016) 0.80
The power of yeast to model diseases of the powerhouse of the cell. Front Biosci (Landmark Ed) (2013) 0.80
Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins. J Biol Chem (2015) 0.79
Viral product trafficking to mitochondria, mechanisms and roles in pathogenesis. Infect Disord Drug Targets (2012) 0.79
Cellular disulfide bond formation in bioactive peptides and proteins. Int J Mol Sci (2015) 0.78
Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System. J Biol Chem (2015) 0.78
Protein oxidation in the intermembrane space of mitochondria is substrate-specific rather than general. Microb Cell (2014) 0.78
NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy. Cell Death Differ (2016) 0.78
Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway. J Biol Chem (2015) 0.78
Charting organellar importomes by quantitative mass spectrometry. Nat Commun (2017) 0.78
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol (2017) 0.77
Labile Low-Molecular-Mass Metal Complexes in Mitochondria: Trials and Tribulations of a Burgeoning Field. Biochemistry (2016) 0.77
Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1. Biosci Rep (2015) 0.77
The MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis. Acc Chem Res (2015) 0.77
Oxidative folding in the mitochondrial intermembrane space: A regulated process important for cell physiology and disease. Biochim Biophys Acta (2016) 0.77
The mitochondrial intermembrane space oxireductase Mia40 funnels the oxidative folding pathway of the cytochrome c oxidase assembly protein Cox19. J Biol Chem (2014) 0.77
Mia40 is a facile oxidant of unfolded reduced proteins but shows minimal isomerase activity. Arch Biochem Biophys (2015) 0.76
The Oxidation Status of Mic19 Regulates MICOS Assembly. Mol Cell Biol (2015) 0.76
The Import of Proteins into the Mitochondrion of Toxoplasma gondii. J Biol Chem (2016) 0.76
Oxidative folding in the mitochondrial intermembrane space in human health and disease. Int J Mol Sci (2013) 0.75
Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk. Biochim Biophys Acta (2016) 0.75
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature (2003) 29.16
The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A (2003) 5.13
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell (2003) 4.46
Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature (2003) 3.46
Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism. Cell (1992) 3.42
The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria. J Cell Biol (2003) 3.11
Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Nature (2003) 2.98
Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors. Cell (1987) 2.61
An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J Biol Chem (2003) 2.59
The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44. EMBO J (1997) 2.28
Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science (1998) 2.27
Assaying protein import into mitochondria. Methods Cell Biol (2001) 2.04
Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature (1996) 2.03
The protein import machinery of mitochondria. J Biol Chem (2004) 2.02
Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc Natl Acad Sci U S A (1998) 2.01
The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell (2002) 1.95
Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles. J Cell Sci (2003) 1.90
Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science (2003) 1.89
Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria. J Biol Chem (2003) 1.83
Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5. Nature (1998) 1.81
The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane. J Cell Biol (1997) 1.80
Mechanisms of protein import into mitochondria. Curr Biol (2003) 1.76
Pam16 has an essential role in the mitochondrial protein import motor. Nat Struct Mol Biol (2004) 1.63
The J domain-related cochaperone Tim16 is a constituent of the mitochondrial TIM23 preprotein translocase. Nat Struct Mol Biol (2004) 1.61
The Tim8-Tim13 complex of Neurospora crassa functions in the assembly of proteins into both mitochondrial membranes. J Biol Chem (2004) 1.61
Protein transport into mitochondria. Curr Opin Microbiol (2000) 1.59
Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway. J Biol Chem (2004) 1.55
The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier. EMBO J (2002) 1.55
Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins. EMBO J (1998) 1.55
Redox switch of hsp33 has a novel zinc-binding motif. J Biol Chem (2000) 1.53
A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Proc Natl Acad Sci U S A (2001) 1.45
Purification, characterization, and localization of yeast Cox17p, a mitochondrial copper shuttle. J Biol Chem (1997) 1.44
Opening the door to mitochondrial protein import. Nat Struct Biol (2001) 1.41
The small Tim proteins and the twin Cx3C motif. Trends Biochem Sci (2004) 1.34
Tim9, a new component of the TIM22.54 translocase in mitochondria. EMBO J (1999) 1.34
Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Mol Cell Biol (1991) 1.33
The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol (2002) 1.33
Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments. Cell (1994) 1.32
Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. Hum Mol Genet (2002) 1.31
Characterization of COX19, a widely distributed gene required for expression of mitochondrial cytochrome oxidase. J Biol Chem (2002) 1.24
Characterization of the preprotein translocase of the outer mitochondrial membrane by blue native electrophoresis. Biol Chem (1997) 1.23
Functional TIM10 chaperone assembly is redox-regulated in vivo. J Biol Chem (2004) 1.22
Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex. Mol Cell Biol (2002) 1.19
Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria. J Cell Biol (2000) 1.17
Import of small Tim proteins into the mitochondrial intermembrane space. EMBO J (2003) 1.12
A mutant of Neurospora crassa deficient in cytochrome c heme lyase activity cannot import cytochrome c into mitochondria. J Biol Chem (1988) 1.07
Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane. EMBO J (2001) 1.05
Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. J Biol Chem (2003) 1.01
Copper chloride, an inhibitor of protein import into chloroplasts. FEBS Lett (1995) 0.99
Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex. EMBO J (2001) 0.93
The structural basis of the TIM10 chaperone assembly. J Biol Chem (2004) 0.92
Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery. J Mol Biol (2003) 0.89
Importing mitochondrial proteins: machineries and mechanisms. Cell (2009) 5.46
The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A (2003) 5.13
Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature (2003) 3.46
Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell (2008) 2.97
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res (2006) 2.92
Mitochondrial protein import: from proteomics to functional mechanisms. Nat Rev Mol Cell Biol (2010) 2.87
Mitochondrial import and the twin-pore translocase. Nat Rev Mol Cell Biol (2004) 2.78
L23 protein functions as a chaperone docking site on the ribosome. Nature (2002) 2.68
An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J Biol Chem (2003) 2.59
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell (2011) 2.52
Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell (2005) 2.49
Multiple pathways for sorting mitochondrial precursor proteins. EMBO Rep (2008) 2.19
Isolation of yeast mitochondria. Methods Mol Biol (2006) 2.09
The protein import machinery of mitochondria. J Biol Chem (2004) 2.02
Assembling the mitochondrial outer membrane. Nat Struct Mol Biol (2004) 2.00
Mitochondrial preprotein translocase of trypanosomatids has a bacterial origin. Curr Biol (2011) 1.98
The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell (2004) 1.98
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell (2009) 1.96
The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell (2002) 1.95
Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J (2005) 1.92
Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science (2003) 1.89
Trigger Factor and DnaK possess overlapping substrate pools and binding specificities. Mol Microbiol (2003) 1.77
Mechanisms of protein import into mitochondria. Curr Biol (2003) 1.76
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell (2006) 1.75
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol (2003) 1.71
Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat Cell Biol (2007) 1.64
Pam16 has an essential role in the mitochondrial protein import motor. Nat Struct Mol Biol (2004) 1.63
Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr Biol (2009) 1.62
Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains. J Mol Biol (2012) 1.61
The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J (2007) 1.58
Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway. J Biol Chem (2004) 1.55
Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome. Mol Biol Cell (2005) 1.55
Tim50 maintains the permeability barrier of the mitochondrial inner membrane. Science (2006) 1.55
Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. J Mol Biol (2006) 1.53
Impaired folding of the mitochondrial small TIM chaperones induces clearance by the i-AAA protease. J Mol Biol (2012) 1.51
Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. Cell Metab (2012) 1.48
Insertion of hydrophobic membrane proteins into the inner mitochondrial membrane--a guided tour. J Mol Biol (2003) 1.43
A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis. EMBO J (2011) 1.42
Regulation of mitochondrial protein import by cytosolic kinases. Cell (2011) 1.42
Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria. Mol Biol Cell (2009) 1.41
The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins. J Mol Biol (2005) 1.40
Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. J Biol Chem (2004) 1.37