Published in Cell on November 15, 2002
Mitochondrial protein import: from proteomics to functional mechanisms. Nat Rev Mol Cell Biol (2010) 2.87
Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J (2004) 2.43
Multiple pathways for sorting mitochondrial precursor proteins. EMBO Rep (2008) 2.19
Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J (2003) 1.84
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol (2003) 1.71
Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J Cell Biol (2009) 1.55
Tim50, a novel component of the TIM23 preprotein translocase of mitochondria. EMBO J (2003) 1.46
Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import. J Cell Biol (2009) 1.42
MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Mol Biol Cell (2011) 1.37
Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain. J Cell Biol (2007) 1.36
Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. EMBO J (2008) 1.34
Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol Cell Biol (2005) 1.34
A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction. Plant Physiol (2004) 1.27
Cooperation of translocase complexes in mitochondrial protein import. J Cell Biol (2007) 1.26
Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J (2003) 1.21
Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol (2006) 1.19
Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space. Mol Cell Biol (2003) 1.14
Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria. Mol Biol Cell (2009) 1.14
Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol Cell Biol (2010) 1.11
Suppression of a defect in mitochondrial protein import identifies cytosolic proteins required for viability of yeast cells lacking mitochondrial DNA. Genetics (2003) 1.10
Quaternary structure of the mitochondrial TIM23 complex reveals dynamic association between Tim23p and other subunits. Mol Biol Cell (2007) 1.08
Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase. Mol Biol Cell (2008) 1.04
Mitochondrial protein import and human health and disease. Biochim Biophys Acta (2006) 1.04
The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import. Mol Biol Cell (2006) 1.03
Residues of Tim44 involved in both association with the translocon of the inner mitochondrial membrane and regulation of mitochondrial Hsp70 tethering. Mol Cell Biol (2008) 1.00
Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation. Cell Metab (2013) 1.00
Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex. J Cell Biol (2011) 0.97
Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet (2010) 0.96
Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes. Front Genet (2015) 0.95
In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work. Proc Natl Acad Sci U S A (2011) 0.94
Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes. J Biol Chem (2010) 0.93
Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force. Nat Struct Mol Biol (2013) 0.91
Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes. J Cell Biol (2012) 0.91
HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis. BMC Cell Biol (2007) 0.90
Involvement of the mitochondrial protein translocator component tim50 in growth, cell proliferation and the modulation of respiration in Drosophila. Genetics (2007) 0.90
The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases. Mol Cell Biol (2008) 0.89
Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell (2010) 0.89
Structural basis for the function of Tim50 in the mitochondrial presequence translocase. J Mol Biol (2011) 0.87
Direct interaction of mitochondrial targeting presequences with purified components of the TIM23 protein complex. J Biol Chem (2011) 0.87
Signal recognition initiates reorganization of the presequence translocase during protein import. EMBO J (2013) 0.87
Role of membrane contact sites in protein import into mitochondria. Protein Sci (2015) 0.84
Tim50 in Trypanosoma brucei possesses a dual specificity phosphatase activity and is critical for mitochondrial protein import. J Biol Chem (2012) 0.83
A novel import route for an N-anchor mitochondrial outer membrane protein aided by the TIM23 complex. EMBO Rep (2014) 0.82
Complex formation and turnover of mitochondrial transporters and ion channels. J Bioenerg Biomembr (2016) 0.82
Molecular insights revealing interaction of Tim23 and channel subunits of presequence translocase. Mol Cell Biol (2013) 0.82
The protein translocation systems in plants - composition and variability on the example of Solanum lycopersicum. BMC Genomics (2013) 0.80
The mitochondrial ADP/ATP carrier associates with the inner membrane presequence translocase in a stoichiometric manner. J Biol Chem (2014) 0.80
Protein sensing with engineered protein nanopores. Methods Mol Biol (2012) 0.78
A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. Biochem J (2005) 0.78
Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signals. PLoS One (2013) 0.77
Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase. Elife (2017) 0.77
The Import of Proteins into the Mitochondrion of Toxoplasma gondii. J Biol Chem (2016) 0.76
Tim62, a Novel Mitochondrial Protein in Trypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex. J Biol Chem (2015) 0.76
Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability. Mol Cell Biol (2017) 0.75
Anti-adaptors use distinct modes of binding to inhibit the RssB-dependent turnover of RpoS (σ(S)) by ClpXP. Front Mol Biosci (2015) 0.75
Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation. J Cell Biol (2016) 0.75
Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space. Cell Tissue Res (2016) 0.75
The structure of Tim50(164-361) suggests the mechanism by which Tim50 receives mitochondrial presequences. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase. J Biol Chem (2016) 0.75
Regulation of human 3β-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche. J Pharmacol Exp Ther (2014) 0.75
Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy. J Am Heart Assoc (2017) 0.75
Protein trafficking in the mitochondrial intermembrane space: mechanisms and links to human disease. Biochem J (2017) 0.75
Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50. Sci Adv (2017) 0.75
Importing mitochondrial proteins: machineries and mechanisms. Cell (2009) 5.46
The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A (2003) 5.13
Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature (2003) 3.46
Protein labeling by iTRAQ: a new tool for quantitative mass spectrometry in proteome research. Proteomics (2007) 2.97
Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell (2008) 2.97
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res (2006) 2.92
Mitochondrial protein import: from proteomics to functional mechanisms. Nat Rev Mol Cell Biol (2010) 2.87
Mitochondrial import and the twin-pore translocase. Nat Rev Mol Cell Biol (2004) 2.78
Identification and functional characterization of microRNAs involved in the malignant progression of gliomas. Brain Pathol (2009) 2.67
An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J Biol Chem (2003) 2.59
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell (2011) 2.52
Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell (2005) 2.49
The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood (2012) 2.47
Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J (2004) 2.43
Multiple pathways for sorting mitochondrial precursor proteins. EMBO Rep (2008) 2.19
Isolation of yeast mitochondria. Methods Mol Biol (2006) 2.09
The protein import machinery of mitochondria. J Biol Chem (2004) 2.02
Assembling the mitochondrial outer membrane. Nat Struct Mol Biol (2004) 2.00
Mitochondrial preprotein translocase of trypanosomatids has a bacterial origin. Curr Biol (2011) 1.98
The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell (2004) 1.98
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell (2009) 1.96
Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J (2005) 1.92
Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation. Nat Rev Mol Cell Biol (2011) 1.91
Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science (2003) 1.89
Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein. Proc Natl Acad Sci U S A (2008) 1.82
Mechanisms of protein import into mitochondria. Curr Biol (2003) 1.76
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell (2006) 1.75
Integral quantification accuracy estimation for reporter ion-based quantitative proteomics (iQuARI). J Proteome Res (2012) 1.72
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell (2008) 1.72
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol (2003) 1.71
Platelet protein interactions: map, signaling components, and phosphorylation groundstate. Arterioscler Thromb Vasc Biol (2008) 1.71
The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. EMBO Rep (2008) 1.68
Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat Cell Biol (2007) 1.64
SearchGUI: An open-source graphical user interface for simultaneous OMSSA and X!Tandem searches. Proteomics (2011) 1.63
Pam16 has an essential role in the mitochondrial protein import motor. Nat Struct Mol Biol (2004) 1.63
Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr Biol (2009) 1.62
A comprehensive interaction map of the human survival of motor neuron (SMN) complex. J Biol Chem (2006) 1.61
Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains. J Mol Biol (2012) 1.61
The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J (2007) 1.58