Published in Toxicol Pathol on August 01, 2012
Scientific and Regulatory Policy Committee (SRPC) Points to Consider : Histopathology Evaluation of the Pubertal Development and Thyroid Function Assay (OPPTS 890.1450, OPPTS 890.1500) in Rats to Screen for Endocrine Disruptors. Toxicol Pathol (2015) 0.96
RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Res (2016) 0.87
Proliferative and non-proliferative lesions of the rat and mouse integument. J Toxicol Pathol (2013) 0.80
Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. PLoS One (2015) 0.79
Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth. Cell Rep (2016) 0.79
Pathology of Aging in NOD scid gamma Female Mice. Vet Pathol (2017) 0.77
Histological characteristics of the regression of corpora lutea in wistar hannover rats: the comparisons with sprague-dawley rats. J Toxicol Pathol (2014) 0.75
Spontaneous infarcted adenoma of the mammary gland in a Wistar Hannover GALAS rat. J Toxicol Pathol (2016) 0.75
Similarity of GATA-3 Expression between Rat and Human Mammary Glands. J Toxicol Pathol (2014) 0.75
A spontaneous myoepithelial carcinoma in the mammary gland of an aged female ICR (CD-1) mouse. J Toxicol Pathol (2017) 0.75
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell (2003) 3.42
Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol Sci (2009) 3.06
Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma. Nat Genet (2011) 2.60
Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol Pathol (2010) 2.09
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev (2005) 1.92
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood (2010) 1.82
Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring. Reprod Toxicol (2004) 1.70
Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis. Arthritis Rheum (2005) 1.67
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell (2006) 1.63
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol (2009) 1.62
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. J Cell Physiol (2007) 1.51
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem (2007) 1.44
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem (2007) 1.41
Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. Proc Natl Acad Sci U S A (2010) 1.38
Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res (2009) 1.37
Morphologic characteristics of retinal degeneration induced by sodium iodate in mice. Curr Eye Res (2002) 1.37
Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis. Am J Pathol (2006) 1.32
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem (2008) 1.31
Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res (2008) 1.26
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res (2009) 1.24
Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma. Mol Cancer Res (2010) 1.19
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat Biotechnol (2005) 1.17
Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo (2011) 1.17
Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells. Anticancer Res (2010) 1.17
Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black. Part Fibre Toxicol (2013) 1.17
Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals. Am J Physiol Cell Physiol (2009) 1.16
On the lifecycle of nanocomposites: comparing released fragments and their in-vivo hazards from three release mechanisms and four nanocomposites. Small (2011) 1.11
Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. Int J Cancer (2008) 1.10
Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells. Int J Oncol (2012) 1.09
Anticancer effects of garlic and garlic-derived compounds for breast cancer control. Anticancer Agents Med Chem (2011) 1.08
Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. Am J Pathol (2006) 1.04
PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia (2013) 1.03
Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res (2013) 1.02
The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer. Endocr Relat Cancer (2009) 0.99
TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle (2007) 0.99
Hepatic enzyme induction: histopathology. Toxicol Pathol (2010) 0.99
Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials. Part Fibre Toxicol (2014) 0.98
Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer. J Histochem Cytochem (2006) 0.98
Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice. Oncol Rep (2011) 0.96
WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone. PLoS One (2013) 0.95
Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas. Breast Cancer Res Treat (2008) 0.92
Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment. Breast Cancer Res (2007) 0.91
Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. Arthritis Rheum (2007) 0.90
p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas. Carcinogenesis (2002) 0.90
Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells. Cancer Lett (2011) 0.89
Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. Lung Cancer (2012) 0.88
Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria. Arch Toxicol (2014) 0.88
Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression. Am J Pathol (2006) 0.87
CrkII transgene induces atypical mammary gland development and tumorigenesis. Am J Pathol (2009) 0.87
Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats. Mutat Res (2011) 0.86
Natural and synthetic progestins accelerate 7,12-dimethylbenz[a]anthracene-initiated mammary tumors and increase angiogenesis in Sprague-Dawley rats. Clin Cancer Res (2006) 0.86
Olfactory epithelial metaplasia and hyperplasia in female Harlan Sprague-Dawley rats following chronic treatment with polychlorinated biphenyls. Toxicol Pathol (2005) 0.86
N-methyl-N-nitrosourea-induced changes in epithelial rests of Malassez and the development of odontomas in rats. Exp Ther Med (2012) 0.86
NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice. Mol Carcinog (2005) 0.86
Green tea extract suppresses N-methyl-N-nitrosourea-induced photoreceptor apoptosis in Sprague-Dawley rats. Graefes Arch Clin Exp Ophthalmol (2014) 0.85
Mechanisms of HDAC inhibitor-induced thrombocytopenia. Eur J Pharmacol (2007) 0.85
Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters. Int J Cancer (2014) 0.84
Vinclozolin--no transgenerational inheritance of anti-androgenic effects after maternal exposure during organogenesis via the intraperitoneal route. Reprod Toxicol (2013) 0.83
Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions. Cell Cycle (2008) 0.83
Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract. Exp Toxicol Pathol (2006) 0.83
Prevention and treatment of experimental osteomyelitis in dogs with ciprofloxacin-loaded crosslinked high amylose starch implants. J Orthop Res (2004) 0.83
Abdominal cysticercosis in a cynomolgus monkey. Vet Parasitol (2009) 0.83
Morphological characterization of systemic changes in KK-Ay mice as an animal model of type 2 diabetes. In Vivo (2013) 0.83
Skeletal effects of bazedoxifene paired with conjugated estrogens in ovariectomized rats. Bone (2011) 0.82
Functional rescue of N-methyl-N-nitrosourea-induced retinopathy by nicotinamide in Sprague-Dawley rats. Curr Eye Res (2003) 0.82
Antisense oligonucleotides targeting the progesterone receptor inhibit hormone-independent breast cancer growth in mice. Breast Cancer Res (2005) 0.81
Spontaneously occurring intracranial lipomatous hamartoma in a young BALB/c mouse and a literature review. J Toxicol Pathol (2012) 0.81
Novel, low cost, highly effective, handmade steroid pellets for experimental studies. PLoS One (2013) 0.81
Curcumin suppresses N-methyl-N-nitrosourea-induced photoreceptor apoptosis in Sprague-Dawley rats. In Vivo (2013) 0.81
Pulmonary lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin-like compounds. Toxicol Pathol (2007) 0.80
Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells. Oncol Rep (2012) 0.80
The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer. Oncotarget (2014) 0.80
Human chorionic gonadotropin suppresses human breast cancer cell growth directly via p53-mediated mitochondrial apoptotic pathway and indirectly via ovarian steroid secretion. Anticancer Res (2014) 0.80
Human chorionic gonadotropin inhibits N-Methyl-N-nitrosourea-induced mammary carcinoma growth in female Lewis rats. In Vivo (2012) 0.80
Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice. In Vivo (2011) 0.80
Effects of short-term estrogen treatment on the progression of N-methyl-N-nitrosourea-induced premalignant mammary lesions in female Lewis rats. Med Mol Morphol (2011) 0.79
Estrogen and progesterone treatment mimicking pregnancy for protection from breast cancer. In Vivo (2008) 0.79
Deposition behavior of inhaled nanostructured TiO2 in rats: fractions of particle diameter below 100 nm (nanoscale) and the slicing bias of transmission electron microscopy. Inhal Toxicol (2012) 0.79
Dietary docosahexaenoic acid protects against N-methyl-N-nitrosourea-induced retinal degeneration in rats. Exp Eye Res (2003) 0.79
Suppression of N-methyl-N-nitrosourea-induced photoreceptor apoptosis in rats by docosahexaenoic acid. Ophthalmic Res (2004) 0.79
Two cases of malignant peritoneal mesothelioma without asbestos exposure: cytologic and immunohistochemical features. Ann Diagn Pathol (2012) 0.78
Isolating the effects of social interactions on cancer biology. Cancer Prev Res (Phila) (2009) 0.78
Nicotinamide prevents N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats and C57BL mice. Exp Eye Res (2002) 0.78
Proceedings of the 2012 National Toxicology Program Satellite Symposium. Toxicol Pathol (2012) 0.78
Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta? Breast Cancer Res Treat (2009) 0.78
Temporal and spatial dependence of inflammatory biomarkers and suppression by fluvastatin in dextran sodium sulfate-induced rat colitis model. Dig Dis Sci (2014) 0.78
Octyl methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration. Food Chem Toxicol (2005) 0.78
Single unpurified breast tumor-initiating cells from multiple mouse models efficiently elicit tumors in immune-competent hosts. PLoS One (2013) 0.77
Nanostructured calcium silicate hydrate seeds accelerate concrete hardening: a combined assessment of benefits and risks. Arch Toxicol (2012) 0.77
Rapid induction of cataract by a single intraperitoneal administration of N-methyl-N-nitrosourea in 15-day-old Sprague-Dawley (Jcl: SD) rats. Exp Toxicol Pathol (2002) 0.77
MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Res Treat (2010) 0.77
Neurotoxic effects of zoniporide: a selective inhibitor of the NA+/H+ exchanger isoform 1. Toxicol Pathol (2008) 0.77
Early elevation in circulating levels of C-telopeptides of type II collagen predicts structural damage in articular cartilage in the rodent model of collagen-induced arthritis. Arthritis Rheum (2006) 0.77
Targeting progesterone receptors in breast cancer. Vitam Horm (2013) 0.76
Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia. Medicina (B Aires) (2010) 0.76
N -ethyl- N -nitrosourea induces retinal photoreceptor damage in adult rats. J Toxicol Pathol (2012) 0.76
PARP inhibitors accelerate N-methyl-N-nitrosourea-induced cataractogenesis in Sprague-Dawley rats. In Vivo (2007) 0.76
Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci (2011) 0.76