Published in Cold Spring Harb Perspect Biol on September 01, 2012
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Microtubules and their role in cellular stress in cancer. Front Oncol (2014) 1.15
Folliculin regulates ampk-dependent autophagy and metabolic stress survival. PLoS Genet (2014) 1.00
Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci (2015) 0.96
Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells. J Biol Chem (2013) 0.93
Restoration of mitochondria function as a target for cancer therapy. Drug Discov Today (2015) 0.93
The Intercellular Metabolic Interplay between Tumor and Immune Cells. Front Immunol (2014) 0.86
ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Mol Cell (2015) 0.85
Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells. Mar Drugs (2015) 0.85
p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget (2015) 0.82
The Warburg effect and drug resistance. Br J Pharmacol (2016) 0.81
Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma. Arch Biochem Biophys (2014) 0.81
PSF knockdown enhances apoptosis via downregulation of LC3B in human colon cancer cells. Biomed Res Int (2013) 0.80
Autophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal. Cell Death Dis (2014) 0.80
Identification of BECN1 and ATG14 Coiled-Coil Interface Residues That Are Important for Starvation-Induced Autophagy. Biochemistry (2016) 0.79
The Streptococcus pyogenes NAD(+) glycohydrolase modulates epithelial cell PARylation and HMGB1 release. Cell Microbiol (2015) 0.79
The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells. PLoS One (2016) 0.79
MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation. PLoS One (2015) 0.79
The CCL2 chemokine is a negative regulator of autophagy and necrosis in luminal B breast cancer cells. Breast Cancer Res Treat (2015) 0.79
Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. Proc Natl Acad Sci U S A (2016) 0.79
Inhibition of an NAD⁺ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl Med (2015) 0.78
Blue-Print Autophagy: Potential for Cancer Treatment. Mar Drugs (2016) 0.77
Role of autophagy in apoptotic regulation by Akt in pancreatic cancer. Anticancer Res (2014) 0.77
A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells. Int J Mol Sci (2016) 0.77
Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells. J Cell Mol Med (2014) 0.77
Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. Cell Death Differ (2014) 0.76
Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells. Cell Death Dis (2014) 0.76
Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy include senescence, necrosis, and autophagy, but not apoptosis. Cancer Med (2015) 0.76
Caveolin-1 in the regulation of cell metabolism: a cancer perspective. Mol Cancer (2016) 0.76
SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers. Autophagy (2016) 0.75
The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma. Oncotarget (2016) 0.75
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget (2017) 0.75
Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy. Oncotarget (2016) 0.75
Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci (2017) 0.75
Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS. Oncotarget (2016) 0.75
Metabolomic Analysis of Mouse Embryonic Fibroblast Cells in Response to Autophagy Induced by Acute Starvation. Sci Rep (2016) 0.75
Malnutrition in Healthy Individuals Results in Increased Mixed Cytokine Profiles, Altered Neutrophil Subsets and Function. PLoS One (2016) 0.75
Database screening of herbal monomers regulating autophagy by constructing a "disease-gene-drug" network. BMC Complement Altern Med (2014) 0.75
Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo. Mol Endocrinol (2015) 0.75
Gene Signature Associated with Upregulation of the Wnt/β-Catenin Signaling Pathway Predicts Tumor Response to Transarterial Embolization. J Vasc Interv Radiol (2017) 0.75
Transformation with oncogenic Ras and the simian virus 40 T antigens induces caspase-dependent sensitivity to fatty acid biosynthetic inhibition. J Virol (2015) 0.75
Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. Sci Rep (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
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mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
Autophagy regulates lipid metabolism. Nature (2009) 13.33
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature (2009) 13.28
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 11.09
PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell (2001) 11.04
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell (2009) 9.24
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Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell (2005) 9.06
Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92
ATP-citrate lyase links cellular metabolism to histone acetylation. Science (2009) 8.82
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Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
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Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
The BCL-2 family reunion. Mol Cell (2010) 7.32
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol (2006) 6.47
Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol (2007) 6.45
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
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hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem (2005) 5.22
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev (2001) 5.12
Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol (2001) 5.10
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell (2002) 5.06
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
Necrotic death as a cell fate. Genes Dev (2006) 4.93
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell (2007) 4.55
MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res (2009) 4.32
GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell (2007) 4.22
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell (2000) 4.10
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science (2010) 4.01
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol (2003) 3.84
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci U S A (2009) 3.84
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell (2010) 3.63
The complexity of p53 stabilization and activation. Cell Death Differ (2006) 3.61
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest (2009) 3.55
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell (2007) 3.54
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ (2007) 3.50
Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J Biol Chem (2006) 3.45
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev (2010) 3.40
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
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Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene (2006) 3.17
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci (2010) 3.17
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol (2007) 3.10
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) (2009) 2.94
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Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun (2001) 2.86
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J (2003) 2.84
Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev (2007) 2.69
Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol (2009) 2.61
Metabolic catastrophe as a means to cancer cell death. J Cell Sci (2007) 2.58
ROS and p53: a versatile partnership. Free Radic Biol Med (2008) 2.52
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene (2002) 2.50
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol (2007) 2.45
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Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. Cardiovasc Res (2010) 2.30
How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res (2006) 2.26
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood (2007) 2.24
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature (2010) 2.23
Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol (2009) 2.20
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A (2011) 2.06
Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem (2007) 2.03
Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J Biol Chem (2007) 2.02
Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J Cell Biol (2008) 2.02
Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. J Neurochem (2009) 1.97
BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death Differ (2006) 1.97
The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose. Mol Cell (2010) 1.95
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The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol (2011) 4.78
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Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol (2008) 3.23
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol (2007) 2.45
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukoc Biol (2008) 2.34
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood (2007) 2.24
Metabolic pathways in T cell fate and function. Trends Immunol (2012) 1.97
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A (2011) 1.86
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Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A (2007) 1.77
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol (2011) 1.62
Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. J Biol Chem (2008) 1.58
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest (2014) 1.58
The metabolic life and times of a T-cell. Immunol Rev (2010) 1.57
Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer Res (2011) 1.53
Homeostatic control of lymphocyte survival: potential origins and implications. Nat Immunol (2002) 1.40
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metab (2006) 1.36
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol (2014) 1.35
Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proc Natl Acad Sci U S A (2012) 1.32
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. J Biol Chem (2010) 1.27
IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol (2010) 1.22
An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. Biochem J (2009) 1.19
New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci (2008) 1.10
Retracted Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat Immunol (2013) 1.09
Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. Mol Biol Cell (2008) 1.08
Activated lymphocytes as a metabolic model for carcinogenesis. Cancer Metab (2013) 1.07
Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Mol Biol Cell (2011) 1.07
Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Res (2010) 1.06
PKM2 and the tricky balance of growth and energy in cancer. Mol Cell (2011) 1.05
Glucose metabolism as a target of histone deacetylase inhibitors. Mol Endocrinol (2008) 1.01
The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer Res (2010) 1.00
Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol (2013) 0.97
The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology (2011) 0.96
ER stress modulates cellular metabolism. Biochem J (2011) 0.95
Autophagy: not good OR bad, but good AND bad. Autophagy (2009) 0.93
Cell metabolism: an essential link between cell growth and apoptosis. Biochim Biophys Acta (2010) 0.92
Mechanisms and methods in glucose metabolism and cell death. Methods Enzymol (2008) 0.92
Metabolic regulation of Akt: roles reversed. J Cell Biol (2006) 0.90
Matched and mismatched metabolic fuels in lymphocyte function. Semin Immunol (2013) 0.88
T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. Eur J Immunol (2005) 0.87
Novel therapeutic targets of tumor metabolism. Cancer J (2015) 0.82
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TGF-beta: a new role for an old AktTOR. Dev Cell (2009) 0.80
Lymphocyte selection by starvation: glucose metabolism and cell death. Trends Immunol (2005) 0.79
Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. J Cell Biochem (2015) 0.78
Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proc Natl Acad Sci U S A (2013) 0.77
Methed-up FOXOs can't in-Akt-ivate. Mol Cell (2008) 0.77
Metabolic reprogramming of the immune response in the tumor microenvironment. Cancer Biol Ther (2013) 0.75