Published in Proc Natl Acad Sci U S A on June 29, 2012
Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. J Biol Chem (2014) 1.48
AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer. Cancer Res (2014) 1.29
Modulation of B-cell exosome proteins by gamma herpesvirus infection. Proc Natl Acad Sci U S A (2013) 1.14
AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV. Front Immunol (2013) 1.07
Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene (2014) 1.04
Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update. Curr Opin Virol (2013) 0.99
Viral activation of cellular metabolism. Virology (2015) 0.96
Natural compounds as regulators of the cancer cell metabolism. Int J Cell Biol (2013) 0.91
An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway. PLoS Pathog (2014) 0.89
Enolase-1 is a therapeutic target in endometrial carcinoma. Oncotarget (2015) 0.88
The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism. Biochim Biophys Acta (2013) 0.87
The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: adipophilin. PLoS One (2012) 0.87
Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival. PLoS Pathog (2015) 0.87
Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Expert Rev Clin Immunol (2014) 0.86
A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling. PLoS Pathog (2015) 0.84
Neutral lipid alterations in human herpesvirus 8-infected HUVEC cells and their possible involvement in neo-angiogenesis. BMC Microbiol (2015) 0.84
Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line. J Exp Clin Cancer Res (2013) 0.83
The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis. J Virol (2013) 0.80
Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. Proc Natl Acad Sci U S A (2016) 0.79
Lymphocyte glucose and glutamine metabolism as targets of the anti-inflammatory and immunomodulatory effects of exercise. Mediators Inflamm (2014) 0.79
Metabolic reprogramming: a hallmark of viral oncogenesis. Oncogene (2015) 0.79
Nutrition and metabolic correlates of obesity and inflammation: clinical considerations. J Nutr (2015) 0.78
An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS Pathog (2016) 0.78
Lipids as tumoricidal components of human α-lactalbumin made lethal to tumor cells (HAMLET): unique and shared effects on signaling and death. J Biol Chem (2013) 0.78
Emmprin and KSHV: new partners in viral cancer pathogenesis. Cancer Lett (2013) 0.78
The PI3K pathway in B cell metabolism. Crit Rev Biochem Mol Biol (2016) 0.78
Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolism. PLoS One (2014) 0.77
Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling. Oncotarget (2016) 0.76
Glycolysis, Glutaminolysis, and Fatty Acid Synthesis Are Required for Distinct Stages of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol (2017) 0.75
Inhibition of fatty acid synthase is protective in pulmonary hypertension. Br J Pharmacol (2016) 0.75
Recent advances in understanding Kaposi's sarcoma-associated herpesvirus. F1000Res (2016) 0.75
Roseomics: a blank slate. Curr Opin Virol (2014) 0.75
Activation of cellular metabolism during latent Kaposi's Sarcoma herpesvirus infection. Curr Opin Virol (2016) 0.75
Metabolism pathways in chronic lymphocytic leukemia. Leuk Lymphoma (2015) 0.75
The KSHV K1 Protein Modulates AMPK Function to Enhance Cell Survival. PLoS Pathog (2016) 0.75
Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Mol Metab (2016) 0.75
Replication of the Shrimp Virus WSSV Depends on Glutamate-Driven Anaplerosis. PLoS One (2016) 0.75
A viral kinase mimics S6 kinase to enhance cell proliferation. Proc Natl Acad Sci U S A (2016) 0.75
Use of confocal laser endomicroscopy with a fluorescently labeled fatty acid to diagnose colorectal neoplasms. Oncotarget (2017) 0.75
Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma. PLoS Pathog (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
On respiratory impairment in cancer cells. Science (1956) 14.07
Cancer cell metabolism: Warburg and beyond. Cell (2008) 11.80
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46
Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35
Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61
Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol (2006) 4.47
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc Natl Acad Sci U S A (2011) 3.66
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition (2000) 3.58
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell (2007) 3.54
Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J Biol Chem (2006) 3.45
IL-7 enhances the survival and maintains the size of naive T cells. J Immunol (2001) 3.39
Activation of T and B lymphocytes in vitro. III. Presence of Ia determinants on allogeneic effect factor. J Exp Med (1974) 3.29
Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci U S A (2000) 2.93
Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS. J Clin Oncol (2005) 2.16
Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol (2010) 2.00
Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR. Cancer Cell (2003) 1.86
Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the treatment of patients with EBV-positive relapsed Hodgkin's disease. Blood (1998) 1.86
Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling. Blood (2006) 1.83
Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells. Proc Natl Acad Sci U S A (2010) 1.65
Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif (2008) 1.65
Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas. Blood (2010) 1.60
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J Biol Chem (2007) 1.56
Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci U S A (2004) 1.52
The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. J Virol (2004) 1.51
The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors. Cancer Res (2004) 1.50
Sugar and fat - that's where it's at: metabolic changes in tumors. Breast Cancer Res (2008) 1.49
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. Cancer Res (2006) 1.49
Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res (2002) 1.47
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas. Biochem Pharmacol (2006) 1.11
The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma. Leukemia (2010) 1.10
Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma. Am J Pathol (2011) 0.94
Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induces apoptosis. J Nutr (2005) 0.88
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci U S A (2005) 5.88
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol (2011) 4.78
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature (2007) 4.59
Metabolic regulation of T lymphocytes. Annu Rev Immunol (2013) 3.67
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell (2007) 3.54
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med (2009) 3.43
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol (2008) 3.23
Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR. J Virol (2002) 2.71
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54
EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3. Cancer Res (2008) 2.46
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol (2007) 2.45
Discovery of a viral NLR homolog that inhibits the inflammasome. Science (2011) 2.36
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukoc Biol (2008) 2.34
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood (2007) 2.24
Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol (2004) 2.20
Moving forward in HIV-associated cancer. J Clin Oncol (2014) 2.14
The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev (2012) 2.01
Metabolic pathways in T cell fate and function. Trends Immunol (2012) 1.97
Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol (2002) 1.94
Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring) (2011) 1.90
Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes (2003) 1.88
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A (2011) 1.86
Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling. Blood (2006) 1.83
Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB J (2004) 1.79
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A (2007) 1.77
Ancient host-pathogen associations maintained by specificity of chemotaxis and antibiosis. PLoS Biol (2006) 1.73
In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell (2007) 1.68
SYBR green-based real-time quantitative PCR assay for detection of West Nile Virus circumvents false-negative results due to strain variability. J Clin Microbiol (2004) 1.64
Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. J Virol (2006) 1.63
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol (2011) 1.62
Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation (2004) 1.60
Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas. Blood (2010) 1.60
Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. J Biol Chem (2008) 1.58
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest (2014) 1.58
Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Cancer Res (2008) 1.57
The metabolic life and times of a T-cell. Immunol Rev (2010) 1.57
Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection. J Virol (2008) 1.57
Toll-like receptor signaling controls reactivation of KSHV from latency. Proc Natl Acad Sci U S A (2009) 1.55
Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis. Cancer Lett (2009) 1.54
Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma. PLoS Pathog (2009) 1.53
Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer Res (2011) 1.53
The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. J Virol (2004) 1.51
The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors. Cancer Res (2004) 1.50
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab (2006) 1.50
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. Cancer Res (2006) 1.49
Early experience after developing a pathology laboratory in Malawi, with emphasis on cancer diagnoses. PLoS One (2013) 1.48
Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. J Biol Chem (2014) 1.48
Faster quantitative real-time PCR protocols may lose sensitivity and show increased variability. Nucleic Acids Res (2005) 1.47
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
Renal aplasia in humans is associated with RET mutations. Am J Hum Genet (2008) 1.41
Homeostatic control of lymphocyte survival: potential origins and implications. Nat Immunol (2002) 1.40
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol (2013) 1.38
More on HIV-associated Kaposi's sarcoma. N Engl J Med (2008) 1.38
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metab (2006) 1.36
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol (2014) 1.35
Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphoma. Blood (2007) 1.34
Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy. J Virol (2006) 1.32
Incidence and timing of cancer in HIV-infected individuals following initiation of combination antiretroviral therapy. Clin Infect Dis (2013) 1.31
Metabolic stress in autophagy and cell death pathways. Cold Spring Harb Perspect Biol (2012) 1.30
Real-time quantitative PCR analysis of viral transcription. Methods Mol Biol (2005) 1.29
Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med (2010) 1.29
DiffSplice: the genome-wide detection of differential splicing events with RNA-seq. Nucleic Acids Res (2012) 1.28
The tumor microenvironment controls primary effusion lymphoma growth in vivo. Cancer Res (2004) 1.28
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. J Biol Chem (2010) 1.27
Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS One (2012) 1.27
The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma. J Clin Invest (2006) 1.26
Whole-genome transcription profiling of rhesus monkey rhadinovirus. J Virol (2005) 1.24
Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression. Breast Cancer Res Treat (2011) 1.24
IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol (2010) 1.22
Epstein-Barr virus lytic infection is required for efficient production of the angiogenesis factor vascular endothelial growth factor in lymphoblastoid cell lines. J Virol (2005) 1.22
Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions. Int J Cancer (2007) 1.21
An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. Biochem J (2009) 1.19
Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer. Clin Cancer Res (2012) 1.15
Azidothymidine inhibits NF-kappaB and induces Epstein-Barr virus gene expression in Burkitt lymphoma. Blood (2005) 1.14
Modulation of B-cell exosome proteins by gamma herpesvirus infection. Proc Natl Acad Sci U S A (2013) 1.14
Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem (2004) 1.14
Potential pitfalls in microRNA profiling. Wiley Interdiscip Rev RNA (2012) 1.14
Identification and characterization of the Orf49 protein of Kaposi's sarcoma-associated herpesvirus. J Virol (2006) 1.12
A genetic system for rhesus monkey rhadinovirus: use of recombinant virus to quantitate antibody-mediated neutralization. J Virol (2006) 1.12
Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression. J Virol (2005) 1.11
Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer. Cancer Med (2014) 1.10
New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci (2008) 1.10
Kinetics of expression of rhesus monkey rhadinovirus (RRV) and identification and characterization of a polycistronic transcript encoding the RRV Orf50/Rta, RRV R8, and R8.1 genes. J Virol (2002) 1.09