Published in J Biol Chem on December 04, 2007
p53 and metabolism. Nat Rev Cancer (2009) 5.05
Transcriptional regulation by p53. Cold Spring Harb Perspect Biol (2010) 3.16
Retracted GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol Cell (2009) 2.30
Metabolic regulation by p53. J Mol Med (Berl) (2011) 2.26
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. J Biol Chem (2010) 1.60
Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas. Blood (2010) 1.60
Regulation of protein synthesis by ionizing radiation. Mol Cell Biol (2009) 1.52
Role of p53 serine 46 in p53 target gene regulation. PLoS One (2011) 1.48
AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem (2008) 1.44
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. J Biol Chem (2010) 1.40
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells. PLoS One (2012) 1.38
AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer. Cancer Res (2012) 1.31
Metabolic stress in autophagy and cell death pathways. Cold Spring Harb Perspect Biol (2012) 1.30
Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J Cell Biol (2011) 1.30
The complexities of obesity and diabetes with the development and progression of pancreatic cancer. Biochim Biophys Acta (2010) 1.29
Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest (2010) 1.27
Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense. Semin Cancer Biol (2008) 1.27
Human pyruvate kinase M2: a multifunctional protein. Protein Sci (2010) 1.23
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer (2011) 1.21
Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell (2014) 1.21
Targeting AMPK for cancer prevention and treatment. Oncotarget (2015) 1.13
Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1. J Biol Chem (2012) 1.08
The effect of metformin and thiazolidinedione use on lung cancer in diabetics. BMC Cancer (2012) 1.08
Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet (2013) 1.07
Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease. J Neurosci (2012) 1.06
Berberine inhibits doxorubicin-triggered cardiomyocyte apoptosis via attenuating mitochondrial dysfunction and increasing Bcl-2 expression. PLoS One (2012) 1.05
Life or death: p53-induced apoptosis requires DNA binding cooperativity. Cell Cycle (2010) 1.05
5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat. Int J Cancer (2011) 1.04
Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation. J Biol Chem (2012) 1.04
The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine. Genes Cancer (2011) 1.02
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc Natl Acad Sci U S A (2013) 1.02
p53: the attractive tumor suppressor in the cancer research field. J Biomed Biotechnol (2010) 1.02
Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status. Cancer (2011) 1.00
Novel Insights into the Interplay between Apoptosis and Autophagy. Int J Cell Biol (2012) 1.00
To be, or not to be: functional dilemma of p53 metabolic regulation. Curr Opin Oncol (2014) 1.00
The tangled circuitry of metabolism and apoptosis. Mol Cell (2013) 0.99
AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma. J Biol Chem (2010) 0.99
Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells. Mol Med Rep (2012) 0.98
Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention. Mol Clin Oncol (2012) 0.96
AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis. Genes Cancer (2012) 0.94
AMP-Activated Protein Kinase α 2 Isoform Suppression in Primary Breast Cancer Alters AMPK Growth Control and Apoptotic Signaling. Genes Cancer (2013) 0.94
IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS One (2011) 0.92
Cell metabolism: an essential link between cell growth and apoptosis. Biochim Biophys Acta (2010) 0.92
Generation of digital responses in stress sensors. J Biol Chem (2009) 0.91
AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol (2013) 0.90
Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH. Transl Oncol (2012) 0.89
Reversible induction of translational isoforms of p53 in glucose deprivation. Cell Death Differ (2015) 0.88
Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells. Am J Respir Cell Mol Biol (2010) 0.88
Ginsenoside Rg-1 protects retinal pigment epithelium (RPE) cells from cobalt chloride (CoCl2) and hypoxia assaults. PLoS One (2013) 0.88
Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells. PLoS One (2015) 0.86
Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy. Cell Death Dis (2013) 0.86
A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation. Diabetes (2013) 0.86
Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy. Int J Mol Sci (2015) 0.86
p53-Dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene. Cell Cycle (2013) 0.84
Metabolic preconditioning of cells with AICAR-riboside: improved cryopreservation and cell-type specific impacts on energetics and proliferation. Cryobiology (2010) 0.84
AMPK couples p73 with p53 in cell fate decision. Cell Death Differ (2014) 0.83
Phospho-ΔNp63α/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistance. Cell Cycle (2012) 0.83
AMPK as a potential anticancer target - friend or foe? Curr Pharm Des (2014) 0.82
AMPK potentiates hypertonicity-induced apoptosis by suppressing NFκB/COX-2 in medullary interstitial cells. J Am Soc Nephrol (2011) 0.82
Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II. EBioMedicine (2017) 0.82
Entosis Is Induced by Glucose Starvation. Cell Rep (2017) 0.81
Identification of the genes chemosensitizing hepatocellular carcinoma cells to interferon-α/5-fluorouracil and their clinical significance. PLoS One (2013) 0.81
The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism. Oncotarget (2015) 0.81
Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice. Mol Nutr Food Res (2013) 0.81
Novel nucleolar pathway connecting intracellular energy status with p53 activation. J Biol Chem (2011) 0.80
BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells. Int J Oncol (2012) 0.79
High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity. J Exp Clin Cancer Res (2014) 0.79
p53 and metabolism: old player in a new game. Transcription (2012) 0.79
Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. Cell Cycle (2013) 0.79
Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the α1 or the α2 isoform of the catalytic domain of AMPK. BMC Nephrol (2013) 0.76
Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells. Oncotarget (2016) 0.76
The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis. Carcinogenesis (2009) 0.76
The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. Sci Rep (2015) 0.75
Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells. Evid Based Complement Alternat Med (2016) 0.75
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2. J Exp Clin Cancer Res (2017) 0.75
Prognostic significance of AMPK in human malignancies: A meta-analysis. Oncotarget (2016) 0.75
Up-regulating telomerase and tumor suppressors: focusing on anti-aging interventions at the population level. Aging Dis (2013) 0.75
MYC and AMPK-Save Energy or Die! Front Cell Dev Biol (2017) 0.75
Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase. Sci Rep (2017) 0.75
Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells. PLoS One (2017) 0.75
Oncogenic mutations of ALK kinase in neuroblastoma. Nature (2008) 5.80
Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res (2003) 3.50
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity (2004) 3.25
Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res (2006) 2.86
Multigene mutation analysis of metastatic lymph nodes in non-small cell lung cancer diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration. Chest (2011) 2.03
Multiplicity of the interactions of Wnt proteins and their receptors. Cell Signal (2006) 2.01
Biology of neuroblastomas that were found by mass screening at 6 months of age in Japan. Pediatr Blood Cancer (2006) 1.99
Prediction of MYCN amplification in neuroblastoma using serum DNA and real-time quantitative polymerase chain reaction. J Clin Oncol (2005) 1.99
Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J (2009) 1.97
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J (2007) 1.95
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med (2006) 1.94
Expression profiling using a tumor-specific cDNA microarray predicts the prognosis of intermediate risk neuroblastomas. Cancer Cell (2005) 1.94
Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling. Dev Cell (2008) 1.89
Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. J Biol Chem (2004) 1.80
Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification. Clin Cancer Res (2010) 1.79
Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression. J Natl Cancer Inst (2002) 1.78
PPM1D is a potential target for 17q gain in neuroblastoma. Cancer Res (2003) 1.75
Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter. Mol Cell Biol (2002) 1.72
Selective activation mechanisms of Wnt signaling pathways. Trends Cell Biol (2009) 1.69
Clinical and biologic features predictive of survival after relapse of neuroblastoma: a report from the International Neuroblastoma Risk Group project. J Clin Oncol (2011) 1.62
Regulation of Wnt signaling by protein-protein interaction and post-translational modifications. Exp Mol Med (2006) 1.60
HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. J Biol Chem (2001) 1.60
Origin of charge density at LaAlO3 on SrTiO3 heterointerfaces: possibility of intrinsic doping. Phys Rev Lett (2007) 1.57
CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res (2005) 1.57
Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a. Genes Cells (2007) 1.55
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Biological role of anaplastic lymphoma kinase in neuroblastoma. Am J Pathol (2005) 1.51
UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme. Cancer Res (2003) 1.49
Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9. Mol Endocrinol (2004) 1.47
Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J (2004) 1.47
LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Cancer Res (2005) 1.44
Epidermoid cyst: rare testicular tumor in children. Pediatr Radiol (2003) 1.42
Wnt-3a and Dvl induce neurite retraction by activating Rho-associated kinase. Mol Cell Biol (2004) 1.41
p73, a sophisticated p53 family member in the cancer world. Cancer Sci (2005) 1.39
New insights into the mechanism of Wnt signaling pathway activation. Int Rev Cell Mol Biol (2011) 1.37
Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol (2006) 1.36
Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med (2009) 1.36
KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death. J Biol Chem (2008) 1.31
NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. J Biol Chem (2003) 1.30
Molecular and genetic bases of neuroblastoma. Int J Clin Oncol (2012) 1.25
Thoracoscopic-assisted repair of a bochdalek hernia in an adult: a case report. J Med Case Rep (2010) 1.24
A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J Biol Chem (2002) 1.22
Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol Biol Cell (2006) 1.21
A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. Biochem Biophys Res Commun (2003) 1.19
Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis. Oncology (2008) 1.19
Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J Biol Chem (2009) 1.19
Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells. Gastroenterology (2009) 1.19
Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Development (2007) 1.16
SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4. Mol Cell Biol (2005) 1.16
Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature. Clin Cancer Res (2010) 1.15
Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma. Dis Model Mech (2012) 1.14
No advantage of dexamethasone over prednisolone for the outcome of standard- and intermediate-risk childhood acute lymphoblastic leukemia in the Tokyo Children's Cancer Study Group L95-14 protocol. J Clin Oncol (2005) 1.13
Tumor formation due to abnormalities in the beta-catenin-independent pathway of Wnt signaling. Cancer Sci (2008) 1.13
Methicillin-resistant Staphylococcus aureus-induced septic arthritis after anterior cruciate ligament reconstruction. Arthroscopy (2008) 1.12
Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. Oncogene (2005) 1.10
Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma. Cancer Med (2014) 1.10
UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination. Oncogene (2005) 1.08
Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. Mol Cell Biol (2002) 1.08
Regulation of Wnt signalling by receptor-mediated endocytosis. J Biochem (2007) 1.05
Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling. J Cell Sci (2012) 1.03
Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis. Int J Cancer (2004) 1.03
Clinicopathological relevance of UbcH10 in breast cancer. Cancer Sci (2009) 1.02
p53: the attractive tumor suppressor in the cancer research field. J Biomed Biotechnol (2010) 1.02
The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochem Biophys Res Commun (2006) 1.01
Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function. J Biol Chem (2002) 1.01
LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse. J Cell Sci (2010) 1.01
Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1. PLoS One (2011) 1.01
Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia. J Am Geriatr Soc (2005) 1.00
Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol (2010) 1.00
High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma. Int J Oncol (2009) 0.97
D-lactic acidosis in short-bowel syndrome managed with antibiotics and probiotics. J Pediatr Surg (2004) 0.97
Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J Biol Chem (2008) 0.97
Umbilicoplasty for large protruding umbilicus accompanying umbilical hernia: a simple and effective technique. Pediatr Surg Int (2004) 0.96
An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis. Mol Cancer Ther (2011) 0.96